Title:
FUNCTION-IMPROVING AGENT FOR CEREBRAL DYSFUNCTION CAUSED BY ENVIRONMENTAL CHEMICAL
Document Type and Number:
WIPO Patent Application WO/2007/139153
Kind Code:
A1
Abstract:
It is intended to provide a function-improving agent for cerebral dysfunction caused by an environmental chemical. According to the invention, the function-improving agent for cerebral dysfunction caused by an environmental chemical containing a compound having an action to inhibit the activated current of G protein-coupled inwardly-rectifying potassium channel (GIRK channel) is provided.
Inventors:
TAKAHAMA KAZUO (JP)
SOEDA FUMIO (JP)
HIRAKAWA EMI (JP)
SHIRASAKI TETSUYA (JP)
SOEDA FUMIO (JP)
HIRAKAWA EMI (JP)
SHIRASAKI TETSUYA (JP)
Application Number:
PCT/JP2007/060996
Publication Date:
December 06, 2007
Filing Date:
May 30, 2007
Export Citation:
Assignee:
UNIV KUMAMOTO (JP)
TAKAHAMA KAZUO (JP)
SOEDA FUMIO (JP)
HIRAKAWA EMI (JP)
SHIRASAKI TETSUYA (JP)
TAKAHAMA KAZUO (JP)
SOEDA FUMIO (JP)
HIRAKAWA EMI (JP)
SHIRASAKI TETSUYA (JP)
International Classes:
A61K45/00; A61K31/216; A61K31/4453; A61K31/4535; A61K31/495; A61P11/14; A61P25/00; A61P25/28; A61P39/02; A61P43/00
Domestic Patent References:
| WO2005084709A1 | 2005-09-15 | |||
| WO2007037258A1 | 2007-04-05 |
Other References:
PONTECORVO M.J. ET AL.: "Possible Cerebroprotective and In Vivo NMDA Antagonist Activities of Sigma Agents", BRAIN RESEARCH BULLETIN, vol. 26, 1991, pages 461 - 465, XP003019733
SCHNATZ S.L. ET AL.: "Cognitive Effects of Endocrine-Disrupting Chemicals in Animals", ENVIRONMENTALS HEALTH PERSPECTIVES, vol. 109, no. 12, 2001, pages 1197 - 1206, XP003019734
TAKAHAMA K. ET AL.: "Kankyo Hormone to No estrogen Juyotai - Kodogakuteki, Shinkei Kagakuteki, Bunshi Seibutsugakuteki Kenkyu no Genjo -", JAPANESE JOURNAL OF PSYCHOPHARMACOLOGY, vol. 21, 2001, pages 103 - 111, XP003019735
KELLY M.J. ET AL.: "Estrogen Modulation of G-Protein-Coupled Receptor Activation of Potassium Channels in the Central Nervous System", ANNALS NEW YORK ACADEMY OF SCIENCES, vol. 1007, 2003, pages 6 - 16, XP003019736
KELLY M.J. ET AL.: "Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system (CNS)", JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 83, 2003, pages 187 - 193, XP003019737
SCHNATZ S.L. ET AL.: "Cognitive Effects of Endocrine-Disrupting Chemicals in Animals", ENVIRONMENTALS HEALTH PERSPECTIVES, vol. 109, no. 12, 2001, pages 1197 - 1206, XP003019734
TAKAHAMA K. ET AL.: "Kankyo Hormone to No estrogen Juyotai - Kodogakuteki, Shinkei Kagakuteki, Bunshi Seibutsugakuteki Kenkyu no Genjo -", JAPANESE JOURNAL OF PSYCHOPHARMACOLOGY, vol. 21, 2001, pages 103 - 111, XP003019735
KELLY M.J. ET AL.: "Estrogen Modulation of G-Protein-Coupled Receptor Activation of Potassium Channels in the Central Nervous System", ANNALS NEW YORK ACADEMY OF SCIENCES, vol. 1007, 2003, pages 6 - 16, XP003019736
KELLY M.J. ET AL.: "Rapid effects of estrogen on G protein-coupled receptor activation of potassium channels in the central nervous system (CNS)", JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 83, 2003, pages 187 - 193, XP003019737
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi1-chome, Chuo-k, Tokyo 31, JP)
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