Title:
FRITILLARY FLOWER EXTRACTIVE PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2017/185281
Kind Code:
A1
Abstract:
A fritillary flower extractive preparation method, comprising the following steps: cold-drying, grinding, sifting, and degreasing fritillary flowers, to obtain a filter cake; drying the filter cake, adding the filter cake to absolute ethyl alcohol for ultrasonic extraction, and performing filtering to obtain an extract solution and residue; performing supercritical carbon dioxide extraction on the residue to obtain an extract liquor, using ethanol water as entrainer; after mixing the extract liquor and the extracting solution, treating the mixture with a macroporous absorption resin, and then performing eluting by using water and ethyl alcohol in sequence, concentrating, and drying, to obtain a fritillary flower extractive. During the supercritical extraction, the extraction temperature is 52-55°C, the temperature of the first separation is 45-50°C, the temperature of the second separation is 35-40°C, the extraction pressure is 30-33 MPa, the flow rate of carbon dioxide is 10-20 L/h, the frequency of receiving a product is 45-50 min per time, and the extraction time is 3-4 h. The method features a high extraction speed, high extraction precision, and low production costs.
Inventors:
ZHU XIAOTAO (CN)
Application Number:
PCT/CN2016/080473
Publication Date:
November 02, 2017
Filing Date:
April 28, 2016
Export Citation:
Assignee:
ZHU XIAOTAO (CN)
International Classes:
A61K36/8966
Foreign References:
| CN105213755A | 2016-01-06 | |||
| CN105218619A | 2016-01-06 | |||
| CN105218620A | 2016-01-06 | |||
| CN104984035A | 2015-10-21 |
Other References:
WANG, LIJIE ET AL.: "Study on Supercritical CO2 Fluid Extraction of Total Alkaloids from Fritillaria Ussuriensis Maxim", JOURNAL OF HEILONGJIANG AUGUST FIRST RECLAMATION UNIVERSITY, vol. 18, no. 3, 30 June 2006 (2006-06-30), pages 74 - 78
YE, YAOHUI ET AL.: "Advances on the Method of Extraction and Purification of Alkaloids in Fritillaria", JOURNAL OF GANNAN MEDICAL UNIVERSITY, vol. 33, no. 4, 31 August 2013 (2013-08-31), pages 629 - 634
YE, YAOHUI ET AL.: "Advances on the Method of Extraction and Purification of Alkaloids in Fritillaria", JOURNAL OF GANNAN MEDICAL UNIVERSITY, vol. 33, no. 4, 31 August 2013 (2013-08-31), pages 629 - 634
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