Title:
THE FUNGAL SREBP PATHWAY AS A TARGET FOR ANTI-FUNGAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2011/031471
Kind Code:
A3
Abstract:
Inhibition of Sre1 activity and/or expression has great potential for antifungal therapeutics. Disclosed herein are novel methods and compositions useful for the identification of novel inhibitors of Sre1 activity and/or function and the treatment of fungal infections.
Inventors:
ESPENSHADE PETER J (US)
BIEN CLARA M (US)
BIEN CLARA M (US)
Application Number:
PCT/US2010/046601
Publication Date:
August 18, 2011
Filing Date:
August 25, 2010
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
ESPENSHADE PETER J (US)
BIEN CLARA M (US)
ESPENSHADE PETER J (US)
BIEN CLARA M (US)
International Classes:
C12N15/62; A61P31/04; C12N1/15; C12N15/65; C12Q1/66; C12R1/66
Other References:
KIM, H-J. ET AL.: "Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.", J. BIOL. CHEM., vol. 279, no. 27, 2004, pages 28122 - 28131
WEBER, L. W. ET AL.: "Maintaining cholestero homeostasis: Sterol regulatory element-binding proteins.", WORLD J. GASTROENTEROL., vol. 10, no. 2, 2004, pages 3081 - 3087
RODRIGUEZ, C. ET AL.: "Modulation of ERG25 expression by LDL in vascular cells.", CARDIOBASCULAR RESEARCH, vol. 58, 2003, pages 178 - 185, XP004722317, DOI: doi:10.1016/S0008-6363(02)00856-8
WEBER, L. W. ET AL.: "Maintaining cholestero homeostasis: Sterol regulatory element-binding proteins.", WORLD J. GASTROENTEROL., vol. 10, no. 2, 2004, pages 3081 - 3087
RODRIGUEZ, C. ET AL.: "Modulation of ERG25 expression by LDL in vascular cells.", CARDIOBASCULAR RESEARCH, vol. 58, 2003, pages 178 - 185, XP004722317, DOI: doi:10.1016/S0008-6363(02)00856-8
Attorney, Agent or Firm:
RUSSELL, Hathaway, P. et al. (Foley Hoag LLPSeaport West, 155 Seaport Boulevar, Boston MA, US)
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