Title:
FTO INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2016/206573
Kind Code:
A1
Abstract:
The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
Inventors:
HUANG NIU (CN)
PENG SHIMING (CN)
PENG SHIMING (CN)
Application Number:
PCT/CN2016/086340
Publication Date:
December 29, 2016
Filing Date:
June 20, 2016
Export Citation:
Assignee:
NAT INST OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
C07C255/51; A61K31/277; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P25/16; C07C255/53
Domestic Patent References:
| WO2008119793A1 | 2008-10-09 | |||
| WO2014082544A1 | 2014-06-05 | |||
| WO2008119793A1 | 2008-10-09 | |||
| WO2014082544A1 | 2014-06-05 |
Foreign References:
| US20140148383A1 | 2014-05-29 | |||
| EP1978014A1 | 2008-10-08 |
Other References:
"The Practice of Medicinal Chemistry", 1996, ACADEMIC PRESS, pages: 203
YANG ET AL.: "FTO genotype is associated with phenotypic variability of body mass index", NATURE, 16 September 2012 (2012-09-16)
FREATHY RM ET AL.: "Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected, given its effect on BMI", DIABETES, vol. 57, no. 5, 2008, pages 1419 - 26
DINA C ET AL.: "Variation in FTO contributes to childhood obesity and severe adult obesity", NATURE GENETICS, vol. 39, no. 6, 2007, pages 724 - 6, XP002465134, DOI: 10.1038/ng2048
CHURCH ET AL.: "Overexpression of Fto leads to increased food intake and results in obesity", NATURE GENETICS, PUBLISHED ONLINE, 14 November 2010 (2010-11-14)
YANG ET AL.: "FTO genotype is associated with phenotypic variability of body mass index", NATURE, 16 September 2012 (2012-09-16)
FREATHY RM ET AL.: "Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected, given its effect on BMI", DIABETES, vol. 57, no. 5, 2008, pages 1419 - 26
DINA C ET AL.: "Variation in FTO contributes to childhood obesity and severe adult obesity", NATURE GENETICS, vol. 39, no. 6, 2007, pages 724 - 6, XP002465134, DOI: 10.1038/ng2048
CHURCH ET AL.: "Overexpression of Fto leads to increased food intake and results in obesity", NATURE GENETICS, PUBLISHED ONLINE, 14 November 2010 (2010-11-14)
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