Title:
FULL-SPECTRUM HIGH-BRIGHTNESS AND HIGH-STABILITY FLUORESCENT DYES, AND SYNTHESIS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/124688
Kind Code:
A1
Abstract:
Provided in the present invention are full-spectrum high-brightness and high-stability fluorescent dyes, the dyes being one or several of the following mixed according to any ratio: 4-amido substituted naphthalimide dye, bisalkoxy substituted naphthalimide fluorescent dye, bisamino substituted naphthalimide fluorescent dye, 9, 10-bisamino substituted perylene imide, six-membered ring rhodamine dye, five-membered ring rhodamine dye, and silicon-based rhodamine dye. Compared to current commercial dyes, the fluorescent dyes of the present invention have higher photostability and narrower full width at half maximum (25 nm), and are not sensitive to various external environments including pH, polarity, and temperature. By means of the introduction of active groups such as click groups, protein tags, and drug molecules, the obtained functionalised fluorescent molecules have high biocompatibility, and can quickly and specifically dye living cells and bodies. Due to the increased photostability and fluorescent brightness, the present series of dyes can implement super-resolution fluorescence imaging in Storm, STED, and SIM modes.
Inventors:
XU ZHAOCHAO (CN)
QIAO QINGLONG (CN)
ZHOU WEI (CN)
QIAO QINGLONG (CN)
ZHOU WEI (CN)
Application Number:
PCT/CN2019/000193
Publication Date:
June 25, 2020
Filing Date:
October 10, 2019
Export Citation:
Assignee:
DALIAN INST CHEM & PHYSICS CAS (CN)
International Classes:
C09K11/06; C07D221/14; C07D473/18; C07K1/13; G01N21/64
Domestic Patent References:
| WO2018102577A1 | 2018-06-07 | |||
| WO2015102541A1 | 2015-07-09 |
Foreign References:
| CN106867515A | 2017-06-20 | |||
| CN108069967A | 2018-05-25 | |||
| CN104220877A | 2014-12-17 |
Attorney, Agent or Firm:
SHENYANG CHENCHUANG TECHNICAL PATENT AGENT LTD (CN)
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