Title:
FULLY ENCLOSED CELL INCUBATION SYSTEM
Document Type and Number:
WIPO Patent Application WO/2020/181709
Kind Code:
A1
Abstract:
Provided is a fully enclosed cell incubation system. The fully enclosed cell incubation system at least comprises the following parts: an incubator, an incubation tank, a gas flow assembly, a liquid flow assembly, a temperature adjustment assembly and a central controller. By means of the system of the present invention, a constant-temperature incubation environment is achieved, cells are incubated by means of perfusion, and a fully enclosed integrated process from cell stimulation, infection and amplification to finished product recycling is achieved. By means of axially stirring the cells and an incubation liquid in a tank body, a radial shear force is reduced as far as possible, the cells can be effectively protected, and the cell yield is improved. In the system, gases are separately introduced, it is ensured that the content of each gas component is stable in the incubation process, it can be ensured that cell incubation is not directly affected by changes of outside gases in the cell incubation process, and it is ensured that the content of each gas component is unchanged. The incubation temperature, liquid amount and gas concentration are controlled in the incubation process, the incubation environment is kept stable, manual operation is reduced, cost is reduced, the risk of operational error in the incubation process is reduced, and the incubation efficiency is improved.
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Inventors:
YU XUEJUN (CN)
XU PENG (CN)
FANG YONGJUN (CN)
FENG DONGGE (CN)
XU PENG (CN)
FANG YONGJUN (CN)
FENG DONGGE (CN)
Application Number:
PCT/CN2019/098474
Publication Date:
September 17, 2020
Filing Date:
July 31, 2019
Export Citation:
Assignee:
HUADAO SHANGHAI BIOPHARMA CO LTD (CN)
International Classes:
C12M3/00; C12M1/02; C12M1/04; C12M1/36; C12M1/38
Foreign References:
| CN102212473A | 2011-10-12 | |||
| CN205506791U | 2016-08-24 | |||
| CN109825436A | 2019-05-31 | |||
| CN105925481A | 2016-09-07 | |||
| CN105385597A | 2016-03-09 | |||
| CN101300339A | 2008-11-05 |
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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