Title:
FUDOSTEINE NEBULIZATION INHALATION SOLUTION COMPOSITION, DRUG ASSEMBLY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/017161
Kind Code:
A1
Abstract:
A fudosteine nebulization inhalation solution composition and use thereof. The fudosteine nebulization inhalation solution consists of fudosteine, a pH-adjusting agent and water. The droplet particle size of the composition is as follows: the D 90 particle size is 7.0-10.0 μm, the D 50 particle size is 2.8-4.5 μm, and the D 10 particle size is 0.5-1.5 μm; and the percent deposition of the particles with the aerodynamic particle size of 1.4-5.4 μm in the fudosteine inhalation solution is not less than 50%. In addition, further provided is a drug assembly for use in conjunction with the nebulization inhalation solution, comprising the inhalation composition, and a nebulizer and a nebulizing cup with specific parameters. The fudosteine nebulization inhalation solution composition and the assembly thereof have the advantages of a small effective dose, acting fast, high drug delivery efficiency, and the like, and are particularly effective in treating tracheal and main bronchial diseases.
Inventors:
ZHANG BAOXIAN (CN)
HU JIE (CN)
WEI HUANLI (CN)
LI CUI (CN)
GONG LI (CN)
HU JIE (CN)
WEI HUANLI (CN)
LI CUI (CN)
GONG LI (CN)
Application Number:
PCT/CN2023/107448
Publication Date:
January 25, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
BEIJING INCREASE INNOVATIVE DRUG CO LTD (CN)
International Classes:
A61K9/72; A61K9/08; A61K31/198; A61M11/00; A61M15/00; A61P11/00; A61P11/06; A61P11/10; A61P31/06
Domestic Patent References:
| WO2019119720A1 | 2019-06-27 |
Foreign References:
| CN115068450A | 2022-09-20 | |||
| CN113768910A | 2021-12-10 | |||
| CN109745301A | 2019-05-14 | |||
| CN108078964A | 2018-05-29 |
Other References:
"Respiratory and Critical Disease Medicine 2018-2019", 31 August 2019, CHINESE MEDICAL ELECTRONIC AUDIO AND VIDEO PUBLISHING HOUSE, CN, ISBN: 978-7-83005-192-1, article CHEN, RONGCHANG: "Atomization Inhalation Device", pages: 673, XP009553448
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
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