Title:
FULLY HUMAN ANTIBODIES TO HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/045495
Kind Code:
A3
Abstract:
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect HMW-MAA in a sample. Methods of diagnosing cancer, or confirming a diagnosis of cancer, are disclosed herein that utilize these antibodies. Methods of treating a subject with cancer are also disclosed.
Inventors:
WANG XINHUI (US)
FERRONE SOLDANO (US)
FERRONE SOLDANO (US)
Application Number:
PCT/US2009/060903
Publication Date:
July 29, 2010
Filing Date:
October 15, 2009
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
WANG XINHUI (US)
FERRONE SOLDANO (US)
WANG XINHUI (US)
FERRONE SOLDANO (US)
International Classes:
C07K16/18; G01N33/574
Other References:
DESAI, S. A. ET AL.: "Characterization of human anti-high molecular weight-me lanoma-associated antigen single-chain Fv fragments isolated from a phage di splay antibody library.", CANCER RESEARCH., vol. 58, no. 11, 1 June 1998 (1998-06-01), pages 2417 - 2425, XP001157268
NORONHA, E. J. ET AL.: "Limited diversity of human scFv fragments isolated by panning a synthetic phage-display scFv library with cultured human melanoma cells.", JOURNAL OF IMMUNOLOGY, vol. 161, no. 6, 15 September 1998 (1998-09-15), pages 2968 - 2976, XP002934517
WAGNER, S. ET AL.: "Vaccination with a human high molecular weight melanoma-a ssociated antigen mimotope induces a humoral response inhibiting melanoma ce 11 growth in vitro.", JOURNAL OF IMMUNOLOGY, vol. 174, no. 2, 15 January 2005 (2005-01-15), pages 976 - 982, XP008136128
RIEMER, A. B. ET AL.: "High-molecular-weight melanoma-associated antigen mimo tope immunizations induce antibodies recognizing melanoma cells.", CANCER IMMUNOLOGY AND IMMUNOTHERAPY., vol. 54, no. 7, 24 November 2004 (2004-11-24), pages 677 - 684, XP019333147
LUO, W. ET AL.: "Differential immunogenicity of two peptides isolated by high molecular weight-melanoma-associated antigen-specific monoclonal antibodies with different affinities.", JOURNAL OF IMMUNOLOGY, vol. 174, no. 11, 1 June 2005 (2005-06-01), pages 7104 - 7110, XP008136129
NORONHA, E. J. ET AL.: "Limited diversity of human scFv fragments isolated by panning a synthetic phage-display scFv library with cultured human melanoma cells.", JOURNAL OF IMMUNOLOGY, vol. 161, no. 6, 15 September 1998 (1998-09-15), pages 2968 - 2976, XP002934517
WAGNER, S. ET AL.: "Vaccination with a human high molecular weight melanoma-a ssociated antigen mimotope induces a humoral response inhibiting melanoma ce 11 growth in vitro.", JOURNAL OF IMMUNOLOGY, vol. 174, no. 2, 15 January 2005 (2005-01-15), pages 976 - 982, XP008136128
RIEMER, A. B. ET AL.: "High-molecular-weight melanoma-associated antigen mimo tope immunizations induce antibodies recognizing melanoma cells.", CANCER IMMUNOLOGY AND IMMUNOTHERAPY., vol. 54, no. 7, 24 November 2004 (2004-11-24), pages 677 - 684, XP019333147
LUO, W. ET AL.: "Differential immunogenicity of two peptides isolated by high molecular weight-melanoma-associated antigen-specific monoclonal antibodies with different affinities.", JOURNAL OF IMMUNOLOGY, vol. 174, no. 11, 1 June 2005 (2005-06-01), pages 7104 - 7110, XP008136129
Attorney, Agent or Firm:
SIEGEL, Susan, Alpert (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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