Title:
FREEZE-DRIED PRODUCT FOR TRANSFERRING NUCLEIC ACID, OLIGONUCLEIC ACID OR DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/132873
Kind Code:
A1
Abstract:
It is intended to provide a freeze-dried product which shows a favorable performance of expressing a function when employed in transferring a gene, an antisense nucleic acid or the like, the concentration of which can be easily controlled and which can be conveniently handled and shows good keeping qualities. A freeze-dried product of a complex which contains a nucleic acid, an oligonucleic acid or a derivative thereof, a cationic polymer or a cationic lipid or a mass containing the same and an anionic polymer; a method of producing the freeze-dried product which comprises the step of blending a nucleic acid, an oligonucleic acid or a derivative thereof with a cationic polymer or a cationic lipid or a mass containing the same and an anionic polymer to form a complex, and the subsequent step of freeze-drying the same; a preparation, a reagent or a kit for transferring a nucleic acid, an oligonucleic acid or a derivative thereof which contains the freeze-dried product; and a method of transferring a nucleic acid, an oligonucleic acid or a derivative thereof into a cell which comprises using the freeze-dried product.
Inventors:
KOYAMA, Yoshiyuki (9-1 Kaminoge 1-chome, Setagaya-ku Tokyo, 93, 1580093, JP)
小山 義之 (〒93 東京都世田谷区上野毛１丁目９番１号 Tokyo, 1580093, JP)
小山 義之 (〒93 東京都世田谷区上野毛１丁目９番１号 Tokyo, 1580093, JP)
Application Number:
JP2007/060002
Publication Date:
November 22, 2007
Filing Date:
May 16, 2007
Export Citation:
Assignee:
KOYAMA, Yoshiyuki (9-1 Kaminoge 1-chome, Setagaya-ku Tokyo, 93, 1580093, JP)
小山 義之 (〒93 東京都世田谷区上野毛１丁目９番１号 Tokyo, 1580093, JP)
小山 義之 (〒93 東京都世田谷区上野毛１丁目９番１号 Tokyo, 1580093, JP)
International Classes:
C12N15/09; A61K9/19; A61K47/18; A61K47/34; A61K47/36; A61K47/42; A61K47/44; C12N15/87; A61K31/7088; A61K48/00; A61P43/00
Attorney, Agent or Firm:
TSUKUNI, Hajime (SVAX TS Bldg, 22-12 Toranomon 1-chom, Minato-ku Tokyo 01, 1050001, JP)