Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
FUNGICIDAL HALOMETHYL KETONES AND HYDRATES
Document Type and Number:
WIPO Patent Application WO/2020/056090
Kind Code:
A1
Abstract:
Disclosed are compounds of Formulae 1 and 10 including all geometric and stereoisomers, tautomers, N oxides, and salts thereof, wherein E, L, J, A, T, R1, R2a, R2b, X, Y, R6a, R6b and R29 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

Inventors:
PASTERIS ROBERT JAMES (US)
CHITTABOINA SRINIVAS (IN)
REDDY RAVISEKHARA P (IN)
MCMAHON TRAVIS CHANDLER (US)
WANG HENGBIN (US)
CREWS JR ALVIN DONALD (US)
HIE LIANA (US)
REED EARL WILLIAM (US)
Application Number:
PCT/US2019/050750
Publication Date:
March 19, 2020
Filing Date:
September 12, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
FMC CORP (US)
International Classes:
A01N43/56; A01N43/28; A01N43/76; A01N43/78; C07D231/14; C07D263/34; C07D275/03; C07D277/56; C07D317/22; C07D405/12; C07D405/14; C07D411/12; C07D413/12; C07D417/12
Domestic Patent References:
WO2018080859A12018-05-03
WO2017085100A12017-05-26
WO2017178549A12017-10-19
WO2018080859A12018-05-03
WO2018118781A12018-06-28
WO2018187553A12018-10-11
WO2019010192A12019-01-10
WO2003024222A12003-03-27
WO1991013546A11991-09-19
WO2013009971A12013-01-17
WO2009132785A12009-11-05
WO2011051243A12011-05-05
WO1999040081A11999-08-12
WO2001014339A22001-03-01
WO2003035617A22003-05-01
WO2011044213A12011-04-14
WO2007017450A12007-02-15
WO2004047538A12004-06-10
WO2004108663A12004-12-16
WO2006058699A12006-06-08
WO2006058700A12006-06-08
WO2008110355A12008-09-18
WO2009030469A12009-03-12
WO2009049716A22009-04-23
WO2009087098A22009-07-16
Foreign References:
JP2001335550A2001-12-04
US20020065246A12002-05-30
US6350892B12002-02-26
US3060084A1962-10-23
US4172714A1979-10-30
US4144050A1979-03-13
US3920442A1975-11-18
DE3246493A11984-06-20
US5180587A1993-01-19
US5232701A1993-08-03
US5208030A1993-05-04
GB2095558A1982-10-06
US3299566A1967-01-24
US3235361A1966-02-15
US3309192A1967-03-14
US2891855A1959-06-23
US20110064324W2011-12-12
US6406690B12002-06-18
Other References:
J.P. DOUCET ET AL: "Structure-activity relationship study of trifluoromethylketones: inhibitors of insect juvenile hormone esterase", SAR AND QSAR IN ENVIRONMENTAL RESEARCH, vol. 24, no. 6, 1 June 2013 (2013-06-01), GB, pages 481 - 499, XP055642633, ISSN: 1062-936X, DOI: 10.1080/1062936X.2013.792499
PIETTRE S R ET AL: "A New Strategy for the Conversion of Aldehydes into Difluoromethyl Ketones", TETRAHEDRON LETTERS, ELSEVIER LTD, AMSTERDAM, NL, vol. 37, no. 27, 1 July 1996 (1996-07-01), pages 4711 - 4712, XP004028999, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)00947-1
CHRISTIAN HARCKEN ET AL: "Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 12, 11 December 2014 (2014-12-11), US, pages 1318 - 1323, XP055643349, ISSN: 1948-5875, DOI: 10.1021/ml500387y
M. M. A. EL-GENDY, U W. HAWAS, M. JASPARS: "Novel Bioactive Metabolites from a Marine Derived Bacterium Nocardia sp. ALAA 2000", JOURNAL OF ANTIBIOTICS, vol. 61, no. 6, 1 June 2008 (2008-06-01), pages 379 - 386, XP002795703, DOI: https://doi.org/10.1038/ja.2008.53
ERNEST L. ELIELSAMUEL H. WILEN: "Seed Treatment: Progress and Prospects", 1994, JOHN WILEY & SONS
ORGANIC LETTERS, vol. 22, no. 17, 2006, pages 3745 - 3748
TETRAHEDRON, vol. 47, 1991, pages 3207 - 3258
CHEM. COMMUNICATIONS, vol. 49, no. 95, 2013, pages 11133 - 11148
JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 22, 1987, pages 5026 - 5030
CHEMICAL COMMUNICATIONS, vol. 49, no. 95, 2013, pages 11133 - 11148
JOURNAL OF FLUORINE CHEMISTRY, vol. 18, 1981, pages 117 - 129
JOURNAL CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, vol. 2, 1989, pages 83 - 84
JOURNAL OF FLUORINE CHEMISTRY, vol. 44, 1989, pages 377 - 394
"Angew. Chem.", vol. 37, 1998, pages: 820 - 821
J. ORG. CHEM., vol. 64, 1999, pages 2873
CHEM. COMMUN., vol. 48, 2012, pages 9610
TETRAHEDRON, vol. 51, 1995, pages 2573 - 2584
TETRAHEDRON LETTERS, vol. 48, 2007, pages 6372 - 6376
EUR. J. ORG. CHEM., 2013, pages 3658 - 3661
"Master Organic Chemistry", ON ACETALS AND HEMIACETALS, 28 May 2010 (2010-05-28), Retrieved from the Internet
"Preparative Organic Chemistry", 1972, WILEY, pages: 381 - 387
MAGNETIC RESONANCE IN CHEMISTRY, vol. 29, 1991, pages 675 - 678
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, WILEY
WATKINS ET AL.: "Handbook of Insecticide Dust Diluents and Carriers", 1950, DORLAND BOOKS
SISELYWOOD: "McCutcheon's Emulsifiers and Detergents", 1964, THE MANUFACTURING CONFECTIONER PUBLISHING CO.
A. S. DAVIDSONB. MILWIDSKY: "Synthetic Detergents,", 1987, JOHN WILEY AND SONS
BROWNING: "Agglomeration", CHEMICAL ENGINEERING, vol. 2, 4 December 1967 (1967-12-04), pages 147 - 48
"Perry's Chemical Engineer's Handbook", 1963, MCGRAW-HILL, pages: 8 - 57
T. S. WOODS: "Proceedings of the 9th International Congress on Pesticide Chemistry", 1999, THE ROYAL SOCIETY OF CHEMISTRY, article "The Formulator's Toolbox - Product Forms for Modern Agriculture'' in Pesticide Chemistry and Bioscience, The Food-Environment Challenge", pages: 120 - 133
KLINGMAN: "Weed Control as a Science", 1961, JOHN WILEY AND SONS, INC., pages: 81 - 96
HANCE ET AL.: "Weed Control Handbook", 1989, BLACKWELL SCIENTIFIC PUBLICATIONS
"Developments in formulation technology", 2000, PJB PUBLICATIONS
K. H. KUCK ET AL.: "Modern Selective Fungicides - Properties, Applications and Mechanisms of Action,", 1995, pages: 205 - 258
"The Pesticide Manual", 2003, BRITISH CROP PROTECTION COUNCIL
"The BioPesticide Manual", 2001, BRITISH CROP PROTECTION COUNCIL
Attorney, Agent or Firm:
STERNBERG, Charlene G. et al. (US)
Download PDF:
Claims:
CLAIMS

What is claimed is:

1. A compound selected from Formula 1, tautomers, A -oxides, and salts thereof,

1 wherein

T is selected from the group consisting of:

T-l T-2 T-3

wherein the bond extending to the left is attached to A;

R1 is CF3, CHF2, CCl3, CHCl2, CF2Cl, CFCl2 or CHFC1;

W is O, S or NR3;

R3 is H, cyano, nitro, C(=0)OH, benzyl, C1-C4 alkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, OR3a or NR3bR3c;

R3a is H, benzyl, ^-C^ alkyl, C2-C4 alkylcarbonyl or C2-C4 haloalkylcarbonyl;

R3b is H, CrC4 alkyl, C2-C4 alkylcarbonyl or C2-C4 haloalkylcarbonyl;

R3C is H or CrC4 alkyl; or

R3b and R3c are taken together to form a 4- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl groups;

X is O, S or NR5a;

Y is O, S or NR5b;

R5a and R5b are each independently H, hydroxy or C \ -C4 alkyl;

R2a and R2b are each independently H, C1-C4 alkyl, C2-C4 alkenyl, (CR4aR4b)p-OH, (CR4aR4b)p-SH, (CR4aR4b)p-Cl or (CR4aR4b)p-Br; or R2a and R2b are taken together with the atoms X and Y to which they are attached to form a 5- to 7-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 2 carbon atom ring members are independently selected from C(=0) and C(=S), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, Cl-C2 alkyl, Cl-C2 haloalkyl, Cl-C2 alkoxy and Cl-C2 haloalkoxy on carbon atom ring members;

R2C is C -C alkyl, Ci-C4 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl or C2-C4 haloalkynyl, each optionally substituted with up 2 substituents independently selected from cyano, hydroxy, SCºN and C j-C2 alkoxy;

R2d is H, cyano, halogen or Ci-C4 alkyl;

each R4a and R4b is independently H or Ci-C4 alkyl;

p is 2 or 3;

when T is T-l or T-2, then A is A'-A2-CRbaRbb, wherein A1 is connected to J, and CR6aR6b is connected to T;

when T is T-3, then A is A^A2, wherein A1 is connected to J, and A2 is connected to

T;

A1 is CR6cR6d, N(R7a), O or S;

A2 is a direct bond, CR6eR6f, N(R7b), O or S;

R6a, R6b, R6c, R6d, R6e and R6f are each independently H, cyano, hydroxy, halogen or CrC4 alkyl;

R7a and R7b are each independently H, C(=0)H, C \ -C4 alkyl or C2-C4 alkyl carbonyl;

J is selected from the group consisting of:

J-13 J-14

wherein the bond extending to the left is attached to L, and the bond extending to the right is attached to A;

each R8 is independently F, Cl, methyl or methoxy;

q is 0, 1 or 2;

L is (CR9aR9b)n;

each R9a and R9b is independently H, halogen, cyano, hydroxy, nitro, C3-C3 alkyl, CrC3 haloalkyl, C3-C3 alkoxy or C3-C3 haloalkoxy;

n is 0, 1, 2 or 3;

E is E1 or E2;

E1 is amino, cyano, hydroxy, nitro, CH(=0), C(=0)OH, C(=0)NH2, C(=S)NH2,

OC(=0)NH2, OC(=S)NH2, NHC(=0)NH2, NHC(=S)NH2, SCºN,

-CH=NNHC(=0)OC1-C6 alkyl or -N(0CH3)C(=0)CrC6 alkyl; or

E1 is Cj-Cg alkoxy, C2-Cg alkenyloxy, C2-Cg alkynyloxy, Cj-Cg alkylthio, C2-Cg alkenylthio, C2-Cg alkynylthio, C \ -Q, alkylsulfmyl, C2-Cg alkenylsulfmyl, C2-Cg alkynylsulfmyl, Cj-Cg alkyl sulfonyl, C2-Cg alkenylsulfonyl, C2-Cg alkynylsulfonyl, Cj-Cg alkylsulfonylamino, C2-Cg alkenylsulfonylamino, C2-Cg alkynylsulfonylamino, Cj-Cg alkylaminosulfonyl, C2-Cg dialkylaminosulfonyl, C2-Cg alkenylaminosulfonyl, C2-Cg alkynylaminosulfonyl, Cj-Cg

alkylaminosulfonylamino, C2-Cg alkenylaminosulfonylamino, C2-Cg

alkynylaminosulfonylamino, C2-C6 alkylcarbonyl, C3-C6 alkenylcarbonyl, C3-C6 alkynylcarbonyl, C2-C6 alkylaminocarbonyl, C3-C6 alkenylaminocarbonyl,

C3-C6 alkynylaminocarbonyl, C2-C6 alkylcarbonylamino, C3-C6

alkenylcarbonylamino, C3-C6 alkynylcarbonylamino, C2-C6 alkylaminocarbonylamino, C3-C6 alkenylaminocarbonylamino, C3-C6 alkynylaminocarbonylamino, C2-C6 alkylcarbonyloxy, C3-C6

alkenylcarbonyloxy, C3-C6 alkynylcarbonyloxy, C2-C6 alkoxycarbonyl, C3-C6 alkenyloxycarbonyl, C3-Cg alkynyloxycarbonyl, C2-Cg alkylaminocarbonyloxy, C3-Cg alkenylaminocarbonyloxy, C3-Cg alkynylaminocarbonyloxy, C2-Cg alkoxycarbonylamino, C3-Cg alkenyloxycarbonylamino, C3-Cg

alkynyloxycarbonylamino, C2-Cg alkylamino(thiocarbonyl)oxy, C3-Cg alkenylamino(thiocarbonyl)oxy, C3-Cg alkynylamino(thiocarbonyl)oxy, C2-Cg alkoxy(thiocarbonyl)amino, C3-Cg alkenyloxy(thiocarbonyl)amino, C3-Cg alkynyloxy(thiocarbonyl)amino, C2-Cg alkyl(thiocarbonyl), C2-Cg

(alkylthio)carbonyl, C3-Cg alkenyl(thiocarbonyl), C3-Cg (alkenylthio)carbonyl, C3-C6 alkynyl(thiocarbonyl), C3-C6 (alkynylthio)carbonyl, C2-C6

alkylamino(thiocarbonyl), C3-C6 alkenylamino(thiocarbonyl), C3-C6

alkynylamino(thiocarbonyl), C2-C6 alkyl(thiocarbonyl)amino, C2-C6

(alkylthio)carbonylamino, C3-C6 alkenyl(thiocarbonyl)amino, C3-C6

(alkenylthio)carbonylamino, C3-C6 alkynyl(thiocarbonyl)amino, C3-C6

(alkynylthio)carbonylamino, C2-C6 alkylamino(thiocarbonyl)amino, C3-C6 alkenylamino(thiocarbonyl)amino or C3-Cg alkynylamino(thiocarbonyl)amino, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R10a and up to 3 substituents independently selected from R10b;

R10a is phenyl optionally substituted with up to 3 substituents independently selected from Rl la; or a 5- to 6-membered heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon atom ring members are independently selected from C(=0) and C(=S), and sulfur atom ring members are independently S(=0)u(=NR12)v, each ring optionally substituted with up to 3 substituents independently selected from Rl la on carbon atom ring members and Rl lb on nitrogen atom ring members;

each R10b is independently amino, cyano, halogen, hydroxy, nitro, SCºN, -SH, C ]-C4 alkyl, C3-C4 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C3-C4 alkoxy, C3-C4 haloalkoxy, C3-C4 alkylthio, C3-C4 alkylsulfmyl, C3-C4 alkylsulfonyl, C3-C4 haloalkylsulfonyl, C3-C4 alkylamino, C2-C4 dialkylamino, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl, C2-C5 haloalkoxycarbonyl, C2-C5 alkylaminocarbonyl or C3-C5 dialkylaminocarbonyl; each Rl la is independently halogen, hydroxy, cyano, amino, nitro, C3-C4 alkyl, C3-C4 haloalkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C4 hydroxyalkyl, C3-C6 cycloalkyl, C4-C7 cycloalkylalkyl, C3-C4 alkoxy, C3-C4 haloalkoxy, C2-C4 alkenyloxy, C2-C4 alkynyloxy, C2-C4 alkoxyalkyl, C2-C6 alkylcarbonyloxy, C3-C4 alkylthio, C3-C4 haloalkylthio, C2-C6 alkylcarbonylthio, C3-C4 alkylsulfmyl, C3-C4 haloalkylsulfmyl, C3-C4 alkylsulfonyl, C3-C4 haloalkylsulfonyl, C3-C4 alkylsulfonyloxy, C3-C4 alkylamino, C2-C8 dialkylamino, C3-C6

cycloalkylamino, C2-C4 alkylcarbonyl, C3-C5 alkenylcarbonyl, C3-C5 alkynylcarbonyl, C4-C7 cycloalkylcarbonyl, C5-C8 cycloalkylalkylcarbonyl, C2-C6 alkoxycarbonyl, C3-C7 alkenyloxycarbonyl, C3-C7 alkynyloxycarbonyl, C4-C7 cycloalkoxylcarbonyl, C5-C8 cycloalkylalkoxylcarbonyl, C2-C6 alkylaminocarbonyl, C3-C6 alkenylaminocarbonyl, C3-C6 alkynylaminocarbonyl, C4-C7 cycloalkylaminocarbonyl, C3-C8 cycloalkylalkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-Cg trialkylsilyl;

each Rl lb is independently C(=0)H, C3-C3 alkyl, C3-C3 alkoxy, C2-C3 alkylcarbonyl or C2-C3 alkoxycarbonyl;

each R12 is independently H, cyano, C3-C3 alkyl or C3-C3 haloalkyl;

each u and v are independently 0, 1 or 2, provided that the sum of u and v are 0, 1 or 2;

E2 is G-Z, wherein Z is attached to L;

G is phenyl optionally substituted with up to 3 substituents independently selected from R13; or

G is a 5- to 6-membered heteroaromatic ring, each ring containing ring members

selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 3 substituents independently selected from R13; or

G is a 3- to 7-membered nonaromatic ring or an 8- to 1 l-membered bicyclic ring

system, each ring or ring system containing ring members selected from carbon atoms and optionally up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from C(=0), C(=S), S(=0) and S(=0)2, each ring or ring system optionally substituted with up to 3 substituents independently selected from R13; each R13 is independently cyano, halogen, hydroxy, nitro, -SH, SF5, CH(=0),

C(=0)OH, NR14aRl4b, C(=0)NR14aR14b, C(=0)C(=0)NR14aR14b,

C(=S)NR14aR14b, C(R15)=NR16, N=CR17NR18aR18b or -U-V-Q; or C1-C6 alkyl, C2-C6 alkenyl, C2-Cg alkynyl, C3-C7 cycloalkyl, C3-C7 cycloalkenyl, C^-Cg alkoxy, C2-Cg alkenyloxy, C2-Cg alkynyloxy, C3-C7 cycloalkoxy, C^-Cg alkylthio, C^-C8 alkylsulfmyl, C^-C8 alkylsulfonyl, Cj-C8 alkylaminosulfmyl, C2-C6 dialkylaminosulfmyl, C^-Cg alkylsulfonyloxy, Cj-Cg alkyl sulfonylamino, C2-C6 alkyl carbonyl, C4-C7 cycloalkylcarbonyl, C2-C6 alkoxycarbonyl, C3-C6 alkenyloxycarbonyl, C3-C6 alkynyloxycarbonyl, C4-C7 cycloalkoxycarbonyl, C3-C6 alkoxycarbonylcarbonyl, C2-C6 alkylcarbonyloxy, C4-C7

cycloalkylcarbonyloxy, C2-C6 alkoxycarbonyloxy, C4-C7

cycloalkoxycarbonyloxy, C2-C6 alkylaminocarbonyloxy, C4-C7

cycloalkylaminocarbonyloxy, C2-C6 alkylcarbonylamino, C4-C7

cycloalkylcarbonylamino, C2-Cg alkoxycarbonylamino, C4-C7

cycloalkoxycarbonylamino, C2-Cg alkylaminocarbonylamino, C4-C7

cycloalkylaminocarbonylamino or C2-Cg dialkoxyphosphinyl, each optionally substituted with up to 3 substituents independently selected from R19;

each R14a is independently H, cyano, hydroxy, Cl-C4 alkyl, Cl-C4 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, Cl-C5 alkoxy, C2-C4 alkoxyalkyl, Cl-C4 alkylsulfonyl, Cl-C4 haloalkylsulfonyl, C2-C4 alkylthioalkyl, C2-C4 alkylsulfmylalkyl, C2-C4 alkylsulfonylalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C4-C7 cycloalkylcarbonyl, C2-C5 alkoxycarbonyl, C3-C5 alkoxycarbonylalkyl, C2-C5 alkylaminocarbonyl or C3-C5 dialkylaminocarbonyl;

each R14b is independently H, Cj-Cg alkyl, Cj-Cg haloalkyl, C2-Cg alkenyl, C2-Cg haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, Cj-C8 hydroxyalkyl, C2-C6 cyanoalkyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, C3-C8 cycloalkenyl, C3-C8 halocycloalkenyl, C4-Cl0 alkyl cycloalkyl, C4-Cl0 cycloalkylalkyl, C4-Cl0 halocycloalkylalkyl, C6-Cl4 cycloalkylcycloalkyl, C5-Cl0 alkyl cycloalkylalkyl, C2-C6 alkoxyalkyl, C2-Cg haloalkoxyalkyl, C4-C2o cycloalkoxyalkyl, C3-C8 alkoxyalkoxy alkyl, C2-Cg alkylthioalkyl, C2-Cg alkylsulfmylalkyl, C2-Cg alkylsulfonylalkyl, C2-Cg alkylaminoalkyl, C2-Cg haloalkylaminoalkyl, C3-C8 dialkylaminoalkyl or C4-CJO cycloalkylaminoalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, nitro, C2-C4

alkylcarbonyl, C2-C4 alkoxycarbonyl, C3-C15 trialkylsilyl and C3-C15 halotrialkylsilyl; or

R14a and R14b are taken together to form a 4- to 6-membered fully saturated

heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 3 substituents independently selected from halogen and C1-C3 alkyl;

each R15 is independently H, cyano, halogen, methyl, methoxy, methylthio or

methoxy carbonyl;

each R16 is independently hydroxy or NR20aR20b; or C j-C4 alkoxy, C2-C4 alkenyloxy, C2-C4 alkynyloxy, C2-C4 alkylcarbonyloxy, C2-C5 alkoxycarbonyloxy, C2-C5 alkylaminocarbonyloxy or C3-C5 dialkylaminocarbonyloxy, each optionally substituted with up to 1 substituent selected from cyano, halogen, hydroxy and C(=0)OH;

each R17 is independently H, methyl, methoxy or methylthio;

each R18a and R18b is independently H or C^-C4 alkyl; or

R18a and R18b are taken together to form a 5- to 6-membered fully saturated

heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl groups;

each R19 is independently amino, cyano, halogen, hydroxy, nitro, -SH, C^-C4 alkyl, Cj-C4 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C^-C4 alkoxy, C^-C4 haloalkoxy, C2-C4 alkoxyalkoxy, Cl-C4 alkylthio, Cj-C4 alkylsulfmyl, Cj-C4 alkylsulfonyl, Cj-C4 haloalkylsulfonyl, C2-C4 alkylcarbonyl, C2-C4

haloalkylcarbonyl, C2-C5 alkoxy carbonyl, C^-C8 alkylamino, C2-C6

dialkylamino, C2-C5 alkylaminocarbonyl, C3-C5 dialkylaminocarbonyl, C3-C5 alkylthioalkylcarbonyl, C3-C15 trialkylsily, C3-C15 halotrialkylsilyl,

C(R21)=NOR22 or C(R23)=NR24;

each U is independently a direct bond, C(=0)0, C(=0)N(R25) or C(=S)N(R26),

wherein the atom to the left is connected to G, and the atom to the right is connected to V;

each V is independently a direct bond; or C^-Cg alkylene, C2-C6 alkenylene, C3-C6 alkynylene, C3-C6 cycloalkylene or C3-C6 cycloalkenylene, wherein up to 1 carbon atom is C(=0), each optionally substituted with up to 3 substituents independently selected from halogen, cyano, nitro, hydroxy, Cl-C2 alkyl, Cl-C2 haloalkyl, Cl-C2 alkoxy and Cl-C2 haloalkoxy;

each Q is independently phenyl or phenoxy, each optionally substituted with up to 2 substituents independently selected from R27; or

each Q is independently a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 2 substituents independently selected from R27; or each Q is independently a 3- to 7-membered nonaromatic heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from C(=0), C(=S), S(=0) and S(=0)2, each ring optionally substituted with up to 2 substituents independently selected from R27;

each R20a is independently H, Ci-C4 alkyl or C2-C4 alkylcarbonyl;

each R20b is independently H, cyano, Cl-C5 alkyl, C2-C5 alkylcarbonyl, C2-C5

haloalkylcarbonyl, C4-C7 cycloalkylcarbonyl, C2-C5 alkoxycarbonyl, C3-C5 alkoxycarbonylalkyl, C2-C5 alkylaminocarbonyl or C3-C5 dialkylaminocarbonyl; or R20a and R20b are taken together to form a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl groups;

each R21 and R23 is independently H, cyano, halogen, C1-C3 alkyl, C1-C3 haloalkyl, C3-C6 cycloalkyl or C [-C3 alkoxy; or phenyl optionally substituted with up to 2 substituents independently selected from halogen and C1-C3 alkyl;

each R22 is independently H, Cl-C5 alkyl, Cl-C5 haloalkyl, C2-C5 alkenyl, C2-C5 haloalkenyl, C2-C5 alkynyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C2-C5 alkylcarbonyl or C2-C5 alkoxycarbonyl; or

each R22 is phenyl optionally substituted with up to 2 substituents independently

selected halogen and Cl-C3 alkyl; or a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 substituents independently selected from halogen and C1-C3 alkyl;

each R24 is independently H, cyano, Cl-C3 alkyl, Cl-C3 haloalkyl, Cl-C4 alkoxy, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl;

each R25 and R26 is independently H, cyano, hydroxy, Ci-C4 alkyl, Ci-C4 haloalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C4 alkoxycarbonyl or C2-C4 haloalkoxycarbonyl;

each R27 is independently halogen, cyano, hydroxy, nitro, Ci-C4 alkyl, Ci-C4

haloalkyl, C2-C4 alkenyl, Ci-C4 alkoxy, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl;

Z is a direct bond, O, S(=0)m, N(R28), C(=0), C(=0)N(R28), NR28C(=0),

N(R28)C(=0)N(R28), N(R28)C(=S)N(R28), 0C(=0)N(R28), N(R28)C(=0)0, S(0)2N(R28), N(R28)S(=0)2 or N(R28)S(0)2N(R28), wherein the atom to the right is connected to L;

each R28 is independently H, Cl-C3 alkyl, Cl-C3 alkoxy, C2-C3 alkylcarbonyl or C2-C3 alkoxycarbonyl; and m is 0, 1 or 2;

provided that:

(c) when A1 is N(R7a), O or S, then A2 is a direct bond or CR6eR6f; and

when A2 is N(R7b), O or S; then A1 is CR6cR6d.

2. A compound Claim 1 wherein

R1 is CF3, CCl3 or CF2Cl;

W is O;

R5a and R5b are each independently H, hydroxy or methyl;

R2a and R2b are each independently H or methyl; or

R2a and R2b are taken together with the atoms X and Y to which they are attached to form a 5- to 6-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 1 carbon atom ring member is selected from C(=0), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl, methoxy and halomethoxy on carbon atom ring members;

R2C is C3-C2 alkyl, C2-C3 alkenyl or C2-C3 alkynyl;

R2d is H or methyl;

A1 is CR6cR6d or O;

A2 is a direct bond, CR6eR6f or O;

R6a, R6b, R6c, R6d, R6e and R6f are each independently H, cyano, hydroxy, Br, Cl, F or methyl;

J is J-l, J-6 or J-14;

each R8 is independently F, Cl or methyl;

each R9a and R9b is independently H, halogen or methyl;

n is 0, 1 or 2;

E1 is C j- , alkoxy, C3-C6 alkyl sulfonyl, C2-C6 alkylcarbonyl or C2-C6 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R10a and up to 3 substituents independently selected from R10b;

R10a is phenyl optionally substituted with up to 2 substituents independently selected from Rl la; or a 5- to 6-membered heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 2 substituents independently selected from Rl la on carbon atom ring members and R1 lb on nitrogen atom ring members;

each R10b is independently halogen, hydroxy, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C \ -C4 alkylsulfonyl, C2-C4 alkylcarbonyl or C2-C5 alkoxycarbonyl;

each Rl la is independently halogen, Cl-C2 alkyl, Cl-C2 haloalkyl, Cl-C2 alkoxy or C2-C3 alkoxycarbonyl;

each Rl lh is independently methyl, methoxy, methylcarbonyl or methoxycarbonyl;

G is selected from the group consisting of:

G-17 G-18 G-19 G-20

G-97 G-98 G-99 G-100

G-117 G-118

wherein the floating bond is connected to Z in Formula 1 through any available carbon or nitrogen atom of the depicted ring or ring system; and x is 0, 1, 2 or 3;

each R13 is independently C(=0)NR14aR14b or -U-V-Q; or -Cg alkyl, C2-Cg alkenyl, C2-C6 alkynyl, C^-Cg alkoxy, C2-Cg alkenyloxy, C2-Cg alkynyloxy, C^-Cg alkylsulfonyl, C^-Cg alkylsulfonyloxy, C j-Cg alkylsulfonylamino, C2-Cg alkylcarbonyl, C2-Cg alkoxycarbonyl, C2-Cg alkenyloxycarbonyl, C2-Cg alkynyloxycarbonyl, C4-Cg cycloalkoxycarbonyl or C2-Cg alkoxycarbonyloxy, each optionally substituted with up to 3 substituents independently selected from Rl9; each R14a is independently H, Ci-C alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl;

each R14b is independently H, Cl-C4 alkyl, Cl-C4 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C3-C5 cycloalkyl, C4-C6 cycloalkylalkyl, C2-C4 alkoxyalkyl, C2-C4 haloalkoxyalkyl, C2-C4 alkylaminoalkyl or C3-C5 dialkylaminoalkyl; or

R 1 a and Rl b are taken together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 substituents independently selected from halogen or methyl;

each R19 is independently cyano, halogen, Cl-C2 alkyl, Cl-C2 haloalkyl, C3-C6

cycloalkyl, C1-C2 alkoxy, C1-C2 haloalkoxy, C2-C3 alkylcarbonyl, C2-C3 haloalkylcarbonyl or C2-C3 alkoxycarbonyl;

each U is independently a direct bond, C(=0)0 or C(=0)N(R25);

each V is independently a direct bond; or Cl-C3 alkylene, each optionally substituted with up to 2 substituents independently selected from halogen, hydroxy, Cl-C2 alkyl, Cl-C2 alkoxy and Cl-C2 haloalkoxy;

each Q is independently phenyl optionally substituted with up to 2 substituents

independently selected from R27; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl or oxazolyl, each optionally substituted with up to 2 substituents independently selected from R27;

each R25 is independently H, cyano, hydroxy or Cl-C2 alkyl;

each R27 is independently halogen, cyano, C1-C2 alkyl, C1-C2 haloalkyl or C1-C2 alkoxy; and

Z is a direct bond, O, NH, C(=0), C(=0)NH, NHC(=0), NHC(=0)NH, OC(=0)NH, NHC(=0)0, S(=0)2NH, NHS(=0)2 or NHS(=0)2NH.

3. A compound of Claim 2 wherein

T is T-2 or T-3;

R1 is CF3;

X is O;

Y is O;

R2a and R2b are each independently H or methyl; or R2a and R2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, the ring optionally substituted with up to 1 substituent selected from halogen, methyl and halomethyl on a carbon atom ring member;

R2C is methyl or ethyl;

R2d is H;

A1 is O;

A2 is a direct bond, CH2 or O;

R6a and R6b are each independently H, cyano hydroxy or methyl;

J is J-l or J-6;

q is 0 or 1;

each R9a and R9b is independently H or methyl;

E1 is C1-C3 alkoxy, C2-C3 alkylcarbonyl or C2-C3 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R10a and up to 3 substituents independently selected from R10b;

Rl°a is pyrazolyl, imidazolyl or triazolyl, each optionally substituted with up to 2

substituents independently selected from Rl la on carbon atom ring members; each R10b is independently halogen, Cl-C2 alkyl, Cl-C2 haloalkyl, Cl-C2 alkoxy or C2-C4 alkoxycarbonyl;

G is G-l, G-3, G-12 or G-22;

x is 1 or 2;

each R13 is independently C(=0)NR14aR14b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5 alkenyloxycarbonyl, C3-C5 alkynyloxycarbonyl or C4-C6

cycloalkoxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R19;

each R14a is independently H or C1-C2 alkyl;

each R14b is independently H, C1-C3 alkyl, C [-C3 haloalkyl, cyclopropylmethyl or C2-C4 alkoxy alkyl;

each R19 is independently cyano, halogen, cyclopropyl, cyclobutyl, methoxy,

halomethoxy or methoxycarbonyl;

each U is independently a direct bond or C(=0)0; each V is independently a direct bond or CH2;

each Q is independently phenyl or pyridinyl, each optionally substituted with up to 2 substituents independently selected from R27;

each R27 is independently halogen, methyl or methoxy; and

Z is a direct bond, O, NH, C(=0), C(=0)NH or NHC(=0).

4. A compound of Claim 3 wherein

R2a and R2b are each H; or

R2a and R2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms;

A2 is a direct bond;

R6a and R6b are each H;

R8 is F or Cl;

L is a direct bond, CH2 or CH2CH2;

E1 is C j-C2 alkoxy or C2-C3 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R10a;

Rl°a is pyrazolyl or imidazolyl, each optionally substituted with up to 2 substituents independently selected from Rl la on carbon atom ring members;

each Rl la is independently methoxy carbonyl or ethoxy carbonyl;

G is G-l and the 2-position of G-l is connected to Z and the 4-position is connected to R13; or G is G-12 and the l-position of G-12 is connected to Z and the 4-position is connected to R13; or G is G-12 and the l-position of G-12 is connected to Z and the 3-position is connected to R13;

x is 1;

R13 is C(=0)NR14aR14b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5

alkynyloxycarbonyl or C4-C6 cycloalkoxycarbonyl, each optionally substituted with up to 1 substituent selected from R19;

R14a is H;

R14b is H, methyl or cyclopropylmethyl;

R19 is cyano, halogen, cyclopropyl or methoxy;

U is C(=0)0;

V is CH2; Q is phenyl optionally substituted with up to 2 substituents independently selected from R27; and

Z is a direct bond, O, NH or C(=0).

5. A compound of Claim 4 wherein

R8 is F;

L is a direct bond or CH2;

E1 is methoxy substituted with 1 substituent selected from R10a;

RlOa js pyrazolyl optionally substituted with up to 1 substituent selected from Rl la on a carbon atom ring member;

G is G-12 and the l-position of G-12 is connected to Z and the 4-position is connected to R13; or G is G-12 and the l-position of G-12 is connected to Z and the 3- position is connected to R13; and

R13 is C2-C5 alkoxycarbonyl optionally substituted with up to 1 substituent selected from R19;

R19 is cyano, Cl, F, cyclopropyl or methoxy; and

Z is a direct bond.

6. A compound of Claim 5 wherein

J is J-l;

q is 0;

L is CH2;

E is E2;

G is G-12 and the l-position of G-12 is connected to Z and the 4-position is connected to R13; and

R13 is methoxycarbonyl or ethoxy carbonyl.

7. A compound of Claim 1 which is selected from the group:

ethyl l-[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]-lF/-pyrazole-4- carboxylate;

ethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl]methyl]-l/7-pyrazole- 4-carboxylate;

ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]-lF/- pyrazole-4-carboxylate; ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]-l//- pyrazole-3-carboxylate;

ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]-3-fluorophenyl]methyl]- 1 //-py razol e-4-carboxy 1 ate;

ethyl l-[[3-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]-l//- pyrazole-4-carboxylate;

ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenoxy]methyl]-l//- pyrazole-4-carboxylate;

/V-(cyclopropylmethyl)-2-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl]- methyl]thiazole-4-carboxamide;

2-methylpropyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl]methyl]- 1 //-py razol e-4-carboxy 1 ate;

cyclopropylmethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2- yl]methoxy]phenyl]methyl]- l //-pyrazole-4-carboxylate;

ethyl 1 -[2-[4-[[( lZ)-2-ethoxy-3,3,3-trifluoro- 1 -propen- 1 -yl ]oxy]phenyl ]ethyl ]-!//- pyrazole-4-carboxylate;

2-methoxy ethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl]methyl]- 1 //-py razol e-4-carboxy 1 ate;

2-butyn- 1 -yl 1 -[[4-[[2-(trifluorom ethyl)- 1 ,3 -dioxolan-2-yl]methoxy]phenyl]methyl]- 1 H- pyrazole-4-carboxylate;

3-cyanopropyl 1 -[[4-[[2-(trifluorom ethyl)-! ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l H- pyrazole-4-carboxylate;

phenylmethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]- 1 //-py razol e-4-carboxy 1 ate;

butyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]-l//- pyrazole-4-carboxylate;

3-chloropropyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]- 1 //-py razol e-4-carboxy 1 ate;

methyl 4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenylcarboxylate;

ethyl l-[[3-fluoro-4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl]methyl]-l//- pyrazole-4-carboxylate;

ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenylmethoxy]methyl]- 1 //-py razol e-4-carboxy 1 ate; methyl l-[[3-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]-li7- pyrazole-4-carboxylate; and

propyl l-[[3-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phenyl]methyl]-l//- py razol e-4-carb oxy 1 ate .

8. A fungicidal composition comprising (a) a compound of Claim 1; and (b) at least one other fungicide.

9. A fungicidal composition comprising (a) a compound of Claim 1; and (b) at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.

10. A method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungi ci dally effective amount of a compound of Claim 1.

11. A compound selected from Formula 10, A -oxides, and salts thereof,

10 wherein

R1 is CF3, CCl3 or CFCl2;

X is O;

Y is O;

R2a and R2b are each independently H or methyl; or

R2a and R2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 1 carbon atom ring member is selected from C(=0), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl, methoxy and halomethoxy on carbon atom ring members;

R6a and R6b are each independently H, cyano, Br, Cl, F or methyl;

R29 is S(=0)2R3°; and R30 is C3-C4 alkyl, C1-C4 haloalkyl, phenyl, 4-methylphenyl 4-bromophenyl or 4-nitrophenyl.

12. A compound of Claim 11 wherein

R1 is CF3;

R2a and R2b are each H; or

R2a and R2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms;

R6a and R6b are each H; and

R30 is CH3, CF3, CH2CF3, (CF2)3CF3, phenyl or 4-methylphenyl.

Description:
TITLE

FUNGICIDAL HALOMETHYL KETONES AND HYDRATES

FIELD OF THE INVENTION

This invention relates to certain halomethyl ketones and hydrates, their L'-oxides, salts and compositions, and methods of using them as fungicides.

BACKGROUND OF THE INVENTION

The control of plant diseases caused by fungal plant pathogens is extremely important in achieving high crop efficiency. Plant disease damage to ornamental, vegetable, field, cereal and fruit crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. Many products are commercially available for these purposes, but the need continues for new compounds which are more effective, less costly, less toxic, environmentally safer or have different sites of action.

PCT Patent Publications WO 2018/080859, WO 2018/118781, WO 2018/187553 and WO 2019/010192 discloses trifluoromethyl-oxadiazole derivatives and their use as fungicides.

SUMMARY OF THE INVENTION

This invention is directed to compounds of Formula 1 (including all stereoisomers), tautomers, A'-oxides, and salts thereof, agricultural compositions containing them and their use as fungicides:

1 wherein

T is selected from the group consisting of:

T-l T-2 T-3

wherein the bond extending to the left is attached to A; R 1 is CF 3 , CHF 2 , CCl 3 , CHCl 2 , CF 2 Cl, CFCl 2 or CHFC1;

W is O, S or NR 3 ;

R 3 is H, cyano, nitro, C(=0)OH, benzyl, C j -C 4 alkyl, C 2 -C 4 alkylcarbonyl, C 2 -C 4

haloalkylcarbonyl, OR 3a or NR 3 ^R 3c ;

R 3a is H, benzyl, C j -C 4 alkyl, C 2 -C 4 alkylcarbonyl or C 2 -C 4 haloalkylcarbonyl;

R 3b is H, C j -C 4 alkyl, C 2 -C 4 alkylcarbonyl or C 2 -C 4 haloalkylcarbonyl;

R 3C is H or C j -C 4 alkyl; or

R 3b and R 3c are taken together to form a 4- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl groups;

X is O, S or NR 5a ;

Y is O, S or NR 5b ;

R 5a and R 5b are each independently H, hydroxy or C j -C 4 alkyl;

R 2a and R 2b are each independently H, C j -C 4 alkyl, C 2 -C 4 alkenyl, (CR 4a R 4b ) p -OH, (CR 4a R 4 b)p-SH, (CR 4a R 4b ) p -Cl or (CR 4a R 4b ) p -Br; or

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5- to 7-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 2 carbon atom ring members are independently selected from C(=0) and C(=S), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, C j -C 2 alkyl, C j -C 2 haloalkyl, C j -C 2 alkoxy and C j -C 2 haloalkoxy on carbon atom ring members;

R 2C is C j -C 4 alkyl, C j -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 haloalkenyl, C 2 -C 4 alkynyl or C 2 -C 4 haloalkynyl, each optionally substituted with up 2 substituents independently selected from cyano, hydroxy, SCºN and C j -C 2 alkoxy;

R2d is H, cyano, halogen or C j -C 4 alkyl;

each R 4a and R 4b is independently H or C j -C 4 alkyl; p is 2 or 3;

when T is T-l or T-2, then A is A 1 -A 2 -CR 6a R 6 ^ ) , wherein A 1 is connected to J, and

CR 6a R 6b is connected to T;

when T is T-3, then A is A '-A 2 , wherein A 1 is connected to J, and A 2 is connected to T; A 1 is CR 6c R 6d , N(R 7a ), O or S;

A 2 is a direct bond, CR 6e R 6f , N(R 7b ), O or S;

R 6a , R 6 b, R 6c , R 6d , R 6e and R 6f are each independently H, cyano, hydroxy, halogen or C r C 4 alkyl;

R 7a and R 7b are each independently H, C(=0)H, C j -C 4 alkyl or C2-C4 alkylcarbonyl; J is selected from the group consisting of:

J-13 J-14

wherein the bond extending to the left is attached to L, and the bond extending to the right is attached to A;

each R 8 is independently F, Cl, methyl or methoxy; q is 0, 1 or 2;

L is (CR 9a R 9b ) n ;

each R 9a and R 9b is independently H, halogen, cyano, hydroxy, nitro, CJ-C3 alkyl, CJ-C3 haloalkyl, CJ-C3 alkoxy or CJ-C3 haloalkoxy;

n is 0, 1, 2 or 3;

E is E 1 or E 2 ;

E 1 is amino, cyano, hydroxy, nitro, CH(=0), C(=0)OH, C(=0)NH 2 , C(=S)NH 2 ,

OC(=0)NH 2 , OC(=S)NH 2 , NHC(=0)NH 2 , NHC(=S)NH 2 , SCºN,

-CH=NNHC(=0)OC 1 -C 6 alkyl or -N(0CH 3 )C(=0)C 1 -C 6 alkyl; or

E 1 is C j -Cg alkoxy, C 2 -Cg alkenyloxy, C 2 -Cg alkynyloxy, C j -Cg alkylthio, C 2 -Cg

alkenylthio, C 2 -Cg alkynylthio, C j -Cg alkylsulfinyl, C 2 -Cg alkenylsulfinyl, C 2 -Cg alkynylsulfinyl, C j -Cg alkylsulfonyl, C 2 - , alkenylsulfonyl, C 2 -Cg alkynylsulfonyl, C j -Cg alkylsulfonylamino, C 2 -Cg alkenylsulfonylamino, C 2 -Cg

alkynylsulfonylamino, C j -C 6 alkylaminosulfonyl, C 2 -C 6 dialky laminosulfonyl, C 2 -Cg alkenylaminosulfonyl, C 2 - , alkynylaminosulfonyl, C j -Cg

alkylaminosulfonylamino, C 2 -Cg alkenylaminosulfonylamino, C 2 -Cg

alkynylaminosulfonylamino, C 2 -Cg alkylcarbonyl, C^- , alkenylcarbonyl, C^-C^ alkynylcarbonyl, C 2 -Cg alkylaminocarbonyl, C^-C^ alkenylaminocarbonyl, C^-C^ alkynylaminocarbonyl, C 2 -C 6 alkylcarbonylamino, C 3 -C 6 alkenylcarbonylamino, C 3 -C 6 alkynylcarbonylamino, C 2 -C 6 alkylaminocarbonylamino, C 3 -C 6

alkenylaminocarbonylamino, C^- , alkynylaminocarbonylamino, C 2 -Cg alkylcarbonyloxy, C^-C^ alkenylcarbonyloxy, C^-C^ alkynylcarbonyloxy, C 2 -Cg alkoxycarbonyl, C^- , alkenyloxycarbonyl, C^-C^ alkynyloxycarbonyl, C 2 -Cg alkylaminocarbonyloxy, C^-C^ alkenylaminocarbonyloxy, C^-C^

alkynylaminocarbonyloxy, C 2 -C 6 alkoxy carbonylamino, C 3 -C 6

alkenyloxy carbonylamino, C^- , alkynyloxy carbonylamino, C 2 -Cg

alkylamino(thiocarbonyl)oxy, C^-C^ alkenylamino(thiocarbonyl)oxy, C^-C^ alkynylamino(thiocarbonyl)oxy, C 2 - , alkoxy(thiocarbonyl)amino, C 3 - , alkenyloxy(thiocarbonyl)amino, C 3 -Cg alkynyloxy(thiocarbonyl)amino, C^- , alkyl(thiocarbonyl), C^- , (alkylthio)carbonyl, C 3 - , alkenyl(thiocarbonyl), C 3 -Cg (alkenylthio)carbonyl, C 3 -Cg alkynyl(thiocarbonyl), C 3 -Cg (alkynylthio)carbonyl, C 2 -C 6 alkylamino(thiocarbonyl), C 3 -C 6 alkenylamino(thiocarbonyl), C 3 -C 6 alkynylamino(thiocarbonyl), C^- , alkyl(thiocarbonyl)amino, C 2 - ,

(alkylthio)carbonylamino, C 3 -Cg alkenyl(thiocarbonyl)amino, C 3 -Cg

(alkenylthio)carbonylamino, C 3 -Cg alkynyl(thiocarbonyl)amino, C 3 - ,

(alkynylthio)carbonylamino, C 2 - , alkylamino(thiocarbonyl)amino, C 3 -Cg alkenylamino(thiocarbonyl)amino or C 3 -Cg alkynylamino(thiocarbonyl)amino, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (,b ;

R 10a is phenyl optionally substituted with up to 3 substituents independently selected from R 1 la ; or a 5- to 6-membered heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2

S and up to 4 N atoms, wherein up to 3 carbon atom ring members are independently selected from C(=0) and C(=S), and sulfur atom ring members are independently S(=0) U (=NR12) v , each ring optionally substituted with up to 3 substituents independently selected from R l la on carbon atom ring members and R 1 ^ on nitrogen atom ring members;

each R 1 (,b is independently amino, cyano, halogen, hydroxy, nitro, SCºN, -SH, CJ-C4 alkyl, CJ-C4 haloalkyl, C 3 -Cg cycloalkyl, C 3 -Cg halocycloalkyl, CJ-C4 alkoxy,

CJ-C4 haloalkoxy, CJ-C4 alkylthio, CJ-C4 alkylsulfinyl, CJ-C4 alkylsulfonyl, CJ-C4 haloalkylsulfonyl, CJ-C4 alkylamino, C2-C4 dialkylamino, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl, C2-C5 haloalkoxycarbonyl, C2-C5 alkylaminocarbonyl or C 3 -C 3 dialky laminocarbonyl;

each R l la is independently halogen, hydroxy, cyano, amino, nitro, CJ-C4 alkyl, CJ-C4 haloalkyl, C2-C4 alkenyl, C2-C4 alkynyl, CJ-C4 hydroxyalkyl, C 3 - , cycloalkyl, C4-C7 cycloalkylalkyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C2-C 4 alkenyloxy, C2-C 4 alkynyloxy, C2-C 4 alkoxyalkyl, C^- , alkylcarbonyloxy, C j -C 4 alkylthio, C j -C 4 haloalkylthio, C^- , alkylcarbonylthio, C j -C 4 alkylsulfmyl, C j -C 4 haloalkylsulfinyl, C j -C 4 alkylsulfonyl, C j -C 4 haloalkylsulfonyl, C j -C 4 alkylsulfonyloxy, C j -C 4 alkylamino, C 2 -C 8 dialkylamino, C 3 -C 6 cycloalkylamino, C 2 -C 4 alkylcarbonyl, C3-C5 alkenylcarbonyl, C3-C5 alkynylcarbonyl, C 4 -C 7 cycloalkylcarbonyl, C^-C^ cycloalkylalkylcarbonyl, C^- , alkoxycarbonyl, C3-C7 alkenyloxycarbonyl, C3-C7 alkynyloxycarbonyl, C 4 -C 7 cycloalkoxylcarbonyl, C^-C^ cycloalkylalkoxylcarbonyl, C 2 -C 6 alkylaminocarbonyl, C^-C^ alkenylaminocarbonyl, C^-C^

alkynylaminocarbonyl, C 4 -C 7 cycloalkylaminocarbonyl, C 5 -C 8

cycloalkylalkylaminocarbonyl, C 3 -C 8 dialkylaminocarbonyl or C^-C^ trialkylsilyl; each R l lb is independently C(=0)H, C j -C 3 alkyl, C j -C 3 alkoxy, C2-C3 alkylcarbonyl or C2-C3 alkoxycarbonyl;

each R 12 is independently H, cyano, C j -C 3 alkyl or C j -C 3 haloalkyl;

each u and v are independently 0, 1 or 2, provided that the sum of u and v are 0, 1 or 2;

E 2 is G-Z, wherein Z is attached to L;

G is phenyl optionally substituted with up to 3 substituents independently selected from R 13 ; or

G is a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 3 substituents independently selected from R 13 ; or

G is a 3- to 7-membered nonaromatic ring or an 8- to 1 l-membered bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and optionally up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from C(=0), C(=S), S(=0) and S(=0) 2 , each ring or ring system optionally substituted with up to 3 substituents independently selected from R 13 ; each R 13 is independently cyano, halogen, hydroxy, nitro, -SH, SF 5 , CH(=0), C(=0)OH, NRl4aRl4b C(=0)NR 14a R 14b , C(=0)C(=0)NR 14a R 14b , C(=S)NR 14a R 14b ,

C(R 15 )=NR 16 , N=CR 17 NR 18a R 18b or -U-V-Q; or C r C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C3-C7 cycloalkyl, C3-C7 cycloalkenyl, C j -C 6 alkoxy, C 2 -C 6 alkenyloxy, C 2 -Cg alkynyloxy, C3-C7 cycloalkoxy, C j -Cg alkylthio, C j -Cg alkylsulfinyl, C j -Cg alkylsulfonyl, C j -Cg alkylaminosulfinyl, C 2 - , dialkylaminosulfinyl, C j -Cg alkylsulfonyloxy, C j -Cg alkylsulfonylamino, C 2 -Cg alkylcarbonyl, C4-C7 cycloalkylcarbonyl, C 2 - , alkoxy carbonyl, C^-C^ alkenyloxy carbonyl, C^-C^ alkynyloxy carbonyl, C4-C7 cycloalkoxy carbonyl, C 3 -C 6 alkoxy carbonylcarbonyl, C 2 -Cg alkylcarbonyloxy, C4-C7 cycloalkylcarbonyloxy, C 2 - , alkoxycarbonyloxy, C4-C7 cycloalkoxycarbonyloxy, C 2 -Cg alkylaminocarbonyloxy, C4-C7

cycloalkylaminocarbonyloxy, C 2 -Cg alkylcarbonylamino, C4-C7

cycloalkylcarbonylamino, C 2 -Cg alkoxycarbonylamino, C4-C7

cycloalkoxycarbonylamino, C 2 - , alkylaminocarbonylamino, C4-C7

cycloalkylaminocarbonylamino or C 2 -C 6 dialkoxyphosphinyl, each optionally substituted with up to 3 substituents independently selected from R 19 ;

each R 14a is independently H, cyano, hydroxy, CJ-C4 alkyl, CJ-C4 haloalkyl, C 2 -C4

alkenyl, C 2 -C4 haloalkenyl, C 2 -C4 alkynyl, C 2 -C4 haloalkynyl, CJ-C5 alkoxy, C 2 -C4 alkoxyalkyl, CJ-C4 alkylsulfonyl, CJ-C4 haloalkylsulfonyl, C 2 -C4 alkylthioalkyl, C 2 -C 4 alkylsulfinylalkyl, C 2 -C4 alkylsulfonylalkyl, C 2 -C4 alkylcarbonyl, C 2 -C4 haloalkylcarbonyl, C4-C7 cycloalkylcarbonyl, C 2 -C 5 alkoxy carbonyl, C3-C5 alkoxycarbonylalkyl, C 2 -C5 alkylaminocarbonyl or C3-C5 dialky laminocarbonyl; each R 14b is independently H, C | - , alkyl, C j -Cg haloalkyl, C 2 -Cg alkenyl, C 2 -Cg

haloalkenyl, C 2 -Cg alkynyl, C 2 - , haloalkynyl, C j -Cg hydroxyalkyl, C 2 -Cg cyanoalkyl, C^-C cycloalkyl, C^-C halocycloalkyl, C3-C8 cycloalkenyl, C^-C halocycloalkenyl, C4-CJ0 alkylcycloalkyl, C4-CJ0 cycloalkylalkyl, C4-CJ0 halocycloalkylalkyl, Cg-C j 4 cycloalkylcycloalkyl, C5-CJ0 alkylcycloalkylalkyl, C 2 -C 6 alkoxyalkyl, C 2 - , haloalkoxyalkyl, C4-CJ0 cycloalkoxyalkyl, C^-C^ alkoxyalkoxyalkyl, C 2 -Cg alkylthioalkyl, C 2 -Cg alkylsulfinylalkyl, C 2 -Cg alkylsulfonylalkyl, C 2 -Cg alkylaminoalkyl, C 2 - , haloalkylaminoalkyl, C^-C^ dialkylaminoalkyl or C4-CJ0 cycloalkylaminoalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, nitro, C 2 -C 4 alkylcarbonyl, C 2 -C 4 alkoxycarbonyl, C3-CJ5 trialkylsilyl and C3-CJ5 halotrialkylsilyl; or

R 14a and R l b are taken together to form a 4- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 3 substituents independently selected from halogen and C j -C 3 alkyl;

each R 15 is independently H, cyano, halogen, methyl, methoxy, methylthio or

methoxy carbonyl ;

each R 16 is independently hydroxy or NR 20a R 20b ; or CJ-C4 alkoxy, C 2 -C4 alkenyloxy, C 2 -C 4 alkynyloxy, C 2 -C 4 alkylcarbonyloxy, C 2 -C 5 alkoxycarbonyloxy, C 2 -C 5 alkylaminocarbonyloxy or C3-C5 dialky laminocarbonyloxy, each optionally substituted with up to 1 substituent selected from cyano, halogen, hydroxy and C(=0)OH;

each R 17 is independently H, methyl, methoxy or methylthio;

each R 18a and R 18b is independently H or CJ-C4 alkyl; or

R 18a and R l 8b are taken together to form a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl groups;

each R 19 is independently amino, cyano, halogen, hydroxy, nitro, -SH, CJ-C4 alkyl, CJ-C4 haloalkyl, C^- , cycloalkyl, C^- , halocycloalkyl, CJ-C4 alkoxy, CJ-C4 haloalkoxy, C 2 -C 4 alkoxyalkoxy, CJ-C4 alkylthio, CJ-C4 alkylsulfinyl, CJ-C4 alkylsulfonyl, C j -C 4 haloalkylsulfonyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl, C j -Cg alkylamino, C^- , dialkylamino, C2-C5 alkylaminocarbonyl, C3-C5 dialky laminocarbonyl, C3-C5 alkylthioalkylcarbonyl, C3-CJ5 trialkylsily, C 3 -C 15 halotnalkylsilyl, C(R 21 )=NOR 22 or C(R 23 )=NR 24 ;

each U is independently a direct bond, C(=0)0, C(=0)N(R 25 ) or C(=S)N(R 26 ), wherein the atom to the left is connected to G, and the atom to the right is connected to V; each V is independently a direct bond; or C j -Cg alkylene, C^- , alkenylene, C^- ,

alkynylene, C^- , cycloalkylene or C^- , cycloalkenylene, wherein up to 1 carbon atom is C(=0), each optionally substituted with up to 3 substituents independently selected from halogen, cyano, nitro, hydroxy, CJ-C2 alkyl, CJ-C2 haloalkyl, CJ-C2 alkoxy and CJ-C2 haloalkoxy;

each Q is independently phenyl or phenoxy, each optionally substituted with up to 2

substituents independently selected from R 27 ; or

each Q is independently a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 2 substituents independently selected from R 27 ; or

each Q is independently a 3- to 7-membered nonaromatic heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from C(=0), C(=S), S(=0) and S(=0) 2 , each ring optionally substituted with up to 2 substituents independently selected from R 27 ;

each R 20a is independently H, C j -C 4 alkyl or C2-C4 alkylcarbonyl;

each R 2(,b is independently H, cyano, CJ-C5 alkyl, C2-C5 alkylcarbonyl, C2-C5

haloalkylcarbonyl, C4-C7 cycloalkylcarbonyl, C2-C5 alkoxycarbonyl, C3-C5 alkoxycarbonylalkyl, C2-C5 alkylaminocarbonyl or C3-C5 dialky laminocarbonyl; or R20a anc j R20b are taken together to form a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 methyl groups;

each R 21 and R 23 is independently H, cyano, halogen, CJ-C3 alkyl, CJ-C3 haloalkyl,

C 3 -C 6 cycloalkyl or C j -C 3 alkoxy; or phenyl optionally substituted with up to 2 substituents independently selected from halogen and CJ-C3 alkyl;

each R 22 is independently H, CJ-C5 alkyl, CJ-C5 haloalkyl, C2-C5 alkenyl, C2-C5

haloalkenyl, C2-C5 alkynyl, C^-C^ cycloalkyl, C^-C^ halocycloalkyl, C2-C5 alkylcarbonyl or C 2 -C 5 alkoxy carbonyl; or

each R 22 is phenyl optionally substituted with up to 2 substituents independently selected halogen and C j -C 3 alkyl; or a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 substituents independently selected from halogen and C j -C 3 alkyl;

each R 24 is independently H, cyano, CJ-C3 alkyl, CJ-C3 haloalkyl, C j -C 4 alkoxy, C2-C4 alkylcarbonyl or C2-C4 alkoxy carbonyl;

each R 25 and R 26 is independently H, cyano, hydroxy, C j -C 4 alkyl, C j -C 4 haloalkyl,

C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C4 alkoxycarbonyl or C2-C4 haloalkoxy carbonyl;

each R 27 is independently halogen, cyano, hydroxy, nitro, C j -C 4 alkyl, C j -C 4 haloalkyl, C2-C4 alkenyl, C j -C 4 alkoxy, C2-C4 alkylcarbonyl or C2-C4 alkoxycarbonyl;

Z is a direct bond, O, S(=0) m , N(R 28 ), C(=0), C(=0)N(R 28 ), NR 28 C(=0),

N(R 28 )C(=0)N(R 28 ), N(R 28 )C(=S)N(R 28 ), 0C(=0)N(R 28 ), N(R 28 )C(=0)0, S(0) 2 N(R 28 ), N(R 28 )S(=0) 2 or N(R 28 )S(0) 2 N(R 28 ), wherein the atom to the right is connected to L; each R 28 is independently H, CJ-C3 alkyl, CJ-C3 alkoxy, C2-C3 alkylcarbonyl or C2-C3 alkoxycarbonyl; and

m is 0, 1 or 2;

provided that:

(a) when A 1 is N(R 7a ), O or S, then A 2 is a direct bond or CR 6e R 6f ; and

(b) when A 2 is N(R 7 ^), O or S; then A 1 is CR 6c R 6c l

More particularly, this invention pertains to a compound of Formula 1 (including all stereoisomers), tautomers, a tautomer, an A'-oxide or a salt thereof.

This invention also relates to a fungicidal composition comprising (a) a compound of the invention (i.e. in a fungicidally effective amount); and (b) at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.

This invention also relates to a fungicidal composition comprising (a) a compound of the invention; and (b) at least one other fungicide (e.g., at least one other fungicide having a different site of action).

This invention further relates to a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of the invention (e.g., as a composition described herein).

This invention also relates to a composition comprising a compound of Formula 1, an iV- oxide, or a salt thereof, and at least one invertebrate pest control compound or agent.

The invention also relates to compounds of Formula 10 (including all stereoisomers), A'-oxides, and salts thereof:

10 wherein

R 29 is S(=0) 2 R 30 ; R 30 is C | -C 4 alkyl, C j -C 4 haloalkyl, phenyl, 4-methylphenyl 4-bromophenyl or

4-nitrophenyl; and

R 1 , R 2a , R 2b , X, Y, R 6a and R 6b are as defined above for above for Formula 1.

Compounds of Formula 10 can be used as process intermediates to prepare compounds of Formula 1.

DETAILS OF THE INVENTION

As used herein, the terms“comprises,”“comprising,” “includes,”“including,” “has,” “having,”“contains,”“containing,”“characterize d by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process, method, article, or apparatus.

The transitional phrase“consisting of’ excludes any element, step, or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase“consisting of’ appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.

The transitional phrase“consisting essentially of’ is used to define a composition, method or apparatus that includes materials, steps, features, components, or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components, or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term“consisting essentially of’ occupies a middle ground between“comprising” and “consisting of’.

Where applicants have defined an invention or a portion thereof with an open-ended term such as“comprising,” it should be readily understood that (unless otherwise stated) the description should be interpreted to also describe such an invention using the terms“consisting essentially of’ or“consisting of.”

Further, unless expressly stated to the contrary,“or” refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).

Also, the indefinite articles“a” and“an” preceding an element or component of the invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore“a” or“an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular.

As referred to in the present disclosure and claims,“plant” includes members of Kingdom Plantae, particularly seed plants (Spermatopsida), at all life stages, including young plants (e.g., germinating seeds developing into seedlings) and mature, reproductive stages (e.g., plants producing flowers and seeds). Portions of plants include geotropic members typically growing beneath the surface of the growing medium (e.g., soil), such as roots, tubers, bulbs and corms, and also members growing above the growing medium, such as foliage (including stems and leaves), flowers, fruits and seeds.

As referred to herein, the term“seedling”, used either alone or in a combination of words means a young plant developing from the embryo of a seed.

As referred to herein, the term“broadleaf’ used either alone or in words such as“broadleaf crop” means dicot or dicotyledon, a term used to describe a group of angiosperms characterized by embryos having two cotyledons.

As referred to in this disclosure, the terms“fungal pathogen” and“fungal plant pathogen” include pathogens in the Ascomycota, Basidiomycota and Zygomycota phyla, and the fungal-like Oomycota class that are the causal agents of a broad spectrum of plant diseases of economic importance, affecting ornamental, turf, vegetable, field, cereal and fruit crops. In the context of this disclosure, “protecting a plant from disease” or“control of a plant disease” includes preventative action (interruption of the fungal cycle of infection, colonization, symptom development and spore production) and/or curative action (inhibition of colonization of plant host tissues).

As used herein, the term“mode of action” (MO A) is as define by the Fungicide Resistance Action Committee (FRAC), and is used to distinguish fungicides according to their biochemical mode of action in the biosynthetic pathways of plant pathogens, and their resistance risk. FRAC-defined modes of actions include (A) nucleic acid synthesis, (B) mitosis and cell division, (C) respiration, (D) amino acid and protein synthesis, (E) signal transduction, (F) lipid synthesis and membrane integrity, (G) sterol biosynthesis in membranes, (H) cell wall biosynthesis, (I) melanin synthesis in cell wall, (P) host plant defense induction, (U) unknown mode of action, (NC) not classified, (M) multi-site contact activity and (BM) biologicals with multiple modes of action. Each mode of action (i.e. letters A through BM) contain one or more subgroups (e.g., A includes subgroups Al, A2, A3 and A4) based either on individual validated target sites of action, or in cases where the precise target site is unknown, based on cross resistance profiles within a group or in relation to other groups. Each of these subgroups (e.g., Al, A2, A3 and A4) is assigned a FRAC code (a number and/or letter). For example, the FRAC code for subgroup Al is 4. Additional information on target sites and FRAC codes can be obtained from publicly available databases maintained, for example, by FRAC.

As used herein, the term“cross resistance” refers to the phenomenon that occurs when a pathogen develops resistance to one fungicide and simultaneously becomes resistant to one or more other fungicides. These other fungicides are typically, but not always, in the same chemical class or have the same target site of action, or can be detoxified by the same mechanism.

Generally when a molecular fragment (i.e. radical) is denoted by a series of atom symbols (e.g., C, H, N, O and S) the implicit point or points of attachment will be easily recognized by those skilled in the art. In some instances herein, particularly when alternative points of attachment are possible, the point or points of attachment may be explicitly indicated by a hyphen (“-”). The dotted line in rings depicted in the present description (e.g., the rings G-44, G-45, G-48 and G-49 shown in Exhibit A) represents that the bond indicated can be a single bond or double bond.

In the above recitations, the term“alkyl”, used either alone or in compound words such as “alkylthio” or“haloalkyl” includes straight- chain and branched alkyl, such as, methyl, ethyl, «-propyl, /-propyl, and the different butyl, pentyl and hexyl isomers.“Alkenyl” includes straight- chain and branched alkenes such as ethenyl, l-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. “Alkenyl” also includes polyenes such as 1 ,2-propadienyl and 2,4-hexadienyl. “Alkynyl” includes straight-chain and branched alkynes such as ethynyl, l-propynyl, 2-propynyl, and the different butynyl, pentynyl and hexynyl isomers. “Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. “Alkylene” denotes a straight-chain or branched alkanediyl. Examples of“alkylene” include CH 2 , CH CH , CH(CH 3 ), CH CH CH , CH 2 CH(CH ), and the different butylene isomers. “Alkenylene” denotes a straight- chain or branched alkenediyl containing one olefinic bond. Examples of “alkenylene” include CH=CH, 0¾0ί=0ί, CH=C(CH 3 ) and the different butenylene isomers. “Alkynylene” denotes a straight-chain or branched alkynediyl containing one triple bond. Examples of“alkynylene” include CH 2 CºC, CºCCH 2 , and the different butynylene, pentynylene or hexynylene isomers. The term“cycloalkylene” denotes a cycloalkanediyl ring. Examples of “cycloalkylene” include cyclobutanediyl, cyclopentanediyl and cyclohexanediyl. The term “cycloalkenylene” denotes a cycloalkenediyl ring containing one olefinic bond. Examples of “cycloalkenylene” include cyclopropenediyl and cyclopentenediyl.

“Alkoxy” includes, for example, methoxy, ethoxy, «-propyloxy, /-propyloxy, and the different butoxy, pentoxy and hexyloxy isomers. “Alkenyloxy” includes straight-chain and branched alkenyl attached to and linked through an oxygen atom. Examples of“alkenyloxy” include H2C=CHCH20 and CH 3 CH=CHCH20. “Alkynyloxy” includes straight-chain and branched alkynyl attached to and linked through an oxygen atom. Examples of“alkynyloxy” include HCºCCH 2 0 and CH 3 CºCCH 2 0.

The term“alkylthio” includes straight-chain and branched alkylthio moieties such as methylthio, ethylthio, and the different propylthio and butylthio isomers.“Alkylsulfinyl” includes both enantiomers of an alkylsulfinyl group. Examples of“alkylsulfinyl” include CH 3 S(=0), CH 3 CH2S(=0), CH 3 CH2CH2S(=0), (CH 3 )2CHS(=0), and the different butylsulfinyl isomers. Examples of “alkylsulfonyl” include CH 3 S(=0)2, CH 3 CH2S(=0)2, CH 3 CH2CH2S(=0)2, (CH 3 )2CHS(=0)2, and the different butylsulfonyl isomers.“Alkenylthio” includes straight-chain and branched alkenyl attached to and linked through a sulfur atom. Examples of“alkenylthio” include H C=CHCH S and CH 3 CH=CHCH S. “Alkenylsulfinyl” includes both enantiomers of an alkenylsulfinyl group. Examples of “alkenylsulfinyl” include H2C=CHCH2S(=0), CH 3 CH=CHCH2S(=0), (CH 3 )2C=CHCH2S(=0), and the different butynylsulfinyl isomers. Examples of“alkenylsulfonyl” include CH 3 CH=CHS(=0)2, (CH 3 )2C=CHCH2S(=0)2, and the different butynylsulfonyl isomers. “Alkynylthio” includes straight-chain and branched alkynyl attached to and linked through a sulfur atom. Examples of“alkynylthio” include HCºCCH 2 S and CH 3 CºCCH2S. “Alkynylsulfinyl” includes both enantiomers of an alkynylsulfinyl group. Examples of“alkynylsulfinyl” include HCºCCH2S(=0), CH3CºCCH2S(=0), and the different butenylsulfinyl isomers. Examples of “alkynylsulfonyl” include CH3CºCS(=0)2, CH 3 C=CCH 2 S ( = 0) 2 , and the different butenylsulfonyl isomers.

“Alkylthioalkyl” denotes alkylthio substitution on alkyl. Examples of “alkylthioalkyl” include CH 3 SCH 2 , CH 3 SCH 2 CH 2 , CH3CH2SCH2, CH 3 CH 2 CH 2 S CH 2 and CH3CH 2 SCH 2 CH 2 ; “alkylsulfinylalkyl” and“alkylsulfonylalkyl” include the corresponding sulfoxides and sulfones, respectively.

“(Alkylthio)carbonyl” denotes a straight-chain or branched alkylthio group bonded to a

C(=0) moiety. Examples of“(alkylthio)carbonyl” include CH3SC(=0), CH^CT^CT^SC^O) and (CH3)2CHSC(=0). The terms“(alkenylthio)carbonyl” and“(alkynylthio)carbonyl” are likewise defined. Examples of “(alkenylthio)carbonyl” include H2C=CHCH2SC(=0) and CH3CH2CH=CHSC(=0). Examples of“(alkynylthio)carbonyl” include HCºCCH2SC(=0) and CH3CºCCH 2 SC(=0).

“Alkyl(thiocarbonyl)” denotes a straight-chain or branched alkyl group bonded to a C(=S) moiety. Examples of “alkyl(thiocarbonyl)” include CH^CT^C^S), CH^CT^CT^C^S) and (CH3)2CHCH2C(=S). The terms “alkenyl(thiocarbonyl)” and “alkynyl(thiocarbonyl)” are likewise defined. Examples of “alkenyl(thiocarbonyl)” include H2C=CHCH2CH2C(=S) and CH3CH2CH=CHC(=S). Examples of“alkynyl(thiocarbonyl)” include HCºCCH2CH2C(=S) and CH 3 CºCCH 2 C(=S).

“Alkylamino(thiocarbonyl)” denotes a straight-chain or branched alkylamino group bonded to a C(=S) moiety. Examples of “alkylamino(thiocarbonyl)” include CH3NHC(=S), CH3 CH2CH2NHC(=S) and (CH3)2CHNHC(=S). The terms“alkenylamino(thiocarbonyl)” and “alkynylamino(thiocarbonyl)” are likewise defined. Examples of“alkenylamino(thiocarbonyl)” include H 2 C=CHCH 2 CH 2 NHC(=S) and CH3CH 2 CH=CHNHC(=S). Examples of

“alkynylamino(thiocarbonyl)” include HCºCCH2CH2NHC(=S) and CH3CºCCH2NHC(=S). “(Alkylthio)carbonylamino” denotes a straight- chain or branched alkylthio group bonded to a C(=0)NH moiety. Examples of “(alkylthio)carbonylamino” include CH3CH2SC(=0)NH, CH3CH2CH2SC(=0)NH and (CH3)2CHSC(=0)NH. The terms“(alkenylthio)carbonylamino” and “(alkynylthio)carbonylamino” are likewise defined. Examples of

“(alkenylthio)carbonylamino include H2C=CHCH2SC(=0)NH and CH3CH=CHSC(=0)NH.

Examples of “(alkynylthio)carbonylamino” include HCºCCH2CH2SC(=0)NH and CH3CºCCH 2 CH 2 SC(=0)NH.

“Alkylamino” includes an NH radical substituted with a straight-chain or branched alkyl group. Examples of “alkylamino” include CH3CH2NH, CH3CH2CH2NH, and

(CH 3 )2CHCH2NH. Examples of “ dialky lamino” include (CH^N, (CH3CH2CH2)2N and CH 3 CH 2 (CH 3 )N. “Alkylaminoalkyl” denotes alkylamino substitution on alkyl. Examples of “alkylammoalkyl” include CH 3 NHCH 2 , CH3NHCH2CH2, CH 3 CH 2 NHCH 2 ,

CH3CH2CH2CH2NHCH2 and CH 3 CH 2 NHCH 2 CH 2 .

“Alkylcarbonyl” denotes a straight-chain or branched alkyl group bonded to a C(=0) moiety. Examples of “alkylcarbonyl” include CH3C(=0), CH^CH^CT^C^O) and

(CH3)2CHC(=0). The terms“alkenylcarbonyl” and“alkynylcarbonyl” are likewise defined. Examples of “alkenylcarbonyl” include H2C=CHCH2C(=0) and CH3CH2CH=CHC(=0). Examples of “alkynylcarbonyl” include HCºCCH2C(=0) and CH3CºCCH2C(=0).

“Alkoxycarbonyl” includes a C(=0) moiety substituted with a straight-chain or branched alkoxy group. Examples of “alkoxycarbonyl” include CH30C(=0), CH^CH^OC^O),

CH3 CH 2 CH 2 O C (=0) , (CH3)2CH0C(=0), and the different butoxy- and pentoxycarbonyl isomers. The terms“alkenyloxycarbonyl” and“alkynyloxycarbonyl” are likewise defined. Examples of“alkenyloxycarbonyl” include H2C=CHCH20C(=0) and CH3CH2CH=CH0C(=0). Examples of“alkynyloxycarbonyl” include HCºCCH20C(=0) and CH3CºCCH20C(=0).

“Alkylaminocarbonyl” denotes a straight-chain or branched alkyl group bonded to a NHC(=0) moiety. Examples of “alkylaminocarbonyl” include CH3NHC(=0),

CH 3 CH 2 NHC(=0), CH3CH 2 CH 2 NHC(=0), (CH3) 2 CHNHC(=0), and the different butylamino- and pentylaminocarbonyl isomers. The terms “alkenylaminocarbonyl” and “alkynylaminocarbonyl” are likewise defined. Examples of “alkenylaminocarbonyl” include H2C=CHCH2NHC(=0) and (CH 3 )2C=CHCH2NEIC(=0). Examples of“alkynylaminocarbonyl” include CH 3 CºCNHC(=0) and CH 3 CºCCH2NHC(=0). Examples of“dialky laminocarbonyl” include (CH 3 ) 2 N(=0), (CH 3 CH 2 ) 2 NC(=0), CH 3 CH 2 (CH 3 )NC(=0), (CH 3 ) 2 CH(CH 3 )NC(=0) and CH 3 CH 2 CH 2 (CH 3 )NC(=0).

The term“alkylcarbonylamino” denotes a straight-chain or branched alkyl group bonded to a C(=0)NH moiety. Examples of “alkylcarbonylamino” include CH 3 CH2C(=0)NH and CH 3 CH2CH2C(=0)NH. The terms“alkenylcarbonylamino” and“alkynylcarbonylamino” are likewise defined. Examples of “alkenylcarbonylamino” include H2C=CHCH2C(=0)NH and (CH 3 )2C=CHCH2C(=0)NH. Examples of “alkynylcarbonylamino” include

CH 3 CºCCH(CH 3 )C(=0)NH and HCºCCH2CH2C(=0)NH. The term“alkoxycarbonylamino” denotes alkoxy bonded to a C(=0)NH moiety. Examples of“alkoxycarbonylamino” include CH 3 OC(=0)NH and CH 3 CH 2 0C(=0)NH.

The term“alkylaminocarbonylamino” denotes a straight-chain or branched alkyl group bonded to a NHC(=0)NH moiety. Examples of “alkylaminocarbonylamino” include CH 3 CH 2 NHC(=0)NH and (CH 3 CH 2 )2CH 2 NHC(=0)NH. The terms

“alkenylaminocarbonylamino” and “alkynylaminocarbonylamino” are likewise defined. Examples of “alkenylaminocarbonylamino” include H2C=CHCH2NHC(=0)NH and (CH 3 )2C=CHCH2NHC(=0)NH. Examples of “alkynylaminocarbonylamino” include

CH 3 CºCCH(CH 3 )NHC(=0)NH and HCºCCH 2 CH 2 NHC(=0)NH.

“Alkylsulfonylamino” denotes an NH radical substituted with alkylsulfonyl. Examples of “alkylsulfonylamino” include CH 3 CH2S(=0)2NH and (CH 3 )2CHS(=0)2NH. The terms “alkenylsulfonylamino” and “alkynylsulfonylamino” are likewise defined. Examples of “alkenylsulfonylammo” include H2C=CHCH 2 CH 2 S(=0)2NH and (CH 3 ) 2 C=CHCH 2 S(=0)2NH. Examples of “alkynylsulfonylamino” include CH 3 CºCCH(CH 3 )S(=0)2NH and HCºCCH2CH2S(=0)2NH. The term“alkylsulfonyloxy” denotes an alkylsulfonyl group bonded to an oxygen atom. Examples of“alkylsulfonyloxy” include CH 3 S(=0)20, CH 3 CH2S(=0)20, CHg CH 2 CH 2 S (=0)20 , (CH3 ) 2 CHS (=0)20, and the different butylsulfonyloxy, pentylsulfonyloxy and hexylsulfonyloxy isomers.

“Alkylaminosulfonyl” denotes a straight-chain or branched alkyl group bonded to a NHS(=0)2 moiety. Examples of “alkylaminosulfonyl” include CHgCH^NEIS^O^ and (CH 3 )2CHNHS(=0)2. The terms “alkenylaminosulfonyl” and “alkynylaminosulfonyl” are likewise defined. Examples of“alkenylaminosulfonyl” include H2C=CHCH2CH2NHS(=0)2 and (CH 3 )2C=CHCH2NHS(=0)2. Examples of “alkynylaminosulfonyl” include

CH 3 CºCCH(CH3)NHS(=0) 2 and HCºCCH 2 CH 2 NHS(=0)2.

“Alkylaminosulfonylamino” denotes a straight-chain or branched alkyl group bonded to a NHS(=0)2NH moiety. Examples of“alkylaminosulfonylamino” include CH3CH2NHS(=0)2NH and (CH 3 ) 2 CHNHS (=0)2NH. The terms “alkenylaminosulfonylamino” and

“alkynylaminosulfonylamino” are likewise defined. Examples of“alkenylaminosulfonylamino” include H 2 C=CHCH 2 CH2NHS(=0)2NH and (CH3) 2 C=CHCH 2 NHS(=0)2NH. Examples of “alkynylaminosulfonylamino” include CH3CºCCH(CH3)NHS(=0)2NH and

HCºCCH 2 CH 2 NHS(=0)2NH.

“Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of“alkoxyalkyl” include CH3OCH2, CH3OCH2CH2, CH3CH2OCH2, CH3 CH 2 CH 2 OCH 2 and CH3CH 2 OCH 2 CH 2 . “Alkoxyalkoxy” denotes alkoxy substitution on another alkoxy moiety. “Alkoxyalkoxyalkyl” denotes alkoxyalkoxy substitution on alkyl. Examples of “alkoxyalkoxyalkyl” include CH3OCH2OCH2, CH3OCH2OCH2CH2 and CH3 CH 2 OCH 2 OCH 2 .

The term“alkylcarbonyloxy” denotes a straight- chain or branched alkyl bonded to a C(=0)0 moiety. Examples of “alkylcarbonyloxy” include CH3CH2C(=0)0 and (CH3)2CHC(=0)0. The terms“alkenylcarbonyloxy” and“alkynylcarbonyloxy” are likewise defined. Examples of “alkenylcarbonyloxy” include H2C=CHCH2CH2C(=0)0 and (CH3)2C=CHCH2C(=0)0. Examples of “alkynylcarbonyloxy” include

CH3CºCCH(CH3)C(=0)0 and HCºCCH2CH2C(=0)0. The term“alkoxy carbonyloxy” denotes a straight-chain or branched alkoxy bonded to a C(=0)0 moiety. Examples of “alkoxy carbonyloxy” include CH3CH2CH20C(=0)0 and (CH3)2CH0C(=0)0. The term “alkoxycarbonylalkyl” denotes alkoxycarbonyl substitution on alkyl. Examples of “alkoxycarbonylalkyl” include CH3CH20C(=0)CH2, (CH3)2CH0C(=0)CH2 and

CH 3 0C(=0)CH2CH2. The term“alkylaminocarbonyloxy” denotes a straight- chain or branched alkylaminocarbonyl attached to and linked through an oxygen atom. Examples of “alkylaminocarbonyloxy” include (CH3)2CHCH 2 NEIC(=0)0 and CH3CH2NHC(=0)0. The terms“alkenylaminocarbonyloxy” and“alkynylaminocarbonyloxy” are likewise defined.

The term“alkylcarbonylthio” denotes a straight-chain or branched alkyl group bonded to a C(=0)S moiety. Examples of “alkylcarbonylthio” include CH3CH2C(=0)S and CH3CH 2 CH 2 C(=0)S.

“Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term“cycloalkylalkyl” denotes cycloalkyl substitution on an alkyl moiety. Examples of “cycloalkylalkyl” include cyclopropylmethyl, cyclopentylethyl, and other cycloalkyl moieties bonded to a straight-chain or branched alkyl group. The term“alkylcycloalkyl” denotes alkyl substitution on a cycloalkyl moiety and includes, for example, ethylcyclopropyl, /-propylcyclobutyl, methylcyclopentyl and methylcyclohexyl. “Alkylcycloalkylalkyl” denotes alkylcycloalkyl substitution on alkyl. Examples of “alkylcycloalkylalkyl” include methylcyclohexylmethyl and ethylcycloproylmethyl. “Cycloalkenyl” includes groups such as cyclopentenyl and cyclohexenyl as well as groups with more than one double bond such as 1,3- or l,4-cyclohexadienyl. The term“cycloalkylcycloalkyl” denotes cycloalkyl substitution on another cycloalkyl ring, wherein each cycloalkyl ring independently has from 3 to 7 carbon atom ring members. Examples of cycloalkylcycloalkyl include cyclopropylcyclopropyl (such as 1,1'- bicyclopropyl-l-yl, l,l'-bicyclopropyl-2-yl), cyclohexylcyclopentyl (such as 4- cyclopentylcyclohexyl) and cyclohexylcyclohexyl (such as l,l'-bicyclohexyl-l-yl), and the different cis- and ra«.s-cycloalkylcycloalkyl isomers, (such as ( 1 R,2S)-\ J '-bicyclopropyl-2-yl and (\R,2R)- 1 , 1 '-bicyclopropyl-2-yl).

The term“cycloalkoxy” denotes cycloalkyl attached to and linked through an oxygen atom including, for example, cyclopentyloxy and cyclohexyloxy. The term“cycloalkoxyalkyl” denotes cycloalkoxy substitution on an alkyl moiety. Examples of “cycloalkoxyalkyl” include cyclopropyloxymethyl, cyclopentyloxyethyl, and other cycloalkoxy groups bonded to a straight-chain or branched alkyl moiety. The term“cycloalkylaminoalkyl” denotes cycloalkylamino substitution on an alkyl group. Examples of“cycloalkylaminoalkyl” include cyclopropylaminomethyl, cyclopentylaminoethyl, and other cycloalkylamino moieties bonded to a straight-chain or branched alkyl group.

“Cycloalkylcarbonyl” denotes cycloalkyl bonded to a C(=0) group including, for example, cyclopropylcarbonyl and cyclopentylcarbonyl. “Cycloalkylcarbonyloxy” denotes cycloalkylcarbonyl attached to and linked through an oxygen atom. Examples of “cycloalkylcarbonyloxy” include cyclohexylcarbonyloxy and cyclopentylcarbonyloxy. The term “cycloalkoxycarbonyl” means cycloalkoxy bonded to a C(=0) group, for example, cyclopropyloxycarbonyl and cyclopentyloxycarbonyl. “Cycloalkylaminocarbonylamino” denotes cycloalkylamino bonded to a C(=0)NH group, for example, cyclopentylaminocarbonylamino and cyclohexylaminocarbonylamino.

The term“halogen”, either alone or in compound words such as“haloalkyl”, or when used in descriptions such as“alkyl substituted with halogen” includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as“haloalkyl”, or when used in descriptions such as“alkyl substituted with halogen” said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of“haloalkyl” or“alkyl substituted with halogen” include CF 3 , ClCH 2 , CF3CH2 and CF 3 CCl 2 . The terms “haloalkenyl”, “haloalkynyl”“haloalkoxy”,“haloalkylsulfonyl”, halocycloalkyl”, and the like, are defined analogously to the term“haloalkyl”. Examples of “haloalkenyl” include Cl2C=CHCH2 and CF 3 CH 2 CH=CHCH 2 . Examples of“haloalkynyl” include HCºCCHCl, CF 3 CºC, CCl 3 CºC and FCH 2 CºCCH 2 . Examples of “haloalkoxy” include CF 3 0, CCl 3 CH 2 0, F2CHCH 2 CH 2 0 and CF 3 CH 2 0. Examples of“haloalkylsulfonyl” include CF 3 S(=0) 2 , CCl 3 S(=0) 2 , CF 3 CH 2 S(=0) 2 and CF 3 CF 2 S(=0)2. Examples of “halocycloalkyl” include 2-chlorocyclopropyl, 2-fluorocyclobutyl, 3-bromocyclopentyl and 4-chorocyclohexyl.

“Cyanoalkyl” denotes an alkyl group substituted with one cyano group. Examples of “cyanoalkyl” include NCCH 2 , NCCH2CH2 and CH 3 CH(CN)CH2· “Hydroxyalkyl” denotes an alkyl group substituted with one hydroxy group. Examples of “hydroxyalkyl” include

HOCH 2 CH 2 , CH 3 CH 2 (OH)CH and Hoa¾a¾a¾a¾ “Trialkylsilyl” includes 3 branched and/or straight-chain alkyl radicals attached to and linked through a silicon atom, such as trimethylsilyl, triethylsilyl and /V-buty 1 di methyl si lyl .

The total number of carbon atoms in a substituent group is indicated by the“C j -Cj” prefix where i and j are numbers from 1 to 15. For example, C j -C 4 alkylsulfonyl designates methylsulfonyl through butylsulfonyl; C 2 alkoxyalkyl designates CH3OCH2; C 3 alkoxyalkyl designates, for example, CFI 3 CFI(OCFI 3 ), CHyOCF^CF^ or CHyCH^OCH^; and C 4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CHyCH^CH^OCH^ and CH^CH^OCH^CH^.

The term“unsubstituted” in connection with a group such as a ring or ring system means the group does not have any substituents other than its one or more attachments to the remainder of Formula 1. The term“optionally substituted” means that the number of substituents can be zero. Unless otherwise indicated, optionally substituted groups may be substituted with as many optional substituents as can be accommodated by replacing a hydrogen atom with a non-hydrogen substituent on any available carbon or nitrogen atom. Commonly, the number of optional substituents (when present) ranges from 1 to 3. As used herein, the term“optionally substituted” is used interchangeably with the phrase “substituted or unsubstituted” or with the term “(un)substituted.”

The number of optional substituents may be restricted by an expressed limitation. For example, the phrase“optionally substituted with up to 3 substituents independently selected from R 13 ” means that 0, 1, 2 or 3 substituents can be present (if the number of potential connection points allows). When a range specified for the number of substituents (e.g., x being an integer from 0 to 3 in Exhibit A) exceeds the number of positions available for substituents on a ring (e.g., 1 position available for (R 13 ) x on G-7 in Exhibit A), the actual higher end of the range is recognized to be the number of available positions.

When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can vary (e.g., (R 13 ) x in Exhibit A wherein x is 1 to 3), then said substituents are independently selected from the group of defined substituents, unless otherwise indicated. When a variable group is shown to be optionally attached to a position, for example ( Rl3 )x in Exhibit A wherein x may be 0, then hydrogen may be at the position even if not recited in the definition of the variable group.

Naming of substituents in the present disclosure uses recognized terminology providing conciseness in precisely conveying to those skilled in the art the chemical structure. For sake of conciseness, locant descriptors may be omitted.

Unless otherwise indicated, a“ring” or“ring system” as a component of Formula 1 (e.g., G) is carbocyclic or heterocyclic. The term“ring system” denotes two or more connected rings. The term“spirocyclic ring system” denotes a ring system consisting of two rings connected at a single atom (so the rings have a single atom in common). The term“bicyclic ring system” denotes a ring system consisting of two rings sharing two or more common atoms. In a“fused bicyclic ring system” the common atoms are adjacent, and therefore the rings share two adjacent atoms and a bond connecting them.

The term“ring member” refers to an atom (e.g., C, O, N or S) or other moiety (e.g., C(=0), C(=S), S(=0) and S(=0) 2 ) forming the backbone of a ring or ring system. The term“aromatic” indicates that each of the ring atoms is essentially in the same plane and has a / orbital perpendicular to the ring plane, and that (4n + 2) p electrons, where n is a positive integer, are associated with the ring to comply with Huckel’s rule

The term“carbocyclic ring” denotes a ring wherein the atoms forming the ring backbone are selected only from carbon. Unless otherwise indicated, a carbocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated carbocyclic ring satisfies HuckeTs rule, then said ring is also called an“aromatic ring”. “Saturated carbocyclic” refers to a ring having a backbone consisting of carbon atoms linked to one another by single bonds; unless otherwise specified, the remaining carbon valences are occupied by hydrogen atoms.

As used herein, the term“partially unsaturated ring" or "partially unsaturated heterocycle” refers to a ring which contains unsaturated ring atoms and one or more double bonds but is not aromatic.

The terms“heterocyclic ring” or“heterocycle” denotes a ring wherein at least one of the atoms forming the ring backbone is other than carbon. Unless otherwise indicated, a heterocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated heterocyclic ring satisfies HuckeTs rule, then said ring is also called a“heteroaromatic ring” or aromatic heterocyclic ring. “Saturated heterocyclic ring” refers to a heterocyclic ring containing only single bonds between ring members.

Unless otherwise indicated, heterocyclic rings and ring systems are attached to the remainder of Formula 1 through any available carbon or nitrogen atom by replacement of a hydrogen on said carbon or nitrogen atom.

Compounds of this invention can exist as one or more stereoisomers. Stereoisomers are isomers of identical constitution but differing in the arrangement of their atoms in space and include enantiomers, diastereomers, cis- and /ra«.s-isomers (also known as geometric isomers) and atropisomers. Atropisomers result from restricted rotation about single bonds where the rotational barrier is high enough to permit isolation of the isomeric species. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. For a comprehensive discussion of all aspects of stereoisomerism, see Ernest L. Eliel and Samuel H. Wilen, Stereochemistry of Organic Compounds, John Wiley & Sons, 1994.

Compounds of this invention may be present as a mixture of stereoisomers, individual stereoisomers, or as an optically active form. For example, when T is T-3, then Formula 1 compounds contain at least one double bond and the configuration of substituents about that double bond can be (Z) or (//) (cis or trans), or a mixture thereof. In the context of the present disclosure and claims, a wavy bond (e.g., as shown in the T-3 moiety in the Summary of the Invention) indicates a single bond which is linked to an adjacent double bond wherein the geometry about the adjacent double bond is either (Z)-configuration (syn-isomer or cv.v-isomer) or (//(-configuration (anti-isomer or ra«.s-isomer), or a mixture thereof. That is, a wavy bond represents an unspecified (Z)- or (//)- (cis- or trans-) isomer, or mixture thereof. In addition, the compounds of the present invention can contain one or more chiral centers and therefore exist in enantiomeric and diastereomeric forms. Unless the structural formula or the language of this application specifically designate a particular cis- or /ra«.v- isomer, or a configuration of a chiral center, the scope of the present invention is intended to cover all such isomers per se, as well as mixtures of cis- and ra«.s-isomers, mixtures of diastereomers and racemic mixtures of enantiomers (optical isomers) as well. This invention also includes compounds of Formula 1 wherein one stereoisomer is enriched relative to the other stereoisomer(s). Of note are compounds of Formula 1 wherein T is T-3 and the substituents attached to the double bond in the T-3 moiety are in a predominately (Z)- configuration, or predominately an (//(-configuration. The ratio of the (Z)- to (E)-isomers in any compounds of Formula 1, whether produced stereoselectivity or non-stereoselectivity, may take on a broad range of values. For example, compounds of Formula 1 may comprise from about 10 to 90 percent by weight of the (Z)-isomer to about 90 to 10 percent by weight of the (E)-isomer. In other embodiments, Formula 1 compounds may contain from about 15 to 85 percent by weight of the (Z)-isomer and about 85 to 15 percent by weight of the (E)-isomer; in another embodiment, the mixture contains about 25 to 75 percent by weight of the (Z)-isomer and about 75 to 25 percent by weight of the (/'/(-isomer; in another embodiment, the mixture contains about 35 to 65 percent by weight of the (Z)-isomer and about 65 to 35 percent by weight of the (//(-isomer; in another embodiment, the mixture contains about 45 to 55 percent by weight of the (Z)-isomer and about 55 to 45 percent by weight of the (E)-isomer. These percentages by weight are based on the total weight of the composition, and it will be understood that the sum of the weight percent of the (Z)- isomer and the (E)-isomer is 100 weight percent. In other words, compounds of Formula 1 might contain 65 percent by weight of the (Z)-isomer and 35 percent by weight of the (//(-isomer, or vice versa.

In addition, this invention includes compounds that are enriched compared to the racemic mixture in an enantiomer of Formula 1. Also included are the essentially pure enantiomers of compounds of Formula 1. When enantiomerically enriched, one enantiomer is present in greater amounts than the other, and the extent of enrichment can be defined by an expression of enantiomeric excess (“ee”), which is defined as (2x-l)· 100%, where x is the mole fraction of the dominant enantiomer in the mixture (e.g., an ee of 20% corresponds to a 60:40 ratio of enantiomers).

Preferably the compositions of this invention have at least a 50% enantiomeric excess; more preferably at least a 75% enantiomeric excess; still more preferably at least a 90% enantiomeric excess; and the most preferably at least a 94% enantiomeric excess of the more active isomer. Of particular note are enantiomerically pure embodiments of the more active isomer.

Compounds of this invention can exist as one or more conformational isomers due to restricted rotation about an amide bond (e.g., C(=0)-N) in Formula 1. This invention comprises mixtures of conformational isomers. In addition, this invention includes compounds that are enriched in one conformer relative to others.

This invention comprises all stereoisomers, conformational isomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds.

One skilled in the art will appreciate that not all nitrogen containing heterocycles can form A'-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen-containing heterocycles which can form A'-oxides. One skilled in the art will also recognize that tertiary amines can form A'-oxides. Synthetic methods for the preparation of A'-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and /«-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as /-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethyldioxirane. These methods for the preparation of A'-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boulton and

A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, Ed., Academic Press; M. Tisler and

B. Stanovnik in Advances in Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

One skilled in the art recognizes that because in the environment and under physiological conditions salts of chemical compounds are in equilibrium with their corresponding nonsalt forms, salts share the biological utility of the nonsalt forms. Thus a wide variety of salts of the compounds of Formula 1 are useful for control of plant diseases caused by fungal plant pathogens (i.e. are agriculturally suitable). The salts of the compounds of Formula 1 include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. When a compound of Formula 1 contains an acidic moiety such as a carboxylic acid, salts also include those formed with organic or inorganic bases such as pyridine, triethylamine or ammonia, or amides, hydrides, hydroxides or carbonates of sodium, potassium, lithium, calcium, magnesium or barium. Accordingly, the present invention comprises compounds selected from Formula 1, L'-oxides, and agriculturally suitable salts, and solvates thereof.

Compounds selected from Formula 1, stereoisomers, tautomers, A'-oxides, and salts thereof, typically exist in more than one form, and Formula 1 thus includes all crystalline and non- crystalline forms of the compounds that Formula 1 represents. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The term“polymorph” refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due to the presence or absence of co-crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound represented by Formula 1 can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound represented by Formula 1. Preparation and isolation of a particular polymorph of a compound represented by Formula 1 can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. For a comprehensive discussion of polymorphism see R. Hilfiker, Ed., Polymorphism in the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006.

One skilled in the art recognizes that compounds of Formula 1 can exist as mixtures of ketonic and solvated forms (e.g., hemiketals, ketals and hydrates) and each are independently interconvertible and agriculturally active. For example, ketones of Formula l 1 (i.e. compounds of Formula 1 wherein T is T-l) may exist in equilibrium with their corresponding hydrates of Formula l 2 (i.e. compounds of Formula 1 wherein T is T-2, and R 2a X and R 2 ^Y are both OH). In cases where the ketone group is in close proximity to an electron-withdrawing group, such as when R 1 is a trifluoromethyl group, the equilibrium typically favors the hydrate form.

This invention comprises all ketonic and solvated forms of Formula 1 compounds, and mixtures thereof in all proportions. Unless otherwise indicated, reference to a compound by one tautomer description is to be considered to include all tautomers.

Additionally, some of the unsaturated rings and ring systems depicted in Exhibit A can have an arrangement of single and double bonds between ring members different from that depicted. Such differing arrangements of bonds for a particular arrangement of ring atoms correspond to different tautomers. For these unsaturated rings and ring systems, the particular tautomer depicted is to be considered representative of all the tautomers possible for the arrangement of ring atoms shown.

Embodiments of the present invention as described in the Summary of the Invention include those described below. In the following Embodiments, Formula 1 includes stereoisomers, L'-oxides, and salts thereof, and reference to“a compound of Formula 1” includes the definitions of substituents specified in the Summary of the Invention unless further defined in the Embodiments.

Embodiment 1. A compound of Formula 1 wherein T is T-l.

Embodiment 2. A compound of Formula 1 wherein T is T-2.

Embodiment 3. A compound of Formula 1 wherein T is T-3.

Embodiment 3a. A compound of Formula 1 wherein T is T-2 or T-3.

Embodiment 4. A compound of Formula 1 or any one of Embodiments 1 through 3a

wherein R 1 is CF 3 , CHF 2 , CCl 3 , CF 2 Cl or CFCl 2 .

Embodiment 5. A compound of Embodiment 4 wherein R 1 is CF 3 , CCl 3 or CF 2 Cl.

Embodiment 6. A compound of Embodiment 5 wherein R 1 is CF 3 .

Embodiment 7. A compound of Formula 1 or any one of Embodiments 1 through 6

wherein W is O or S. Embodiment 8. A compound of Embodiment 7 wherein W is O.

Embodiment 9. A compound of Formula 1 or any one of Embodiments 1 through 6

wherein W is NR 3 .

Embodiment 10. A compound of Formula 1 or Embodiments 1 and 9 wherein R 3 is H, cyano, C(=0)OH, C j -C2 alkyl, C2-C3 alkylcarbonyl, C2-C3 haloalkylcarbonyl,

OR 3a or NR 3b R 3c .

Embodiment 11. A compound of Embodiment 10 wherein R 3 is H, cyano, CJ-C2 alkyl or OR 3a .

Embodiment 12. A compound of Embodiment 11 wherein R 3 is H, cyano or OR 3a .

Embodiment 13. A compound of Formula 1 or any one of Embodiments 1 through 12 wherein R 3a is H, CJ-C2 alkyl, C2-C3 alkylcarbonyl or C2-C3 haloalkylcarbonyl.

Embodiment 14. A compound of Embodiment 13 wherein R 3a is H.

Embodiment 15. A compound of Formula 1 or any one of Embodiments 1 and 14 wherein when R 3b is separate (i.e. not taken together with R 3c to form a ring), then R 3b is H, CJ-C3 alkyl, C2-C3 alkylcarbonyl or C2-C3 haloalkylcarbonyl.

Embodiment 16. A compound of Embodiment 15 wherein R 3b is H or methyl.

Embodiment 17. A compound of Formula 1 or any one of Embodiments 1 and 16 wherein when R 3C is separate (i.e. not taken together with R 3b to form a ring), then R 3c is H or C j -C 2 alkyl.

Embodiment 18. A compound of Embodiment 17 wherein R 3c is H or methyl.

Embodiment 19. A compound of Formula 1 or any one of Embodiments 1 through 18 wherein X is O or NR 5a .

Embodiment 20. A compound of Formula 1 or any one of Embodiments 1 through 18 wherein X is O, S, NH or NOH.

Embodiment 20a. A compound of Embodiment 20 wherein X is O or NOH.

Embodiment 21. A compound of Embodiment 20 wherein X is O.

Embodiment 22. A compound of Formula 1 or any one of Embodiments 1 through 21 wherein Y is O or NR 5b . Embodiment 23. A compound of Formula 1 or any one of Embodiments 1 through 21 wherein Y is O, S, NH or NOH.

Embodiment 23a. A compound of Embodiment 23 wherein Y is O or NOH.

Embodiment 24. A compound of Embodiment 22 wherein Y is O.

Embodiment 25. A compound of Formula 1 or any one of Embodiments 1 and 24 wherein

R 5a and R 5b are each independently H, hydroxy or C j -C2 alkyl.

Embodiment 26. A compound of Embodiment 25 wherein R 5a and R 5b are each

independently H, hydroxy or methyl.

Embodiment 27. A compound of Formula 1 or any one of Embodiments 1 through 26

wherein when R 2a and R 2b are separate (i.e. not taken together to form a ring), then

R 2a and R 2b are each independently H, CJ-C3 alkyl, C2-C3 alkenyl, (CR 4a R 4b ) p -OH, (CR 4a R 4 b)p-Cl or (CR 4a R 4b ) p -Br.

Embodiment 28. A compound of Embodiment 27 wherein R 2a and R 2b are each

independently H, C r C 3 alkyl, (CR 4a R 4b ) p -Cl or (CR 4a R 4b ) p -Br.

Embodiment 29. A compound of Embodiment 28 wherein R 2a and R 2b are each

independently H, methyl, (CR 4a R 4b ) p -Cl or (CR 4a R 4b ) p -Br.

Embodiment 30. A compound of Embodiment 28 wherein R 2a and R 2b are each

independently H or CJ-C3 alkyl.

Embodiment 31. A compound of Embodiment 30 wherein R 2a and R 2b are each

independently H or CJ-C2 alkyl.

Embodiment 32. A compound of Embodiment 31 wherein R 2a and R 2b are each

independently H or methyl.

Embodiment 33. A compound of Embodiment 32 wherein R 2a and R 2b are each H.

Embodiment 34. A compound of Formula 1 or any one of Embodiments 1 through 33

wherein when R 2a and R 2b are separate (i.e. not taken together to form a ring), then one of R 2a and R 2b is (CR 4a R 4b ) p -OH, (CR 4a R 4b ) p -SH, (CR 4a R 4b ) p -Cl or

(CR 4a R 4b ) p -Br, and the other is H. Embodiment 35. A compound of Embodiment 34 wherein one of R 2a and R 2 ^ is

(CR 4a R 4b )p-Cl or (CR 4a R 4b )p-Br, and the other is H.

Embodiment 36. A compound of Formula 1 or any one of Embodiments 1 through 35

wherein R 2a and R 2b are each independently H, methyl, (CR 4a R 4b ) p -OH,

(CR 4a R 4b )p-Cl or (CR 4a R 4b )p-Br; or R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5- to 6-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 2 carbon atom ring members are independently selected from C(=0) and C(=S), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, C j -C2 alkyl, C j -C2 haloalkyl, C j -C2 alkoxy and C j -C2 haloalkoxy on carbon atom ring members.

Embodiment 37. A compound of Embodiment 36 wherein R 2a and R 2 ^ are each

independently H or methyl; or R 2a and R 2b are taken together with the atoms X and

Y to which they are attached to form a 5- to 6-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 1 carbon atom ring member is selected from C(=0), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl, methoxy and halomethoxy on carbon atom ring members.

Embodiment 38. A compound of Embodiment 37 wherein R 2a and R 2 ^ are each

independently H or methyl; or R 2a and R 2b are taken together with the atoms X and

Y to which they are attached to form a 5 -member ed saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, the ring optionally substituted with up to 1 substituent selected from halogen, cyano and methyl on carbon atom ring members.

Embodiment 39. A compound of Embodiment 38 wherein R 2a and R 2 ^ are each H; or R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, the ring optionally substituted with up to 1 substituent selected methyl on a carbon atom ring member.

Embodiment 40. A compound of Embodiment 39 wherein R 2a and R 2 ^ are each H; or R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms

X and Y, selected from carbon atoms.

Embodiment 41. A compound of Formula 1 or any one of Embodiments 1 through 40 wherein when R 2a and R 2b are taken together to form a ring (i.e. not separate), then R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5- to 6-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 1 carbon atom ring member is selected from C(=0), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl, methoxy and halomethoxy on carbon atom ring members.

Embodiment 42. A compound of Embodiment 41 wherein R 2a and R 2 ^ are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl and methoxy on carbon atom ring members.

Embodiment 43. A compound of Embodiment 42 wherein R 2a and R 2 ^ are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, the ring optionally substituted with up to 1 substituent selected from halogen, methyl and halomethyl on a carbon atom ring member.

Embodiment 44. A compound of Embodiment 43 wherein R 2a and R 2 ^ are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms. Embodiment 45. A compound of Formula 1 or any one of Embodiments 1 through 44 wherein R 2c is C j -C 3 alkyl, C j -C 3 haloalkyl, C 2 -C 3 alkenyl, C 2 -C 3 haloalkenyl, C 2 -C 3 alkynyl or C 2 -C 3 haloalkynyl, each optionally substituted with up 1 substituent selected from cyano, hydroxy, SCºN and C j -C 2 alkoxy.

Embodiment 46. A compound of Embodiment 45 wherein R 2c is C j -C 2 alkyl, C j -C 2 haloalkyl, C 2 -C 3 alkenyl, C 2 -C 3 haloalkenyl, C 2 -C 3 alkynyl or C 2 -C 3 haloalkynyl, each optionally substituted with up 1 substituent selected from cyano and methoxy.

Embodiment 46a. A compound of Embodiment 46 wherein R 2c is C j -C 2 alkyl, C j -C 2 haloalkyl, C 2 -C 3 alkenyl, C 2 -C 3 haloalkenyl or C 2 -C 3 alkynyl.

Embodiment 47. A compound of Embodiment 46a wherein R 2c is C j -C 2 alkyl, C 2 -C 3 alkenyl or C 2 -C 3 alkynyl.

Embodiment 48. A compound of Embodiment 47 wherein R 2c is methyl or ethyl.

Embodiment 48a. A compound of Embodiment 48 wherein R 2c is ethyl.

Embodiment 49. A compound of Formula 1 or any one of Embodiments 1 through 48a wherein R 2d is H, cyano, halogen or C j -C 2 alkyl.

Embodiment 49a. A compound of Embodiment 49 wherein R 2 ^ is H, cyano, Cl, F or methyl.

Embodiment 50. A compound of Embodiment 49a wherein R 2 ^ is H or methyl.

Embodiment 51. A compound of Embodiment 50 wherein R 2 ^ is H.

Embodiment 52. A compound of Formula 1 or any one of Embodiments 1 through 51 wherein each R 4a and R 4b is independently H or C j -C 2 alkyl.

Embodiment 53. A compound of Embodiment 52 wherein each R 4a and R 4 ^ is

independently H or methyl.

Embodiment 54. A compound of Embodiment 53 wherein each R 4a and R 4 ^ is H.

Embodiment 55. A compound of Formula 1 or any one of Embodiments 1 through 54 wherein p is 2.

Embodiment 56. A compound of Formula 1 or any one of Embodiments 1 through 54 wherein p is 3. Embodiment 57. A compound of Formula 1 or any one of Embodiments 1 through 56 wherein A 1 is CR 6c R 6 ^ O or S.

Embodiment 58. A compound of Embodiment 57 wherein A 1 is CR 6c R 6 ^ or O.

Embodiment 59. A compound of Embodiment 58 wherein A 1 is CR 6c R 6 ^.

Embodiment 60. A compound of Embodiment 58 wherein A 1 is O.

Embodiment 61. A compound of Formula 1 or any one of Embodiments 1 through 60 wherein A 1 is CH 2 , NH, O or S.

Embodiment 62. A compound of Formula 1 or any one of Embodiments 1 through 61 wherein A 1 is N(R 7a ).

Embodiment 63. A compound of Formula 1 or any one of Embodiments 1 through 62 wherein A 2 is a direct bond, CR 6e R 6f , O or S.

Embodiment 64. A compound of Embodiment 63 wherein A 2 is a direct bond, CR 6e R 6f or O.

Embodiment 65. A compound of Embodiment 64 wherein A 2 is a direct bond or O.

Embodiment 66. A compound of Embodiment 65 wherein A 2 is a direct bond.

Embodiment 67. A compound of Formula 1 or any one of Embodiments 1 through 66 wherein A 2 is a direct bond, CH 2 , NH, O or S.

Embodiment 67a. A compound of Embodiment 67 wherein A 2 is a direct bond, CH 2 or O.

Embodiment 68. A compound of Embodiment 67a wherein A 2 is a direct bond or O.

Embodiment 69. A compound of Formula 1 or any one of Embodiments 1 through 68 wherein A 2 is N(R 7 ^).

Embodiment 70. A compound of Formula 1 or any one of Embodiments 1 through 69 wherein when A is A!-A 2 -CR 6a R 6 b, then A l -A 2 -CR f,a R^ is selected from OCH 2 ,

OCH(Me), CH(OH)CH 2 , CH 2 CH 2 , SCH 2 , OCF 2 and CH 2 OCH 2 .

Embodiment 71. A compound of Embodiment 70 wherein Al-A 2 -CR 6a R 6 b is selected from OCH 2 , OCH(Me) and CH 2 CH 2 .

Embodiment 72. A compound of Embodiment 71 wherein Al-A 2 -CR 6a R 6 b is selected from OCH 2 and CH 2 CH 2 .

Embodiment 73. A compound of Embodiment 72 wherein Al-A 2 -CR 6a R 6 b is OCH 2 . Embodiment 74. A compound of Formula 1 or any one of Embodiments 1 through 73 wherein when A is A 1 -A 2 , then A 1 -A 2 is selected from O, CH 2 , OCH 2 and CH 2 0.

Embodiment 75. A compound of Embodiment 74 wherein A J -A 2 is selected from O, CH 2 and CH 2 0.

Embodiment 76. A compound of Embodiment 75 wherein A J -A 2 is selected from O and

CH 2 .

Embodiment 77. A compound of Embodiment 76 wherein A J -A 2 is O.

Embodiment 78. A compound of Formula 1 or any one of Embodiments 1 through 77

wherein R 6a , R 6 ^ R6C ? R6CI ^ R6C anc j R6f are eac h independently H, cyano, hydroxy, Br, Cl, F or methyl.

Embodiment 79. A compound of Embodiment 78 wherein R 6a , R 6c , FC’d, R 6e and R 6f are each independently H, cyano hydroxy or methyl.

Embodiment 80. A compound of Embodiment 79 wherein R 6a , R 6c , R 6 ^ ^ R6e anc j R6f are each independently H or methyl.

Embodiment 81. A compound of Embodiment 80 wherein R 6a , R 6 ^ R6C ? R6CI R6e anc j R6f are each H.

Embodiment 82. A compound of Formula 1 or any one of Embodiments 1 through 81

wherein R 7a and R 7b are each independently H, C j -C 2 alkyl or C 2 -C 3 alkyl carbonyl.

Embodiment 83. A compound of Embodiment 82 wherein R 7a and R 7 ^ are each

independently H or C j -C 2 alkyl.

Embodiment 84. A compound of Embodiment 83 wherein R 7a and R 7 ^ are each H.

Embodiment 85. A compound of Formula 1 or any one of Embodiments 1 through 84

wherein when T is T-l or T-2, then A is A!-A 2 -CH 2 .

Embodiment 86. A compound of Formula 1 or any one of Embodiments 1 through 85

wherein when T is T-l or T-2, then A is OCH 2 , SCH 2 , NHCH 2 , CH 2 CH 2 ,

OCH 2 CH 2 , SCH 2 CH 2 , NHCH 2 CH 2 , CH 2 OCH 2 , CH 2 SCH 2 or CH 2 NHCH 2 .

Embodiment 87. A compound of Embodiment 86 wherein when T is T-l or T-2, then A is OCH 2 , SCH 2 , CH 2 CH 2 , OCH 2 CH 2 , SCH 2 CH 2 , CH 2 OCH 2 or CH 2 SCH 2 . Embodiment 88. A compound of Embodiment 87 wherein when T is T-l or T-2, then A is OCH 2 or CH 2 CH 2 .

Embodiment 89. A compound of Embodiment 88 wherein when T is T-l or T-2, then A is

OCH 2 .

Embodiment 90. A compound of Formula 1 or any one of Embodiments 1 through 89 wherein when T is T-3, then A is O, OCH 2 , SCH 2 , NHCH 2 , CH 2 , CH 2 CH 2 , CH 2 0, CH 2 S or CH 2 NH.

Embodiment 91. A compound of Embodiment 82 wherein when T is T-3, then A is O, CH 2 or OCH 2 .

Embodiment 92. A compound of Embodiment 91 wherein when T is T-3, then A is O or

CH 2 .

Embodiment 93. A compound of Embodiment 92 wherein when T is T-3, then A is O.

Embodiment 94. A compound of Formula 1 or any one of Embodiments 1 through 93 wherein J is J-l through J-3, J-6 through J-10 or J-14.

Embodiment 95. A compound of Embodiment 94 wherein J is J-l, J-2, J-3, J-6 or J-l 4.

Embodiment 96. A compound of Embodiment 95 wherein J is J-l, J-6 or J-14.

Embodiment 97. A compound of Embodiment 96 wherein J is J-l or J-6.

Embodiment 97a. A compound of Embodiment 96 wherein J is J-l 4.

Embodiment 98. A compound of Embodiment 97 wherein J is J-l .

Embodiment 99. A compound of Embodiment 97 wherein J is J-6.

Embodiment 100. A compound of Formula 1 or any one of Embodiments 1 through 99 wherein each R 8 is independently F, Cl or methyl.

Embodiment lOOa. A compound of Embodiment 100 wherein each R 8 is independently F or Cl.

Embodiment 101. A compound of Embodiment 100 wherein each R 8 is independently F or methyl.

Embodiment lOla. A compound of Embodiment 101 wherein each R 8 is F.

Embodiment 102. A compound of Formula 1 or any one of Embodiments 1 through lOla wherein q is 0 or 1. Embodiment 103. A compound of Embodiment 102 wherein q is 0.

Embodiment 103 a. A compound of Embodiment 102 wherein q is 1.

Embodiment 104. A compound of Formula 1 or any one of Embodiments 1 through l03a wherein each R 9a and R 9b is independently H, halogen, CJ-C3 alkyl, CJ-C3 haloalkyl, CJ-C3 alkoxy or CJ-C3 haloalkoxy.

Embodiment 105. A compound of Embodiment 104 wherein each R 9a and R 9 ^ is

independently H, halogen, CJ-C2 alkyl or CJ-C2 haloalkyl.

Embodiment 106. A compound of Embodiment 105 wherein each R 9a and R 9 ^ is

independently H, halogen or methyl.

Embodiment 107. A compound of Embodiment 106 wherein each R 9a and R 9 ^ is

independently H or methyl.

Embodiment 108. A compound of Embodiment 107 wherein each R 9a and R 9 ^ is H.

Embodiment 109. A compound of Formula 1 or any one of Embodiments 1 through 108 wherein n is 0, 1 or 2.

Embodiment l09a. A compound of Embodiment 109 wherein n is 1 or 2.

Embodiment 110. A compound of Formula 1 or any one of Embodiments 1 through 108 wherein n is 0 or 1.

Embodiment 111. A compound of Embodiments 109, 109a or 110 wherein n is 1.

Embodiment 112. A compound of Embodiments 109 or 110 wherein n is 0.

Embodiment 113. A compound of Formula 1 or any one of Embodiments 1 through 112 wherein L is a direct bond, CH 2 , CH(Me) or CH2CH2.

Embodiment 113a. A compound of Embodiment 113 wherein L is a direct bond, 0¾ or

CH 2 CH 2 .

Embodiment 114. A compound of Embodiment 1 l3a wherein L is a direct bond or 0¾. Embodiment 115. A compound of Embodiment 114 wherein L is CH 2 .

Embodiment 115a. A compound of Embodiment 114 wherein L is a direct bond.

Embodiment 116. A compound of Formula 1 or any one of Embodiments 1 through 1 l5a wherein E is E 1 . Embodiment 116a. A compound of Formula 1 or any one of Embodiments 1 through 1 l5a wherein when L is a direct bond, then E is E 1 .

Embodiment 117. A compound of Formula 1 or any one of Embodiments 1 through 1 l6a wherein E 1 is cyano, nitro, C(=0)H, C(=0)OH or SCºN; or C j -Cg alkoxy, C 2 -Cg alkenyloxy, C j -Cg alkylsulfonyl, C 2 -Cg alkenylsulfonyl, C 2 -Cg alkynylsulfonyl, C j -Cg alkylsulfonylamino, C 2 -Cg alkenylsulfonylamino, C 2 -Cg

alkynylsulfonylamino, C j -Cg alkylaminosulfonyl, C 2 -Cg dialkylaminosulfonyl, C 2 -C 6 alkenylaminosulfonyl, C 2 -Cg alkylcarbonyl, C 2 -Cg alkylaminocarbonyl, C3-C6 alkenylaminocarbonyl, C^-C^ alkynylaminocarbonyl, C 2 -Cg alkoxy carbonyl, C3-C6 alkenyloxy carbonyl, C^-C alkynyloxy carbonyl or C 2 -Cg

alkoxycarbonylamino, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (, b.

Embodiment 118. A compound of Embodiment 117 wherein E 1 is cyano, nitro, C(=0)H, C(=0)OH or SCºN; or C j -Cg alkoxy, C 2 -Cg alkenyloxy, C j -Cg alkylsulfonyl, C j - Cg alkylsulfonylamino, C 2 -Cg alkenylsulfonylamino, C 2 -Cg alkylcarbonyl, C 2 -Cg alkoxy carbonyl, C^-Cg alkenyloxy carbonyl or C^-C^ alkynyloxy carbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (,b .

Embodiment 119. A compound of Embodiment 118 wherein E 1 is C j -Cg alkoxy, C j -Cg alkylsulfonyl, C 2 -Cg alkylcarbonyl or C 2 -Cg alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (,b .

Embodiment 120. A compound of Embodiment 119 wherein E 1 is CJ-C3 alkoxy, C 2 -C3 alkylcarbonyl or C 2 -C3 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (,b . Embodiment l20a. A compound of Embodiment 120 wherein E 1 is CJ-C3 alkoxy or C2-C3 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a .

Embodiment 121. A compound of Embodiment 120 wherein E 1 is C j -C 2 alkoxy, wherein each carbon atom is optionally substituted with up to 1 substituent selected from

R 10a and up to 3 substituents independently selected from R l (,b .

Embodiment 12 la. A compound of Embodiment 120 wherein E 1 is C j -C 2 alkoxy, wherein each carbon atom is optionally substituted with up to 1 substituent selected from RtOa

Embodiment 12 lb. A compound of Embodiment l2la wherein E 1 is methoxy optionally substituted with up to 1 substituent selected from R 10a .

Embodiment 121 c. A compound of Embodiment 121 a wherein E 1 is methoxy substituted with 1 substituent selected from R 10a .

Embodiment 122. A compound of Formula 1 or any one of Embodiments 1 through l2lc wherein R 10a is phenyl optionally substituted with up to 3 substituents

independently selected from R l la ; or a 5- to 6-membered heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 3 substituents independently selected from R 1 la on carbon atom ring members and Rlh> on nitrogen atom ring members.

Embodiment 123. A compound of Embodiment 122 wherein R 10a is phenyl optionally substituted with up to 2 substituents independently selected from R l la ; or a 5- to 6- membered heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 2 substituents independently selected from R l la on carbon atom ring members and R 1 ^ on nitrogen atom ring members.

Embodiment l23a. A compound of Embodiment 123 wherein R 10a is a 5-membered

heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O and up to 3 N atoms, each ring optionally substituted with up to 2 substituents independently selected from R 1 la on carbon atom ring members.

Embodiment l23b. A compound of Embodiment l23a wherein R 10a is pyrazolyl,

imidazolyl or triazolyl, each optionally substituted with up to 2 substituents independently selected from R l la on carbon atom ring members.

Embodiment l23c. A compound of Embodiment l23b wherein R 10a is pyrazolyl or

imidazolyl, each optionally substituted with up to 2 substituents independently selected from R 1 la on carbon atom ring members.

Embodiment l23d. A compound of Embodiment l23c wherein R 10a is pyrazolyl optionally substituted with up to 1 substituent selected from R l la on a carbon atom ring member.

Embodiment 124. A compound of Formula 1 or any one of Embodiments 1 through l23c wherein each R l (,b is independently cyano, halogen, hydroxy, C j -C 4 alkyl, C j -C 4 haloalkyl, C^- , cycloalkyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C j -C 4 alkylsulfonyl,

C j -C 4 haloalkylsulfonyl, C j -C 4 alkylamino, C 2 -C 4 dialkylamino, C 2 -C 4 alkylcarbonyl or C 2 -C5 alkoxycarbonyl.

Embodiment 125. A compound of Embodiment 124 wherein each R l (, b is independently halogen, hydroxy, C j -C 4 alkyl, C j -C 4 haloalkyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C j -C 4 alkylsulfonyl, C 2 -C 4 alkylcarbonyl or C 2 -C5 alkoxycarbonyl.

Embodiment l25a. A compound of Embodiment 125 wherein each R l (, b is independently halogen, C j -C 2 alkyl, C j -C 2 haloalkyl, C j -C 2 alkoxy or C 2 -C 4 alkoxycarbonyl.

Embodiment 126. A compound of Formula 1 or any one of Embodiments 1 through l25a wherein each R l la is independently halogen, C j -C 4 alkyl, C j -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C 2 -C 4 alkenyloxy, C 2 -C 4 alkynyloxy, C 2 -C 4 alkoxyalkyl, C 2 -Cg alkylcarbonyloxy, C j -C 4 alkylsulfonyl,

C j -C 4 haloalkylsulfonyl, C j -C 4 alkylsulfonyloxy, C 2 -C 4 alkylcarbonyl, C3-C5 alkenylcarbonyl, C3-C5 alkynylcarbonyl, C 2 -Cg alkoxycarbonyl, C3-C7 alkenyloxy carbonyl, C3-C7 alkynyloxy carbonyl, C 2 - , alkylaminocarbonyl, C^- , alkenylaminocarbonyl, C^- , alkynylaminocarbonyl or C^-C^

dialkylaminocarbonyl.

Embodiment 127. A compound of Embodiment 126 wherein each R l la is independently halogen, C j -C 4 alkyl, C j -C 4 haloalkyl, C 2 -C 4 alkenyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C 2 -C 4 alkenyloxy, C 2 -C 4 alkoxyalkyl, C 2 -C 4 alkylcarbonyl, C 2 - , alkoxy carbonyl, C3-C7 alkenyloxy carbonyl or C 2 -Cg alkylaminocarbonyl.

Embodiment 128. A compound of Embodiment 127 wherein each R l la is independently halogen, C j -C 4 alkyl, C j -C 4 haloalkyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C 2 -C 4 alkenyloxy, C 2 -C 4 alkylcarbonyl, C 2 -C 4 alkoxycarbonyl or C3-C5

alkenyloxy carbonyl.

Embodiment l28a. A compound of Embodiment 128 wherein each R l la is independently halogen, C j -C 2 alkyl, C j -C 2 haloalkyl, C j -C 2 alkoxy or C 2 -C3 alkoxycarbonyl.

Embodiment l28b. A compound of Embodiment l28a wherein each R l la is independently methoxycarbonyl or ethoxycarbonyl.

Embodiment l28c. A compound of Embodiment l28b wherein each R l la is

ethoxycarbonyl.

Embodiment 129. A compound of Formula 1 or any one of Embodiments 1 through l28c wherein each R l lb is independently C j -C 2 alkyl, C j -C 2 alkoxy, C 2 -C3 alkylcarbonyl or C 2 -C 3 alkoxycarbonyl.

Embodiment 130. A compound of Embodiment 129 wherein each R 1 ^ is independently methyl, methoxy, methylcarbonyl or methoxycarbonyl.

Embodiment 131. A compound of Embodiment 130 wherein each R 1 ^ is independently methyl or methoxy.

Embodiment 132. A compound of Formula 1 or any one of Embodiments 1 through 131 wherein E is E 2 .

Embodiment 133. A compound of Formula 1 or any one of Embodiments 1 through 132 wherein G is phenyl optionally substituted with up to 3 substituents independently selected from R 13 ; or a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 3 substituents independently selected from R 13 ; or a 3- to 7- membered nonaromatic ring or an 8- to 1 l-membered bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and optionally up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from C(=0), S(=0) and S(=0)2, each ring or ring system optionally substituted with up to 3 substituents independently selected from R 13 .

Embodiment 134. A compound of Embodiment 133 wherein G is selected from G-l

through G-l 18 as shown in Exhibit A.

Exhibit A

G-9 G-10 G-l l G-12

G-57 G-58 G-59 G-60

(R 13 )X 4

G-105 G-106 G-107 G-108

G-117 G-118

wherein the floating bond is connected to Z in Formula 1 through any available carbon or nitrogen atom of the depicted ring or ring system; and x is 0, 1, 2 or 3.

Embodiment 135. A compound of Embodiment 134 wherein G is G-l through G-l 6, G-20, G-22 through G-30, G-36 through G-42, G-54 through G-60, G-85, G-86, G-108, G-l 10 or G-l 11.

Embodiment 136. A compound of Embodiment 135 wherein G is G-l through G-l 6, G-22,

G-24, G-25, G-26, G-28, G-29, G-30, G-36, G-37, G-38, G-41, G-42, G-54, G-57,

G-58, G-59, G-60, G-85, G-86, G-108, G-l 10 or G-l 11.

Embodiment 137. A compound of Embodiment 136 wherein G is G-l through G-13, G-22, G-24, G-25, G-26, G-28, G-29, G-41, G-42, G-54, G-57, G-58, G-59 or G-60.

Embodiment 138. A compound of Embodiment 137 wherein G is G-l, G-2, G-3, G-7, G-8, G-9, G-10, G-l 2, G-13, G-22, G-29, G-42, G-54 or G-58.

Embodiment 139. A compound of Embodiment 138 wherein G is G-l, G-3, G-12, G-13, G-22 or G-42.

Embodiment 140. A compound of Embodiment 139 wherein G is G-l, G-3, G-12, G-13 or G-22. Embodiment 141. A compound of Embodiment 140 wherein G is G-l, G-3, G-12 or G-22.

Embodiment 142. A compound of Embodiment 141 wherein G is G-l or G-12.

Embodiment 143. A compound of Embodiment 142 wherein G is G-l.

Embodiment 144. A compound of Embodiment 142 wherein G is G-12.

Embodiment 145. A compound of Embodiment 140 wherein G is G-3.

Embodiment 146. A compound of Embodiment 140 wherein G is G-22.

Embodiment 147. A compound of Embodiment 143 wherein the 2-position of G-l is

connected to Z and the 4-position is connected to R 13 .

Embodiment 148. A compound of Embodiment 143 wherein the 2-position of G-l is

connected to Z and the 5-position is connected to R 13 .

Embodiment 149. A compound of Embodiment 144 wherein the l-position of G-12 is connected to Z and the 4-position is connected to R 13 .

Embodiment 150. A compound of Embodiment 144 wherein the l-position of G-12 is connected to Z and the 3 -position is connected to R 13 .

Embodiment 151. A compound of Embodiment 144 wherein the l-position of G-l 2 is connected to Z and the 3- and 5-positions are connected to R 13 .

Embodiment 152. A compound of Embodiment 144 wherein the l-position of G-l 2 is connected to Z and the 5-position is connected to R 13 .

Embodiment 153. A compound of Embodiment 145 wherein the l-position of G-3 is

connected to Z and the 4-position is connected to R 13 .

Embodiment 154. A compound of Embodiment 146 wherein the 4-position of G-22 is connected to Z and the 2-position is connected to R 13 .

Embodiment 155. A compound of any one of Embodiments 147 through 154 wherein Z is a direct bond.

Embodiment 156. A compound of any one of Embodiments 147 through 155 wherein x is 1 and R 13 is methoxy carbonyl or ethoxy carbonyl.

Embodiment 157. A compound of any one of Embodiments 134 through 155 wherein x is 1 or 2.

Embodiment 158. A compound of Embodiment 157 wherein x is 1.

Embodiment 159. A compound of Embodiment 157 wherein x is 2. Embodiment 160. A compound of any one of Embodiments 134 through 155 wherein x is 0

Embodiment 161. A compound of Formula 1 or any one of Embodiments 1 through 159 wherein each R 33 is independently cyano, halogen, NR 14a R 14 ^, C(=0)NR 14a R 14b , C(R 15 )=NR 16 , N=CR 17 NR 18a R 18b or -U-V-Q; or C j -Cg alkyl, C 2 -C 6 alkenyl,

C 2 -C 6 alkynyl, C j -Cg alkoxy, C 2 -Cg alkenyloxy, C 2 -Cg alkynyloxy, C j -Cg alkylsulfonyl, C j -Cg alkylsulfonyloxy, C j -Cg alkylsulfonylamino, C 2 -Cg alkylcarbonyl, C 2 -Cg alkoxycarbonyl, C 3 -Cg alkenyloxycarbonyl, C 3 -Cg alkynyloxycarbonyl, C4-C7 cycloalkoxycarbonyl, C 2 -Cg alkylcarbonyloxy, C 2 -Cg alkoxycarbonyloxy, C4-C7 cycloalkoxycarbonyloxy, C 2 -Cg alkylaminocarbonyloxy, C 2 -Cg alkylcarbonylamino, C 2 -Cg alkoxycarbonylamino or C 2 -Cg

alkylaminocarbonylamino, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment 162. A compound of Embodiment 161 wherein each R 13 is independently cyano, halogen, C(=0)NR l a R l b or -U-V-Q; or C j -Cg alkyl, C 2 -Cg alkenyl, C 2 -Cg alkynyl, C j -Cg alkoxy, C 2 -Cg alkenyloxy, C 2 -Cg alkynyloxy, C j -Cg alkylsulfonyl, C j -Cg alkylsulfonyloxy, C j -Cg alkylsulfonylamino, C 2 -Cg alkylcarbonyl, C 2 -Cg alkoxycarbonyl, C 3 -Cg alkenyloxycarbonyl, C 3 -Cg alkynyloxycarbonyl or C 2 -Cg alkoxycarbonyloxy, each optionally substituted with up to 3 substituents

independently selected from R 19 .

Embodiment 163. A compound of Embodiment 162 wherein each R 13 is independently

C(=0)NR 14a R 14b or -U-V-Q; or C r C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C j -Cg alkoxy, C 2 -Cg alkenyloxy, C 2 -Cg alkynyloxy, C j -Cg alkylsulfonyl, C j -Cg alkylsulfonyloxy, C j -Cg alkylsulfonylamino, C 2 -Cg alkylcarbonyl, C 2 -Cg alkoxycarbonyl, C 3 -Cg alkenyloxycarbonyl, C 3 -Cg alkynyloxycarbonyl, C4-Cg cycloalkoxycarbonyl or C 2 -Cg alkoxycarbonyloxy, each optionally substituted with up to 3 substituents independently selected from R 19 . Embodiment 163 a. A compound of Embodiment 162 wherein each R 13 is independently C(=0)NR 14a R 14b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5 alkenyloxycarbonyl, C3-C5 alkynyloxy carbonyl or C 4 - , cycloalkoxy carbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment l63b. A compound of Embodiment l63a wherein each R 13 is independently

C(=0)NR l a R l b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5 alkynyloxycarbonyl or C pCg cycloalkoxycarbonyl, each optionally substituted with up to 1 substituent selected from R 19 .

Embodiment 164. A compound of Embodiment l63a wherein each R 13 is independently C(=0)NR l a R l b or -U-V-Q; or C^- , alkoxycarbonyl, C^- , alkenyloxycarbonyl,

C3-C6 alkynyloxycarbonyl or C^- , alkoxycarbonyloxy, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment l64a. A compound of Embodiment 164 wherein each R 13 is independently C(=0)NR l 4a R l 4b or -U-V-Q; or C^- , alkoxycarbonyl, C^- , alkenyloxycarbonyl, or C3-C6 alkynyloxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment 165. A compound of Embodiment l64a wherein each R 13 is independently C(=0)NR l 4a R l 4b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5 alkenyloxycarbonyl, or C3-C5 alkynyloxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment l65a. A compound of Embodiment 165 wherein each R 13 is independently alkoxycarbonyl or C3-C5

alkenyloxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment 166. A compound of Embodiment 165 wherein each R 13 is independently

C2-C5 alkoxycarbonyl or C3-C5 alkenyloxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 . Embodiment 167. A compound of Embodiment 166 wherein each R 13 is independently C2-C5 alkoxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment 168. A compound of Embodiment 167 wherein each R 13 is independently methoxycarbonyl or ethoxycarbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 .

Embodiment 169. A compound of Embodiment 168 wherein each R 13 is independently methoxycarbonyl or ethoxycarbonyl, each optionally substituted with up to 1 substituent selected from R 19 .

Embodiment 170. A compound of Embodiment 169 wherein each R 13 is independently ethoxycarbonyl optionally substituted with up to 1 substituent selected from R 19 .

Embodiment 171. A compound of Embodiment 169 wherein each R 13 is independently methoxycarbonyl or ethoxycarbonyl.

Embodiment 172. A compound of Embodiment 171 wherein each R 13 is ethoxycarbonyl.

Embodiment 173. A compound of Formula 1 or any one of Embodiments 1 through 172 wherein when each R 14a is separate (i.e. not taken together with R l b to form a ring), then each R 14a is independently H, cyano, hydroxy, C j -C 4 alkyl, C j -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 haloalkenyl, C 2 -C 4 alkynyl, C 2 -C 4 haloalkynyl, C 2 -C 4 alkylcarbonyl, C 2 -C 5 alkoxycarbonyl or C3-C5 dialkylaminocarbonyl.

Embodiment 174. A compound of Embodiment 173 wherein each R 14a is independently H, cyano, C j -C 4 alkyl, C j -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4 alkylcarbonyl, C 2 -C5 alkoxycarbonyl or C3-C5 dialkylaminocarbonyl.

Embodiment 175. A compound of Embodiment 174 wherein each R 14a is independently H, C j -C 2 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4 alkylcarbonyl or C 2 -C 4 alkoxycarbonyl.

Embodiment 176. A compound of Embodiment 175 wherein each R 14a is independently H or C j -C 2 alkyl.

Embodiment 177. A compound of Embodiment 176 wherein each R 14a is independently H or methyl. Embodiment l77a. A compound of Embodiment 177 wherein each R 14a is H.

Embodiment 178. A compound of Formula 1 or any one of Embodiments 1 through l77a wherein when each R l b is separate (i.e. not taken together with R 14a to form a ring), then each R l 4b is independently H, C j -C 6 alkyl, C j -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -Cg haloalkenyl, C 2 - , alkynyl, C 2 - , haloalkynyl, C 2 -Cg cyanoalkyl, C3-C8 cycloalkyl, C^-C halocycloalkyl, C^-C cycloalkenyl, C3-C8

halocycloalkenyl, C4-CJ0 alkylcycloalkyl, C4-CJ0 cycloalkylalkyl, C4-CJ0 halocycloalkylalkyl, C 2 -Cg alkoxyalkyl, C 2 -Cg haloalkoxyalkyl, C 2 -Cg

alkylthioalkyl, C 2 -Cg alkylsulfonylalkyl, C 2 -Cg alkylaminoalkyl or C^-C

dialkylaminoalkyl, each optionally substituted with up to 1 substituent selected from cyano, hydroxy, nitro, C 2 -C4 alkylcarbonyl or C 2 -C4 alkoxycarbonyl.

Embodiment 179. A compound of Embodiment 178 wherein each R 14 ^ is independently H, CJ-C4 alkyl, CJ-C4 haloalkyl, C 2 -C4 alkenyl, C 2 -C4 haloalkenyl, C 2 -C4 alkynyl, C3-C5 cycloalkyl, C^- , cycloalkylalkyl, C 2 -C4 alkoxyalkyl, C 2 -C4

haloalkoxyalkyl, C 2 -C 4 alkylaminoalkyl or C3-C5 dialkylaminoalkyl.

Embodiment 180. A compound of Embodiment 179 wherein each R 14 ^ is independently H, C j -C 3 alkyl, C j -C 3 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 haloalkenyl, C3-C5 cycloalkyl, C4-C6 cycloalkylalkyl or C 2 -C4 alkoxyalkyl.

Embodiment 181. A compound of Embodiment 180 wherein each R 14 ^ is independently H, C j -C 3 alkyl, C j -C 3 haloalkyl, cyclopropylmethyl or C 2 -C 4 alkoxyalkyl.

Embodiment l 8la. A compound of Embodiment 181 wherein each R 14 ^ is independently H, C j -C 2 alkyl, C j -C 2 haloalkyl or cyclopropylmethyl.

Embodiment 18lb. A compound of Embodiment 18 la wherein each R 14 ^ is independently H, methyl or cyclopropylmethyl.

Embodiment 182. A compound of Formula 1 or any one of Embodiments 1 through 18lb wherein when R 14a and R 14 ^ are taken together to form a 4- to 6-membered fully saturated heterocyclic ring, then said ring contains ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 1 heteroatom selected from up to 1 O, up to 1 S and up to 1 N atom, each ring optionally substituted with up to 2 substituents independently selected from halogen or methyl.

Embodiment 183. A compound of Embodiment 182 wherein R 14a and R 14 ^ are taken

together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 substituents independently selected from halogen or methyl.

Embodiment 184. A compound of Embodiment 183 wherein R 14a and R 14 ^ are taken

together to form an azetidinyl or pyrrolidinyl ring, each ring optionally substituted with up to 2 substituents independently selected from halogen or methyl.

Embodiment 185. A compound of Formula 1 or any one of Embodiments 1 through 185 wherein each R 15 is independently H, cyano, halogen, methyl or methoxy.

Embodiment 186. A compound of Embodiment 185 wherein each R 15 is independently H or methyl.

Embodiment 187. A compound of Formula 1 or any one of Embodiments 1 through 186 wherein each R 16 is independently hydroxy, NR 20a R 20b , C j -C2 alkoxy, C2-C4 alkenyloxy, C2-C4 alkylcarbonyloxy or C2-C4 alkoxycarbonyloxy.

Embodiment 188. A compound of Embodiment 187 wherein each R 16 is independently hydroxy, NR 20a R 2 °b or CJ-C4 alkoxy.

Embodiment 189. A compound of Embodiment 188 wherein each R 16 is independently hydroxy, NR 2(,a R 2(4) or methoxy.

Embodiment 190. A compound of Embodiment 189 wherein each R 16 is hydroxy.

Embodiment 191. A compound of Formula 1 or any one of Embodiments 1 through 190 wherein each R 17 is independently H or methyl.

Embodiment 192. A compound of Embodiment 191 wherein each R 17 is H.

Embodiment 193. A compound of Formula 1 or any one of Embodiments 1 through 192 wherein when each R 18a and R 18b is separate (i.e. not taken together to form a ring), then each R 18a and R 1 8 ^ is independently H, methyl or ethyl.

Embodiment 194. A compound of Embodiment 193 wherein each R 18a and R 18 ^ is

independently H or methyl. Embodiment 195. A compound of Formula 1 or any one of Embodiments 1 through 194 wherein when R 18a and R 18 ^ are taken together to form a 5- to 6-membered fully saturated heterocyclic ring, then said ring contains ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 1 heteroatom selected from up to 1 O, up to 1 S and up to 1 N atom, each ring optionally substituted with up to 2 methyl groups.

Embodiment 196. A compound of Embodiment 195 wherein R 18a and R 18 ^ are taken

together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl, or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl groups.

Embodiment 197. A compound of Formula 1 or any one of Embodiments 1 through 196 wherein each R 19 is independently cyano, halogen, hydroxy, CJ-C3 alkyl, CJ-C3 haloalkyl, C^- , cycloalkyl, CJ-C3 alkoxy, CJ-C3 haloalkoxy, C2-C3 alkoxyalkoxy, CJ-C3 alkylthio, CJ-C3 alkylsulfinyl, CJ-C3 alkylsulfonyl, CJ-C3 haloalkylsulfonyl, C2-C3 alkylcarbonyl, C2-C3 haloalkylcarbonyl, C2-C3 alkoxycarbonyl, C2-C3 alkylaminocarbonyl or C3-C5 dialky laminocarbonyl.

Embodiment 198. A compound of Embodiment 197 wherein each R 19 is independently cyano, halogen, hydroxy, CJ-C2 alkyl, CJ-C2 haloalkyl, C^- , cycloalkyl, CJ-C2 alkoxy, CJ-C2 haloalkoxy, CJ-C2 alkylthio, CJ-C2 alkylsulfonyl, CJ-C2

haloalkylsulfonyl, C 2 -C 3 alkylcarbonyl, C 2 -C 3 haloalkylcarbonyl, C 2 -C 3 alkoxycarbonyl or C2-C3 alkylaminocarbonyl.

Embodiment 199. A compound of Embodiment 197 wherein each R 19 is independently cyano, halogen, CJ-C2 alkyl, CJ-C2 haloalkyl, C^-C^ cycloalkyl, CJ-C2 alkoxy, C r C 2 haloalkoxy, C2-C3 alkylcarbonyl, C2-C3 haloalkylcarbonyl or C2-C3 alkoxycarbonyl.

Embodiment 200. A compound of Embodiment 199 wherein each R 19 is independently cyano, halogen, cyclopropyl, cyclobutyl, methoxy, halomethoxy or

methoxy carbonyl.

Embodiment 200a. A compound of Embodiment 200 wherein each R 19 is independently cyano, halogen, cyclopropyl or methoxy. Embodiment 200b. A compound of Embodiment 200a wherein each R 19 is independently cyano, Cl, F, cyclopropyl or methoxy.

Embodiment 201. A compound of Formula 1 or any one of Embodiments 1 through 200b wherein each U is independently a direct bond, C(=0)0 or C(=0)N(R 25 ).

Embodiment 202. A compound of Embodiment 201 wherein each U is independently a direct bond or C(=0)0.

Embodiment 203. A compound of Embodiment 202 wherein each U is C(=0)0.

Embodiment 204. A compound of Formula 1 or any one of Embodiments 1 through 203 wherein each V is independently a direct bond; or C j -Cg alkylene, C 2 - , alkenylene or C 3 - , alkynylene, each optionally substituted with up to 2 substituents independently selected from halogen, cyano, nitro, hydroxy, C j -C 2 alkyl, C j -C 2 haloalkyl, C j -C 2 alkoxy and C j -C 2 haloalkoxy.

Embodiment 205. A compound of Embodiment 204 wherein each V is independently a direct bond; or C j -C 3 alkylene, each optionally substituted with up to 2 substituents independently selected from halogen, hydroxy, C j -C 2 alkyl, C j -C 2 alkoxy and

C j -C 2 haloalkoxy.

Embodiment 206. A compound of Embodiment 205 wherein each V is independently a direct bond or C j -C 3 alkylene.

Embodiment 207. A compound of Embodiment 206 wherein each V is independently a direct bond or CH 2 .

Embodiment 208. A compound of Embodiment 207 wherein each V is a direct bond.

Embodiment 209. A compound of Embodiment 207 wherein each V is independently

C j -C 2 alkylene.

Embodiment 210. A compound of Embodiment 209 wherein each V is CH 2 .

Embodiment 211. A compound of Formula 1 or any one of Embodiments 1 through 210 wherein each Q is independently phenyl optionally substituted with up to 2 substituents independently selected from R 27 ; or a 5- to 6-membered heteroaromatic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 2 substituents independently selected from R 27 ; or a 3- to 6-membered nonaromatic heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 2 ring members are independently selected from C(=0), C(=S), S(=0) and S(=0) 2 , each ring optionally substituted with up to 2 substituents independently selected from R 27 .

Embodiment 212. A compound of Embodiment 210 wherein each Q is independently phenyl optionally substituted with up to 2 substituents independently selected from R 27 ; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, thienyl, isoxazolinyl, piperidinyl, morpholinyl or piperazinyl, each optionally substituted with up to 2 substituents independently selected from R 27 .

Embodiment 213. A compound of Embodiment 212 wherein each Q is independently phenyl optionally substituted with up to 2 substituents independently selected from R 27 ; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl or oxazolyl, each optionally substituted with up to 2 substituents independently selected from R 27 .

Embodiment 214. A compound of Embodiment 213 wherein each Q is independently phenyl optionally substituted with up to 2 substituents independently selected from R 27 ; or pyridinyl or pyrazolyl, each optionally substituted with up to 2 substituents independently selected from R 27 .

Embodiment 2l4a. A compound of Embodiment 214 wherein each Q is independently phenyl or pyridinyl, each optionally substituted with up to 2 substituents independently selected from R 27 .

Embodiment 2l4b. A compound of Embodiment 2l4a wherein each Q is independently phenyl optionally substituted with up to 2 substituents independently selected from

R 27 .

Embodiment 215. A compound of Formula 1 or any one of Embodiments 1 through 214b wherein when each R 20a is separate (i.e. not taken together with R 2(,b to form a ring), then each R 20a is independently H, methyl or methylcarbonyl. Embodiment 216. A compound of Formula 1 or any one of Embodiments 1 through 215 wherein when each R 2(,b is separate (i.e. not taken together with R 20a to form a ring), then each R 2(,b is independently H, cyano, methyl, methylcarbonyl, methoxycarbonyl, methoxycarbonylmethyl, methylaminocarbonyl or

dimethylaminocarbonyl.

Embodiment 217. A compound of Formula 1 or any one of Embodiments 1 through 216 wherein when R 20a and R 2 °b are taken together to form a 5- to 6-membered fully saturated heterocyclic ring, then said ring contains ring members, in addition to the connecting nitrogen atom, selected from carbon atoms and up to 1 heteroatom selected from up to 1 O, up to 1 S and up to 1 N atom, each ring optionally substituted with up to 2 methyl groups.

Embodiment 218. A compound of Embodiment 217 wherein R 20a and R 2 °b are taken together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 methyl groups.

Embodiment 219. A compound of Formula 1 or any one of Embodiments 1 through 218 wherein each R 21 and R 23 is independently H, cyano, halogen, methyl or methoxy.

Embodiment 220. A compound of Formula 1 or any one of Embodiments 1 through 219 wherein each R 22 is independently H, C j -C 3 alkyl, C j -C 3 haloalkyl, C 2 -C 3 alkylcarbonyl or C 2 -C 3 alkoxycarbonyl; or phenyl optionally substituted with up to 2 substituents independently selected halogen and methyl; or a 5- to 6-membered fully saturated heterocyclic ring, each ring containing ring members selected from carbon atoms and up to 2 heteroatoms independently selected from up to 2 O, up to 2 S and up to 2 N atoms, each ring optionally substituted with up to 2 substituents independently selected from halogen and methyl.

Embodiment 221. A compound of Embodiment 220 wherein each R 22 is independently H or C j -C 2 alkyl.

Embodiment 222. A compound of Formula 1 or any one of Embodiments 1 through 221 wherein each R 24 is independently H, cyano or C j -C 2 alkyl. Embodiment 223. A compound of Formula 1 or any one of Embodiments 1 through 222 wherein each R 25 and R 26 is independently H, cyano, hydroxy, C j -C 4 alkyl or C j -C 4 haloalkyl.

Embodiment 224. A compound of Embodiment 223 wherein each R 25 and R 26 is

independently H, cyano, hydroxy or C j -C2 alkyl.

Embodiment 225. A compound of Formula 1 or any one of Embodiments 1 through 224 wherein each R 27 is independently halogen, cyano, C j -C 4 alkyl, C j -C 4 haloalkyl or C j -C 4 alkoxy.

Embodiment 226. A compound of Embodiment 225 wherein each R 27 is independently halogen, cyano, C j -C2 alkyl, C j -C2 haloalkyl or C j -C2 alkoxy.

Embodiment 227. A compound of Embodiment 226 wherein each R 27 is independently halogen, methyl or methoxy.

Embodiment 228. A compound of Embodiment 227 wherein each R 27 is independently halogen.

Embodiment 229. A compound of Formula 1 or any one of Embodiments 1 through 228 wherein Z is a direct bond, O, NH, C(=0), C(=0)NH, NHC(=0), NHC(=0)NH, OC(=0)NH, NHC(=0)0, S(=0) 2 NH, NHS(=0) 2 or NHS(=0) 2 NH.

Embodiment 230. A compound of Embodiment 229 wherein Z is a direct bond, O, NH, C(=0), C(=0)NH or NHC(=0).

Embodiment 231. A compound of Embodiment 230 wherein Z is a direct bond, O, NH or

C(=0).

Embodiment 232. A compound of Embodiment 231 wherein Z is a direct bond.

Embodiment 233. A compound of Formula 1 or any one of Embodiments 1 through 232 wherein each R 28 is independently H or C j -C 3 alkyl.

Embodiment 234. A compound of Embodiment 233 wherein each R 28 is independently H or methyl.

Embodiment 235. A compound of Formula 1 or any one of Embodiments 1 through 234 wherein m is 0 or 2.

Embodiment 236. A compound of Embodiment 235 wherein m is 2. Embodiments of this invention, including Embodiments 1-236 above as well as any other embodiments described herein, can be combined in any manner, and the descriptions of variables in the embodiments pertain not only to the compounds of Formula 1 but also to the starting compounds and intermediate compounds (e.g. compounds of Formula 10) useful for preparing the compounds of Formula 1. In addition, embodiments of this invention, including Embodiments 1- 236 above as well as any other embodiments described herein, and any combination thereof, pertain to the compositions and methods of the present invention.

Combinations of Embodiments 1-236 are illustrated by:

Embodiment A. A compound of Formula 1 wherein

R 1 is CF 3 , CCl 3 or CF 2 Cl;

W is O;

R 5a and R 5b are each independently H, hydroxy or methyl;

R 2a and R 2 ^ are each independently H or methyl; or

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5- to 6-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, wherein up to 1 carbon atom ring member is selected from C(=0), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl, methoxy and halomethoxy on carbon atom ring members;

R 2C is C j -C 2 alkyl, C 2 -C 3 alkenyl or C 2 -C 3 alkynyl;

R2d is H or methyl;

A 1 is CR 6c R 6d or O;

A 2 is a direct bond, CR 6e R 6f or O;

R 6a , R 6 ^ R6C ? R6CI R6C anc j R 6f are eac h independently H, cyano, hydroxy, Br, Cl, F or methyl;

J is J-l, J-6 or J-14;

each R 8 is independently F, Cl or methyl;

each R 9a and R 9b is independently H, halogen or methyl;

n is 0, 1 or 2; E 1 is C j -Cg alkoxy, C j -Cg alkylsulfonyl, C 2 - , alkylcarbonyl or C 2 - , alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (,b ;

R 10a is phenyl optionally substituted with up to 2 substituents independently selected from R l la ; or a 5- to 6-membered heterocyclic ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 2 substituents independently selected from R l la on carbon atom ring members and R 1 ^ on nitrogen atom ring members;

each R l (,b is independently halogen, hydroxy, C j -C 4 alkyl, C j -C 4 haloalkyl, C j -C 4 alkoxy, C j -C 4 haloalkoxy, C j -C 4 alkylsulfonyl, C 2 -C 4 alkylcarbonyl or C2-C5

alkoxycarbonyl;

each R l la is independently halogen, C j -C 2 alkyl, C j -C 2 haloalkyl, C j -C 2 alkoxy or C 2 -C 3 alkoxycarbonyl;

each Rllb is independently methyl, methoxy, methylcarbonyl or methoxy carbonyl;

G is selected from the group consisting of:

G-57 G-58 G-59 G-60

(R 13 )X 4

G-105 G-106 G-107 G-108

G-117 G-118

wherein the floating bond is connected to Z in Formula 1 through any available carbon or nitrogen atom of the depicted ring or ring system; and x is 0, 1, 2 or 3;

each R 13 is independently C(=0)NR l a R l b or -U-V-Q; or C j -Cg alkyl, C 2 -Cg alkenyl, C 2 -C 6 alkynyl, C j -Cg alkoxy, C 2 -Cg alkenyloxy, C 2 -Cg alkynyloxy, C j -Cg alkylsulfonyl, C j -Cg alkylsulfonyloxy, C j -Cg alkylsulfonylamino, C 2 -Cg alkylcarbonyl, C 2 -Cg alkoxycarbonyl, C 3 -Cg alkenyloxycarbonyl, C 3 -Cg alkynyloxycarbonyl, C 4 -Cg cycloalkoxycarbonyl or C 2 -Cg alkoxycarbonyloxy, each optionally substituted with up to 3 substituents independently selected from R 19 ; each R 14a is independently H, C j -C 2 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4

alkylcarbonyl or C 2 -C 4 alkoxycarbonyl;

each R l 4b is independently H, C j -C 4 alkyl, C j -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4

haloalkenyl, C 2 -C 4 alkynyl, C 3 -C 3 cycloalkyl, C 4 -Cg cycloalkylalkyl, C 2 -C 4 alkoxyalkyl, C 2 -C 4 haloalkoxyalkyl, C 2 -C 4 alkylaminoalkyl or C 3 -C 3

dialky laminoalkyl; or R 14a and R 14 ^ are taken together to form an azetidinyl, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl or thiomorpholinyl ring, each ring optionally substituted with up to 2 substituents independently selected from halogen or methyl; each R 19 is independently cyano, halogen, C j -C2 alkyl, C j -C2 haloalkyl, C^- , cycloalkyl, C r C 2 alkoxy, C j -C2 haloalkoxy, C2-C3 alkylcarbonyl, C2-C3 haloalkylcarbonyl or C2-C3 alkoxy carbonyl;

each U is independently a direct bond, C(=0)0 or C(=0)N(R 25 );

each V is independently a direct bond; or CJ-C3 alkylene, each optionally substituted with up to 2 substituents independently selected from halogen, hydroxy, C j -C 2 alkyl, C r C 2 alkoxy and CJ-C2 haloalkoxy;

each Q is independently phenyl optionally substituted with up to 2 substituents

independently selected from R 27 ; or pyridinyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl or oxazolyl, each optionally substituted with up to 2 substituents independently selected from R 27 ;

each R 25 is independently H, cyano, hydroxy or CJ-C2 alkyl;

each R 27 is independently halogen, cyano, CJ-C2 alkyl, CJ-C2 haloalkyl or CJ-C2 alkoxy; and

Z is a direct bond, O, NH, C(=0), C(=0)NH, NHC(=0), NHC(=0)NH, OC(=0)NH,

NHC(=0)0, S(=0) 2 NH, NHS(=0) 2 or NHS(=0) 2 NH.

Embodiment AA. A compound of Embodiment A wherein

R 1 is CF 3 ;

X is O;

Y is O;

L is a direct bond or CH 2 ; and

Z is a direct bond.

Embodiment AAA. A compound of Embodiment A wherein

R 1 is CF 3 ;

Z is a direct bond.

Embodiment B. A compound of Embodiment A wherein T is T-2 or T-3;

R 1 is CF 3 ;

X is O;

Y is O;

R 2a and R 2 ^ are each independently H or methyl; or

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms, the ring optionally substituted with up to 1 substituent selected from halogen, methyl and halomethyl on a carbon atom ring member;

R 2C is methyl or ethyl;

R 2d is H;

A 1 is O;

A 2 is a direct bond, CH 2 or O;

R 6a and R 6b are each independently H, cyano hydroxy or methyl;

J is J-l or J-6;

q is 0 or 1 ;

each R 9a and R 9b is independently H or methyl;

E 1 is C | -C 3 alkoxy, C2-C3 alkylcarbonyl or C2-C3 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a and up to 3 substituents independently selected from R l (,b ;

Rl° a is pyrazolyl, imidazolyl or triazolyl, each optionally substituted with up to 2

substituents independently selected from R 1 la on carbon atom ring members;

each R l (,b is independently halogen, C | -C 2 alkyl, C | -C 2 haloalkyl, C | -C 2 alkoxy or C2-C4 alkoxycarbonyl;

G is G-l, G-3, G-12 or G-22;

x is 1 or 2; each R 13 is independently C(=0)NR l a R l b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5 alkenyloxy carbonyl, C3-C5 alkynyloxy carbonyl or C^- , cy cl oalkoxy carbonyl, each optionally substituted with up to 3 substituents independently selected from R 19 ; each R 14a is independently H or C j -C 2 alkyl;

each R l 4b is independently H, CJ-C3 alkyl, CJ-C3 haloalkyl, cyclopropylmethyl or C2-C4 alkoxy alkyl;

each R 19 is independently cyano, halogen, cyclopropyl, cyclobutyl, methoxy, halomethoxy or methoxy carbonyl;

each U is independently a direct bond or C(=0)0;

each V is independently a direct bond or CH 2 ;

each Q is independently phenyl or pyridinyl, each optionally substituted with up to 2

substituents independently selected from R 27 ;

each R 27 is independently halogen, methyl or methoxy; and

Z is a direct bond, O, NH, C(=0), C(=0)NH or NHC(=0).

Embodiment BB. A compound of Embodiment B wherein

L is a direct bond or CH 2 ;

G is G-l or G-12; and

Z is a direct bond.

Embodiment BBB. A compound of Embodiment B wherein

Z is a direct bond.

Embodiment C. A compound of Embodiment B wherein

R 2a and R 2 ^ are each H; or

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms;

A 2 is a direct bond;

R 6a and R 6 ^ are each H;

R 8 is F or Cl;

L is a direct bond, CH 2 or CH2CH2; E 1 is C r C 2 alkoxy or C2-C3 alkoxycarbonyl, wherein each carbon atom is optionally substituted with up to 1 substituent selected from R 10a ;

RlOa is pyrazolyl or imidazolyl, each optionally substituted with up to 2 substituents

independently selected from R l la on carbon atom ring members;

each R l la is independently methoxycarbonyl or ethoxycarbonyl;

G is G-l and the 2-position of G-l is connected to Z and the 4-position is connected to R 13 ; or G is G- 12 and the 1 -position of G-l 2 is connected to Z and the 4-position is connected to R 13 ; or G is G-l 2 and the 1 -position of G-l 2 is connected to Z and the 3 -position is connected to R 13 ;

x is 1;

R 13 is C(=0)NR 14a R 14b or -U-V-Q; or C2-C5 alkoxycarbonyl, C3-C5 alkynyloxycarbonyl or C pCg cycloalkoxycarbonyl, each optionally substituted with up to 1 substituent selected from R 19 ;

R 14a is H;

R Mb is H, methyl or cyclopropylmethyl;

R 19 is cyano, halogen, cyclopropyl or methoxy;

U is C(=0)0;

V is CH 2 ;

Q is phenyl optionally substituted with up to 2 substituents independently selected from R 27 ; and

Z is a direct bond, O, NH or C(=0).

Embodiment CC. A compound of Embodiment C wherein

L is a direct bond or CH 2 ; and

Z is a direct bond.

Embodiment D. A compound of Embodiment C wherein

R 8 is F;

L is a direct bond or CH 2 ;

E 1 is methoxy substituted with 1 substituent selected from R 10a ; R 10a is pyrazolyl optionally substituted with up to 1 substituent selected from R 1 la on a carbon atom ring member;

G is G-12 and the 1 -position of G-12 is connected to Z and the 4-position is connected to R 13 ; or G is G-12 and the 1 -position of G-12 is connected to Z and the 3 -position is connected to R 13 ; and

R 13 is C2-C5 alkoxy carbonyl optionally substituted with up to 1 substituent selected from R19;

R 19 is cyano, Cl, F, cyclopropyl or methoxy; and

Z is a direct bond.

Embodiment DD. A compound of Embodiment D wherein

L is a direct bond or CH 2 , provided that when L is a direct bond, then E is E 1 , and when L is CH 2 , then E is E 2 .

Embodiment E. A compound of Embodiment D wherein

J is J-l;

q is 0;

L is CH 2 ;

E is E 2 ;

G is G-12 and the 1 -position of G-12 is connected to Z and the 4-position is connected to R 13 ; and

R 13 is methoxy carbonyl or ethoxy carbonyl.

Embodiment F. A compound of any one of Embodiments A through E wherein

T is T-2; and

R 13 is ethoxy carbonyl.

Embodiment G. A compound of any one of Embodiments A through E wherein

T is T-3; and

R 13 is ethoxy carbonyl.

Specific embodiments include compounds of Formula 1 selected from the group consisting of: ethyl 1 -[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- l //-pyrazole-4-carboxylate (Compound 1);

ethyl 1 -[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l //-pyrazole-4- carboxylate (Compound 32);

ethyl 1 -[[4-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]phenyl] methyl]-! //-pyrazole-4- carboxylate (Compound 64);

ethyl 1 -[[4-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]phenyl] methyl]-! //-pyrazole-3- carboxylate (Compound 231);

ethyl 1 -[[4-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]-3-fluorophenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 262);

ethyl l -[[3-[[( l Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]phenyl] methyl]-! //-pyrazole-4- carboxylate (Compound 265);

ethyl 1 -[[4-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]phenoxy]methyl]- l //-pyrazole- 4-carboxylate (Compound 364);

A'-(cyclopropylmethyl)-2-[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]- methyl]thiazole-4-carboxamide (Compound 71);

2-methylpropyl 1 -[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 126);

cyclopropylmethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl ]methyl]- 1 //-pyrazole-4-carboxylate (Compound 127);

ethyl 1 -[2-[4-[[( l Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]phenyl]ethyl]- l //-pyrazole-4- carboxylate (Compound 132);

2-methoxyethyl 1 -[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 162);

2-butyn-l-yl 1 -[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 163);

3-cyanopropyl 1 -[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 171);

phenylmethyl 1 -[[4-[[( l Z)-2-ethoxy-3,3,3-trifluoro- l -propen- 1 -yl]oxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 186); butyl l-[[4-[[(lZ)-2-ethoxy-3, 3, 3-trifluoro-l -propen- l-yl]oxy]phenyl]methyl]-lif-pyrazole-4- carboxylate (Compound 218);

3-chloropropyl 1 -[[4-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- 1 -propen- 1 -yl]oxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 221);

methyl 4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenylcarboxylate (Compound 229);

ethyl 1 -[[3-fluoro-4-[[2-(trifluorom ethyl)-! ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- 1 H- pyrazole-4-carboxylate (Compound 263);

ethyl 1 -[[4-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- 1 -propen- 1 -yl]oxy]phenylmethoxy]methyl]- l H- pyrazole-4-carboxylate (Compound 297);

methyl 1 -[[3-[[( 1 Z)-2-ethoxy-3,3,3-trifluoro- 1 -propen- 1 -yl]oxy]phenyl]methyl]- l //-pyrazole- 4-carboxylate (Compound 330); and

propyl l-[[3-[[(lZ)-2-ethoxy-3, 3, 3-trifluoro-l -propen- l-yl]oxy]phenyl]methyl]-lif-pyrazole- 4-carboxylate (Compound 331).

Embodiments of the present invention also include:

Embodiment Bl . A compound of Formula 10 wherein R 30 is C j -C2 alkyl, C | -C 4 haloalkyl, phenyl, 4-methylphenyl, 4-bromophenyl or 4-nitrophenyl.

Embodiment B2. A compound of Embodiment B 1 wherein R 30 is CHg, CF 3 , CH2CF3,

(CF 2 )3CF 3 , phenyl or 4-methylphenyl.

Embodiment B3. A compound of Embodiment B2 wherein R 30 is CH3, CF3, CH2CF3, phenyl or 4-methylphenyl.

Embodiment B4. A compound of Embodiment B3 wherein R 30 is CH3, CF3 or 4-methylphenyl. Embodiment B5. A compound of Embodiment B4 wherein R 30 is CF3. As noted in the Summary of the Invention, this invention also relates to a compound of

Formula 10, or an A'-oxide or salt thereof. Also noted is that the embodiments of this invention, including Embodiments 1-236 above, relate also to compounds of Formula 10. Accordingly, combinations of Embodiments 1-236 are further illustrated by:

Embodiment Cl . A compound of Formula 10, or an A'-oxide or salt thereof, wherein

R 1 is CF 3 , CCI3 or CFCl 2 ; X is O;

Y is O;

R 2a and R 2 ^ are each independently H or methyl; or

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and

Y, selected from carbon atoms, wherein up to 1 carbon atom ring member is selected from C(=0), the ring optionally substituted with up to 2 substituents independently selected from halogen, cyano, methyl, halomethyl, methoxy and halomethoxy on carbon atom ring members;

R 6a and R 6b are each independently H, cyano, Br, Cl, F or methyl; and

R 30 is C | -C 4 alkyl, C j -C 4 haloalkyl, phenyl, 4-methylphenyl 4-bromophenyl or

4-nitrophenyl.

Embodiment C2. A compound of Embodiment Cl wherein

R 1 is CF 3 ;

R 2a and R 2 ^ are each H; or

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a

5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms;

R 6a and R 6b are each independently H or methyl; and

R 30 is CH 3 , CF 3 , CH 2 CF 3 , (CF 2 ) 3 CF 3 , phenyl or 4-methylphenyl.

Embodiment C3. A compound of Embodiment C2 wherein

R 6a and R 6b are H; and

R 30 is CH 3 , CF 3 or 4-methylphenyl.

Embodiment C4. A compound of Embodiment C3 wherein

R 30 is CF 3 .

Embodiment C5. A compound of Embodiment C4 wherein

R 2a and R 2b are taken together with the atoms X and Y to which they are attached to form a 5-membered saturated ring containing ring members, in addition to the atoms X and Y, selected from carbon atoms; and R 30 is CF 3 .

In addition to the embodiments described above, this invention also provides a fungicidal composition comprising a compound of Formula 1 (including all stereoisomers, L'-oxides, and salts thereof), and at least one other fungicide. Of note as embodiments of such compositions are compositions comprising a compound corresponding to any of the compound embodiments described above.

This invention also provides a fungicidal composition comprising a compound of Formula 1 (including all stereoisomers, A'-oxides, and salts thereof) (i.e. in a fungici dally effective amount), and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. Of note as embodiments of such compositions are compositions comprising a compound corresponding to any of the compound embodiments described above.

This invention provides a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to a plant seed, a fungicidally effective amount of a compound of Formula 1 (including all stereoisomers, N- oxides, and salts thereof). Of note as embodiments of such methods are methods comprising applying a fungicidally effective amount of a compound corresponding to any of the compound embodiments describe above. Of particular note are embodiments where the compounds are applied as compositions of this invention.

One or more of the following methods and variations as described in Schemes 1-17 can be used to prepare the compounds of Formula 1. The definitions of E, L, A, A 1 , A 2 , J, T, X, Y, R 1 , R2a, R2b R2C R2C( R6a j^6b compounds of Formulae 1-14 below are as defined above in the Summary of the Invention unless otherwise noted. Compounds of Formulae la-la 1 , lb-lb 6 and lc-lc 1 are various subsets of Formula 1, and all substituents for Formulae la-la 1 , lb- lb 6 and lc-lc 1 are as defined above for Formula 1 unless otherwise noted. As the synthetic literature includes many halomethyl ketone and hydrate-forming methods, which can readily be adapted to prepare compounds of the present invention, the following methods in Schemes 1-17 are simply representative examples of a wide variety of procedures useful for the preparation of the compounds of Formula 1. For reviews of ketone and hydrate-forming methods, see, for example, Tetrahedron 1991, 47, 3207-3258 and Chem. Communications 2013, 49(95), 11133- 11148, and references cited therein. Also see the methods outlined in U.S. Patent 6,350,892. As shown in Scheme 1, Compounds of Formula la (i.e. Formula 1 wherein T is T-l and W is O) wherein R 1 is CF 3 can be prepared by trifluoroacetylation of organometallic compounds of Formula 2. Typically, the ethyl ester of trifluoroacetic acid (i.e. ethyl trifluoroacetate) is used as the source of the trifluoroacetyl group in this method, but trifluoroacetonitrile and various trifluoroacetate salts can also be used. Depending on the reaction conditions, double-addition on the trifluoroacetyl compound can occur. Conducting the reaction at -65 °C, or more preferably at -78 °C, can reduce the occurrence of double addition adducts to trace amounts, particularly when using organometallic species of Formula 2 wherein M is Li or MgBr. Many other organometallic species yield similar results. For reaction conditions useful in the method of Scheme 1, as well as other well-established routes for the synthesize trifluoromethyl ketones see, for example, Journal of Organic Chemistry 1987, 52(22), 5026-5030; Chemical Communications 2013, 49(95), 11133-11148; and Journal of Fluorine Chemistry 1981, 18, 117-129. Conditions described in these references can easily be modified to prepare compounds of Formula la wherein R 1 is other than CF 3 (e.g., dihalo- or trichloro-moieties).

Scheme 1

M is, e.g., Li, Na, K, Cs or MgBr wherein R 1 is CF 3

Compounds of Formula la (i.e. Formula 1 wherein T is T-l and W is O) wherein R 1 is CF 3 can also be prepared via alkylation of ethyl 4,4,4-trifluoroacetoacetate (ETFAA) with compounds of Formula 3 wherein L a is a leaving group such as halogen (e.g., Cl, Br) or sulfonate (e.g., mesylate). In this method ETFAA is first treated with a base such as sodium hydride in a polar aprotic solvent such tetrahydrofuran (THF), THF/hexamethylphosphoramide (HMPA) or acetone. The ETFAA anion then displaces the leaving group in compounds of Formula 3 to give an intermediate ester which undergoes hydrolysis and decarboxylation in the presence of lithium chloride (LiCl) and N, /V-dimethylformamide (DMF) to give the ketone compound of Formula la. For reaction conditions see Journal Chemical Society, Chemical Communications 1989, (2), 83- 84; Chemical Communications 2013, 49(95), 11133-11148; and Journal of Fluorine Chemistry 1989, 44, 377-394.

Scheme 2

1. base (e.g., NaH)

ET

3

wherein R 1 is CF 3

3. LiCl, DMF wherein R 1

is CF 3

L a is a leaving group such as Cl, Br or OMs As shown in Scheme 3, compounds of Formula la (i.e. Formula 1 wherein T is T-l and W is O) wherein R 1 is CF 3 can also be prepared by trifluoromethylation of an ester of Formula 5 with trifluoromethyltrimethylsilane (TMS-CF3). The reaction is run in the present of a fluoride initiator such as tetrabutylammonium fluoride, and in an anhydrous solvent such as toluene or dichloromethane at about -78 °C (for reaction conditions see, for example, Angew. Chem., Int. Ed. 1998, 37(6), 820-821). Cesium fluoride can also be used as an initiator in a solvent such as l,2-dimethoxy ethane (glyme) at room temperature (for reaction conditions see, for example, J. Org. Chem., 1999, 64, 2873). The reaction proceeds through a trimethylsilicate intermediate, which is hydrolyzed with aqueous acid to give the desired trifluoromethyl ketone compound of Formula la. Weinreb amides may also be used in place of the starting esters (see, for example, Chem. Commun. 2012, 48, 9610).

Scheme 3

5 la

wherein R ' is CF3

As shown in Scheme 4, compounds of Formula la 1 (i.e. Formula la wherein A is A ' -A 2 - CR 6a R 6b ) wherein R 1 is CF 3 and at least one R 6a or R 6b is H can be prepared by reacting acid chlorides of Formula 6 with trifluoroacetic anhydride (TFAA) and pyridine in a solvent such as dichloromethane or toluene at a temperature between about 0 to 80 °C followed by aqueous hydrolysis (for reaction conditions see, for example, Tetrahedron 1995, 51, 2573-2584). Compounds of Formula 6 can be prepared from compounds of Formula 5 by ester hydrolysis to the corresponding carboxylic acid and treatment with oxalyl chloride, as known to one skilled in the art.

Scheme 4

wherein at least one R ba or R bb is H wherein R 1 is CF 3 and

at least one R ba or R bb is H

As shown in Scheme 5, compounds of Formula lb (i.e. Formula 1 wherein T is T-2) wherein R 2a X and R 2b Y are OH can be prepared by oxidation of alcohols of Formula 4 to the corresponding dihydroxy. The oxidation reaction can be performed by a variety of means, such as by treatment of the alcohols of Formula 4 with manganese dioxide, Dess-Martin periodinane, pyridinium chlorochromate or pyridinium di chromate. For typical reaction conditions, see present Example 6, Step F and Example 8, Step F.

Scheme 5

lb

4

wherein R 2a X and R 2b Y are both OH

Scheme 6 illustrates a specific example of the general method of Scheme 5 for the preparation of a compound of Formula lb 1 (i.e. Formula lb wherein L is CH 2 , J is phenyl (i.e. J-l), A is OCH 2 and R 1 is CF 3 ). In this method a compound of Formula 4a (i.e. Formula 4 wherein L is CH 2 , J is phenyl (i.e. J-l), A is OCH 2 and R 1 is CF 3 ) is reacted with an oxidizing reagent such as Dess-Martin periodinane in a solvent such as dichloromethane at a temperature between about 0 to 80 °C. Present Example 1, Step C illustrates the method of Scheme 6.

Scheme 6

wherein R zd X and R ZD Y are both OH

As shown in Scheme 7, compounds of Formula 4 can be prepared by reaction of compounds of Formula 2 with RdCFIO. For reactions conditions see, Tetrahedron Letters 2007, 48, 6372-6376.

Scheme 7

M is, e.g., Li, Na, K, Cs or MgBr

As shown in Scheme 8, compounds of Formula 4b (i.e. Formula 4 wherein A is OCR 6a R 6b ) can be prepared by reacting a compound of Formula 7 with an epoxide of Formula 8 The reaction is typically carried out in a solvent such as acetonitrile with a catalytic amount of a base such as cesium or potassium carbonate at a temperature between about 20 to 80 °C; or in a solvent such as dichloromethane with a catalytic amount of a Lewis acid such as boron trifluoride etherate at a temperature between about 0 to 40 °C. Present Example 8, Step E illustrates the method of Scheme 8. One skilled in the art will recognize that the method of Scheme 8 can also be performed when A is thus providing other compounds of

Formula 4b. Compounds of Formulae 7 and 8 are available from commercial sources and can easily be prepared using commercial precursors and known methods. Present Example 1, Step A, Example 6, Step D and Example 8, Step D illustrate the preparation of a compound of Formula 7.

Scheme 8

Scheme 9 illustrates a specific example of the general method of Scheme 8 for the preparation of a compound of Formula 4b 1 (i.e. Formula 4b wherein L is CH 2 , J is phenyl (i.e. J-l), R 6a and R 6b are H and R 1 is CF 3 ) In this method a compound of Formula 7a (i.e. Formula 7 wherein L is CH 2 and J is phenyl (i.e. J-l)) is reacted with 2-(trifluoromethyl)oxirane (i.e. Formula 8a) in the presence of cesium carbonate in a solvent such as acetonitrile at a temperature between about 60 to 80 °C. Present Example 1, Step B illustrates the method of Scheme 9.

Scheme 9

As illustrated in Scheme 10, ketones of Formula la (i.e. Formula 1 wherein T is T-l and W is O) may exist in equilibrium with their corresponding ketone hydrates (i.e. dihydroxy) of Formula lb (i.e. Formula 1 wherein T is T-2) wherein R 2a X and R^Y are OH. The predominance of Formula la or Formula lb is dependent upon several factors, such as environment and structure. For example, in an aqueous environment ketones of Formula la can react with water to give ketone hydrates (also known as l,l-geminal diols) of Formula lb. Conversion back to the keto-form can usually be achieved by treatment with a dehydrating agent such as magnesium sulfate or molecular sieves. When the ketone moiety is in close proximity to an electron- withdrawing group, such as when R 1 is a trifluoromethyl group, the equilibrium typically favors the dihydrate form. In these cases, conversion back to the keto-form may require a strong dehydrating agent, such as phosphorus pentoxide (P2O5). For reaction conditions see, for example, Eur. J Org. Chem. 2013, 3658-3661; and Chemical Communications 2013, 49(95), 11133-11148, and references cited therein.

Scheme 10

lb

wherein R 2a X and R 2b Y are both OH

As shown in Scheme 11, ketones of Formula la may also exist in equilibrium with their hemiketals, hemithioketals and hemiaminals of Formula lb 2 (i.e. Formula lb wherein R^Y is OH and R 2a is other than H) along with their ketals, thioketals aminals of Formula lb wherein R 2a and R 2b are other than H. Compounds of Formula lb 2 can be prepared by reacting a compound of Formula la with a compound of formula R 2a X-H (e.g., alcohols for X being O, thiols for X being S or amines for X being NR 5a ), usually in the presence of an catalysis, such as a Bronsted (i.e. protic) acid or Lewis acid (e.g. BF3), (see, for example, Master Organic Chemistry (Online), On Acetals and Hemiacetals, May 28, 2010, www.masterorganic- chemistry.com/20l0/05/28/on-acetals-and-hemiacetals). In a subsequent step, compounds of Formula lb 2 can be treated with a compound of formula R 2b Y-H (e.g., alcohols for Y being O, thiols for Y being S or amines for Y being NR 5b ) under dehydrating conditions, or other means of water removal that will drive the equilibrium in the reaction to the right, to provide compounds of Formula lb wherein R 2a and R 2 ^ are other than H. Alternatively, ketones of Formula la can initially be treated with two equivalents (or an excess amount) of an alcohol, thiol or amine typically in the presence of a catalysis together with a dehydrating agent to provide compounds of Formula lb directly (see, for example, the preparation of the dimethylketals using methanol and trimethyl orthoformate in US 6,350,892).

wherein R 2a is other than H wherein R 2a and R 2b are other than H

As illustrated in Scheme 12, cyclic ketals of Formula lb 3 (i.e. Formula lb wherein X and Y are O, and R 2a and R 2b are taken together to form a 5- to 7-membered ring) can be prepared by treating the corresponding ketones of Formula la with haloalcohols (e.g., 2-chloroethanol or 2- bromopropanol) in the presence of a base such as potassium carbonate or potassium / /v-butoxide and in as solvent such as acetonitrile or /V,/V-dimethylformamide (DMF). For reactions conditions see, Organic Letters 2006 5(17), 3745-3748.

Scheme 12

ase

h lb 3

wherein R is halogen

wherein X and Y are O, and

R 2a and R 2b are taken togher to fom a ring

The method of Scheme 12 is also useful for preparing cyclic ketals stating from the corresponding ketone hydrate form. Scheme 13 illustrates a specific example where a ketone hydrate of Formula lb 4 (i.e. Formula lb wherein L is CH 2 , J is phenyl (i.e. J-l), A is OCH 2 , R 2a X and R 2b Y are OH and R 1 is CF 3 ) is reacted with 2-chloroethanol in the presence of potassium carbonate in acetonitrile at a temperature between about 25 to 70 °C to provide a compound of Formula lb 5 (i.e. Formula lb wherein L is CH 2 , J is phenyl (i.e. J-l), A is OCH 2 , X and Y are O, R 2a and R 2 ^ are taken together to form a 5-membered ring and R 1 is CF 3 ). Present Example 2 illustrates the method of Scheme 13.

Scheme 13

As shown in Scheme 14, Compounds of Formula lb 6 (i.e. compounds of Formula lb wherein A is A 1 -A 2 -CR 6a R 6 ^ ) ) wherein A 1 is N(R 7a ), O or S and A 2 is a direct bond, or wherein A 1 is CR 6c R 6d and A 2 is N(R 7b ), O or S can be prepared by reacting compounds of Formula 9 wherein A 1 is O, S or N(R 7a ) and A 2 is a direct bond, or where A 1 is CR 6c R 6d and A 2 is O, S or N(R 7b ) with compounds of Formula 10. The reaction is typically run in a solvent such A', N- dimethylformamide (DMF) or dimethyl sulfoxide with a base such as cesium or potassium carbonate or sodium hydride at a temperature between about 20 to 80 °C. The method of Scheme 14 is illustrated in Example 4, Step D.

Of note as starting materials in the method of Scheme 14 are compounds of Formula 10 specifically disclosed in Table 3 below.

Scheme 14

wherein A 1 is N(R 7a ), O or S and A 2 I 7a 2

wherein A is N(R ), O or S and A is a direct is a direct bond, or wherein A* is

bond, or wherein A 1 is CR 6c R 6d and A 2 is N(R 7b ), CR 6c R 6d and A 2 is N(R 7b ), O or S

O or S

Compounds of Formula 10 can be prepared using commercial precursors and known methods. For example, as shown in Scheme 15, compounds of Formula 10a (i.e. Formula 10 wherein R 6a and R 6 ^ are H, X and Y are O and R 2a and R 2b) are taken together to form a 5- membered ring) can be prepared reacting compounds of Formula 11 with haloalcohols (e.g., 2- chloroethanol or 3-bromopropanol) under basic conditions (e.g., potassium c/ -butoxide in a solvent such as A' A'-di m ethyl formam i de or tetrahydrofuran) to provide compounds of Formula 12. A variety of methods are disclosed in the chemical literature for the conversion of ketones to cyclic ketals and can be readily adapted to prepare compounds of Formula 12 (see, for example, G. Hilgetag and A. Martini, Ed., Preparative Organic Chemistry, pp 381-387: Wiley, New York, 1972, and references sited therein; also see present Example 4, Step A). The ester moiety of the resulting cyclic ketal of Formula 12 can be reduced to the corresponding alcohol of Formula 13 by standard methods known to one skilled in the art (Example 4, Step B illustrates a typical procedure). The hydroxy moiety in the compounds of Formula 13 can then be converted to a wide variety of R 29 groups to provide compounds of Formula 10a. For example, a mesylate or tosylate group can be installed by treating the alcohol with methanesulfonyl chloride (mesyl chloride) or 4-toluenesulfonyl chloride (tosyl chloride) in the presence of a base such as triethylamine at a temperature between about 0 to 40 °C and in a solvent such as dichloromethane. A triflate group can be installed by treating the alcohol with triflic anhydride (CF 3 S 02)20 as illustrated in Example 4, Step C. Compounds of Formula 11 are known and can be prepared by methods known to one skilled in the art.

Scheme 15

R > % 29

10a

Compounds of Formula lc (i.e. Formula 1 wherein T is T-3 and X is O) can be prepared by reacting a compound of Formula la (i.e. Formula 1 wherein T is T-l and W is O) wherein at least one of R 6a and R 6b is H with a compound of Formula 14 in the presence of a base, as illustrated in Scheme 16. Suitable bases include cesium or potassium carbonate in a solvent such as L',L'-dimethylformamide (DMF) or dimethyl sulfoxide at temperatures from about 20 to 80 °C. In some cases, the method of Scheme 16 results in a mixture of O-alkylated product (typically as a mixture of ( E )- and (Z)-isomers), along with C-alkylated product. Purification can be achieved using standard techniques such as column chromatography (s QQ Magnetic Resonance in Chemistry 1991, 29, 675-678). Compounds of Formula 14 are commercially available and can be easily synthesized by general methods known to one skilled in the art.

Scheme 16

wherein at least one L a is a leaving group such as

of R 6a and R 6b is H Cl, Br, I, OMs, OTs or OTf The method of Scheme 16 is also useful for preparing compounds of Formula lc stating from the corresponding ketone hydrate. Scheme 17 illustrates a specific example where a ketone hydrate of Formula lb 4 (i.e. Formula lb wherein L is CH 2 , J is phenyl (i.e. J-l), A is OCH 2 , R 2a X and R 2b Y are OH and R 1 is CF 3 ) is reacted with iodoethane in the presence of cesium carbonate in dimethyl sulfoxide at a temperature between about 25 to 75 °C to provide a compound of Formula lc 1 (i.e. Formula lc wherein L is CH 2 , J is phenyl (i.e. J-l), A is O, R 2d is H, XR 2c is OCH 2 CH 3 and R 1 is CF 3 ). Present Example 5 illustrates the method of Scheme 17.

Scheme 17

Compounds of Formula 1 wherein T is T-l and W is S can be prepared from the corresponding compounds wherein W is O by treatment with phosphorus pentasulfide or 2,4- bis(4-methoxyphenyl)-l, 3 -dithia-2,4-diphosphetane-2, 4-disulfide (Lawesson’s reagent) in solvents such as toluene, xylene or tetrahydrofuran. One skilled in the art will also recognize that the compounds of Formula 1 wherein T is T-l and W is NR 3 can be prepared from the compounds of Formula 1 wherein T is T-l and W is O or S by treatment with an amine of Formula R 3 NH 2 under dehydrating conditions. The E-L- moieties present in the compounds of Formula 1 and the intermediate compounds of Formulae 2 through 7 and 9 are common organic functional groups whose methods of preparation have been documented in the literature. One skilled in the art will recognize that these well-known chemistry classes (esters, amides, sulfonamides, sulfones, ethers, carbamates, ureas, heterocycles) can be readily prepared by a variety of methods (see, for example, WO 2018/080859, WO 2018/118781, WO 2018/187553 and WO 2019/010192).

It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula 1 may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice of the protecting groups will be apparent to one skilled in chemical synthesis (see, for example, T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 2 nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as it is depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula 1. One skilled in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the above schemes in an order other than that implied by the particular sequence presented to prepare the compounds of Formula 1.

One skilled in the art will also recognize that compounds of Formula 1 and the intermediates described herein can be subjected to various electrophilic, nucleophilic, radical, organometallic, oxidation, and reduction reactions to add substituents or modify existing substituents.

Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Steps in the following Examples illustrate a procedure for each step in an overall synthetic transformation, and the starting material for each step may not have necessarily been prepared by a particular preparative run whose procedure is described in other Examples or Steps. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. ¾ NMR spectra are reported in ppm downfield from tetramethylsilane;“s” means singlet,“br s” means broad singlet,“d” means doublet,“dd” means doublet of doublets, “t” means triplet,“q” means quartet and“m” means multi plet. 19 F NMR spectra are reported in ppm using trichlorofluoromethane as the reference.

EXAMPLE 1

Preparation of ethyl 1 -[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- l //-pyrazole-

4-carboxylate (Compound 1)

Step A: Preparation of ethyl 1 -[(4-hydroxyphenyl)methyl]- l //-pyrazole-4-carboxylate

A mixture of ethyl lif-pyrazole-4-carboxylate (1.40 g, 10 mmol), 4-(chloromethyl)phenyl acetate (2.0 g, 11 mmol) and potassium carbonate (1.6 g, 11 mmol) in N, A- di m ethyl formam i de (10 mL) was stirred at room temperature for 16 h. Ethanol (10 mL) was added and the reaction mixture was heated at 65 °C for 16 h, cooled, and poured into ice water. The resulting precipitate was collected by filtration, washed with water and air dried. The resulting solid (2.0 g) was crystalized from acetonitrile to provide the title compound as a white solid melting at 113-115 °C. !H NMR CDClg): d 1.32 (t, 3H), 3.10 (d, 1H), 4.10-4.40 (m, 5H), 5.24 (s, 2H), 6.91 (d, 2H), 7.22 (d, 2H), 7.83 (s, 1H), 7.93 (s, 1H).

Step B: Preparation of ethyl 1 -[[4-(3,3,3-trifluoro-2-hydroxypropoxy)phenyl] methyl]-! H- pyrazole-4-carboxylate

A mixture of ethyl 1 -[(4-hydroxyphenyl)methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Step A) (2.36 g, 9.6 mmol), 2-(trifluoromethyl)oxirane (1.3 g, 11.6 mmol) and cesium carbonate (50 mg, 0.15 mmol) in acetonitrile (20 mL) was heated at 65 °C. After 3 days, the reaction mixture was cooled and concentrated under reduced pressure. The resulting material was purified by silica gel chromatography (eluting with a gradient of 0 to 50% ethyl acetate in hexanes) to provide the title compound as a white solid (2.46 g).

!H NMR (CDCl 3 ): d 1.33 (t, 3H), 4.29 (q, 2H), 5.21 (s, 2H), 5.95 (br s, 1H), 6.76 (d, 2H), 7.09 (d, 2H), 7.84 (s, 1H), 7.95 (s, 1H).

19 F NMR (CDCI3): d -77.54.

Step C: Preparation of ethyl l-[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- lif-pyrazole-4-carboxylate A mixture of ethyl l-[[4-(3,3,3-trifluoro-2-hydroxypropoxy)phenyl]methyl]-li/-p yrazole- 4-carboxylate (i.e. the product of Step B) (1.23 g, 3.4 mmol) and Dess-Martin periodinane (2.2 g, 5.2 mmol) in dichloromethane (20 mL) was stirred at room temperature for 16 h, and then concentrated under reduced pressure. The resulting material was dissolved in ethyl acetate and washed with sodium bisulfite solution (2 M aqueous solution), followed by saturated aqueous sodium bicarbonate solution. The organic layer was dried, filtered and the filtrate was concentrated under reduced pressure. The resulting tan solid (1.77 g) was crystalized from acetonitrile to provide the title compound, a compound of the present invention, as solid needles melting at 120-123 °C.

!H NMR (CDCl 3 ): d 1.32 (t, 3H), 3.80 (br s, 1.7H), 4.18 (s, 2H), 4.28 (q, 2H), 5.25 (s, 2H), 6.95 (d, 2H), 7.22 (d, 2H), 7.82 (s, 1H), 7.95 (s, 1H).

19 F NMR (CDCI3): d -84.92.

EXAMPLE 2

Preparation of ethyl 1 -[[4-[[2-(trifluoromethyl)- l ,3-dioxolan-2-yl]methoxy]phenyl]methyl]- l H- pyrazole-4-carboxylate (Compound 32)

A mixture of ethyl 1 -[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]-l H- pyrazole-4-carboxylate (i.e. the product of Example 1) (1.07 g, 3.0 mmol), 2-chloroethanol (0.24 g, 3.0 mmol) and potassium carbonate (0.5 g, 3.6 mmol) in N, A- di m ethyl formam i de (3.5 mL) was stirred at room temperature for 16 h, and then heated at 65 °C (briefly). After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The resulting material was diluted with diethyl ether and washed with saturated aqueous sodium chloride solution. The organic layer was dried, filtered and the filtrate was concentrated under reduced pressure to provide the title compound, a compound of the present invention, as a colorless oil (1.06 g).

!H NMR (CDCI3): d 1.32 (t, 3H), 4.21 (s, 4H), 4.23 (s, 2H), 4.27 (q, 2H), 5.24 (s, 2H), 6.94 (d, 2H), 7.20 (d, 2H), 7.81 (s, 1H), 7.93 (s, 1H).

19 F NMR (CDCI3): d -81.39.

EXAMPLE 3 Preparation of ethyl l-[[4-[[4,4-dimethyl-2-(trifluoromethyl)-l,3-dioxolan-2-yl]m ethoxy]- phenyljmethyl]- 1 //-pyrazole-4-carboxylate (Compound 12)

The title compound was prepared by a procedure analogous to Example 2.

NMR (CDCl 3 ): d 1.32 (t, 3H), 1.13 (s, 3H), 1.45 (s, 3H), 3.95 (d, 1H), 4.00 (d, 1H), 4.18 (m, 2H), 4.27 (q, 2H), 5.24 (s, 2H), 6.94 (d, 2H), 7.20 (d, 2H), 7.81 (s, 1H), 7.93 (s, 1H).

19 F NMR (CDCI3): d -81.01.

EXAMPLE 4

Alternative preparation of ethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]phenyl ]- methyl]- 1 //-pyrazole-4-carboxylate (Compound 32) Step A: Preparation of methyl 2-(trifluoromethyl)-l,3-dioxolane-2-carboxylate

To a mixture of methyl 3,3,3-trifluoro-2-oxopropanoate (31.2 g, 200 mmol) in petroleum ether (100 mL) was added 2-bromoethanol (25.0 g, 200 mmol) over a period of 15 minutes. The reaction mixture was stirred at room temperature for 30 minutes, then cooled to 5 °C and potassium carbonate (28 g, 200 mmol) was added with vigorous stirring. Stirring was continued for an additional 4 h at 5 °C, and then the reaction mixture was allowed to warm to room temperature, diluted with diethyl ether (100 mL) and filtered. The filtrate was concentrated under reduced pressure, and the resulting material was dissolved in diethyl ether (200 mL) and washed with saturated aqueous sodium chloride solution (3x). The organic layer was dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to provide the title compound as a colorless oil (29 g).

!H NMR CDClg): d 3.80 (s, 3H), 4.30 (m, 4H).

19 F NMR (CDCI3): d -80.52.

Step B: Preparation of 2-(trifluoromethyl)-l ,3-dioxolane-2-methanol

To a mixture of methyl 2-(trifluoromethyl)-l,3-dioxolane-2-carboxylate (i.e. the product of Step A) (5 g, 25 mmol) in tetrahydrofuran (75 mL) was added sodium bis(2-methoxy- ethoxy)aluminum hydride (60% in toluene) (12.2 mL, 37.5 mmol). The reaction mixture was heated at 40 °C for 1.5 h, and then cooled to room temperature and a solution of ethyl acetate (3.30 g, 37.5 mmol) in tetrahydrofuran (15 mL) was added dropwise over a period of 15 minutes. The reaction mixture was stirred for 45 minutes and then concentrated under reduced pressure. The resulting material was diluted with diethyl ether (400 mL), washed with saturated aqueous sodium chloride solution (2x), dried over magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to provide the title compound as an oil (3.8 g).

!H NMR CDClg): d 2.59 (t, 1H), 3.82 (d, 2H), 4.19 (m, 4H).

19 F NMR (CDCl 3 ): d -81.50.

Step C: Preparation of [2-(trifluoromethyl)-l,3-dioxolan-2-yl]methyl 1 , 1 , 1 -trifluoro- methanesulfonate

A mixture of 2-(trifluoromethyl)-l,3-dioxolane-2-methanol (i.e. the product of Step B)

(1.67 g, 9.70 mmol) and triethylamine (1.5 mL, 10.8 mmol) in dichloromethane (50 mL) was cooled to -78 °C, and then a solution of trifluoromethanesulfonic anhydride (1.81 mL, 10.8 mmol) in dichloromethane (50 mL) was added over a period of 30 minutes. The reaction mixture was stirred at -78 °C for 1.5 h, and then water (50 mL) was added dropwise while allowing the reaction to warm to room temperature. The resulting mixture was partitioned between dichloromethane-water, and the organic layer washed with water, dried over magnesium sulfate and filtered. The filtrated was concentrated under reduced pressure to provide the title compound as a colorless solid (3.0 g).

¾ NMR (CDCI3): d 4.24 (m, 4H), 4.60 (br s, 2H).

1 9 F NMR (CDCI3): d -74.84, -81.50.

Step D: Preparation of ethyl l-[[4-[[2-(trifluoromethyl)-l,3-dioxolan-2-yl]methoxy]- phenyl]methyl] - lif-pyrazole-4-carboxylate

To a mixture of ethyl 1 -[(4-hydroxyphenyl)methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Example 1, Step A) (16.85 g, 68.0 mmol) and cesium carbonate (53.53 g, 164.5 mmol) in N,/V-dimethylformamide (100 mL) was added [2-(trifluoromethyl)-l,3-dioxolan-2-yl]methyl l,l,l-trifluoromethanesulfonate (i.e. the product of Step C) (24.9 g, 82.0 mmol). The reaction mixture was stirred for 24 h at room temperature, and then diluted with diethyl ether. The organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting material was purified by silica gel chromatography (eluting with a gradient of 0 to 60% ethyl acetate in hexanes) to provide the title compound, a compound of the present invention, as a white solid (23 g) melting at 59-60 °C.

!H NMR (CDCl 3 ): d 1.32 (t, 3H), 4.21 (s, 4H), 4.23 (s, 2H), 4.27 (q, 2H), 5.24 (s, 2H), 6.94 (d, 2H), 7.20 (d, 2H), 7.81 (s, 1H), 7.93 (s, 1H).

19 F NMR (CDCI3): d -81.39.

EXAMPLE 5

Preparation of ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phen yl]methyl]- lif-pyrazole-4-carboxylate (Compound 64)

A mixture of ethyl 1 -[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- l H- pyrazole-4-carboxylate (i.e. the product of Example 1) (1.0 g, 2.67 mmol), iodoethane (2.5 g, 16 mmol) and cesium carbonate (1.75 g, 5.37 mmol) in dimethyl sulfoxide (10 mL) was heated at 40 °C for 45 minutes. The reaction mixture was diluted with diethyl ether, washed with water and saturated aqueous sodium chloride solution, dried and filtered. The filtrate was concentrated under reduced pressure to provide the title compound, a compound of the present invention, as a white solid (0.80 g). A portion of the solid was further purified by silica gel chromatography (eluting with a gradient of 0 to 50% ethyl acetate in hexanes) to provide a solid melting at 59- 60 °C. A nuclear Overhauser effect (NOE) was observed between the trifluoromethyl moiety and the vinyl proton indicating a cv.s-configuration.

!H NMR (CDCI3): d 1.30-1.40 (m, 6H), 4.17 (q, 2H), 4.27 (q, 2H), 5.28 (s, 2H), 6.78 (q, 1H), 7.05 (m, 2H), 7.29 (m, 2H), 7.86 (s, 1H), 7.94 (s, 1H).

19 F NMR (CDCI3): d -70.13.

EXAMPLE 6 Preparation of ethyl 1 -[[3-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- 1 //-pyrazole-

4-carboxylate (Compound 266)

Step A: Preparation of 3-(bromomethyl)phenol

A mixture of l-(bromomethyl)-3-methoxybenzene (15.48 g, 76.99 mmol) in dichloromethane (150 mL) was cooled to -78 °C, and then boron tribromide (1 M solution in dichloromethane) was added dropwise. The reaction mixture was allowed to warm to room temperature, stirred for 2 h, and then cooled to -20 °C and methanol (150 mL) was added dropwise. After warming to room temperature, the reaction mixture was concentrated under reduced pressure and the resulting material was diluted with dichloromethane and washed with saturated aqueous sodium bicarbonate solution. The organic layer was dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting material was purified by silica gel chromatography (eluting with a gradient of 0 to 100% ethyl acetate in hexanes) to provide the title compound as a white solid (14.16 g).

!H NMR (CDCl 3 ): d 4.44 (s, 2H), 4.89 (s, 1H), 6.76 (dd, 1H), 6.87 (s, 1H), 6.95 (d, 1H), 7.19- 7.23 (t, 1H).

Step B: Preparation of 3-(bromomethyl)phenyl acetate

A solution of 3-(bromomethyl)phenol (i.e. the product of Step A) (14.16 g, 75.7 mmol) in dichloromethane (130 mL) was cooled to 0 °C, and then acetic anhydride was added (12.96 g, 12 mL, 126.9 mmol), followed by concentrated sulfuric acid (5 drops). The reaction mixture was allowed to warm to room temperature, stirred for 1 h, and then saturated aqueous sodium bicarbonate solution (300 mL, 318 mmol) was added. The organic layer was separated, washed with water, dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to provide the title compound as a solid (16.68 g).

!H NMR CDClg): d 4.47 (s, 2H), 7.02-7.04 (m, 1H), 7.14 (s, 1H), 7.25 (m, 1H), 7.35 (t, 1H). Step C: Preparation of ethyl 1 -[[3-(acetyloxy)phenyl]methyl]- l //-pyrazole-4-carboxylate

To a mixture of 3-(bromomethyl)phenyl acetate (i.e. the product of Step B) (16.68 g, 72.8 mmol) in acetonitrile (300 mL) was added ethyl lif-pyrazole-4-carboxylate (10.61 g, 75.7 mmol) followed by potassium carbonate (19.35 g, 140 mmol). The reaction mixture was heated at 70 °C overnight, cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to provide the title compound as a yellow oil (20.5 g). !H NMR CCDC^): d 2.30 (s, 3H), 4.47 (s, 2H), 7.02 (dd, 1H), 7.15 (s, 1H), 7.25 (m, 1H).

Step D: Preparation of ethyl 1 -[(3-hydroxyphenyl)methyl]- l //-pyrazole-4-carboxylate

To a mixture of ethyl 1 -[[3-(acetyloxy)phenyl]methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Step C) (20.5 g, 72.8 mmol) in ethanol was added potassium carbonate (10.1 g, 73 mmol). The reaction mixture was heated at reflux for 3 h, cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the resulting material was purified by MPLC silica gel chromatography (eluting with a gradient of 0 to 100% ethyl acetate in hexanes) to provide the title compound as a white solid (10.02 g).

¾ NMR (CDCl 3 ): d 1.33 (t, 3H) 4.29 (q, 2H), 5.20 (br s, 1H), 5.25 (s, 2H), 6.66 (m, 1H), 6.78- 6.81 (m, 2H), 7.21-7.24 (m, 1H), 7.87 (s, 1H), 7.94 (s, 1H).

Step E: Preparation of ethyl 1 -[[3 -(3,3,3-trifluoro-2-hydroxypropoxy)phenyl] methyl]-! H- pyrazole-4-carboxylate

To a mixture of ethyl 1 -[(3-hydroxyphenyl)methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Step D) (2.38 g 9.66 mmol) in acetonitrile (100 mL) was added 3-bromo-l,l,l- trifluoro-2-propanol (1.93 g, 1.04 mL, 10 mmol) followed by potassium carbonate (2.86 g, 20.7 mmol). The reaction mixture was heated at reflux for 48 h, cooled to room temperature, filtered and the filtrate was concentrated under reduced pressure. The resulting material was purified by MPLC silica gel chromatography, (eluting with a gradient of 0 to 100% ethyl acetate in hexanes) to provide the title compound as a solid (2.75 g).

!H NMR CDClg): d 1.33 (q, 3H), 4.1-4.4 (m, 5H), 5.27 (s, 2H), 6.80 (m, 1H), 6.87-6.89 (m, 2H), 7.28-7.31 (m, 1H), 7.88 (s, 1H), 7.94 (s, 1H).

19 P NMR (CDCI3): d -77.53.

Step L: Preparation of ethyl l-[[3-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- lif-pyrazole-4-carboxylate

To a mixture of ethyl 1 -[[3-(3,3,3-trifluoro-2-hydroxypropoxy)phenyl]methyl]-l H- pyrazole-4-carboxylate (i.e. the product of Step E) (5.7 g, 14.9 mmol) in dichlorom ethane (300 mL) was added Dess-Martin periodinane (9.13 g, 20.3 mmol) in one portion. After 3 h, the reaction mixture was concentrated under reduced pressure, diluted with ethyl acetate and washed with sodium bisulfite solution (10% aqueous solution), saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution. The organic layer was dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting material was triturated with 1 -chlorobutane to provide the title compound, a compound of the present invention, as a white solid (4.89 g).

¾ NMR (DMSO-i/ 6 ): d 1.27 (t, 3H), 4.01 (s, 2H), 4.20 (m, 2H), 5.33 (s, 2H), 6.86-6.92 (m, 3H), 7.26-7.29 (m, 1H), 7.31 (s, 2H,), 7.87 (s, 1H), 8.48 (s, 1H).

19 F NMR (DMSO- ): d -81.82.

EXAMPLE 7

Preparation of ethyl l-[[3-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phen yl]methyl]- lif-pyrazole-4-carboxylate (Compound 265)

To a mixture of ethyl 1 -[[3-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenyl]methyl]- l H- pyrazole-4-carboxylate (i.e. the product of Example 6) (2.94 g, 7.85 mmol) in dimethyl sulfoxide (24 mL) was added iodoethane (2.39 g, 15.3 mmol). The reaction mixture was heated at 65 °C, and then cesium carbonate (4.21 g, 12.92 mmol) was added. After 45 minutes, the reaction mixture was cooled to room temperature, and poured into diethyl ether/water (400 mL, 1 : 1 ratio). The organic layer was separated and washed with water, saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting material was purified by silica gel chromatography (eluting with a gradient of 0 to 100% ethyl acetate in hexanes) to provide the title compound, a compound of the present invention, as a white solid (2.59 g) melting at 41-43 °C.

!H NMR CDClg): d 1.32 (m, 6H), 4.16 (m, 2H,), 4.30 (m, 2H,), 5.31 (s, 2H,), 6.76 (s, 1H), 6.93 (m, 1H), 7.00-7.03 (m, 2H), 7.34-7.37 (m, 1H), 7.90 (s, 1H), 7.95 (s, 1H).

19 F NMR (CDCl 3 ): d -70.09.

EXAMPLE 8

Preparation of ethyl 1 -[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenoxy]methyl]- l H- pyrazole-4-carboxylate (Compound 366)

Step A: Preparation of ethyl 1 -(hydroxymethyl)- lif-pyrazole-4-carboxylate

A mixture of ethyl lif-pyrazole-4-carboxylate (6.0 g, 43 mmol), formaldehyde (37% aqueous solution, 12 mL) and ethanol (50 mL) was heated at reflux overnight. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting material was triturated with l-chlorobutane to provide the title compound as a white solid (6.2 g). !H NMR (DMSO- g): d 1.27 (t, 3H) 4.22 (q, 2H), 5.41 (s, 2H), 7.89 (s, 1H), 8.36 (s, 1H).

Step B: Preparation of ethyl 1 -(chloromethyl)- l //-pyrazole-4-carboxylate

To a mixture of ethyl 1 -(hydroxymethyl)- lif-pyrazole-4-carboxylate (i.e. the product of Step A) (6.2 g, 36 mmol) in dichloroethane (100 mL) was added A' A'-dimethylformamide (2 drops), followed by thionyl chloride (5.3 mL, 73 mmol) dropwise. After 3 h, the reaction mixture, was concentrated under reduced pressure to provide the title compound as a yellow solid (6.2 g).

!H NMR CDC^): d 1.35 (t, 3H), 4.31 (q, 2H), 5.85 (s, 2H), 7.99 (s, 1H), 8.11 (s, 1H).

Step C: Preparation of ethyl 1 -[(4-methoxyphenoxy)methyl]- l //-pyrazole-4-carboxylate

A mixture of ethyl 1 -(chloromethyl)- l //-pyrazole-4-carboxylate (i.e. the product of Step B) (2.0 g, 11 mmol), 4-methoxyphenol (1.24 g, 10 mmol), potassium carbonate (2.8 g, 20 mmol) and A',A'-dimethylformamide (25 mL) was stirred at room temperature. After 3 days, the reaction mixture was poured into ice water (150 mL) and extracted with diethyl ether (2 x 100 mL). The combined organic layers were washed with water (50 mL), saturated aqueous sodium chloride solution (25 mL), dried over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The resulting material was purified by silica gel chromatography (eluting with a gradient of 10 to 100% ethyl acetate in hexanes) to provide the title compound as a colorless oil (2.7 g).

!HNMR CDClg): d 1.34 (t, 3H), 3.78 (s, 3H), 4.29 (q, 2H), 5.90 (s, 2H), 6.80-6.84 (m, 2H), 6.88- 6.91 (m, 2H), 7.96 (s, 1H), 8.05 (s, 1H).

Step D: Preparation of ethyl 1 -[(4-hydroxyphenoxy)methyl]- l //-pyrazole-4-carboxylate

To a mixture of ethyl 1 -[(4-methoxyphenoxy)methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Step C) (1.7 g, 6.2 mmol) in dichloromethane (3 mL) was added boron tribromide solution (1 M in dichloromethane, 12.4 mL, 12.4 mmol). After 4 h, saturated aqueous ammonium chloride solution (25 mL) was added to the reaction mixture and stirring was continued for another 15 minutes. The reaction mixture was diluted with dichloromethane (25 mL) and saturated aqueous ammonium chloride solution (25 mL). The organic layer was separated and washed with saturated aqueous sodium bicarbonate solution (25 mL) and saturated aqueous sodium chloride solution (25 mL), drying over magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to provide the title compound as a solid (1.65 g).

NMR (DMSO- ): d 1.26 (t, 3H), 4.21 (q, 2H), 5.76 (s, 1H), 5.96 (s, 2H), 6.62-6.71 (m, 2H), 6.82-6.88 (m, 2H), 7.93 (d, 1H), 8.48 (d, 1H).

Step E: Preparation of ethyl l-[[4-(3,3,3-trifluoro-2-hydroxypropoxy)phenoxy]methyl]- lif-pyrazole-4-carboxylate

To a mixture of ethyl 1 -[(4-hydroxyphenoxy)methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Step D) (6.2 mmol) in acetonitrile (20 mL) was added 2-(trifluoromethyl)oxirane (0.62 mL, 7.6 mmol) and cesium carbonate (approximately 10 mg). The reaction mixture was heated at 75 °C overnight, and then cooled to room temperature and concentrated under reduced pressure. The resulting material was purified by silica gel chromatography (eluting with a gradient of 10 to 100% ethyl acetate in hexanes) to provide the title compound as a white solid (0.95 g). ¾ NMR (DMSO- g): d 1.26 (t, 3H), 3.96-4.08 (m, 1H), 4.12 (dd, 1H), 4.22 (q, 2H), 4.33-4.36 (m, 1H), 6.04 (s, 2H), 6.62 (d, 1H), 6.88-6.97 (m, 2H), 7.00-7.03 (m, 2H), 7.95 (s, 1H), 8.54 (s, 1H).

Step L: Preparation of ethyl l-[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenoxy]- methyl]- 1 //-pyrazole-4-carboxylate

To a mixture of ethyl 1 -[[4-(3,3,3-trifluoro-2-hydroxypropoxy)phenoxy]methyl]- l H- pyrazole-4-carboxylate (i.e. the product of Step E) (0.95 g, 2.5 mmol) in dichloromethane (25 mL) was added Dess-Martin periodinane (1.5 g, 3.5 mmol) in one portion. The reaction mixture was stirred for 2.5 h, and then saturated aqueous sodium thiosulfate solution (30 mL) was added and the mixture was concentrated under reduced pressure. The resulting mixture was extracted with ethyl acetate (150 mL) and the combined organic layers were washed with saturated aqueous sodium thiosulfate solution (50 mL), saturated aqueous sodium bicarbonate solution (50 mL) and saturated aqueous sodium chloride solution (25 mL), drying over magnesium sulfate and filtered. The filtered was concentrated under reduced pressure and the resulting material was triturated with dichloromethane to provide the title compound, a compound of the present invention, as a solid (0.65 g).

¾ NMR (DMSO- ): d 1.26 (t, 3H), 3.98 (s, 2H), 4.21 (q, 2H), 6.03 (s, 2H), 6.86-6.94 (m, 2H), 6.95-7.06 (m, 2H), 7.27 (s, 2H), 7.94 (s, 1H), 8.53 (s, 1H). EXAMPLE 9

Preparation of ethyl l-[[4-[[(lZ)-2-ethoxy-3,3,3-trifluoro-l-propen-l-yl]oxy]phen oxy]methyl]- lif-pyrazole-4-carboxylate (Compound 364)

A mixture of iodoethane (2.7 mL, 34 mmol), potassium carbonate (0.84 g, 6.1 mmol) and dimethyl sulfoxide (7 mL) was stirred at room temperature for 20 minutes, and then a solution of ethyl 1 -[[4-(3,3,3-trifluoro-2,2-dihydroxypropoxy)phenoxy]methyl]- l //-pyrazole-4-carboxylate (i.e. the product of Example 8) (0.64 g, 1.6 mmol) in dimethyl sulfoxide (7 mL) was added portionwise over 20 minutes. After stirring at room temperature for 1.5 hours, the reaction mixture was poured into ice water (150 mL) and extracted with ethyl acetate (125 mL). The organic layer was washed with water (2 x 50 mL) and saturated aqueous sodium chloride solution (50 mL), drying over magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting material was purified by silica gel chromatography (eluting with a gradient of 10 to 100% ethyl acetate in hexanes) to provide the title compound, a compound of the present invention, as a colorless oil (0.46 g).

iff NMR (DMSO- g): d 1.23-1.27 (m, 6H), 4.11 (q, 2H), 4.22 (q, 2H), 6.10 (s, 2H), 7.07-7.24 (m, 4H) 7.95 (s, 1H) 8.58 (s, 1H).

By the procedures described herein, together with methods known in the art, the following compounds of Tables 1, 1A-48A, 2, 1B-48B and 3 can be prepared. The following abbreviations are used in the Tables: t means tertiary, s means secondary, n means normal, z means iso, c means cyclo, Me means methyl, Et means ethyl, Pr means propyl, z-Pr means isopropyl, c-Pr means cyclopropyl, Bu means butyl, z-Bu means isobutyl, Z-Bu means tert- butyl, and Ph means phenyl.

Table 1

In the above formula, E is equal to E J is equal G-Z-, and G is optionally substituted with FC T The definitions of G are as defined Exhibit A in the above Embodiments. In the column G, the number in parentheses refers to the attachment point of the G-ring to Z. The ( R ^ ) x column refers to the substituent(s) attached to the G-ring as shown in Exhibit A above. A dash in the (R^) x colunui means that no substituent is present and the remaining valences on the G-ring are occupied by hydrogen atoms.

is J-l, L is CH 2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-l (4)

G-l (4) 2 -Me 4 -Me

G-l (4) 2-Et 4-Et

G-l (4) 2-n-Pr 4-n-Pr

G-l (4) 2-z-Pr 4-z-Pr

G-l (4) 2-c-Pr 4-c-Pr

G-l (4) 2-n-Bu 4-n-Bu

G-l (4) 2-z-Bu 4-z-Bu

G-l (4) 2-i-Bu 4-/-Bu

G-l (4) 2-F 4-F

G-l (4) 2 -Cl 4 -Cl

G-l (4) 2-Br 4-Br

G-l (4) 2-CF 3 4-CF3

G-l (4) 2 -HO 4 -HO

G-l (4) 2-NºC 4-NºC

G-l (4) 2-NºCCH 2 4-NºCCH 2

G-l (4) 2-(MeO) 4-(MeO)

G-l (4) 2-(MeOCH 2 ) 4-(MeOCH 2 )

G-l (4) 2-(EtOCH 2 ) 4-(EtOCH 2 )

G-l (4) 2-(CH(=0)) 4-(CH(=0))

G-l (4) 2-(H0C(=0)) 4-(H0C(=0))

G-l (4) 2-(Me0C(=0)) 4-(Me0C(=0))

G-l (4) 2-(Et0C(=0)) 4-(Et0C(=0))

G-l (4) 2-(z-Pr0C(=0)) 4-(z-Pr0C(=0))

G-l (4) 2-(n-Pr0C(=0)) 4-(n-Pr0C(=0))

G-l (4) 2-(Bu0C(=0)) 4-(Bu0C(=0))

G-l (4) 2-(z-Bu0C(=0)) 4-(z-Bu0C(=0))

-l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-l (4) 2-(/-Bu0C(=0)) 4-(i-Bu0C(=0)) G-l (4) 2-(CF 3 CH 2 0C(=0) 4-(CF 3 CH 2 0C(=0) G-l (4) 2-(CH 2 =CH0C(=0)) 4-(CH 2 =CH0C(=0)) G-l (4) 2-(CH 2 =CHCH 2 0C(=0)) 4-(CH 2 =CHCH 2 0C(=0)) G-l (4) 2-(CH 2 =CBrCH 2 0C(=0)) 4-(CH 2 =CBrCH 2 0C(=0)) G-l (4) 2-(CH 2 =CHCF 2 0C(=0)) 4-(CH 2 =CHCF 2 0C(=0)) G-l (4) 2-(Me 2 C=CHCH 2 0C(=0)) 4-(Me 2 C=CHCH 2 0C(=0)) G-l (4) 2-(CH 2 =C(Me)CH 2 0C(=0)) 4-(CH 2 =C(Me)CH 2 0C(=0)) G-l (4) 2-(CHºCCH 2 0C(=0)) 4-(CHºCCH 2 0C(=0)) G-l (4) 2-(NºCCH 2 0C(=0)) 4-(NºCCH 2 0C(=0)) G-l (4) 2-(MeNHC(=0)) 4-(MeNHC(=0)) G-l (4) 2-(Me 2 NC(=0)) 4-(Me 2 NC(=0)) G-l (4) 2-(MeNHC(=0)) 4-(MeNHC(=0)) G-l (4) 2-(EtNHC(=0)) 4-(EtNHC(=0)) G-l (4) 2-(PrNHC(=0)) 4-(PrNHC(=0)) G-l (4) 2-(/-PrNHC(=0)) 4-(/-PrNHC(=0)) G-l (4) 2-(BuNHC(=0)) 4-(BuNHC(=0)) G-l (4) 2-(i-BuNHC(=0)) 4-(i-BuNHC(=0)) G-l (4) 2-(/-BuNHC(=0)) 4-(/-BuNHC(=0)) G-l (4) 2-(CF 3 CH 2 NHC(=0)) 4-(CF 3 CH 2 NHC(=0)) G-l (4) 2-(c-PrCH 2 NHC(=0)) 4-(c-PrCH 2 NHC(=0)) G-l (4) 2-(Me0CH 2 NHC(=0)) 4-(Me0CH 2 NHC(=0)) G-l (4) 2-(Me0CH 2 CH 2 NHC(=0)) 4-(Me0CH 2 CH 2 NHC(=0)) G-l (4) 2-(CH 2 =CHCH 2 NHC(=0)) 4-(CH 2 =CHCH 2 NHC(=0)) G-l (4) 2-(NºCCH 2 NHC(=0)) 4-(NºCCH 2 NHC(=0)) G-l (4) 2-(OH-N=CH) 4-(OH-N=CH) G-l (4) 2-(Me 2 N =CH) 4-(Me 2 N =CH)

G-l (4) 2-(Me0C(=0)NHN=CH) 4-(Me0C(=0)NHN=CH) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 13 ) X

G-l (4) 2-(0HC(=0)CH 2 0N=CH) 4-(0HC(=0)CH 2 0N=CH) G-l (2) 5 -Me, 3-(Et0C(=0)) G-l (2) 4 -Me 3 -Me G-l (2) 4-Et 3-Et

G-l (2) 4-«-Pr 3-«-Pr G-l (2) 4-z-Pr 3-z-Pr G-l (2) 4-c-Pr 3-c-Pr G-l (2) 4-«-Bu 3-«-Bu G-l (2) 4-z-Bu 3-z-Bu G-l (2) 4-/-Bu 3-i-Bu G-l (2) 4-F 3-F

G-l (2) 4 -Cl 3 -Cl

G-l (2) 4-Br 3-Br

G-l (2) 4-CF3 3-CF3 G-l (2) 4 -HO 3 -HO

G-l (2) 4-NºC 3-NºC G-l (2) 4-NºCCH 2 3-NºCCH 2

G-l (2) 4-(MeO) 3-(MeO) G-l (2) 4-(MeOCH 2 ) 3-(MeOCH 2 )

G-l (2) 4-(EtOCH 2 ) 3-(EtOCH 2 ) G-l (2) 4-(CH(=0)) 3-(CH(=0)) G-l (2) 4-(HOC(=0)) 3-(H0C(=0)) G-l (2) 4-(MeOC(=0)) 3-(Me0C(=0)) G-l (2) 4-(EtOC(=0)) 3-(Et0C(=0)) G-l (2) 4-(z-PrOC(=0)) 3-(/-Pr0C(=0)) G-l (2) 4-(«-Pr0C(=0)) 3-(«-Pr0C(=0)) G-l (2) 4-(BuOC(=0)) 3-(Bu0C(=0)) G-l (2) 4-(z-BuOC(=0)) 3-(/-Bu0C(=0)) G-l (2) 4-(i-BuOC(=0)) 3-(i-Bu0C(=0)) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-l (2) 4-(CF 3 CH 2 0C(=0) 3-(CF 3 CH 2 0C(=0) G-l (2) 4-(CH 2 =CH0C(=0)) 3-(CH 2 =CH0C(=0)) G-l (2) 4-(CH 2 =CHCH 2 0C(=0)) 3 -(CH 2 =CHCH 2 0C(=0)) G-l (2) 4-(CH 2 =CBrCH 2 0C(=0)) 3-(CH 2 =CBrCH 2 0C(=0)) G-l (2) 4-(CH 2 =CHCF 2 0C(=0)) 3-(CH 2 =CHCF 2 0C(=0)) G-l (2) 4-(Me 2 C=CHCH 2 0C(=0)) 3 -(Me 2 C=CHCH 2 0C(=0)) G-l (2) 4-(CH 2 =C(Me)CH 2 0C(=0)) 3 -(CH 2 =C(Me)CH 2 0C(=0)) G-l (2) 4-(CHºCCH 2 0C(=0)) 3-(CHºCCH 2 0C(=0)) G-l (2) 4-(NºCCH 2 0C(=0)) 3-(NºCCH 2 0C(=0)) G-l (2) 4-(MeNHC(=0)) 3-(MeNHC(=0)) G-l (2) 4-(Me 2 NC(=0)) 3-(Me 2 NC(=0)) G-l (2) 4-(MeNHC(=0)) 3-(MeNHC(=0)) G-l (2) 4-(EtNHC(=0)) 3-(EtNHC(=0)) G-l (2) 4-(PrNHC(=0)) 3-(PrNHC(=0)) G-l (2) 4-(/-PrNHC(=0)) 3-(/-PrNHC(=0)) G-l (2) 4-(BuNHC(=0)) 3-(BuNHC(=0)) G-l (2) 4-(i-BuNHC(=0)) 3-(i-BuNHC(=0)) G-l (2) 4-(/-BuNHC(=0)) 3-(/-BuNHC(=0)) G-l (2) 4-(CF 3 CH 2 NHC(=0)) 3-(CF 3 CH 2 NHC(=0)) G-l (2) 4-(c-PrCH 2 NHC(=0)) 3-(c-PrCH 2 NHC(=0)) G-l (2) 4-(Me0CH 2 NHC(=0)) 3-(Me0CH 2 NHC(=0)) G-l (2) 4-(Me0CH 2 CH 2 NHC(=0)) 3-(Me0CH 2 CH 2 NHC(=0)) G-l (2) 4-(CH 2 =CHCH 2 NHC(=0)) 3-(CH 2 =CHCH 2 NHC(=0)) G-l (2) 4-(NºCCH 2 NHC(=0)) 3-(NºCCH 2 NHC(=0)) G-l (2) 4-(OH-N=CH) 3-(OH-N=CH) G-l (2) 4-(Me 2 N =CH) 3-(Me 2 N =CH) G-l (2) 4-(Me0C(=0)NHN=CH) 3-(Me0C(=0)NHN=CH) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G (R 1 3 ) X (R 13 ) X

G-l (2) 4-(0HC(=0)CH 2 0N=CH) 3-(0HC(=0)CH 2 0N=CH) G-3 (1)

G-3 (1) 4 -Me 5 -Me G-3 (1) 4-Et 5-Et

G-3 (1) 4-«-Pr 5-«-Pr G-3 (1) 4-/-Pr 5-/-Pr G-3 (1) 4-c-Pr 5-c-Pr G-3 (1) 4-«-Bu 5-«-Bu G-3 (1) 4-/-Bu 5-/-Bu G-3 (1) 4-/-Bu 5-i-Bu G-3 (1) 4-F 5-F

G-3 (1) 4 -Cl 5 -Cl

G-3 (1) 4-Br 5-Br

G-3 (1) 4-CF3 5-CF3 G-3 (1) 4 -HO 5 -HO

G-3 (1) 4-NºC 5-NºC G-3 (1) 4-NºCCH 2 5-NºCCH 2

G-3 (1) 4-(MeO) 5-(MeO) G-3 (1) 4-(MeOCH 2 ) 5-(MeOCH 2 )

G-3 (1) 4-(EtOCH 2 ) 5-(EtOCH 2 ) G-3 (1) 4-(CH(=0)) 5-(CH(=0)) G-3 (1) 4-(H0C(=0)) 5-(HOC(=0))

G-3 (1) 4-(Me0C(=0)) 5-(MeOC(=0)) G-3 (1) 4-(Et0C(=0)) 5-(EtOC(=0)) G-3 (1) 4-(/-Pr0C(=0)) 5-(/-PrOC(=0)) G-3 (1) 4-(«-Pr0C(=0)) 5-(«-PrOC(=0)) G-3 (1) 4-(Bu0C(=0)) 5-(BuOC(=0)) G-3 (1) 4-(/-Bu0C(=0)) 5-(/-BuOC(=0)) G-3 (1) 4-(i-Bu0C(=0)) 5-(i-BuOC(=0)) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-3 (1) 4-(CF 3 CH 2 0C(=0) 5-(CF 3 CH 2 0C(=0) G-3 (1) 4-(CH 2 =CH0C(=0)) 5-(CH 2 =CH0C(=0)) G-3 (1) 4-(CH 2 =CHCH 2 0C(=0)) 5 -(CH 2 =CHCH 2 0C(=0)) G-3 (1) 4-(CH 2 =CBrCH 2 0C(=0)) 5-(CH 2 =CBrCH 2 0C(=0)) G-3 (1) 4-(CH 2 =CHCF 2 0C(=0)) 5-(CH 2 =CHCF 2 0C(=0)) G-3 (1) 4-(Me 2 C=CHCH 2 0C(=0)) 5-(Me 2 C=CHCH 2 0C(=0)) G-3 (1) 4-(CH 2 =C(Me)CH 2 0C(=0)) 5-(CH 2 =C(Me)CH 2 0C(=0)) G-3 (1) 4-(CHºCCH 2 0C(=0)) 5-(CHºCCH 2 0C(=0)) G-3 (1) 4-(NºCCH 2 0C(=0)) 5-(NºCCH 2 0C(=0)) G-3 (1) 4-(MeNHC(=0)) 5-(MeNHC(=0)) G-3 (1) 4-(Me 2 NC(=0)) 5-(Me 2 NC(=0)) G-3 (1) 4-(MeNHC(=0)) 5-(MeNHC(=0)) G-3 (1) 4-(EtNHC(=0)) 5-(EtNHC(=0)) G-3 (1) 4-(PrNHC(=0)) 5-(PrNHC(=0)) G-3 (1) 4-(/-PrNHC(=0)) 5-(/-PrNHC(=0)) G-3 (1) 4-(BuNHC(=0)) 5-(BuNHC(=0)) G-3 (1) 4-(i-BuNHC(=0)) 5-(i-BuNHC(=0)) G-3 (1) 4-(/-BuNHC(=0)) 5-(/-BuNHC(=0)) G-3 (1) 4-(CF 3 CH 2 NHC(=0)) 5-(CF 3 CH 2 NHC(=0)) G-3 (1) 4-(c-PrCH 2 NHC(=0)) 5-(c-PrCH 2 NHC(=0)) G-3 (1) 4-(Me0CH 2 NHC(=0)) 5-(Me0CH 2 NHC(=0)) G-3 (1) 4-(Me0CH 2 CH 2 NHC(=0)) 5-(Me0CH 2 CH 2 NHC(=0)) G-3 (1) 4-(CH 2 =CHCH 2 NHC(=0)) 5-(CH 2 =CHCH 2 NHC(=0)) G-3 (1) 4-(NºCCH 2 NHC(=0)) 5-(NºCCH 2 NHC(=0)) G-3 (1) 4-(OH-N=CH) 5-(OH-N=CH) G-3 (1) 4-(Me 2 N =CH) 5-(Me 2 N =CH) G-3 (1) 4-(Me0C(=0)NHN=CH) 5-(Me0C(=0)NHN=CH) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G (R 1 3 ) X (R 13 ) X

G-3 (1) 4-(0HC(=0)CH 2 0N=CH) 5-(0HC(=0)CH 2 0N=CH) G-9 (1)

G-9 (1) 3 -Me 4 -Me G-9 (1) 3-Et 4-Et

G-9 (1) 3-«-Pr 4-«-Pr G-9 (1) 3-/-Pr 4-/-Pr G-9 (1) 3-c-Pr 4-c-Pr G-9 (1) 3-«-Bu 4-«-Bu G-9 (1) 3-z-Bu 4-/-Bu G-9 (1) 3-i-Bu 4-i-Bu G-9 (1) 3-F 4-F

G-9 (1) 3 -Cl 4 -Cl

G-9 (1) 3-Br 4-Br

G-9 (1) 3-CF3 4-CF3 G-9 (1) 3 -HO 4 -HO

G-9 (1) 3-NºC 4-NºC G-9 (1) 3-NºCCH 2 4-NºCCH 2

G-9 (1) 3-(MeO) 4-(MeO) G-9 (1) 3-(MeOCH 2 ) 4-(MeOCH 2 )

G-9 (1) 3-(EtOCH 2 ) 4-(EtOCH 2 ) G-9 (1) 3-(CH(=0)) 4-(CH(=0)) G-9 (1) 3-(H0C(=0)) 4-(HOC(=0))

G-9 (1) 3-(Me0C(=0)) 4-(MeOC(=0)) G-9 (1) 3-(Et0C(=0)) 4-(EtOC(=0)) G-9 (1) 3-(/-Pr0C(=0)) 4-(/-PrOC(=0)) G-9 (1) 3-(«-Pr0C(=0)) 4-(«-PrOC(=0)) G-9 (1) 3-(Bu0C(=0)) 4-(BuOC(=0)) G-9 (1) 3-(/-Bu0C(=0)) 4-(/-BuOC(=0)) G-9 (1) 3-(i-Bu0C(=0)) 4-(i-BuOC(=0)) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-9 (1) 3-(CF 3 CH 2 0C(=0) 4-(CF 3 CH 2 0C(=0) G-9 (1) 3-(CH 2 =CH0C(=0)) 4-(CH 2 =CH0C(=0)) G-9 (1) 3 -(CH 2 =CHCH 2 0C(=0)) 4-(CH 2 =CHCH 2 0C(=0)) G-9 (1) 3-(CH 2 =CBrCH 2 0C(=0)) 4-(CH 2 =CBrCH 2 0C(=0)) G-9 (1) 3-(CH 2 =CHCF 2 0C(=0)) 4-(CH 2 =CHCF 2 0C(=0)) G-9 (1) 3 -(Me 2 C=CHCH 2 0C(=0)) 4-(Me 2 C=CHCH 2 0C(=0)) G-9 (1) 3 -(CH 2 =C(Me)CH 2 0C(=0)) 4-(CH 2 =C(Me)CH 2 0C(=0)) G-9 (1) 3-(CHºCCH 2 0C(=0)) 4-(CHºCCH 2 0C(=0)) G-9 (1) 3-(NºCCH 2 0C(=0)) 4-(NºCCH 2 0C(=0)) G-9 (1) 3-(MeNHC(=0)) 4-(MeNHC(=0)) G-9 (1) 3-(Me 2 NC(=0)) 4-(Me 2 NC(=0)) G-9 (1) 3-(MeNHC(=0)) 4-(MeNHC(=0)) G-9 (1) 3-(EtNHC(=0)) 4-(EtNHC(=0)) G-9 (1) 3-(PrNHC(=0)) 4-(PrNHC(=0)) G-9 (1) 3-(/-PrNHC(=0)) 4-(/-PrNHC(=0)) G-9 (1) 3-(BuNHC(=0)) 4-(BuNHC(=0)) G-9 (1) 3-(i-BuNHC(=0)) 4-(i-BuNHC(=0)) G-9 (1) 3-(/-BuNHC(=0)) 4-(/-BuNHC(=0)) G-9 (1) 3 -(CF 3 CH 2 NHC(=0)) 4-(CF 3 CH 2 NHC(=0)) G-9 (1) 3-(c-PrCH 2 NHC(=0)) 4-(c-PrCH 2 NHC(=0)) G-9 (1) 3-(Me0CH 2 NHC(=0)) 4-(Me0CH 2 NHC(=0)) G-9 (1) 3-(Me0CH 2 CH 2 NHC(=0)) 4-(Me0CH 2 CH 2 NHC(=0)) G-9 (1) 3-(CH 2 =CHCH 2 NHC(=0)) 4-(CH 2 =CHCH 2 NHC(=0)) G-9 (1) 3-(NºCCH 2 NHC(=0)) 4-(NºCCH 2 NHC(=0)) G-9 (1) 3-(OH-N=CH) 4-(OH-N=CH) G-9 (1) 3-(Me 2 N =CH) 4-(Me 2 N =CH) G-9 (1) 3 -(MeOC(=0)NHN=CH) 4-(Me0C(=0)NHN=CH) J is J-l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G (R 1 3 ) X (R 13 )X

G-9 (1) 3-(0HC(=0)CH 2 0N=CH) 4-(0HC(=0)CH 2 0N=CH)

The present disclosure also includes Tables 1A through 48 A, each of which is constructed the same as Table 1 above, except that the row heading in Table 1 (i.e.“J is J-l, L is CH2 and Z is a direct bond”) is replaced with the respective row headings shown below.

Table Row Heading Table Row Heading

1A J is J-l, L is CH 2 CH 2 and Z is a direct bond. 25A J is J-10, L is CH 2 and Z is a direct bond.

2A J is J-l, L is CH 2 (Me) and Z is a direct bond. 26A J is J-10, L is CH 2 CH 2 and Z is a direct bond.

3A J is J-l, L is (CH 2 )3 and Z is a direct bond. 27A J is J-10, L is CH 2 (Me) and Z is a direct bond.

4A J is J-l, L is CH 2 and Z is O. 28A J is J-10, L is (CH 2 )3 and Z is a direct bond.

5A J is J-2, L is CH 2 and Z is a direct bond. 29A J is J-10, L is CH 2 and Z is O.

6A J is J-2, L is CH 2 CH 2 and Z is a direct bond. 30A J is J-14, L is CH 2 and Z is a direct bond.

7A J is J-2, L is CH 2 (Me) and Z is a direct bond. 31 A J is J-14, L is CH 2 CH 2 and Z is a direct bond.

8A J is J-2, L is (CH 2 )3 and Z is a direct bond. 32A J is J-14, L is CH 2 (Me) and Z is a direct bond.

9A J is J-2, L is CH 2 and Z is O. 33A J is J-14, L is (CH 2 )3 and Z is a direct bond.

10A J is J-6, L is CH 2 and Z is a direct bond. 34A J is J-14, L is CH 2 and Z is O.

11A J is J-6, L is CH 2 CH 2 and Z is a direct bond. 35A J is J-3, L is CH 2 and Z is a direct bond.

12A J is J-6, L is CH 2 (Me) and Z is a direct bond. 36A J is J-3, L is CH 2 CH 2 and Z is a direct bond.

13A J is J-6, L is (CH 2 )3 and Z is a direct bond. 37A J is J-3, L is CH 2 (Me) and Z is a direct bond.

14A J is J-6, L is CH 2 and Z is O. 38A J is J-3, L is (CH 2 )3 and Z is a direct bond.

15A J is J-7, L is CH 2 and Z is a direct bond. 39A J is J-3, L is CH 2 and Z is O.

16A J is J-7, L is CH 2 CH 2 and Z is a direct bond. 40A J is J-4, L is CH 2 and Z is a direct bond.

17A J is J-7, L is CH 2 (Me) and Z is a direct bond. 41 A J is J-4, L is CH 2 CH 2 and Z is a direct bond.

18A J is J-7, L is (CH 2 )3 and Z is a direct bond. 42A J is J-4, L is CH 2 (Me) and Z is a direct bond.

19A J is J-7, L is CH 2 and Z is O. 43 A J is J-4, L is (CH 2 )3 and Z is a direct bond.

20A J is J-8, L is CH 2 and Z is a direct bond. 44A J is J-4, L is CH 2 and Z is O.

21A J is J-8, L is CH 2 CH 2 and Z is a direct bond. 45A J is J-5, L is CH 2 and Z is a direct bond. Table Row Heading Table Row Heading

22A J is J-8, L is Ct^/Me) and Z is a direct bond. 46A J is J-5, L is CH2CH2 and Z is a direct bond.

23 A J is J-8, L is (CH2)3 and Z is a direct bond. 47A J is J-5, L is CH2(Me) and Z is a direct bond.

24A J is J-8, L is CH2 and Z is O. 48A J is J-5, L is (CH2)3 and Z is a direct bond.

Table 2

In the above formula, E is equal to EA is equal G-Z-, and G is optionally substituted with R ' The definitions of G are as defined Exhibit A in the above Embodiments. In the column G, the number in parentheses refers to the attachment point of the G-ring to Z. The (R^) x column refers to the substituent(s) attached to the

G-ring as shown in Exhibit A above. A dash“ in the ( R ^ ) x column means that no , 13 is present and the remaining valences on the G-ring are occupied by hydrogen atoms.

-l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-l (4) 2-NºC 4-NºC

G-l (4) 2-NºCCH 2 4-NºCCH 2 G-l (4) 2-(MeO) 4-(MeO) G-l (4) 2-(MeOCH 2 ) 4-(MeOCH 2 )

G-l (4) 2-(EtOCH 2 ) 4-(EtOCH 2 ) G-l (4) 2-(CH(=0)) 4-(CH(=0)) G-l (4) 2-(H0C(=0)) 4-(H0C(=0)) G-l (4) 2-(Me0C(=0)) 4-(Me0C(=0)) G-l (4) 2-(Et0C(=0)) 4-(Et0C(=0)) G-l (4) 2-(/-Pr0C(=0)) 4-(/-Pr0C(=0)) G-l (4) 2-(«-Pr0C(=0)) 4-(«-Pr0C(=0)) G-l (4) 2-(Bu0C(=0)) 4-(Bu0C(=0)) G-l (4) 2-(/-Bu0C(=0)) 4-(/-Bu0C(=0)) G-l (4) 2-(i-Bu0C(=0)) 4-(i-Bu0C(=0)) G-l (4) 2-(CF 3 CH 2 0C(=0) 4-(CF 3 CH 2 0C(=0) G-l (4) 2-(CH 2 =CH0C(=0)) 4-(CH 2 =CH0C(=0)) G-l (4) 2-(CH 2 =CHCH 2 0C(=0)) 4-(CH 2 =CHCH 2 0C(=0)) G-l (4) 2-(CH 2 =CBrCH 2 0C(=0)) 4-(CH 2 =CBrCH 2 0C(=0)) G-l (4) 2-(CH 2 =CHCF 2 0C(=0)) 4-(CH 2 =CHCF 2 0C(=0)) G-l (4) 2-(Me 2 C=CHCH 2 0C(=0)) 4-(Me 2 C=CHCH 2 0C(=0)) G-l (4) 2-(CH 2 =C(Me)CH 2 0C(=0)) 4-(CH 2 =C(Me)CH 2 0C(=0)) G-l (4) 2-(CHºCCH 2 0C(=0)) 4-(CHºCCH 2 0C(=0)) G-l (4) 2-(NºCCH 2 0C(=0)) 4-(NºCCH 2 0C(=0)) G-l (4) 2-(MeNHC(=0)) 4-(MeNHC(=0)) G-l (4) 2-(Me 2 NC(=0)) 4-(Me 2 NC(=0)) G-l (4) 2-(MeNHC(=0)) 4-(MeNHC(=0)) G-l (4) 2-(EtNHC(=0)) 4-(EtNHC(=0)) G-l (4) 2-(PrNHC(=0)) 4-(PrNHC(=0)) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 13 ) X

G-l (4) 2-(/-PrNHC(=0)) 4-(/-PrNHC(=0)) G-l (4) 2-(BuNHC(=0)) 4-(BuNHC(=0)) G-l (4) 2-(i-BuNHC(=0)) 4-(i-BuNHC(=0)) G-l (4) 2-(/-BuNHC(=0)) 4-(/-BuNHC(=0)) G-l (4) 2-(CF 3 CH 2 NHC(=0)) 4-(CF 3 CH 2 NHC(=0)) G-l (4) 2-(c-PrCH 2 NHC(=0)) 4-(c-PrCH 2 NHC(=0)) G-l (4) 2-(Me0CH 2 NHC(=0)) 4-(Me0CH 2 NHC(=0)) G-l (4) 2-(Me0CH 2 CH 2 NHC(=0)) 4-(Me0CH 2 CH 2 NHC(=0)) G-l (4) 2-(CH 2 =CHCH 2 NHC(=0)) 4-(CH 2 =CHCH 2 NHC(=0)) G-l (4) 2-(NºCCH 2 NHC(=0)) 4-(NºCCH 2 NHC(=0))

G-l (4) 2-(OH-N=CH) 4-(OH-N=CH) G-l (4) 2-(Me 2 N =CH) 4-(Me 2 N =CH)

G-l (4) 2-(Me0C(=0)NHN=CH) 4-(Me0C(=0)NHN=CH) G-l (4) 2-(0HC(=0)CH 2 0N=CH) 4-(0HC(=0)CH 2 0N=CH) G-l (2) 5 -Me, 3-(Et0C(=0)) G-l (2) 4 -Me 3 -Me

G-l (2) 4-Et 3-Et

G-l (2) 4-«-Pr 3-«-Pr G-l (2) 4-z-Pr 3-z-Pr

G-l (2) 4-c-Pr 3-c-Pr G-l (2) 4-«-Bu 3-«-Bu

G-l (2) 4-z-Bu 3-z-Bu

G-l (2) 4-/-Bu 3-i-Bu

G-l (2) 4-F 3-F

G-l (2) 4 -Cl 3 -Cl

G-l (2) 4-Br 3-Br

G-l (2) 4-CF 3 3-CF 3

G-l (2) 4 -HO 3 -HO

G-l (2) 4-NºC 3-NºC

-l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 1 3 )X

G-l (2) 4-NºCCH 2 3-NºCCH 2 G-l (2) 4-(MeO) 3-(MeO) G-l (2) 4-(MeOCH 2 ) 3-(MeOCH 2 )

G-l (2) 4-(EtOCH 2 ) 3-(EtOCH 2 ) G-l (2) 4-(CH(=0)) 3-(CH(=0)) G-l (2) 4-(H0C(=0)) 3-(H0C(=0)) G-l (2) 4-(Me0C(=0)) 3-(Me0C(=0)) G-l (2) 4-(Et0C(=0)) 3-(Et0C(=0)) G-l (2) 4-(/-Pr0C(=0)) 3-(/-Pr0C(=0)) G-l (2) 4-(«-Pr0C(=0)) 3-(«-Pr0C(=0)) G-l (2) 4-(Bu0C(=0)) 3-(Bu0C(=0)) G-l (2) 4-(/-Bu0C(=0)) 3-(/-Bu0C(=0)) G-l (2) 4-(i-Bu0C(=0)) 3-(i-Bu0C(=0)) G-l (2) 4-(CF 3 CH 2 0C(=0) 3-(CF 3 CH 2 0C(=0) G-l (2) 4-(CH 2 =CH0C(=0)) 3-(CH 2 =CH0C(=0)) G-l (2) 4-(CH 2 =CHCH 2 0C(=0)) 3 -(CH 2 =CHCH 2 0C(=0)) G-l (2) 4-(CH 2 =CBrCH 2 0C(=0)) 3-(CH 2 =CBrCH 2 0C(=0)) G-l (2) 4-(CH 2 =CHCF 2 0C(=0)) 3-(CH 2 =CHCF 2 0C(=0)) G-l (2) 4-(Me 2 C=CHCH 2 0C(=0)) 3 -(Me 2 C=CHCH 2 0C(=0)) G-l (2) 4-(CH 2 =C(Me)CH 2 0C(=0)) 3 -(CH 2 =C(Me)CH 2 0C(=0)) G-l (2) 4-(CHºCCH 2 0C(=0)) 3-(CHºCCH 2 0C(=0)) G-l (2) 4-(NºCCH 2 0C(=0)) 3-(NºCCH 2 0C(=0)) G-l (2) 4-(MeNHC(=0)) 3-(MeNHC(=0)) G-l (2) 4-(Me 2 NC(=0)) 3-(Me 2 NC(=0)) G-l (2) 4-(MeNHC(=0)) 3-(MeNHC(=0)) G-l (2) 4-(EtNHC(=0)) 3-(EtNHC(=0)) G-l (2) 4-(PrNHC(=0)) 3-(PrNHC(=0)) G-l (2) 4-(/-PrNHC(=0)) 3-(/-PrNHC(=0)) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G (R 1 3 ) X (R 1 3 )X

G-l (2) 4-(BuNHC(=0)) 3-(BuNHC(=0)) G-l (2) 4-(i-BuNHC(=0)) 3-(i-BuNHC(=0)) G-l (2) 4-(/-BuNHC(=0)) 3-(z-BuNHC(=0)) G-l (2) 4-(CF 3 CH 2 NHC(=0)) 3 -(CF 3 CH 2 NHC(=0)) G-l (2) 4-(c-PrCH 2 NHC(=0)) 3-(c-PrCH 2 NHC(=0)) G-l (2) 4-(Me0CH 2 NHC(=0)) 3-(Me0CH 2 NHC(=0)) G-l (2) 4-(Me0CH 2 CH 2 NHC(=0)) 3-(Me0CH 2 CH 2 NHC(=0)) G-l (2) 4-(CH 2 =CHCH 2 NHC(=0)) 3-(CH 2 =CHCH 2 NHC(=0)) G-l (2) 4-(NºCCH 2 NHC(=0)) 3-(NºCCH 2 NHC(=0)) G-l (2) 4-(OH-N=CH) 3-(OH-N=CH) G-l (2) 4-(Me 2 N =CH) 3-(Me 2 NN=CH) G-l (2) 4-(Me0C(=0)NHN=CH) 3-(MeOC(=0)NHN=CH) G-l (2) 4-(0HC(=0)CH 2 0N=CH) 3-(0HC(=0)CH 2 0N=CH) G-3 (1)

G-3 (1) 4 -Me 5 -Me

G-3 (1) 4-Et 5-Et

G-3 (1) 4-w-Pr 5-w-Pr G-3 (1) 4-z-Pr 5-z-Pr

G-3 (1) 4-c-Pr 5-c-Pr G-3 (1) 4-«-Bu 5-«-Bu

G-3 (1) 4-z-Bu 5-z-Bu

G-3 (1) 4-i-Bu 5-i-Bu

G-3 (1) 4-F 5-F

G-3 (1) 4 -Cl 5 -Cl

G-3 (1) 4-Br 5-Br

G-3 (1) 4-CF3 5-CF3

G-3 (1) 4 -HO 5 -HO

G-3 (1) 4-NºC 5-NºC

G-3 (1) 4-NºCCH 2 5-NºCCH 2

-l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G (R 1 3 ) X (R 1 3 )X

G-3 (1) 4-(MeO) 5-(MeO) G-3 (1) 4-(MeOCH 2 ) 5-(MeOCH 2 ) G-3 (1) 4-(EtOCH 2 ) 5-(EtOCH 2 ) G-3 (1) 4-(CH(=0)) 5-(CH(=0)) G-3 (1) 4-(H0C(=0)) 5-(H0C(=0))

G-3 (1) 4-(Me0C(=0)) 5-(Me0C(=0)) G-3 (1) 4-(Et0C(=0)) 5-(Et0C(=0)) G-3 (1) 4-(/-Pr0C(=0)) 5-(/-Pr0C(=0)) G-3 (1) 4-(«-Pr0C(=0)) 5-(«-Pr0C(=0)) G-3 (1) 4-(Bu0C(=0)) 5-(Bu0C(=0)) G-3 (1) 4-(/-Bu0C(=0)) 5-(/-Bu0C(=0)) G-3 (1) 4-(i-Bu0C(=0)) 5-(i-Bu0C(=0)) G-3 (1) 4-(CF 3 CH 2 0C(=0) 5-(CF 3 CH 2 0C(=0) G-3 (1) 4-(CH 2 =CH0C(=0)) 5-(CH 2 =CH0C(=0)) G-3 (1) 4-(CH 2 =CHCH 2 0C(=0)) 5 -(CH 2 =CHCH 2 0C(=0)) G-3 (1) 4-(CH 2 =CBrCH 2 0C(=0)) 5-(CH 2 =CBrCH 2 0C(=0)) G-3 (1) 4-(CH 2 =CHCF 2 0C(=0)) 5-(CH 2 =CHCF 2 0C(=0)) G-3 (1) 4-(Me 2 C=CHCH 2 0C(=0)) 5-(Me 2 C=CHCH 2 0C(=0)) G-3 (1) 4-(CH 2 =C(Me)CH 2 0C(=0)) 5-(CH 2 =C(Me)CH 2 0C(=0)) G-3 (1) 4-(CHºCCH 2 0C(=0)) 5-(CHºCCH 2 0C(=0)) G-3 (1) 4-(NºCCH 2 0C(=0)) 5-(NºCCH 2 0C(=0)) G-3 (1) 4-(MeNHC(=0)) 5-(MeNHC(=0)) G-3 (1) 4-(Me 2 NC(=0)) 5-(Me 2 NC(=0)) G-3 (1) 4-(MeNHC(=0)) 5-(MeNHC(=0)) G-3 (1) 4-(EtNHC(=0)) 5-(EtNHC(=0)) G-3 (1) 4-(PrNHC(=0)) 5-(PrNHC(=0)) G-3 (1) 4-(/-PrNHC(=0)) 5-(/-PrNHC(=0)) G-3 (1) 4-(BuNHC(=0)) 5-(BuNHC(=0)) -l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G

(R 1 3 )X (R 13 ) X

G-3 (1) 4-( -BuNHC(=0)) 5-(i-BuNHC(=0)) G-3 (1) 4-(/-BuNHC(=0)) 5-(/-BuNHC(=0)) G-3 (1) 4-(CF 3 CH 2 NHC(=0)) 5 -(CF 3 CH 2 NHC(=0)) G-3 (1) 4-(c-PrCH 2 NHC(=0)) 5-(c-PrCH 2 NHC(=0)) G-3 (1) 4-(Me0CH 2 NHC(=0)) 5-(Me0CH 2 NHC(=0)) G-3 (1) 4-(Me0CH 2 CH 2 NHC(=0)) 5-(Me0CH 2 CH 2 NHC(=0)) G-3 (1) 4-(CH 2 =CHCH 2 NHC(=0)) 5-(CH 2 =CHCH 2 NHC(=0)) G-3 (1) 4-(NºCCH 2 NHC(=0)) 5-(NºCCH 2 NHC(=0)) G-3 (1) 4-(OH-N=CH) 5-(OH-N=CH) G-3 (1) 4-(Me 2 N =CH) 5-(Me 2 N =CH)

G-3 (1) 4-(Me0C(=0)NHN=CH) 5-(Me0C(=0)NHN=CH) G-3 (1) 4-(0HC(=0)CH 2 0N=CH) 5-(0HC(=0)CH 2 0N=CH) G-9 (1)

G-9 (1) 3 -Me 4 -Me

G-9 (1) 3-Et 4-Et

G-9 (1) 3-«-Pr 4-«-Pr G-9 (1) 3-z-Pr 4-z-Pr

G-9 (1) 3-c-Pr 4-c-Pr G-9 (1) 3-«-Bu 4-«-Bu

G-9 (1) 3-z-Bu 4-z-Bu

G-9 (1) 3-i-Bu 4-i-Bu

G-9 (1) 3-F 4-F

G-9 (1) 3 -Cl 4 -Cl

G-9 (1) 3-Br 4-Br

G-9 (1) 3-CF3 4-CF3

G-9 (1) 3 -HO 4 -HO

G-9 (1) 3-NºC 4-NºC

G-9 (1) 3-NºCCH 2 4-NºCCH 2 G-9 (1) 3-(MeO) 4-(MeO)

-l, L is CH2 and Z is a direct bond. H 2 and Z is a direct bond.

G (R 1 3 ) X (R 1 3 )X

G-9 (1) 3-(MeOCH 2 ) 4-(MeOCH 2 ) G-9 (1) 3-(EtOCH 2 ) 4-(EtOCH 2 ) G-9 (1) 3-(CH(=0)) 4-(CH(=0)) G-9 (1) 3-(H0C(=0)) 4-(H0C(=0))

G-9 (1) 3-(Me0C(=0)) 4-(Me0C(=0)) G-9 (1) 3-(Et0C(=0)) 4-(Et0C(=0)) G-9 (1) 3-(/-Pr0C(=0)) 4-(/-Pr0C(=0)) G-9 (1) 3-(«-Pr0C(=0)) 4-(«-Pr0C(=0)) G-9 (1) 3-(Bu0C(=0)) 4-(Bu0C(=0)) G-9 (1) 3-(/-Bu0C(=0)) 4-(/-Bu0C(=0)) G-9 (1) 3-(i-Bu0C(=0)) 4-(i-Bu0C(=0)) G-9 (1) 3-(CF 3 CH 2 0C(=0) 4-(CF 3 CH 2 0C(=0) G-9 (1) 3-(CH 2 =CH0C(=0)) 4-(CH 2 =CH0C(=0)) G-9 (1) 3 -(CH 2 =CHCH 2 0C(=0)) 4-(CH 2 =CHCH 2 0C(=0)) G-9 (1) 3-(CH 2 =CBrCH 2 0C(=0)) 4-(CH 2 =CBrCH 2 0C(=0)) G-9 (1) 3-(CH 2 =CHCF 2 0C(=0)) 4-(CH 2 =CHCF 2 0C(=0)) G-9 (1) 3 -(Me 2 C=CHCH 2 0C(=0)) 4-(Me 2 C=CHCH 2 0C(=0)) G-9 (1) 3 -(CH 2 =C(Me)CH 2 0C(=0)) 4-(CH 2 =C(Me)CH 2 0C(=0)) G-9 (1) 3-(CHºCCH 2 0C(=0)) 4-(CHºCCH 2 0C(=0)) G-9 (1) 3-(NºCCH 2 0C(=0)) 4-(NºCCH 2 0C(=0)) G-9 (1) 3-(MeNHC(=0)) 4-(MeNHC(=0)) G-9 (1) 3-(Me 2 NC(=0)) 4-(Me 2 NC(=0)) G-9 (1) 3-(MeNHC(=0)) 4-(MeNHC(=0)) G-9 (1) 3-(EtNHC(=0)) 4-(EtNHC(=0)) G-9 (1) 3-(PrNHC(=0)) 4-(PrNHC(=0)) G-9 (1) 3-(/-PrNHC(=0)) 4-(/-PrNHC(=0)) G-9 (1) 3-(BuNHC(=0)) 4-(BuNHC(=0)) G-9 (1) 3-(i-BuNHC(=0)) 4-(i-BuNHC(=0))

The present disclosure also includes Tables 1B through 48B, each of which is constructed the same as Table 2 above, except that the row heading in Table 2 (i.e.“J is J-l, L is CH2, and Z is a direct bond”) is replaced with the respective row headings shown below.

Table Row Heading Table Row Heading

IB J is J-l, L is CH2CH2 and Z is a direct bond. 25B J is J-10, L is CH 2 and Z is a direct bond.

2B J is J-l, L is OH 2 (Me) and Z is a direct bond. 26B J is J-10, L is CH2CH2 and Z is a direct bond.

3B J is J-l, L is (OH 2 )3 and Z is a direct bond. 27B J is J-10, L is OH 2 (Me) and Z is a direct bond.

4B J is J-l, L is CH 2 and Z is O. 28B J is J-10, L is (OH 2 )3 and Z is a direct bond.

5B J is J-2, L is CH 2 and Z is a direct bond. 29B J is J-10, L is CH 2 and Z is O.

6B J is J-2, L is CH2CH2 and Z is a direct bond. 30B J is J-14, L is CH 2 and Z is a direct bond.

7B J is J-2, L is CH 2( Mc) and Z is a direct bond. 3 IB J is J-14, L is CH2CH2 and Z is a direct bond.

8B J is J-2, L is (OH 2 )3 and Z is a direct bond. 32B J is J-14, L is OH 2 (Me) and Z is a direct bond.

9B J is J-2, L is CH 2 and Z is O. 33B J is J-14, L is (OH 2 )3 and Z is a direct bond.

10B J is J-6, L is CH 2 and Z is a direct bond. 34B J is J-14, L is CH 2 and Z is O.

11B J is J-6, L is CH2CH2 and Z is a direct bond. 35B J is J-3, L is CH 2 and Z is a direct bond.

12B J is J-6, L is CH 2( Mc) and Z is a direct bond. 36B J is J-3, L is CH2CH2 and Z is a direct bond. Table Row Heading Table Row Heading

13B J is J-6, L is (CH 2 ) 3 and Z is a direct bond. 37B J is J-3, L is CH 2 (Me) and Z is a direct bond.

14B J is J-6, L is CH 2 and Z is O. 38B J is J-3, L is (CH 2 ) 3 and Z is a direct bond.

15B J is J-7, L is CH 2 and Z is a direct bond. 39B J is J-3, L is CH 2 and Z is O.

16B J is J-7, L is CH 2 CH 2 and Z is a direct bond. 40B J is J-4, L is CH 2 and Z is a direct bond.

17B J is J-7, L is CH 2 (Me) and Z is a direct bond. 41B J is J-4, L is CH 2 CH 2 and Z is a direct bond.

18B J is J-7, L is (CH 2 ) 3 and Z is a direct bond. 42B J is J-4, L is CH 2 (Me) and Z is a direct bond.

19B J is J-7, L is CH 2 and Z is O. 43B J is J-4, L is (CH 2 ) 3 and Z is a direct bond.

20B J is J-8, L is CH 2 and Z is a direct bond. 44B J is J-4, L is CH 2 and Z is O.

21B J is J-8, L is CH 2 CH 2 and Z is a direct bond. 45B J is J-5, L is CH 2 and Z is a direct bond.

22B J is J-8, L is CH 2 (Me) and Z is a direct bond. 46B J is J-5, L is CH 2 CH 2 and Z is a direct bond.

23B J is J-8, L is (CH 2 ) 3 and Z is a direct bond. 47B J is J-5, L is CH 2 (Me) and Z is a direct bond.

24B J is J-8, L is CH 2 and Z is O. 48B J is J-5, L is (CH 2 ) 3 and Z is a direct bond.

Table 3 discloses specific compounds Formula 10 which are useful as process intermediates for preparing compounds of Formula 1, as described in Scheme 14 above.

TABLE 3

10

R 29 is S(=0) 2 R 30

R 1 R 6a R 6b X Y R 2a R 2b R30

CF 3 H H o o H H CF 3

CF 3 H H o o H H CH 3

CF 3 H H o o H H CH 2 CF 3

CF 3 H H o o H H (CF 2 ) 3 CF 3

CF 3 H H o o H H Ph

CF 3 H H o o H H 4-Me-Ph

CF 3 H H o o H H 4-N0 2 -Ph

CF 3 H H O NH H H CF 3

CF 3 H H O NH H H CH 3

CF 3 H H O NH H H CH 2 CF 3

CF3 H H O NH H H (CF 2 ) 3 CF 3

CF 3 H H O NH H H Ph

CF 3 H H O NH H H 4-Me-Ph

CF 3 H H O NH H H 4-Br-Ph

CF 3 H H O NH H H 4-N02-Ph

CF 3 H H O NH H Me CF 3

CF 3 H H O NH H Me CH 3

CF 3 H H O NH H Me CH 2 CF 3

CF 3 H H O NH H Me (CF 2 ) 3 CF 3

CF 3 H H O NH H Me Ph

CF 3 H H O NH H Me 4-Me-Ph

CF 3 H H O NH H Me 4-Br-Ph

CF 3 H H O NH H Me 4-N0 2 -Ph

CF 3 H Me O O H H CF 3

CF 3 H Me O O H H CH 3

CF 3 H Me O O H H CH 2 CF 3

CF 3 H Me O O H H (CF 2 ) 3 CF 3

CF 3 H Me O O H H Ph

CF 3 H Me O O H H 4-Me-Ph

CF 3 H Me O O H H 4-Br-Ph

CHF 2 H Me O O H H 4-N0 2 -Ph R 29 is S(=0) 2 R 30 .

R 1 R 6a R 6b X Y R 2a R 2b R 30

CHF 2 H ΊG o o H H CF 3

CHF 2 H H o o H H CH 3

CHF 2 H H o o H H CH 2 CF 3

CHF 2 H H o o H H (CF 2 ) 3 CF 3

CHF 2 H H o o H H Ph

CHF2 H H o o H H 4-Me-Ph

CHF 2 H H o o H H 4-Br-Ph

CHF 2 H H o o H H 4-N0 2 -Ph

CC1 3 H H o o H H CF 3

CC1 3 H H o o H H CH 3

CC13 H H o o H H CH 2 CF 3

CC13 H H o o H H (CF 2 ) 3 CF 3

CC13 H H o o H H Ph

CC13 H H o o H H 4-Me-Ph

CC13 H H o o H H 4-Br-Ph

CC13 H H o o H H 4-N0 2 -Ph

CF 3 Me Me o o H H CF 3

CF 3 Me Me o o H H CH 3

CF 3 Me Me o o H H CH 2 CF 3

CF 3 Me Me o o H H (CF 2 ) 3 CF 3

CF 3 Me Me o o H H Ph

CF 3 Me Me o o H H 4-Me-Ph

CF 3 Me Me o o H H 4-Br-Ph

CF 3 Me Me o o H H 4-N0 2 -Ph

CF 3 H H o o -CH 2 CH 2 - CF 3

CF 3 H H o o -CH 2 CH 2 - CH 3

CF 3 H H O O -CH 2 CH 2 - (CF 2 ) 3 CF 3

CF3 H H O O -CH 2 CH 2 - Ph

CF 3 H H O O -CH 2 CH 2 - 4-Me-Ph

CF 3 H H O O -CH 2 CH 2 - 4-Br-Ph

CF 3 H H O O -CH 2 CH 2 - 4-N0 2 -Ph

CF3 H H O O -CH 2 CH(=0)- CF 3

CF 3 H H O O -CH 2 CH(=0)- CH 3

CF 3 H H O O -CH 2 CH(=0)- CH 2 CF 3

CF 3 H H O O -CH 2 CH(=0)- (CF 2 ) 3 CF 3

CF 3 H H O O -CH 2 CH(=0)- Ph

CF 3 H H O O -CH 2 CH(=0)- 4-Me-Ph

CF 3 H H O O -CH 2 CH(=0)- 4-Br-Ph

CF3 H H O o -CH 2 CH 2 - 4-N0 2 -Ph

CF 3 H H O O -CH 2 CH(Me)- CF 3

CF 3 H H O O -CH 2 CH(Me)- CH 3

CF 3 H H O O -CH 2 CH(Me)- CH 2 CF 3

CF3 H H O O -CH 2 CH(Me)- (CF 2 ) 3 CF 3

CF 3 H H O O -CH2CH(Me)- Ph

CF 3 H H O O -CH 2 CH(Me)- 4-Me-Ph

CF 3 H H O O -CH 2 CH(Me)- 4-Br-Ph

CF 3 H H O O -CH 2 CH(Me)- 4-N0 2 -Ph

Formulation/Utilitv

A compound of Formula 1 of this invention (including A- ox ides and salts thereof) will generally be used as a fungicidal active ingredient in a composition, i.e. formulation, with at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, which serve as a carrier. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature.

Useful formulations include both liquid and solid compositions. Liquid compositions include solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions, oil-in-water emulsions, flowable concentrates and/or suspoemulsions) and the like, which optionally can be thickened into gels. The general types of aqueous liquid compositions are soluble concentrate, suspension concentrate, capsule suspension, concentrated emulsion, microemulsion, oil-in-water emulsion, flowable concentrate and suspoemulsion. The general types of nonaqueous liquid compositions are emulsifiable concentrate, microemulsifiable concentrate, dispersible concentrate and oil dispersion.

The general types of solid compositions are dusts, powders, granules, pellets, prills, pastilles, tablets, filled films (including seed coatings) and the like, which can be water-dispersible (“wettable”) or water-soluble. Films and coatings formed from film-forming solutions or flowable suspensions are particularly useful for seed treatment. Active ingredient can be (micro)encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or“overcoated”). Encapsulation can control or delay release of the active ingredient. An emulsifiable granule combines the advantages of both an emulsifiable concentrate formulation and a dry granular formulation. High-strength compositions are primarily used as intermediates for further formulation.

Sprayable formulations are typically extended in a suitable medium before spraying. Such liquid and solid formulations are formulated to be readily diluted in the spray medium, usually water, but occasionally another suitable medium like an aromatic or paraffinic hydrocarbon or vegetable oil. Spray volumes can range from about one to several thousand liters per hectare, but more typically are in the range from about ten to several hundred liters per hectare. Sprayable formulations can be tank mixed with water or another suitable medium for foliar treatment by aerial or ground application, or for application to the growing medium of the plant. Liquid and dry formulations can be metered directly into drip irrigation systems or metered into the furrow during planting. Liquid and solid formulations can be applied onto seeds of crops and other desirable vegetation as seed treatments before planting to protect developing roots and other subterranean plant parts and/or foliage through systemic uptake. The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges which add up to 100 percent by weight.

Weight Percent

Active

Ingredient Diluent Surfactant

Water-Dispersible and Water- 0.001-90 0-99.999 0-15

soluble Granules, Tablets and

Powders

Oil Dispersions, Suspensions, 1-50 40-99 0-50

Emulsions, Solutions

(including Emulsifiable

Concentrates)

Dusts 1-25 70-99 0-5

Granules and Pellets 0.001-95 5-99.999 0-15

High Strength Compositions 90-99 0-10 0-2

Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, gypsum, cellulose, titanium dioxide, zinc oxide, starch, dextrin, sugars (e.g., lactose, sucrose), silica, talc, mica, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Typical solid diluents are described in Watkins et al, Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, New Jersey.

Liquid diluents include, for example, water, L',L'-di m ethy 1 al kanam i des (e.g., L',L'-dimethylformamide), limonene, dimethyl sulfoxide, A'-alkylpyrrolidones (e.g., A'-methylpyrrolidinone), alkyl phosphates (e.g., triethyl phosphate), ethylene glycol, tri ethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, propylene carbonate, butylene carbonate, paraffins (e.g., white mineral oils, normal paraffins, isoparaffins), alkylbenzenes, alkylnaphthalenes, glycerine, glycerol triacetate, sorbitol, aromatic hydrocarbons, dearomatized aliphatics, alkylbenzenes, alkylnaphthalenes, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, acetates such as isoamyl acetate, hexyl acetate, heptyl acetate, octyl acetate, nonyl acetate, tridecyl acetate and isobornyl acetate, other esters such as alkylated lactate esters, dibasic esters, alkyl and aryl benzoates and g- butyrolactone, and alcohols, which can be linear, branched, saturated or unsaturated, such as methanol, ethanol, «-propanol, isopropyl alcohol, «-butanol, isobutyl alcohol, «-hexanol, 2- ethylhexanol, «-octanol, decanol, isodecyl alcohol, isooctadecanol, cetyl alcohol, lauryl alcohol, tridecyl alcohol, oleyl alcohol, cyclohexanol, tetrahydrofurfuryl alcohol, diacetone alcohol, cresol and benzyl alcohol. Liquid diluents also include glycerol esters of saturated and unsaturated fatty acids (typically such as plant seed and fruit oils (e.g., oils of olive, castor, linseed, sesame, corn (maize), peanut, sunflower, grapeseed, safflower, cottonseed, soybean, rapeseed, coconut and palm kernel), animal-sourced fats (e.g., beef tallow, pork tallow, lard, cod liver oil, fish oil), and mixtures thereof. Liquid diluents also include alkylated fatty acids (e.g., methylated, ethylated, butylated) wherein the fatty acids may be obtained by hydrolysis of glycerol esters from plant and animal sources, and can be purified by distillation. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950.

The solid and liquid compositions of the present invention often include one or more surfactants. When added to a liquid, surfactants (also known as“surface-active agents”) generally modify, most often reduce, the surface tension of the liquid. Depending on the nature of the hydrophilic and lipophilic groups in a surfactant molecule, surfactants can be useful as wetting agents, dispersants, emulsifiers or defoaming agents.

Surfactants can be classified as nonionic, anionic or cationic. Nonionic surfactants useful for the present compositions include, but are not limited to: alcohol alkoxylates such as alcohol alkoxylates based on natural and synthetic alcohols (which may be branched or linear) and prepared from the alcohols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof; amine ethoxylates, alkanolamides and ethoxylated alkanolamides; alkoxylated triglycerides such as ethoxylated soybean, castor and rapeseed oils; alkylphenol alkoxylates such as octylphenol ethoxylates, nonylphenol ethoxylates, dinonyl phenol ethoxylates and dodecyl phenol ethoxylates (prepared from the phenols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); block polymers prepared from ethylene oxide or propylene oxide and reverse block polymers where the terminal blocks are prepared from propylene oxide; ethoxylated fatty acids; ethoxylated fatty esters and oils; ethoxylated methyl esters; ethoxylated tristyrylphenol (including those prepared from ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); fatty acid esters, glycerol esters, lanolin-based derivatives, polyethoxylate esters such as polyethoxylated sorbitan fatty acid esters, polyethoxylated sorbitol fatty acid esters and polyethoxylated glycerol fatty acid esters; other sorbitan derivatives such as sorbitan esters; polymeric surfactants such as random copolymers, block copolymers, alkyd peg (polyethylene glycol) resins, graft or comb polymers and star polymers; polyethylene glycols (pegs); polyethylene glycol fatty acid esters; silicone-based surfactants; and sugar-derivatives such as sucrose esters, alkyl polyglycosides and alkyl polysaccharides.

Useful anionic surfactants include, but are not limited to: alkylaryl sulfonic acids and their salts; carboxylated alcohol or alkylphenol ethoxylates; diphenyl sulfonate derivatives; lignin and lignin derivatives such as lignosulfonates; maleic or succinic acids or their anhydrides; olefin sulfonates; phosphate esters such as phosphate esters of alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates and phosphate esters of styryl phenol ethoxylates; protein-based surfactants; sarcosine derivatives; styryl phenol ether sulfate; sulfates and sulfonates of oils and fatty acids; sulfates and sulfonates of ethoxylated alkylphenols; sulfates of alcohols; sulfates of ethoxylated alcohols; sulfonates of amines and amides such as L',L'-alkyltaurates; sulfonates of benzene, cumene, toluene, xylene, and dodecyl and tridecylbenzenes; sulfonates of condensed naphthalenes; sulfonates of naphthalene and alkyl naphthalene; sulfonates of fractionated petroleum; sulfosuccinamates; and sulfosuccinates and their derivatives such as dialkyl sulfosuccinate salts.

Useful cationic surfactants include, but are not limited to: amides and ethoxylated amides; amines such as L'-alkyl propanediamines, tripropylenetriamines and dipropylenetetramines, and ethoxylated amines, ethoxylated diamines and propoxylated amines (prepared from the amines and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); amine salts such as amine acetates and diamine salts; quaternary ammonium salts such as quaternary salts, ethoxylated quaternary salts and diquaternary salts; and amine oxides such as alkyldimethylamine oxides and bis-(2-hydroxyethyl)-alkylamine oxides.

Also useful for the present compositions are mixtures of nonionic and anionic surfactants or mixtures of nonionic and cationic surfactants. Nonionic, anionic and cationic surfactants and their recommended uses are disclosed in a variety of published references including McCutcheon’s Emulsifiers and Detergents, annual American and International Editions published by McCutcheon’s Division, The Manufacturing Confectioner Publishing Co.; Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964; and A. S. Davidson and B. Milwidsky, Synthetic Detergents, Seventh Edition, John Wiley and Sons, New York, 1987.

Compositions of this invention may also contain formulation auxiliaries and additives, known to those skilled in the art as formulation aids (some of which may be considered to also function as solid diluents, liquid diluents or surfactants). Such formulation auxiliaries and additives may control: pH (buffers), foaming during processing (antifoams such polyorganosiloxanes), sedimentation of active ingredients (suspending agents), viscosity (thixotropic thickeners), in-container microbial growth (antimicrobials), product freezing (antifreezes), color (dyes/pigment dispersions), wash-off (film formers or stickers), evaporation (evaporation retardants), and other formulation attributes. Film formers include, for example, polyvinyl acetates, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers and waxes. Examples of formulation auxiliaries and additives include those listed in McCutcheon’s Volume 2: Functional Materials, annual International and North American editions published by McCutcheon’s Division, The Manufacturing Confectioner Publishing Co.; and PCT Publication WO 03/024222.

The compound of Formula 1 and any other active ingredients are typically incorporated into the present compositions by dissolving the active ingredient in a solvent or by grinding in a liquid or dry diluent. Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. If the solvent of a liquid composition intended for use as an emulsifiable concentrate is water-immiscible, an emulsifier is typically added to emulsify the active-containing solvent upon dilution with water. Active ingredient slurries, with particle diameters of up to 2,000 pm can be wet milled using media mills to obtain particles with average diameters below 3 pm. Aqueous slurries can be made into finished suspension concentrates (see, for example, ET.S. 3,060,084) or further processed by spray drying to form water-dispersible granules. Dry formulations usually require dry milling processes, which produce average particle diameters in the 2 to 10 pm range. Dusts and powders can be prepared by blending and usually grinding (such as with a hammer mill or fluid-energy mill). Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning,“Agglomeration”, Chemical Engineering, December 4, 1967, pp 147-48, Perry’s Chemical Engineer’s Handbook, 4th Ed., McGraw-Hill, New York, 1963, pp 8-57 and following, and WO 91/13546. Pellets can be prepared as described in U.S. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. 4,144,050, U.S. 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. 5,180,587, U.S. 5,232,701 and U.S. 5,208,030. Films can be prepared as taught in GB 2,095,558 and U.S. 3,299,566.

One embodiment of the present invention relates to a method for controlling fungal pathogens, comprising diluting the fungicidal composition of the present invention (a compound of Formula 1 formulated with surfactants, solid diluents and liquid diluents or a formulated mixture of a compound of Formula 1 and at least one other fungicide) with water, and optionally adding an adjuvant to form a diluted composition, and contacting the fungal pathogen or its environment with an effective amount of said diluted composition.

Although a spray composition formed by diluting with water a sufficient concentration of the present fungicidal composition can provide sufficient efficacy for controlling fungal pathogens, separately formulated adjuvant products can also be added to spray tank mixtures. These additional adjuvants are commonly known as“spray adjuvants” or“tank-mix adjuvants”, and include any substance mixed in a spray tank to improve the performance of a pesticide or alter the physical properties of the spray mixture. Adjuvants can be anionic or nonionic surfactants, emulsifying agents, petroleum-based crop oils, crop-derived seed oils, acidifiers, buffers, thickeners or defoaming agents. Adjuvants are used to enhancing efficacy (e.g., biological availability, adhesion, penetration, uniformity of coverage and durability of protection), or minimizing or eliminating spray application problems associated with incompatibility, foaming, drift, evaporation, volatilization and degradation. To obtain optimal performance, adjuvants are selected with regard to the properties of the active ingredient, formulation and target (e.g., crops, insect pests).

The amount of adjuvants added to spray mixtures is generally in the range of about 2.5% to 0.1 % by volume. The application rates of adjuvants added to spray mixtures are typically between about 1 to 5 F per hectare. Representative examples of spray adjuvants include: Adigor® (Syngenta) 47% methylated rapeseed oil in liquid hydrocarbons, Silwet® (Helena Chemical Company) polyalkyleneoxide modified heptamethyltrisiloxane and Assist® (BASF) 17% surfactant blend in 83% paraffin based mineral oil. One method of seed treatment is by spraying or dusting the seed with a compound of the invention (i.e. as a formulated composition) before sowing the seeds. Compositions formulated for seed treatment generally comprise a film former or adhesive agent. Therefore typically a seed coating composition of the present invention comprises a biologically effective amount of a compound of Formula 1 and a film former or adhesive agent. Seeds can be coated by spraying a flowable suspension concentrate directly into a tumbling bed of seeds and then drying the seeds. Alternatively, other formulation types such as wetted powders, solutions, suspoemulsions, emulsifiable concentrates and emulsions in water can be sprayed on the seed. This process is particularly useful for applying film coatings on seeds. Various coating machines and processes are available to one skilled in the art. Suitable processes include those listed in P. Kosters et al, Seed Treatment: Progress and Prospects, 1994 BCPC Mongraph No. 57, and references listed therein.

For further information regarding the art of formulation, see T. S. Woods, “The Formulator’s Toolbox - Product Forms for Modern Agriculture” in Pesticide Chemistry and Bioscience, The Food Environment Challenge, T. Brooks and T. R. Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. Also see U.S. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41 ; FT.S. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989; and Developments in formulation technology, PJB Publications, Richmond, UK, 2000.

In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Active ingredient refers to the compounds in Index Tables A-L disclosed herein. Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be constructed as merely illustrative, and not limiting of the disclosure in any way whatsoever.

Example A High Strength Concentrate

Compound 262 98.5% silica aerogel 0.5% synthetic amorphous fine silica 1.0%

Example B

Wettable Powder

Compound 231 65.0% dodecylphenol polyethylene glycol ether 2.0% sodium ligninsulfonate 4.0% sodium silicoaluminate 6.0% montmorillonite (calcined) 23.0%

Example C

Granule

Compound 64 10.0% attapulgite granules (low volatile matter, 0.71/0.30 mm; 90.0%

U.S.S. No. 25-50 sieves)

Example D

Extruded Pellet

Compound 32 25.0% anhydrous sodium sulfate 10.0% crude calcium ligninsulfonate 5.0% sodium alkylnaphthalenesulfonate 1.0% calcium/magnesium bentonite 59.0%

Example E

Emulsifiable Concentrate

Compound 64 10.0% polyoxyethylene sorbitol hexoleate 20.0%

C 6 -C JO fatty acid methyl ester 70.0%

Example F Microemulsion

Compound 231 5.0% polyvinylpyrrolidone-vinyl acetate copolymer 30.0% alkylpolygly coside 30.0% glyceryl monooleate 15.0% water 20.0%

Example G

Seed Treatment

Compound 262 20.00% polyvinylpyrrolidone-vinyl acetate copolymer 5.00% montan acid wax 5.00% calcium ligninsulfonate 1.00% poly oxy ethylene/poly oxypropylene block copolymers 1.00% stearyl alcohol (POE 20) 2.00% polyorganosilane 0.20% colorant red dye 0.05% water 65.75%

Example H

Fertilizer Stick

Compound 32 2.50% pyrrolidone-styrene copolymer 4.80% tristyrylphenyl 16-ethoxy late 2.30% talc 0.80% corn starch 5.00% slow-release fertilizer 36.00% kaolin 38.00% water 10.60%

Example

Suspension Concentrate

Compound 64 35% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic aci d/poly ethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1%

1 ,2-benzisothiazolin-3-one 0.1% water 53.7%

Example J

Emulsion in Water

Compound 33 10.0% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic aci d/poly ethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1%

1 ,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon 20.0 water 58.7%

Example K

Oil Dispersion

Compound 3 25% polyoxyethylene sorbitol hexaoleate 15% organically modified bentonite clay 2.5% fatty acid methyl ester 57.5%

Example L

Suspoemulsion

Compound 9 10.0% imidacloprid 5.0% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic aci d/poly ethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1%

1 ,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon 20.0% water 53.7%

Water-soluble and water-dispersible formulations are typically diluted with water to form aqueous compositions before application. Aqueous compositions for direct applications to the plant or portion thereof (e.g., spray tank compositions) typically contain at least about 1 ppm or more (e.g., from 1 ppm to 100 ppm) of the compound(s) of this invention.

Seed is normally treated at a rate of from about 0.001 g (more typically about 0.1 g) to about

10 g per kilogram of seed (i.e. from about 0.0001 to 1% by weight of the seed before treatment). A flowable suspension formulated for seed treatment typically comprises from about 0.5 to about 70% of the active ingredient, from about 0.5 to about 30% of a film-forming adhesive, from about 0.5 to about 20% of a dispersing agent, from 0 to about 5% of a thickener, from 0 to about 5% of a pigment and/or dye, from 0 to about 2% of an antifoaming agent, from 0 to about 1% of a preservative, and from 0 to about 75% of a volatile liquid diluent.

The compounds of this invention are useful as plant disease control agents. The present invention therefore further comprises a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof to be protected, or to the plant seed to be protected, an effective amount of a compound of the invention or a fungicidal composition containing said compound. The compounds and/or compositions of this invention provide control of diseases caused by a broad spectrum of fungal plant pathogens in the Ascomycota, Basidiomycota, Zygomycota phyla, and the fungal-like Oomycata class. They are effective in controlling a broad spectrum of plant diseases, particularly foliar pathogens of ornamental, turf, vegetable, field, cereal, and fruit crops. These pathogens include but are not limited to those listed in Table 1 -1. For Ascomycetes and Basidiomycetes, names for both the sexual/teleomorph/perfect stage as well as names for the asexual/anamorph/imperfect stage (in parentheses) are listed where known. Synonymous names for pathogens are indicated by an equal sign. For example, the sexual/teleomorph/perfect stage name Phaeosphaeria nodorum is followed by the corresponding asexual/anamorph/imperfect stage name Stagnospora nodorum and the synonymous older name Septoria nodorum.

Table 1 -1

In addition to their fungicidal activity, the compositions or combinations also have activity against bacteria such as Erwinia amylovora, Xanthomonas campestris, Pseudomonas syringae, and other related species. By controlling harmful microorganisms, the compounds of the invention are useful for improving (i.e. increasing) the ratio of beneficial to harmful microorganisms in contact with crop plants or their propagules (e.g., seeds, corms, bulbs, tubers, cuttings) or in the agronomic environment of the crop plants or their propagules.

Compounds of the invention are useful in treating all plants, plant parts and seeds. Plant and seed varieties and cultivars can be obtained by conventional propagation and breeding methods or by genetic engineering methods. Genetically modified plants or seeds (transgenic plants or seeds) are those in which a heterologous gene (transgene) has been stably integrated into the plant's or seed’s genome. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

Genetically modified plant cultivars which can be treated according to the invention include those that are resistant against one or more biotic stresses (pests such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, cold temperature, soil salinity, etc.), or that contain other desirable characteristics. Plants can be genetically modified to exhibit traits of, for example, herbicide tolerance, insect-resistance, modified oil profiles or drought tolerance. Treatment of genetically modified plants and seeds with compounds of the invention may result in super-additive or enhanced effects. For example, reduction in application rates, broadening of the activity spectrum, increased tolerance to biotic/abiotic stresses or enhanced storage stability may be greater than expected from just simple additive effects of the application of compounds of the invention on genetically modified plants and seeds.

Compounds of this invention are useful in seed treatments for protecting seeds from plant diseases. In the context of the present disclosure and claims, treating a seed means contacting the seed with a biologically effective amount of a compound of this invention, which is typically formulated as a composition of the invention. This seed treatment protects the seed from soil- borne disease pathogens and generally can also protect roots and other plant parts in contact with the soil of the seedling developing from the germinating seed. The seed treatment may also provide protection of foliage by translocation of the compound of this invention or a second active ingredient within the developing plant. Seed treatments can be applied to all types of seeds, including those from which plants genetically transformed to express specialized traits will germinate. Representative examples include those expressing proteins toxic to invertebrate pests, such as Bacillus thuringiensis toxin or those expressing herbicide resistance such as glyphosate acetyltransferase, which provides resistance to glyphosate. Seed treatments with compounds of this invention can also increase vigor of plants growing from the seed.

Compounds of this invention and their compositions, both alone and in combination with other fungicides, nematicides and insecticides, are particularly useful in seed treatment for crops including, but not limited to, maize or corn, soybeans, cotton, cereal (e.g., wheat, oats, barley, rye and rice), potatoes, vegetables and oilseed rape.

Furthermore, the compounds of this invention are useful in treating postharvest diseases of fruits and vegetables caused by fungi and bacteria. These infections can occur before, during and after harvest. For example, infections can occur before harvest and then remain dormant until some point during ripening (e.g., host begins tissue changes in such a way that infection can progress); also infections can arise from surface wounds created by mechanical or insect injury. In this respect, the compounds of this invention can reduce losses (i.e. losses resulting from quantity and quality) due to postharvest diseases which may occur at any time from harvest to consumption. Treatment of postharvest diseases with compounds of the invention can increase the period of time during which perishable edible plant parts (e.g., fruits, seeds, foliage, stems, bulbs, tubers) can be stored refrigerated or un-refrigerated after harvest, and remain edible and free from noticeable or harmful degradation or contamination by fungi or other microorganisms. Treatment of edible plant parts before or after harvest with compounds of the invention can also decrease the formation of toxic metabolites of fungi or other microorganisms, for example, my cotoxins such as aflatoxins.

Plant disease control is ordinarily accomplished by applying an effective amount of a compound of this invention either pre- or post-infection, to the portion of the plant to be protected such as the roots, stems, foliage, fruits, seeds, tubers or bulbs, or to the media (soil or sand) in which the plants to be protected are growing. The compounds can also be applied to seeds to protect the seeds and seedlings developing from the seeds. The compounds can also be applied through irrigation water to treat plants. Control of postharvest pathogens which infect the produce before harvest is typically accomplished by field application of a compound of this invention, and in cases where infection occurs after harvest the compounds can be applied to the harvested crop as dips, sprays, fumigants, treated wraps and box liners.

The compounds can also be applied using an unmanned aerial vehicle (UAV) for the dispension of the compositions disclosed herein over a planted area. In some embodiments the planted area is a crop-containing area. In some embodiments, the crop is selected from a monocot or dicot. In some embodiments, the crop is selected form rice, corn, barley, sobean, wheat, vegetable, tobacco, tea tree, fruit tree and sugar cane. In some embodiments, the compositions disclosed herein are formulated for spraying at an ultra-low volume. Products applied by drones may use water or oil as the spray carrier. Typical spray volume (including product) used for drone applications globally. 5.0 liters/ha - 100 liters/ha (approximately 0.5-10 gpa). This includes the range of ultra low spray volume (ULV) to low spray volume (LV). Although not common there may be situations where even lower spray volumes could be used as low as 1.0 liter/ha (0.1 gpa).

Rates of application for these compounds (i.e. a fungici dally effective amount) can be influenced by factors such as the plant diseases to be controlled, the plant species to be protected, ambient moisture and temperature and should be determined under actual use conditions. One skilled in the art can easily determine through simple experimentation the fungicidally effective amount necessary for the desired level of plant disease control. Foliage can normally be protected when treated at a rate of from less than about 1 g/ha to about 5,000 g/ha of active ingredient. Seed and seedlings can normally be protected when seed is treated at a rate of from about 0.001 g (more typically about 0.1 g) to about 10 g per kilogram of seed.

Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including fungicides, insecticides, nematocides, bactericides, acaricides, herbicides, herbicide safeners, growth regulators such as insect molting inhibitors and rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, plant nutrients, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agricultural protection. Thus the present invention also pertains to a composition comprising a compound of Formula 1 (in a fungicidally effective amount) and at least one additional biologically active compound or agent (in a biologically effective amount) and can further comprise at least one of a surfactant, a solid diluent or a liquid diluent. The other biologically active compounds or agents can be formulated in compositions comprising at least one of a surfactant, solid or liquid diluent. For mixtures of the present invention, one or more other biologically active compounds or agents can be formulated together with a compound of Formula 1, to form a premix, or one or more other biologically active compounds or agents can be formulated separately from the compound of Formula 1, and the formulations combined together before application (e.g., in a spray tank) or, alternatively, applied in succession.

As mentioned in the Summary of the Invention, one aspect of the present invention is a fungicidal composition comprising (i.e. a mixture or combination of) a compound of Formula 1, an L'-oxide, or a salt thereof (i.e. component a), and at least one other fungicide (i.e. component b). Of note is such a combination where the other fungicidal active ingredient has different site of action from the compound of Formula 1. In certain instances, a combination with at least one other fungicidal active ingredient having a similar spectrum of control but a different site of action will be particularly advantageous for resistance management. Thus, a composition of the present invention can further comprise a fungicidally effective amount of at least one additional fungicidal active ingredient having a similar spectrum of control but a different site of action.

Of note is a composition which in addition to the Formula 1 compound of component (a), includes as component (b) at least one fungicidal compound selected from the group consisting of the FRAC-defined mode of action (MO A) classes (A) nucleic acid synthesis, (B) mitosis and cell division, (C) respiration, (D) amino acid and protein synthesis, (E) signal transduction, (F) lipid synthesis and membrane integrity, (G) sterol biosynthesis in membranes, (H) cell wall biosynthesis in membranes, (I) melanin synthesis in cell wall, (P) host plant defense induction, multi-site contact activity and unknown mode of action.

FRAC-recognized or proposed target sites of action along with their FRAC target site codes belonging to the above MOA classes are (Al) RNA polymerase I, (A2) adenosine deaminase, (A3) DNA/RNA synthesis (proposed), (A4) DNA topoisom erase, (B1-B3) B-tubulin assembly in mitosis, (B4) cell division (proposed), (B5) delocalization of spectrin-like proteins, (Cl) complex I NADH odxido-reductase, (C2) complex II: succinate dehydrogenase, (C3) complex III: cytochrome bc\ (ubiquinol oxidase) at Qo site, (C4) complex III: cytochrome bc\ (ubiquinone reductase) at Qi site, (C5) uncouplers of oxidative phosphorylation, (C6) inhibitors of oxidative phosphorylation, ATP synthase, (C7) ATP production (proposed), (C8) complex III: cytochrome bc\ (ubiquinone reductase) at Qx (unknown) site, (Dl) methionine biosynthesis (proposed), (D2- D5) protein synthesis, (El) signal transduction (mechanism unknown), (E2-E3) MAP/histidine kinase in osmotic signal transduction, (F2) phospholipid biosynthesis, methyl transferase, (F3) lipid peroxidation (proposed), (F4) cell membrane permeability, fatty acids (proposed), (F6) microbial disrupters of pathogen cell membranes, (F7) cell membrane disruption (proposed), (Gl) C14- demethylase in sterol biosynthesis , (G2) D 14-reductase and A8 A7-isomerase in sterol biosynthesis, (G3) 3-keto reductase, C4-demethylation, (G4) squalene epoxidase in sterol biosynthesis, (H3) trehalase and inositol biosynthesis, (H4) chitin synthase, (H5) cellulose synthase, (II) reductase in melanin biosynthesis and (12) dehydratase in melanin biosynthesis.

Of particular note is a composition which in addition to the Formula 1 compound of component (a), includes as component (b) at least one fungicidal compound selected from the group consisting of the classes (bl) methyl benzimidazole carbamate (MBC) fungicides; (b2) dicarboximide fungicides; (b3) demethylation inhibitor (DMI) fungicides; (b4) phenylamide fungicides; (b5) amine/morpholine fungicides; (b6) phospholipid biosynthesis inhibitor fungicides; (b7) succinate dehydrogenase inhibitor fungicides; (b8) hydroxy(2-amino-)pyrimidine fungicides; (b9) anilinopyrimidine fungicides; (blO) A-phenyl carbamate fungicides; (bl l) quinone outside inhibitor (Qol) fungicides; (bl2) phenylpyrrole fungicides; (bl 3) azanaphthalene fungicides; (bl4) lipid peroxidation inhibitor fungicides; (bl 5) melanin biosynthesis inhibitor- reductase (MBI-R) fungicides; (bl6) melanin biosynthesis inhibitor-dehydratase (MBI-D) fungicides; (b!7) sterol biosynthesis inhibitor (SBI): Class III fungicides; (b!8) squalene- epoxidase inhibitor fungicides; (bl9) polyoxin fungicides; (b20) phenylurea fungicides; (b2l) quinone inside inhibitor (Qil) fungicides; (b22) benzamide and thiazole carboxamide fungicides; (b23) enopyranuronic acid antibiotic fungicides; (b24) hexopyranosyl antibiotic fungicides; (b25) glucopyranosyl antibiotic: protein synthesis fungicides; (b26) glucopyranosyl antibiotic: trehalase and inositol biosynthesis fungicides; (b27) cyanoacetamideoxime fungicides; (b28) carbamate fungicides; (b29) oxidative phosphorylation uncoupling fungicides; (b30) organo tin fungicides; (b3 l) carboxylic acid fungicides; (b32) heteroaromatic fungicides; (b33) phosphonate fungicides; (b34) phthalamic acid fungicides; (b35) benzotriazine fungicides; (b36) benzene-sulfonamide fungicides; (b37) pyridazinone fungicides; (b38) thiophene-carboxamide fungicides; (b39) complex I NADH oxidoreductase inhibitor fungicides; (b40) carboxylic acid amide (CAA) fungicides; (b4l) tetracycline antibiotic fungicides; (b42) thiocarbamate fungicides; (b43) benzamide fungicides; (b44) microbial fungicides; (b45) Q X I fungicides; (b46) plant extract fungicides; (b47) host plant defense induction fungicides; (b48) multi-site contact activity fungicides; (b49) fungicides other than fungicides of classes (bl) through (b48); and salts of compounds of classes (bl) through (b48).

Further descriptions of these classes of fungicidal compounds are provided below.

(bl)“Methyl benzimidazole carbamate (MBC) fungicides” (FRAC code 1) inhibit mitosis by binding to b-tubulin during microtubule assembly. Inhibition of microtubule assembly can disrupt cell division, transport within the cell and cell structure. Methyl benzimidazole carbamate fungicides include benzimidazole and thiophanate fungicides. The benzimidazoles include benomyl, carbendazim, fuberidazole and thiabendazole. The thiophanates include thiophanate and thiophanate-methyl.

(b2)“Dicarboximide fungicides” (FRAC code 2) inhibit a MAP/histidine kinase in osmotic signal transduction. Examples include chlozolinate, iprodione, procymidone and vinclozolin.

(b3)“Demethylation inhibitor (DMI) fungicides” (FRAC code 3) (Sterol Biosynthesis Inhibitors (SBI): Class I) inhibit Cl4-demethylase, which plays a role in sterol production. Sterols, such as ergosterol, are needed for membrane structure and function, making them essential for the development of functional cell walls. Therefore, exposure to these fungicides results in abnormal growth and eventually death of sensitive fungi. DMI fungicides are divided between several chemical classes: azoles (including triazoles and imidazoles), pyrimidines, piperazines, pyridines and triazolinthiones. The triazoles include azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole (including diniconazole-M), epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, uniconazole-P, a-(l-chlorocyclopropyl)-a- [2-(2, 2-dichlorocyclopropyl)ethyl]-li/-l, 2, 4-triazole-l -ethanol, rel-\-[[(2R, S)- -(2- chlorophenyl)-2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-lif- l, 2, 4-triazole, rel-2-\\(2R, S)- -

(2-chlorophenyl)-2-(2,4-difluorophenyl)-2-oxiranyl]methyl ]- l ,2-dihydro-3//- 1 ,2,4-triazole-3- thione, and rel- 1 -[[(2//,35')-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)-2-oxi ranyl]methyl]-5-(2- propen-l-ylthio)-lif-l, 2, 4-triazole. The imidazoles include econazole, imazalil, oxpoconazole, prochloraz, pefurazoate and triflumizole. The pyrimidines include fenarimol, nuarimol and triarimol. The piperazines include triforine. The pyridines include buthiobate, pyrifenox, pyrisoxazole (3-[(3R)-5-(4-chlorophenyl)-2,3-dimethyl3-isoxazolidinyl]pyr idine, mixture of 3R,5R- and 3//,55’-isomers) and (oA)-[3-(4-chloro-2-fluorophenyl)5-(2,4-difluorophenyl)-4- isoxazolyl]-3-pyridinemethanol. The triazolinthiones include prothioconazole and 2-[2-(l- chlorocyclopropyl)-4-(2,2-dichlorocyclopropyl)2-hydroxybutyl ]- l ,2-dihydro-3//- 1 ,2,4-triazole- 3-thione. Biochemical investigations have shown that all of the above mentioned fungicides are DMI fungicides as described by K. H. Kuck et al. in Modem Selective Fungicides - Properties, Applications and Mechanisms of Action, H. Lyr (Ed.), Gustav Fischer Verlag: New York, 1995, 205-258.

(b4)“Phenylamide fungicides” (FRAC code 4) are specific inhibitors of RNA polymerase in Oomycete fungi. Sensitive fungi exposed to these fungicides show a reduced capacity to incorporate uridine into rRNA. Growth and development in sensitive fungi is prevented by exposure to this class of fungicide. Phenylamide fungicides include acylalanine, oxazolidinone and butyrolactone fungicides. The acylalanines include benalaxyl, benalaxyl-M (also known as kiralaxyl), furalaxyl, metalaxyl and metalaxyl-M (also known as mefenoxam). The oxazolidinones include oxadixyl. The butyrolactones include ofurace.

(b5)“Amine/morpholine fungicides” (FRAC code 5) (SBI: Class II) inhibit two target sites within the sterol biosynthetic pathway, D 8 D 7 isomerase and D 14 reductase. Sterols, such as ergosterol, are needed for membrane structure and function, making them essential for the development of functional cell walls. Therefore, exposure to these fungicides results in abnormal growth and eventually death of sensitive fungi. Amine/morpholine fungicides (also known as non-DMI sterol biosynthesis inhibitors) include morpholine, piperidine and spiroketal-amine fungicides. The morpholines include aldimorph, dodemorph, fenpropimorph, tridemorph and trimorphamide. The piperidines include fenpropidin and piperalin. The spiroketal-amines include spiroxamine.

(b6)“Phospholipid biosynthesis inhibitor fungicides” (FRAC code 6) inhibit growth of fungi by affecting phospholipid biosynthesis. Phospholipid biosynthesis fungicides include phophorothiolate and dithiolane fungicides. The phosphorothiolates include edifenphos, iprobenfos and pyrazophos. The dithiolanes include isoprothiolane.

(b7) “Succinate dehydrogenase inhibitor (SDHI) fungicides” (FRAC code 7) inhibit Complex P fungal respiration by disrupting a key enzyme in the Krebs Cycle (TCA cycle) named succinate dehydrogenase. Inhibiting respiration prevents the fungus from making ATP, and thus inhibits growth and reproduction. SDHI fungicides include phenylbenzamide, furan carboxamide, oxathiin carboxamide, thiazole carboxamide, pyrazole-4-carboxamide, pyridine carboxamide, phenyl oxoethyl thiophene amides and pyridinylethyl benzamides. The benzamides include benodanil, flutolanil and mepronil. The furan carboxamides include fenfuram. The oxathiin carboxamides include carboxin and oxycarboxin. The thiazole carboxamides include thifluzamide. The pyrazole-4-carboxamides include benzovindiflupyr (A'-[9-(dichloro- methylene)- 1 ,2,3,4-tetrahydro- 1 ,4-methanonaphthalen-5-yl] -3-(difluoromethyl)- 1 -methyl- 1 H- pyrazole-4-carboxamide), bixafen, fluindapyr, fluxapyroxad (3-(difluoromethyl)-l -methyl-A'- (3',4',5'-trifluoro[l,l '-biphenyl]-2-yl)-lif-pyrazole-4-carboxamide), furametpyr, isoflucypram, isopyrazam (3-(difluoromethyl)-l -methyl-A'-[l ,2,3,4-tetrahydro-9-( 1 -methylethyl)-l ,4-methano- naphthalen-5-yl]- 1 //-pyrazole-4-carboxamide), penflufen (A'-[2-(l ,3-dimethylbutyl)phenyl]-5- fluoro- 1,3 -dimethyl- IH- pyrazole-4-carboxamide), penthiopyrad, pydiflumetofen, sedaxane (N- [2-[l,l'-bicyclopropyl]-2-ylphenyl]-3-(difluoromethyl)-l -methyl- lif-pyrazole-4-carboxamide), N- [2-( 1 S,2R)- [1,1 '-bicy clopropy 1] -2-ylphenyl] -3 -(difluorom ethyl)- 1 -methyl-1 //-pyrazole-4- carboxamide, 3 -(difluoromethyl)-/V-(2, 3 -dihydro- 1 , 1 ,3 -trimethyl- lif-inden-4-yl)- 1 -methyl-1 H- pyrazole-4-carboxamide, A'-[2-(2,4-dichlorophenyl)2-methoxy-l -methylethyl]-3-(difluoro- methyl)-! -methyl- lif-pyrazole-4-carboxamide and A'-cyclopropyl-3-(difluoromethyl)-5-fluoro- 1 -methyl- A'-[[2-( l -methylethyl)phenyl]methyl]- l //-pyrazole-4-carboxamide. The pyridine carboxamides include boscalid. The phenyl oxoethyl thiophene amides include isofetamid (N- [l,l-dimethyl-2-[2-methyl-4-(l-methylethoxy)phenyl]-2-oxoeth yl]-3-methyl-2- thiophenecarboxamide). The pyridinylethyl benzamides include fluopyram.

(b8) “Hydroxy-(2-amino-)pyrimidine fungicides” (FRAC code 8) inhibit nucleic acid synthesis by interfering with adenosine deaminase. Examples include bupirimate, dimethirimol and ethirimol.

(b9)“Anilinopyrimidine fungicides” (FRAC code 9) are proposed to inhibit biosynthesis of the amino acid methionine and to disrupt the secretion of hydrolytic enzymes that lyse plant cells during infection. Examples include cyprodinil, mepanipyrim and pyrimethanil.

(blO)“A'-Phenyl carbamate fungicides” (FRAC code 10) inhibit mitosis by binding to b- tubulin and disrupting microtubule assembly. Inhibition of microtubule assembly can disrupt cell division, transport within the cell and cell structure. Examples include diethofencarb.

(bl l)“Quinone outside inhibitor (Qol) fungicides” (FRAC code 11) inhibit Complex III mitochondrial respiration in fungi by affecting ubiquinol oxidase. Oxidation of ubiquinol is blocked at the“quinone outside” (Q 0 ) site of the cytochrome hc \ complex, which is located in the inner mitochondrial membrane of fungi. Inhibiting mitochondrial respiration prevents normal fungal growth and development. Quinone outside inhibitor fungicides include methoxyacrylate, methoxycarbamate, oximinoacetate, oximinoacetamide and dihydrodioxazine fungicides (collectively also known as strobilurin fungicides), and oxazolidinedione, imidazolinone and benzylcarbamate fungicides. The methoxyacrylates include azoxystrobin, coumoxystrobin (methyl (a/i)-2-[[(3-butyl-4-methyl-2-oxo-2//- 1 -benzopyran-7-yl)oxy]methyl]-a-(methoxy- methylene)benzeneacetate), enoxastrobin (methyl (a/i)-2-[[[(/i)-[(2/i)-3-(4-chlorophenyl)- l - methyl-2-propen-l-ybdene]amino]oxy]methyl]-a-(methoxymethyle ne)benzeneaceate) (also known as enestroburin), flufenoxystrobin (methyl (a/i)-2-[[2-chloro-4-(trifluoromethyl)- phenoxy]methyl]-a-(methoxymethylene)benzeneacetate), picoxystrobin, and pyraoxystrobin (methyl (a£)-2-[[[3-(4-chlorophenyl)-l -methyl- lif-pyrazol-5-yl]oxy]methyl]-a-(methoxy- methylene)benzeneacetate). The methoxycarbamates include pyraclostrobin, pyrametostrobin (methyl A'-[2-[[( l ,4-dimethyl-3 -phenyl- 1 //-pyrazol-5-yl)oxy]methyl]phenyl]-A'-methoxy- carbamate) and triclopyricarb (methyl A'-methoxy-A'-[2-[[(3,5,6-trichloro-2-pyridinyl)oxy]- methyl]phenyl]carbamate). The oximinoacetates include kresoxim-methyl and trifloxystrobin. The oximinoacetamides include dimoxystrobin, fenaminstrobin ((aA )-2-[[[(A )-[(2A )-3-(2,6- dichlorophenyl)-l-methyl-2-propen-l-ylidene]amino]oxy]methyl ]-a-(methoxyimino)-A-methyl- benzeneacetamide), metominostrobin, orysastrobin and a-[methoxyimino]-A'-methyl-2-[[[ l -[3- (trifluoromethyl)phenyl]ethoxy]imino]methyl]benzeneacetamide . The dihydrodioxazines include fluoxastrobin. The oxazolidinediones include famoxadone. The imidazolinones include fenamidone. The benzylcarbamates include pyribencarb. Class (bl 1) also includes mandestrobin

(2-[(2,5-dimethylphenoxy)methyl]-a-methoxy-A'-benzeneacet amide).

(bl2) “Phenylpyrrole fungicides” (FRAC code 12) inhibit a MAP/histidine kinase associated with osmotic signal transduction in fungi. Fenpiclonil and fludioxonil are examples of this fungicide class.

(bl 3) “Azanaphthalene fungicides” (FRAC code 13) are proposed to inhibit signal transduction by a mechanism which is as yet unknown. They have been shown to interfere with germination and/or appressorium formation in fungi that cause powdery mildew diseases. Azanaphthalene fungicides include aryloxyquinolines and quinazolinones. The aryloxyquinolines include quinoxyfen. The quinazolinones include proquinazid.

(bl4)“Lipid peroxidation inhibitor fungicides” (FRAC code 14) are proposed to inhibit lipid peroxidation which affects membrane synthesis in fungi. Members of this class, such as etridiazole, may also affect other biological processes such as respiration and melanin biosynthesis. Lipid peroxidation fungicides include aromatic hydrocarbon and l,2,4-thiadiazole fungicides. The aromatic hydrocarboncarbon fungicides include biphenyl, chloroneb, dicloran, quintozene, tecnazene and tolclofos-methyl. The l,2,4-thiadiazoles include etridiazole.

(bl 5)“Melanin biosynthesis inhibitors-reductase (MBI-R) fungicides” (FRAC code 16.1) inhibit the naphthal reduction step in melanin biosynthesis. Melanin is required for host plant infection by some fungi. Melanin biosynthesis inhibitors-reductase fungicides include isobenzofuranone, pyrroloquinolinone and triazolobenzothiazole fungicides. The isobenzofuranones include fthalide. The pyrroloquinolinones include pyroquilon. The triazolobenzothiazoles include tricyclazole. (bl6)“Melanin biosynthesis inhibitors-dehydratase (MBI-D) fungicides” (FRAC code 16.2) inhibit scytalone dehydratase in melanin biosynthesis. Melanin in required for host plant infection by some fungi. Melanin biosynthesis inhibitors-dehydratase fungicides include cyclopropanecarboxamide, carboxamide and propionamide fungicides. The cyclopropanecarboxamides include carpropamid. The carboxamides include diclocymet. The propionamides include fenoxanil.

(bl7)“Sterol Biosynthesis Inhibitor (SBI): Class III fungicides (FRAC code 17) inhibit 3- ketoreductase during C4-demethylation in sterol production. SBI: Class III inhibitors include hydroxyanilide fungicides and amino-pyrazolinone fungicides. Hydroxyanilides include fenhexamid. Amino-pyrazolinones include fenpyrazamine (L-2-propen- l -yl 5-amino-2,3-di- hydro-2-( 1 -methylethyl)-4-(2-methylphenyl)-3 -oxo- lif-pyrazole- 1 -carbothioate).

(bl8)“Squalene-epoxidase inhibitor fungicides” (FRAC code 18) (SBI: Class IV) inhibit squalene-epoxidase in the sterol biosynthesis pathway. Sterols such as ergosterol are needed for membrane structure and function, making them essential for the development of functional cell walls. Therefore exposure to these fungicides results in abnormal growth and eventually death of sensitive fungi. Squalene-epoxidase inhibitor fungicides include thiocarbamate and allylamine fungicides. The thiocarbamates include pyributicarb. The allylamines include naftifine and terbinafine.

(bl9)“Polyoxin fungicides” (FRAC code 19) inhibit chitin synthase. Examples include polyoxin.

(b20)“Phenylurea fungicides” (FRAC code 20) are proposed to affect cell division. Examples include pencycuron.

(b2l)“Quinone inside inhibitor (Qil) fungicides” (FRAC code 21) inhibit Complex III mitochondrial respiration in fungi by affecting ubiquinone reductase. Reduction of ubiquinone is blocked at the“quinone inside” (Q j ) site of the cytochrome hc \ complex, which is located in the inner mitochondrial membrane of fungi. Inhibiting mitochondrial respiration prevents normal fungal growth and development. Quinone inside inhibitor fungicides include cyanoimidazole and sulfamoyltriazole fungicides. The cyanoimidazoles include cyazofamid. The sulfamoyltriazoles include amisulbrom. (b22)“Benzamide and thiazole carboxamide fungicides” (FRAC code 22) inhibit mitosis by binding to b-tubulin and disrupting microtubule assembly. Inhibition of microtubule assembly can disrupt cell division, transport within the cell and cell structure. The benzamides include zoxamide. The thiazole carboxamides include ethaboxam.

(b23)“Enopyranuronic acid antibiotic fungicides” (FRAC code 23) inhibit growth of fungi by affecting protein biosynthesis. Examples include blasticidin-S.

(b24)“Hexopyranosyl antibiotic fungicides” (FRAC code 24) inhibit growth of fungi by affecting protein biosynthesis. Examples include kasugamycin.

(b25)“Glucopyranosyl antibiotic: protein synthesis fungicides” (FRAC code 25) inhibit growth of fungi by affecting protein biosynthesis. Examples include streptomycin.

(b26)“Glucopyranosyl antibiotic: trehalase and inositol biosynthesis fungicides” (FRAC code 26) inhibit trehalase and inositol biosynthesis. Examples include validamycin.

(b27)“Cyanoacetamideoxime fungicides (FRAC code 27) include cymoxanil.

(b28)“Carbamate fungicides” (FRAC code 28) are considered multi-site inhibitors of fungal growth. They are proposed to interfere with the synthesis of fatty acids in cell membranes, which then disrupts cell membrane permeability. Propamacarb, iodocarb, and prothiocarb are examples of this fungicide class.

(b29)“Oxidative phosphorylation uncoupling fungicides” (FRAC code 29) inhibit fungal respiration by uncoupling oxidative phosphorylation. Inhibiting respiration prevents normal fungal growth and development. This class includes 2,6-dinitroanilines such as fluazinam, and dinitrophenyl crotonates such as dinocap, meptyldinocap and binapacryl.

(b30)“Organo tin fungicides” (FRAC code 30) inhibit adenosine triphosphate (ATP) synthase in oxidative phosphorylation pathway. Examples include fentin acetate, fentin chloride and fentin hydroxide.

(b3l)“Carboxylic acid fungicides” (FRAC code 31) inhibit growth of fungi by affecting deoxyribonucleic acid (DNA) topoisomerase type II (gyrase). Examples include oxolinic acid.

(b32)“Heteroaromatic fungicides” (Fungicide Resistance Action Committee (FRAC) code 32) are proposed to affect DNA/ribonucleic acid (RNA) synthesis. Heteroaromatic fungicides include isoxazoles and isothiazolones. The isoxazoles include hymexazole and the isothiazolones include octhilinone. (b33)“Phosphonate fungicides” (FRAC code 33) include phosphorous acid and its various salts, including fosetyl-aluminum.

(b34)“Phthalamic acid fungicides” (FRAC code 34) include teclofthalam.

(b35)“Benzotriazine fungicides” (FRAC code 35) include triazoxide.

(b36)“Benzene-sulfonamide fungicides” (FRAC code 36) include flusulfamide.

(b37)“Pyridazinone fungicides” (FRAC code 37) include diclomezine.

(b38)“Thiophene-carboxamide fungicides” (FRAC code 38) are proposed to affect ATP production. Examples include silthiofam.

(b39)“Complex I NADH oxidoreductase inhibitor fungicides” (FRAC code 39) inhibit electron transport in mitochondria and include pyrimidinamines such as diflumetorim, and pyrazole-5-carboxamides such as tolfenpyrad.

(b40)“Carboxylic acid amide (CAA) fungicides” (FRAC code 40) inhibit cellulose synthase which prevents growth and leads to death of the target fungus. Carboxylic acid amide fungicides include cinnamic acid amide, valinamide and other carbamate, and mandelic acid amide fungicides. The cinnamic acid amides include dimethomorph, flumorph and pyrimorph (3-(2- chloro-4-pyridinyl)-3-[4-(l,l-dimethylethyl)phenyl]-l-(4-mor pholinyl)-2-propene-l-one). The valinamide and other carbamates include benthiavalicarb, benthiavalicarb-isopropyl, iprovalicarb, tolprocarb (2,2,2-trifluoroethyl A-[(lS -2-methyl-l-[[(4-methylbenzoyl)amino]methyl]propyl]- carbamate) and valifenalate (methyl A'-[( l -methylethoxy)carbonyl]-L-valyl-3-(4-chlorophenyl)- b-alaninate) (also known as valiphenal). The mandelic acid amides include mandipropamid, N- [2-[4-[[3-(4-chlorophenyl)-2-propyn-l-yl]oxy]-3-methoxypheny l]ethyl]-3-methyl-2- [(methylsulfony l)amino] butanamide and N- [2- [4- [ [3 -(4-chloropheny l)-2-propyn- 1 -y l]oxy ] -3 - methoxyphenyl]ethyl]-3-methyl-2-[(ethylsulfonyl)amino]butana mide.

(b4l)“Tetracycline antibiotic fungicides” (FRAC code 41) inhibit growth of fungi by affecting protein synthesis. Examples include oxytetracycline.

(b42)“Thiocarbamate fungicides” (FRAC code 42) include methasulfocarb.

(b43)“Benzamide fungicides” (FRAC code 43) inhibit growth of fungi by delocalization of spectrin-like proteins. Examples include pyridinylmethyl benzamide fungicides such as fluopicolide (now FRAC code 7, pyridinylethyl benzamides). (b44)“Microbial fungicides” (FRAC code 44) disrupt fungal pathogen cell membranes. Microbial fungicides include Bacillus species such as Bacillus amyloliquefaciens strains QST 713, FZB24, MB 1600, D747 and the fungicidal lipopeptides which they produce.

(b45)“Q X I fungicides” (FRAC code 45) inhibit Complex III mitochondrial respiration in fungi by affecting ubiquinone reductase at an unknown (Q x ) site of the cytochrome hc \ complex. Inhibiting mitochondrial respiration prevents normal fungal growth and development. Q X I fungicides include triazolopyrimidylamines such as ametoctradin (5-ethyl-6- octyl[l,2,4]triazolo[l,5-a]pyrimidin-7-amine).

(b46)“Plant extract fungicides” are proposed to act by cell membrane disruption. Plant extract fungicides include terpene hydrocarbons and terpene alcohols such as the extract from Melaleuca alternifolia (tea tree).

(b47)“Host plant defense induction fungicides” (FRAC code P) induce host plant defense mechanisms. Host plant defense induction fungicides include benzothiadiazoles, benzisothiazole and thiadiazole-carboxamide fungicides. The benzothiadiazoles include acibenzolar-S-methyl. The benzisothiazoles include probenazole. The thiadiazole-carboxamides include tiadinil and isotianil.

(b48)“Multi-site contact fungicides” inhibit fungal growth through multiple sites of action and have contact/preventive activity. This class of fungicides includes: (b48. l) “copper fungicides” (FRAC code Ml)”, (b48.2) “sulfur fungicides” (FRAC code M2), (b48.3) “dithiocarbamate fungicides” (FRAC code M3), (b48.4)“phthalimide fungicides” (FRAC code M4), (b48.5)“chloronitrile fungicides” (FRAC code M5), (b48.6)“sulfamide fungicides” (FRAC code M6), (b48.7) multi-site contact“guanidine fungicides” (FRAC code M7), (b48.8)“triazine fungicides” (FRAC code M8), (b48.9) “quinone fungicides” (FRAC code M9), (b48. l0) “quinoxaline fungicides” (FRAC code M10) and (b48.11)“maleimide fungicides” (FRAC code Ml l). “Copper fungicides” are inorganic compounds containing copper, typically in the copper(II) oxidation state; examples include copper oxychloride, copper sulfate and copper hydroxide, including compositions such as Bordeaux mixture (tribasic copper sulfate). “Sulfur fungicides” are inorganic chemicals containing rings or chains of sulfur atoms; examples include elemental sulfur. “Dithiocarbamate fungicides” contain a dithiocarbamate molecular moiety; examples include mancozeb, metiram, propineb, ferbam, maneb, thiram, zineb and ziram. “Phthalimide fungicides” contain a phthalimide molecular moiety; examples include folpet, captan and captafol. “Chloronitrile fungicides” contain an aromatic ring substituted with chloro and cyano; examples include chlorothalonil. “Sulfamide fungicides” include dichlofluanid and tolyfluanid. Multi-site contact“guanidine fungicides” include, guazatine, iminoctadine albesilate and iminoctadine triacetate. “Triazine fungicides” include anilazine. “Quinone fungicides” include dithianon. “Quinoxaline fungicides” include quinomethionate (also known as chinomethionate). “Maleimide fungicides” include fluoroimide.

(b49)“Fungicides other than fungicides of classes (bl) through (b48)” include certain fungicides whose mode of action may be unknown. These include: (b49. l),“phenyl-acetamide fungicides” (FRAC code U6), (b49.2)“ aryl-phenyl-ketone fungicides” (FRAC code U8), (b49.3) “guanidine fungicides” (FRAC code U12), (b49.4)“thiazolidine fungicides” (FRAC code U13), (b49.5)“pyrimidinone-hydrazone fungicides” (FRAC code U14) and (b49.6) compounds that bind to oxysterol-binding protein as described in PCT Patent Publication WO 2013/009971. The phenyl-acetamides include cyflufenamid and A'-[[(cyclopropyhnethoxy)ainino][6-

(difluoromethoxy)-2,3-difluorophenyl]-methylene]benzeneac etamide. The aryl-phenyl ketones include benzophenones such as metrafenone, and benzoylpyridines such as pyriofenone (5- chloro-2-methoxy-4-methyl-3-pyridinyl)(2,3,4-trimethoxy-6-me thylphenyl)methanone). The quanidines include dodine. The thiazolidines include flutianil ((2Z)-2-[[2-fluoro-5-

(trifluoromethyl)phenyl]thio]-2-[3-(2-methoxyphenyl)-2-th iazolidinylidene]acetonitrile). The pyrimidinonehydrazones include ferimzone. The (b49.6) class includes oxathiapiprolin (l-[4-[4- [5-(2, 6-difluorophenyl)-4, 5 -dihydro- 3 -isoxazoly 1] -2-thiazoly 1] - 1 -piperidiny 1] -2- [5 -methyl-3 - (trifluoromethyl )- 1 //-pyrazol-1 -yl] ethanone) and its //-enantiomer which is 1 -[4-[4-[5//-(2,6- difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-l-pip eridinyl]-2-[5-methyl-3-(trifluoro- m ethyl)-! //-pyrazol- 1 -yl]ethanone (Registry Number 1003319-79-6). The (b49) class also includes bethoxazin, flometoquin (2-ethyl-3,7-dimethyl-6-[4-(trifluoromethoxy)phenoxy]-4- quinolinyl methyl carbonate), fluoroimide, neo-asozin (ferric methanearsonate), picarbutrazox (l,l-dimethylethyl A-[6-[[[[((Z)l -methyl-17/-tetrazol-5-yl)phenylmethylene]amino]oxy]- methyl]-2-pyridinyl] carbamate), pyrrolnitrin, quinomethionate, tebufloquin (6-(l,l- dimethylethyl)-8-fluoro-2,3-dimethyl-4-quinolinyl acetate), tolnifanide (A'-(4-chloro-2-nitro- phenyl)-A-ethyl-4-methy lbenzenesulfonamide), 2-butoxy-6-iodo-3 -propy 1-477- 1 -benzopyran-4- one, 3-butyn-l-yl, A'-[6-[[[[(l -methyl-1 //-tetrazol-5-yl)phenylmethylene]amino]oxy]methyl]-2- pyridinyl] carbamate, (A'-(4-chloro-2-nitrophenyl)-A'-ethyl-4-methylbenzenesulfona mide), A n - [4- [4-chloro-3-(trifluoromethyl)phenoxy]-2,5-dimethylphenyl]-A' -ethyl-A'-methylmethanimid- amide, A'-[[(cyclopropylmethoxy)amino][6-(difluoromethoxy)-2,3-difl uorophenyl] methylene]- benzeneacetamide, 2,6-dimethyl-li7,5i7-[l,4]dithiino[2,3-c:5,6-c']dipyrrole-l, 3,5,7(2i7,6i/)- tetrone, 5-fluoro-2-[(4-methylphenyl)methoxy]-4-pyrimidinamine, 5-fluoro-2-[(4-fluoro- phenyl)methoxy]-4-pyrimidinamine and 4-fluorophenyl A- [ 1 -[[[ 1 -(4-cyanophenyl)ethyl]- sulfonyl]methyl]propyl]carbamate, pentyl A'-[6-[[[[( l -methyl - 1 //-tetrazol-5-yl)phenyl- methylene]amino]oxy]methyl]-2-pyridinyl]carbamate, pentyl A'-[4-[[[[( l -methyl-1 //-tetrazol-5- yl)phenylmethylene]amino]oxy]methyl]-2-thiazolyl]carbamate and pentyl A'-[6-[[[[(Z)-( l - methyl-1 //-tetrazol-5-yl)phenylmethylene]amino]oxy]methyl]-2-pyridin yl] carbamate. The (b46) class further includes mitosis- and cell division-inhibiting fungicides besides those of the particular classes described above (e.g., (bl), (blO) and (b22)).

Additional“Fungicides other than fungicides of classes (1) through (46)” whose mode of action may be unknown, or may not yet be classified include a fungicidal compound selected from components (b49.7) through (b49.13), as shown below.

Component (b49.7) relates to a compound of Formula b49.7

Examples of a compound of Formula b49.7 include (b49.7a) (2-chloro-6-fluorophenyl)methyl 2- [1 -[2-[3,5-bis(difluoromethyl)-l //-pyrazol-1 -yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylate (Registry Number 1299409-40-7) and (b49.7b) (1 R)- \ ,2,3,4-tetrahydro-l -naphthalenyl 2-[l-[2- [3,5-bis(difluoromethyl)-l //-pyrazol-1 -yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylate (Registry Number 1299409-42-9). Methods for preparing compounds of Formula b46.2 are described in PCT Patent Publications WO 2009/132785 and WO 2011/051243.

Component (b49.8) relates to a compound of Formula b49.8

wherein R b2 is CH 3 , CF 3 or CHF 2 ; R b3 is CH 3 , CF 3 or CHF 2 ; R b4 is halogen or cyano; and n is 0, 1, 2 or 3.

Examples of a compound of Formula b49.8 include (b49.8a) l-[4-[4-[5-[(2,6-difluorophenoxy)- methyl]-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-l-piperdinyl] -2-[5-methyl-3-(trifluoromethyl)- 1 //-pyrazol- 1 -yl]ethanone. Methods for preparing compounds of Formula b49.8 are described in PCT Patent Application PCT/US 11/64324.

Component (b4799) relates to a compound of Formula b49.9

wherein Rb5 is -CH 2 0C(0)CH(CH 3 ) 2 , -C(0)CH 3 , -CH 2 0C(0)CH 3 ,

-C(0)0CH 2 CH(CH 3 ) 2 or

Examples of a compound of Formula b49.9 include (b49.9a) [[4-methoxy-2-[[[(3<S',7i?,8i?,9<S)-9- methyl-8-(2-methyl-l-oxopropoxy)-2,6-dioxo-7-(phenylmethyl)- l,5-dioxonan-3-yl]amino]- carbonyl]-3-pyridinyl]oxy]methyl 2-methylpropanoate (Registry Number 517875-34-2; common name fenpicoxamid), (b49.9b) (3 < S',6 < S',7i?,8i?)-3-[[[3-(acetyloxy)-4-methoxy-2-pyridinyl]- carbonyl]amino]-6-methyl-4,9-dioxo-8-(phenylmethyl)-l,5-diox onan-7-yl 2-methylpropanoate (Registry Number 234112-93-7), (b49.9c) (3S , ,6S , ,7i?,8i?)-3[[[3[(acetyloxy)methoxy]-4-methoxy- 2-pyridinyl]carbonyl]amino]-6-methyl-4,9-dioxo-8-(phenylmeth yl)-l,5-dioxonan-7-yl 2-methyl- propanoate (Registry Number 517875-31-9), (b49.9d) (35',65',7//,8//)-3-[[[4-methoxy-3-[[(2- methylpropoxy)carbonyl]oxy]-2-pyridinyl]carbonyl]amino]6-met hyl-4,9-dioxo-8- (phenylmethyl)-l,5-dioxonan-7-yl 2-methylpropanoate (Registry Number 328256-72-0), and (b49.9e) /V-[[3-(l,3-benzodioxol-5-ylmethoxy)-4-methoxy-2-pyridinyl]c arbonyl]-0-[2,5- dideoxy-3-0-(2-methyl-l-oxopropyl)-2-(phenylmethyl)L-arabino noyl]-L-serine, (l 4')-lactone (Registry Number 1285706-70-8). Methods for preparing compounds of Formula b49.9 are described in PCT Patent Publications WO 99/40081, WO 2001/014339, WO 2003/035617 and WO 2011044213.

Component (b49. l0) relates to a compound of Formula b49. l0

wherein R b6 is H or F, and R b7 is -CF2CHFCF3 or -CF2CF2H. Examples of a compound of Formula b49. l0 are (b49. l0a) 3-(difluoromethyl)-A'-[4-fluoro-2-( l , 1 , 2,3,3, 3-hexafluoro- propoxy)phenyl]- l -methyl- 1 //-pyrazole-4-carboxamide (Registry Number 1172611-40-3) and (b49.10b) 3 -(difluoromethy 1)- 1 -methyl-A'- [2-( 1 , 1 ,2,2-tetrafluoroethoxy)pheny 1] - 1 //-pyrazole- 4-carboxamide (Registry Number 923953-98-4). Compounds of Formula 49.10 can be prepared by methods described in PCT Patent Publication WO 2007/017450.

Component b49.11 relates a compound of Formula b49.11 wherein

R b8 is halogen, C j -C 4 alkoxy or C2-C4 alkynyl;

R b9 is H, halogen or C j -C 4 alkyl;

R b l ° is C j -C j 2 alkyl, C j -C j 2 haloalkyl, C j — C j 2 alkoxy, C2-CJ2 alkoxyalkyl, C2-CJ2 alkenyl, C 2 -C j 2 alkynyl, C 4 -C 12 alkoxyalkenyl, C 4 -C 12 alkoxyalkynyl, C j -C 12 alkylthio or C 2 -C 12 alkylthioalkyl;

R b l 1 is methyl or -Y b l3 -R b12 ;

R b l2 is C r C 2 alkyl; and

Y bl3 is CH 2 , O or S.

Examples of compounds of Formula b49.11 include (b49. l la) 2-[(3-bromo-6-quinolinyl)oxy]-A'- (l,l-dimethyl-2-butyn-l-yl)-2-(methylthio)acetamide, (b49. l lb) 2[(3-ethynyl-6-quinolinyl)oxy]- N-[ 1 -(hydroxymethyl)- 1 -methyl-2-propyn- 1 -yl] -2-(methylthio)acetamide, (b49.11 c) N-( 1,1- dimethyl-2-butyn-l-yl)-2-[(3-ethynyl-6-quinolinyl)oxy]-2-(me thylthio)acetamide, (b49. l ld) 2- [(3-bromo-8-methyl-6-quinolinyl)oxy]-/V-(l,l-dimethyl-2-prop yn-l-yl)-2- (methylthio)acetamide and (b49. l le) 2-[(3-bromo-6-quinolinyl)oxy]-A'-( l , 1 -dimethylethyl)- butanamide. Compounds of Formula b49. l l, their use as fungicides and methods of preparation are generally known; see, for example, PCT Patent Publications WO 2004/047538, WO 2004/108663, WO 2006/058699, WO 2006/058700, WO 2008/110355, WO 2009/030469, WO 2009/049716 and WO 2009/087098.

Component 49.12 relates to /V-[4-[[3-[(4-chlorophenyl)methyl]-l,2,4-thiadiazol-5-yl]oxy ]- 2,5-dimethylphenyl]-A'-ethyl-A'-methylmethanimidamide, which is believed to inhibit C24- methyl transferase involved in the biosynthesis of sterols.

Component 49.13 relates to (FV)-2,2-bis(4-fluorophenyl)- l -methylethyl A'-[[3-(acetyloxy)- 4-methoxy-2-pyridinyl] carbonyl] -F-alaninate (Registry Number 1961312-55-9, common name florylpicoxamid), which is believed to be a Quinone inside inhibitor (Qil) fungicide (FRAC code 21) inhibiting the Complex III mitochondrial respiration in fungi.

Therefore of note is a mixture (i.e. composition) comprising a compound of Formula 1 and at least one fungicidal compound selected from the group consisting of the aforedescribed classes (1) through (49). Also of note is a composition comprising said mixture (in fungicidally effective amount) and further comprising at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. Of particular note is a mixture (i.e. composition) comprising a compound of Formula 1 and at least one fungicidal compound selected from the group of specific compounds listed above in connection with classes (1) through (49). Also of particular note is a composition comprising said mixture (in fungicidally effective amount) and further comprising at least one additional surfactant selected from the group consisting of surfactants, solid diluents and liquid diluents.

Examples of component (b) fungicides include acibenzolar-S-methyl, aldimorph, ametoctradin, amisulbrom, anilazine, azaconazole, azoxystrobin, benalaxyl (including benalaxyl- M), benodanil, benomyl, benthiavalicarb (including benthiavalicarb-isopropyl), benzovindiflupyr, bethoxazin, binapacryl, biphenyl, bitertanol, bixafen, blasticidin-S, boscalid, bromuconazole, bupirimate, buthiobate, captafol, captan, carbendazim, carboxin, carpropamid, chloroneb, chlorothalonil, chlozobnate, clotrimazole, copper hydroxide, copper oxychloride, copper sulfate, coumoxystrobin, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, dichlofluanid, diclocymet, diclomezine, dicloran, diethofencarb, difenoconazole, diflumetorim, dimethirimol, dimethomorph, dimoxystrobin, diniconazole (including diniconazole-M), dinocap, dithianon, dithiolanes, dodemorph, dodine, econazole, edifenphos, enoxastrobin (also known as enestroburin), epoxiconazole, etaconazole, ethaboxam, ethirimol, etridiazole, famoxadone, fenamidone, fenarimol, fenaminstrobin, fenbuconazole, fenfuram, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fenpyrazamine, fentin acetate, fentin chloride, fentin hydroxide, ferbam, ferimzone, flometoquin, florylpicoxamid, fluazinam, fludioxonil, flufenoxystrobin, fluindapyr, flumorph, fluopicolide, fluopyram, flouroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutianil, flutolanil, flutriafol, fluxapyroxad, folpet, fthalide, fuberidazole, furalaxyl, furametpyr, guazatine, hexaconazole, hymexazole, imazalil, imibenconazole, iminoctadine albesilate, iminoctadine triacetate, iodocarb, ipconazole, iprobenfos, iprodione, iprovabcarb, isoconazole, isofetamid, isoprothiolane, isoflucypram, isopyrazam, isotianil, kasugamycin, kresoxim-methyl, mancozeb, mandepropamid, mandestrobin, maneb, mepanipyrim, mepronil, meptyldinocap, metalaxyl (including metalaxyl- M/mefenoxam), mefentrifluconazole, metconazole, methasulfocarb, metiram, metominostrobin, metrafenone, miconazole, myclobutanil, naftifine, neo-asozin, nuarimol, octhilinone, ofurace, orysastrobin, oxadixyl, oxathiapiprolin, oxolinic acid, oxpoconazole, oxycarboxin, oxytetracycline, pefurazoate, penconazole, pencycuron, penflufen, penthiopyrad, phosphorous acid (including salts thereof, e.g., fosetyl-aluminum), picarbutrazox, picoxystrobin, piperalin, polyoxin, probenazole, prochloraz, procymidone, propamacarb, propiconazole, propineb, proquinazid, prothiocarb, prothioconazole, pyraclostrobin, pyrametostrobin, pyraoxystrobin, pyrazophos, pyribencarb, pyributicarb, pyrifenox, pyrimethanil, pyriofenone, pyrisoxazole, pyroquilon, pyrrolnitrin, quinconazole, quinomethionate, quinoxyfen, quintozene, sedaxane, silthiofam, simeconazole, spiroxamine, streptomycin, sulfur, tebuconazole, tebufloquin, teclofthalam, tecnazene, terbinafine, tetraconazole, thiabendazole, thifluzamide, thiophanate, thiophanate-methyl, thiram, tiadinil, tolclofos-methyl, tolnifanide, tolprocarb, tolyfluanid, triadimefon, triadimenol, triarimol, triticonazole, triazoxide, tribasic copper sulfate, tricyclazole, triclopyricarb, tridemorph, trifloxystrobin, triflumizole, triforine, trimorphamide, uniconazole, uniconazole-P, validamycin, valifenalate (also known as valiphenal), vinclozolin, zineb, ziram, zoxamide, (35 , ,65',7//,8//)-3-[[[3-[(acetyloxy)methoxy]-4-methoxy-2- pyridinyl]carbonyl]amino]- 6-methyl-4,9-dioxo-8-(phenylmethyl)-l,5-dioxonan-7-yl 2-methylpropanoate, (3S,6S,7R,SR)-3- [[[3-(acetyloxy)-4-methoxy-2-pyridinyl]carbonyl]amino]-6-met hyl-4,9-dioxo-8-(phenylmethyl)- 1 , 5-dioxonan-7-yl 2-methylpropanoate, N- [ [3 -( 1 , 3 -benzodioxol-5-ylmethoxy)-4-methoxy-2- pyridinyl]carbonyl]-0-[2,5-dideoxy-3-0-(2-methyl-l-oxopropyl )-2-(phenylmethyl)-L- arabinonoyl] -L-serine, ( 1 4')-lactone, N- [2-( 1 S,2R)-[ 1 , 1 '-bicyclopropyl] -2-y lpheny 1] -3 -

(difluoromethyl)-l -methyl- lif-pyrazole-4-carboxamide, 2-[(3-bromo-6-quinolinyl)oxy]-A'-( l , 1 - dimethyl-2-butyn-l-yl)-2-(methylthio)acetamide, 2-[(3-bromo-6-quinolinyl)oxy]-A'-( l , 1 - dimethylethyl)butanamide, 2-[(3-bromo-8-methyl-6-quinolinyl)oxy]-A'-( l , 1 -dimethyl-2-propyn- 1 -yl)-2-(methylthio)acetamide, 2-butoxy-6-iodo-3 -propy 1-477- 1 -benzopyran-4-one, 3 -butyn- 1 -y 1 A'-[6-[[[[( l -methyl- 1 //-tetrazol-5-yl)phenylmethylene]amino]oxy]methyl]-2-pyridin yl]- carbamate, a-( 1 -chlorocyclopropyl)-a-[2-(2,2-dichlorocyclopropyl)ethyl]- l H- 1 ,2,4-triazole- 1 - ethanol, 2-[2-(l-chlorocyclopropyl)-4-(2,2-dichlorocyclopropyl)-2-hyd roxybutyl]-l,2-dihydro- 3/7- l ,2,4-triazole-3-thione, (< .S')-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-4- isoxazolyl]-3-pyridinemethanol, re I- 1 -[[(2A,3A)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)-2- oxiranyl]methyl]- 177-1,2, 4-triazole, re/-2-[[(27?,3A)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)- 2-oxiranyl]methyl]- l ,2-dihydro-3//- 1 ,2,4-triazole-3-thione, rei- \ -[[(2A,3A)-3-(2-chlorophenyl)-

2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-5-(2-propen-l-y lthio)-l77-l, 2, 4-triazole, 3-[5-(4- chlorophenyl)-2,3-dimethyl-3-isoxazolidinyl]pyridine, (2-chloro-6-fluorophenyl)methyl 2-[l-[2- [3,5-bis(difluoromethyl)- l //-pyrazol- 1 -yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylate, 7V-[4- [[3-[(4-chlorophenyl)methyl]- l ,2,4-thiadiazol-5-yl]oxy]-2,5-dimethylphenyl]-A'-ethyl-A'-me thyl- methanimidamide, A'-[2-[4-[[3-(4-chlorophenyl)-2-propyn- l -yl]oxy]-3-methoxyphenyl]ethyl]-3- methyl-2- [(methy lsulfonyl)amino]butanamide, N- [2- [4- [ [3 -(4-chloropheny l)-2-propyn- 1 - yl]oxy]-3-methoxyphenyl]ethyl]-3-methyl-2-[(ethylsulfonyl)am ino]butanamide, /V-[4-[4-chloro-

3-(trifluoromethyl)phenoxy]-2,5-dimethylphenyl]-A'-ethyl- A'-methylmethanimidamide, N- cyclopropyl-3-(difluoromethyl)-5-fluoro- l -methyl -A'- [[2-( l -methylethyl)phenyl]methyl]- l H- pyrazole-4-carboxamide, A'-[[(cyclopropylmethoxy)amino][6-(difluoromethoxy)-2,3-difl uoro- phenyl]methylene]benzeneacetamide, A'-[2-(2,4-dichlorophenyl)-2-methoxy- l -methylethyl]-3- (difluoromethyl)-l -methyl- lif-pyrazole-4-carboxamide, A r -(3’,4'-difluoro[ 1 , 1 '-biphenyl]-2-yl)-3- (trifluoromethyl)-2-pyrazinecarboxamide, 3 -(difluoromethyl)-A'-(2, 3 -dihydro- 1 , 1 ,3-trimethyl- lif-inden-4-yl)-l -methyl- lif-pyrazole-4-carboxamide, 3-(difluoromethyl)-A'-[4-fluoro-2-

( 1 , 1 ,2, 3 ,3 , 3 -hexafluoropropoxy)pheny 1] - 1 -methyl- lif-pyrazole-4-carboxamide, 5,8-difluoro-A'- [2-[3-methoxy-4-[[4-(trifluoromethyl)-2-pyridinyl]oxy]phenyl ]ethyl]-4-quinazolinamine, 3- (difluoromethyl)- l -methyl-A'-[2-( l , 1 ,2,2-tetrafluoroethoxy)phenyl]- l //-pyrazole-4-carbox- amide, 1 - [4- [4- [5i?- [(2,6-difluorophenoxy)methyl] -4, 5 -dihydro-3 -isoxazolyl] -2-thiazolyl] - 1 - piperdinyl]-2-[5-methyl-3-(trifluoromethyl)-l //-pyrazol- 1 -yl]ethanone, A'-( l , 1 -dimethyl-2- butyn-l-yl)-2-[(3-ethynyl-6-quinolinyl)oxy]-2-(methylthio)ac etamide, 2,6-dimethyl- l H,5H- [l,4]dithiino[2,3-c:5,6-c']dipyrrole-l,3,5,7(2if,6i/)-tetron e, 2-[(3-ethynyl-6-quinolinyl)oxy]- N- [ 1 -(hydroxymethyl)- 1 -methy l-2-propyn- 1 -yl] -2-(methylthio)acetamide, 4-fluorophenyl A'-[ l - [[[l-(4-cyanophenyl)ethyl]sulfonyl]methyl]propyl]carbamate, 5-fluoro-2-[(4-fluorophenyl)- methoxy]-4-pyrimidinamine, 5-fluoro-2-[(4-methylphenyl)methoxy]-4-pyrimidinamine,

(3A,6A,7A,8A)-3-[[[4-methoxy-3-[[(2-methylpropoxy)carbony l]oxy]-2-pyridinyl] carbonyl]- amino]-6-methyl-4,9-dioxo-8-(phenylmethyl)-l,5-dioxonan-7-yl -2-methylpropanoate, a-(methoxyimino)-A'-methyl-2-[[[ l -[3-(trifluoromethyl)phenyl]ethoxy]imino]methyl]benzene- acetamide, [[4-methoxy-2-[[[(3A,7A,8A,9A)-9-methyl-8-(2-methyl- l -oxopropoxy)-2,6-dioxo-7- (phenylmethyl)-l,5-dioxonan-3-yl]amino]carbonyl]-3-pyridinyl ]oxy]methyl 2-methylpropan- oate, pentyl A'-[6-[[[[( l -methyl- 1 //-tetrazol-5-yl)phenylmethylene]amino]oxy]methyl]-2- pyridinyl] carbamate, pentyl A'-[4-[[[[( l -methyl- 1 //-tetrazol-5-yl)phenylmethylene]amino]- oxy]methyl]-2-thiazolyl]carbamate, and pentyl A'-[6-[[[[(Z)-( l -methyl- 1 //-tetrazol-5-yl)phenyl- methylene]amino]oxy]methyl]-2-pyridinyl]carbamate and ( 1 R)- 1 ,2,3 ,4-tetrahydro- 1 -naphtha- lenyl 2-[ 1 -[2-[3,5-bis(difluoromethyl)- l //-pyrazol- 1 -yl]acetyl]-4-piperidinyl]-4-thiazolecarboxy- late. Therefore of note is a fungicidal composition comprising as component (a) a compound of Formula 1 (or an N- oxide or salt thereof) and as component (b) at least one fungicide selected from the preceding list.

Of particular note are combinations of compounds of Formula 1 (or an A'-oxide or salt thereof) (i.e. Component (a) in compositions) with azoxystrobin, benzovindiflupyr, bixafen, captan, carpropamid, chlorothalonil, copper hydroxide, copper oxychloride, copper sulfate, cymoxanil, cyproconazole, cyprodinil, diethofencarb, difenoconazole, dimethomorph, epoxiconazole, ethaboxam, fenarimol, fenhexamid, fluazinam, fludioxonil, fluindapyr, fluopyram, flusilazole, flutianil, flutriafol, fluxapyroxad, folpet, iprodione, isofetamid, isoflucypram, isopyrazam, kresoxim-methyl, mancozeb, mandestrobin, meptyldinocap, metalaxyl (including metalaxyl-M/mefenoxam), mefentrifluconazole, metconazole, metrafenone, myclobutanil, oxathiapiprobn, penflufen, penthiopyrad, phosphorous acid (including salts thereof, e.g., fosetyl-aluminum), picoxystrobin, propiconazole, proquinazid, prothioconazole, pyraclostrobin, pyrimethanil, sedaxane spiroxamine, sulfur, tebuconazole, thiophanate-methyl, trifloxystrobin, zoxamide, a-( 1 -chlorocyclopropyl)-a-[2-(2,2-dichlorocyclopropyl)ethyl]- l H- 1,2, 4-triazole- 1 -ethanol, 2-[2-(l-chlorocyclopropyl)-4-(2,2-dichlorocyclopropyl)-2- hydroxybutyl]- 1 ,2-dihydro-3//- 1 ,2,4-triazole-3-thione, A'-[2-(2,4-dichlorophenyl)-2-methoxy- l - methylethy 1] -3 -(difluoromethyl)-l -methyl- liF-pyrazole-4-carboxamide, 3-(difluoromethyl)-A'-

(2, 3-dihydro-l, 1, 3-trimethyl- l//-inden-4-yl)-l -methyl- l//-pyrazole-4-carboxamide, 1 -[4-[4-[5A- (2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]- l-piperidinyl]-2-[5-methyl-3- (trifluoromethyl )- 1 //-pyrazol- 1 -yl] ethanone, 1 , 1 -dimethylethyl A'-[6-[[[[( l -methyl- 1 //-tetrazol- 5-yl)phenylmethylene]amino]oxy]methyl]-2-pyridinyl]carbamate , 2,6-dimethyl- l H,5H-[ \ ,4]di- thiino[2,3-c:5,6-c']dipyrrole-l,3,5,7(2iF,6i/)-tetrone, 5-fluoro-2-[(4-fluorophenyl)methoxy]-4- pyrimidinamine, 5-fluoro-2-[(4-methylphenyl)methoxy]-4-pyrimidinamine, (aA)-[3-(4-chloro-2- fluorophenyl)-5-(2,4-difluorophenyl)-4-isoxazolyl]-3-pyridin emethanol, re l- 1 -[[(2A,3L -3-(2- chlorophenyl)-2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-li7- l, 2, 4-triazole, re l-2-\[(2R,3 S)-3-

(2-chlorophenyl)-2-(2,4-difluorophenyl)-2-oxiranyl]methyl ]- l ,2-dihydro-3//- 1 ,2,4-triazole-3- thione, and ret- 1 -[[(2//,35')-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)-2-oxi ranyl]methyl]-5-(2- propen-l -ylthio)-lif-l, 2, 4-triazole (i.e. as Component (b) in compositons).

Examples of other biologically active compounds or agents with which compounds of this invention can be formulated are: invertebrate pest control compounds or agents such as abamectin, acephate, acetamiprid, acrinathrin, afidopyropen

([(3<S , ,4i?,4ai?,6<S',6aS', 12i?, 12aS', 12b-S)-3 -[(cyclopropylcarbonyl)oxy] - 1 ,3,4,4a, 5,6,6a, 12, 12a, 12b- decahydro-6, 12-dihydroxy-4, 6a, 12b-trimethyl- 11 -oxo-9-(3 -pyridiny l)-2if, 1 1 //-naphtho[2, 1 - Z>]pyrano[3,4-e]pyran-4-yl]methyl cyclopropanecarboxylate), amidoflumet (S-1955), avermectin, azadirachtin, azinphos-methyl, bifenthrin, bifenazate, buprofezin, carbofuran, cartap, chlorantraniliprole, chlorfenapyr, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl, chromafenozide, clothianidin, cyantraniliprole (3-bromo- 1 -(3-chloro-2-pyridinyl)-A'-[4-cyano-2- methyl-6-[(methylamino)carbonyl]phenyl]- l //-pyrazole-5-carboxamide), cyclaniliprole (3- bromo-L'- [2-bromo-4-chloro-6- [ [( 1 -cyclopropylethy l)amino] carbonyl] phenyl] - 1 -(3 -chloro-2- pyridinyl)-! //-pyrazole-5-carboxamide), cycloxaprid ((5A,8A)- 1 -[(6-chloro-3-pyridinyl)methyl]- 2,3,5,6,7,8-hexahydro-9-nitro-5,8-epoxy-li7-imidazo[l ,2-a]azepine), cyflumetofen, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, dieldrin, diflubenzuron, dimefluthrin, dimethoate, dinotefuran, diofenolan, emamectin, endosulfan, esfenvalerate, ethiprole, fenothiocarb, fenoxycarb, fenpropathrin, fenvalerate, fipronil, flonicamid, flubendiamide, flucythrinate, flufenoxystrobin

(methyl (a/i)-2-[[2-chloro-4-(trifluoromethyl)phenoxy]methyl]-a-(met hoxymethylene)benzene- acetate), fluensulfone (5-chloro-2-[(3,4,4-trifluoro-3-buten-l -yl)sulfonyl]thiazole), flupiprole (1 - [2, 6-dichloro-4-(trifluoromethyl)pheny 1] - 5- [(2-methyl-2-propen- 1 -y l)amino] -4- [(trifluoro- methyl)sulfinyl]- l //-pyrazole-3-carbonitrile), flupyradifurone (4-[[(6-chloro-3-pyridinyl)- methyl](2,2-difluoroethyl)amino]-2(5//)-furanone), tau-fluvalinate, flufenerim (UR-50701), flufenoxuron, fonophos, halofenozide, heptafluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)- phenyl]methyl 2,2-dimethyl-3-[(lZ)-3,3,3-trifluoro-l -propen-l-yl]cyclopropanecarboxylate), hexaflumuron, hydramethylnon, imidacloprid, indoxacarb, isofenphos, lufenuron, malathion, meperfluthrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl ( 1 A,36')-3-(2,2-dichloro- ethenyl)-2,2-dimethylcyclopropanecarboxylate), metaflumizone, metaldehyde, methamidophos, methidathion, methomyl, methoprene, methoxychlor, methoxyfenozide, metofluthrin, milbemycin oxime, momfluorothrin ([2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl-3-(2- cyano-l -propen- 1 -yl)-2,2-dimethylcy cl opropanecarboxylate), monocrotophos, nicotine, nitenpyram, nithiazine, novaluron, noviflumuron (XDE-007), oxamyl, pyflubumide (1,3,5- trimethyl-A'-(2-methyl- l -oxopropyl)-A'-[3-(2-methylpropyl)-4-[2,2,2-trifluoro- l -methoxy- 1 - (trifluoromethyl)ethyl]phenyl] - lif-pyrazole-4-carboxamide), parathion, parathi on-methyl, permethrin, phorate, phosalone, phosmet, phosphamidon, pirimicarb, profenofos, profluthrin, pymetrozine, pyrafluprole, pyrethrin, pyridalyl, pyrifluquinazon, pyriminostrobin (methyl (a E)- 2-[[[2-[(2,4-dichlorophenyl)amino]-6-(trifluoromethyl)-4-pyr imidinyl]oxy]methyl]-a-(methoxy- methylene)benzeneacetate), pyriprole, pyriproxyfen, rotenone, ryanodine, spinetoram, spinosad, spirodiclofen, spiromesifen (BSN 2060), spirotetramat, sulfoxaflor, sulprofos, tebufenozide, teflubenzuron, tefluthrin, terbufos, tetrachlorvinphos, tetramethylfluthrin, thiacloprid, thiamethoxam, thiodicarb, thiosultap-sodium, tolfenpyrad, tralomethrin, triazamate, trichlorfon and triflumuron; and biological agents including entomopathogenic bacteria, such as Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, and the encapsulated delta- endotoxins of Bacillus thuringiensis (e.g., Cellcap, MPV, MPVII); entomopathogenic fungi, such as green muscardine fungus; and entomopathogenic virus including baculovirus, nucleopolyhedro virus (NPV) such as HzNPV, AfNPV; and granulosis virus (GV) such as CpGV.

Compounds of this invention and compositions thereof can be applied to plants genetically transformed to express proteins toxic to invertebrate pests (such as Bacillus thuringiensis delta- endotoxins). The effect of the exogenously applied fungicidal compounds of this invention may provide an enhanced effect with the expressed toxin proteins.

General references for agricultural protectants (i.e. insecticides, fungicides, nematocides, acaricides, herbicides and biological agents) include The Pesticide Manual, 13th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, EG.K., 2003 and The BioPesticide Manual, 2nd Edition, L. G. Copping, Ed., British Crop Protection Council, Farnham, Surrey, U.K., 200l.

For embodiments where one or more of these various mixing partners are used, the weight ratio of these various mixing partners (in total) to the compound of Formula 1 is typically between about 1 :3000 and about 3000: 1. Of note are weight ratios between about 1 :300 and about 300: 1 (for example ratios between about 1 :30 and about 30: 1). One skilled in the art can easily determine through simple experimentation the biologically effective amounts of active ingredients necessary for the desired spectrum of biological activity. It will be evident that including these additional components may expand the spectrum of diseases controlled beyond the spectrum controlled by the compound of Formula 1 alone.

In certain instances, combinations of a compound of this invention with other biologically active (particularly fungicidal) compounds or agents (i.e. active ingredients) can result in a greater-than-additive (i.e. enhanced) effect. Reducing the quantity of active ingredients released in the environment while ensuring effective pest control is always desirable. When an enhanced effect of fungicidal active ingredients occurs at application rates giving agronomically satisfactory levels of fungal control, such combinations can be advantageous for reducing crop production cost and decreasing environmental load.

Also in certain instances, combinations of a compound of the invention with other biologically active compounds or agents can result in a less-than-additive (i.e. safening) effect on organisms beneficial to the agronomic environment. For example, a compound of the invention may safen a herbicide on crop plants or protect a beneficial insect species (e.g., insect predators, pollinators such as bees) from an insecticide.

Fungicides of note for formulation with compounds of Formula 1 to provide mixtures useful in seed treatment include but are not limited to amisulbrom, azoxystrobin, boscalid, carbendazim, carboxin, cymoxanil, cyproconazole, difenoconazole, dimethomorph, florylpicoxamid, fluazinam, fludioxonil, flufenoxystrobin, fluquinconazole, fluopicolide, fluoxastrobin, flutriafol, fluxapyroxad, ipconazole, iprodione, metalaxyl, mefenoxam, mefentrifluconazole, metconazole, myclobutanil, paclobutrazole, penflufen, picoxystrobin, prothioconazole, pyraclostrobin, sedaxane, silthiofam, tebuconazole, thiabendazole, thiophanate-methyl, thiram, trifloxystrobin and triticonazole.

Invertebrate pest control compounds or agents with which compounds of Formula 1 can be formulated to provide mixtures useful in seed treatment include but are not limited to abamectin, acetamiprid, acrinathrin, afidopyropen, amitraz, avermectin, azadirachtin, bensultap, bifenthrin, buprofezin, cadusafos, carbaryl, carbofuran, cartap, chlorantranibprole, chlorfenapyr, chlorpyrifos, clothianidin, cyantraniliprole, cyclanibprole, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, cypermethrin, alpha-cypermethrin, zeta- cypermethrin, cyromazine, deltamethrin, dieldrin, dinotefuran, diofenolan, emamectin, endosulfan, esfenvalerate, ethiprole, etofenprox, etoxazole, fenothiocarb, fenoxycarb, fenvalerate, fipronil, flonicamid, flubendiamide, fluensulfone, flufenoxuron, flufiprole, flupyradifurone, fluvalinate, formetanate, fosthiazate, heptafluthrin, hexaflumuron, hydramethylnon, imidacloprid, indoxacarb, lufenuron, meperfluthrin, metaflumizone, methiocarb, methomyl, methoprene, methoxyfenozide, momfluorothrin, nitenpyram, nithiazine, novaluron, oxamyl, pyflubumide, pymetrozine, pyrethrin, pyridaben, pyriminostrobin, pyridalyl, pyriproxyfen, ryanodine, spinetoram, spinosad, spirodiclofen, spiromesifen, spirotetramat, sulfoxaflor, tebufenozide, tetramethrin, tetramethylfluthrin, thiacloprid, thiamethoxam, thiodicarb, thiosultap-sodium, tralomethrin, triazamate, triflumuron, Bacillus thuringiensis delta-endotoxins, strains of Bacillus thuringiensis and strains of Nucleo polyhydrosis viruses.

Compositions comprising compounds of Formula 1 useful for seed treatment can further comprise bacteria and fungi that have the ability to provide protection from the harmful effects of plant pathogenic fungi or bacteria and/or soil born animals such as nematodes. Bacteria exhibiting nematicidal properties may include but are not limited to Bacillus firmus, Bacillus cereus, Bacillius subtiliis and Pasteuria penetrans. A suitable Bacillus firmus strain is strain CNCM I- 1582 (GB-126) which is commercially available as BioNem™. A suitable Bacillus cereus strain is strain NCMM 1-1592. Both Bacillus strains are disclosed in US 6,406,690. Other suitable bacteria exhibiting nematicidal activity are B. amyloliquefaciens IN937a and B. subtilis strain GB03. Bacteria exhibiting fungicidal properties may include but are not limited to B. pumilus strain GB34. Fungal species exhibiting nematicidal properties may include but are not limited to Myrothecium verrucaria, Paecilomyces lilacinus and Purpureocillium lilacinum.

Seed treatments can also include one or more nematicidal agents of natural origin such as the elicitor protein called harpin which is isolated from certain bacterial plant pathogens such as Erwinia amylovora. An example is the Harpin-N-Tek seed treatment technology available as N- Hibit™ Gold CST.

Seed treatments can also include one or more species of legume-root nodulating bacteria such as the microsymbiotic nitrogen-fixing bacteria Bradyrhizobium japonicum. These inocculants can optionally include one or more lipo-chitooligosaccharides (LCOs), which are nodulation (Nod) factors produced by rhizobia bacteria during the initiation of nodule formation on the roots of legumes. For example, the Optimize® brand seed treatment technology incorporates LCO Promoter Technology™ in combination with an inocculant.

Seed treatments can also include one or more isoflavones which can increase the level of root colonization by mycorrhizal fungi. Mycorrhizal fungi improve plant growth by enhancing the root uptake of nutrients such as water, sulfates, nitrates, phosphates and metals. Examples of isoflavones include, but are not limited to, genistein, biochanin A, formononetin, daidzein, glycitein, hesperetin, naringenin and pratensein. Formononetin is available as an active ingredient in mycorrhizal inocculant products such as PHC Colonize® AG.

Seed treatments can also include one or more plant activators that induce systemic acquired resistance in plants following contact by a pathogen. An example of a plant activator which induces such protective mechanisms is acibenzolarX'-methyl.

The following TESTS demonstrate the control efficacy of compounds of this invention on specific pathogens. The pathogen control protection afforded by the compounds is not limited, however, to these species. See Index Tables A through L below for compound descriptions. The following abbreviations are used in the Index Tables: Me means methyl, Et means ethyl, «- Pr means «-propyl, /-Pr means Ao-propyl, c-Pr means cyclopropyl, «-Bu means «-butyl, /-Bu means Aobutyl, c-Bu means cyclobutyl, ohexyl means cyclohexyl, Ph means phenyl, MeO means methoxy and EtO means ethoxy. The abbreviation“Cmpd. No.” stands for“Compound Number”, and the abbreviation“Ex.” stands for“Example” and is followed by a number indicating in which example the compound is prepared. The abbreviation“m.p.” stands for melting point. The numerical value reported in the column“MS” is the molecular weight of the highest isotopic abundance positively charged parent ion (M+l) formed by addition of H + (molecular weight of 1) to the molecule having the highest isotopic abundance, or the highest isotopic abundance negatively charged ion (M-l) formed by loss of H + (molecular weight of 1). The presence of molecular ions containing one or more higher atomic weight isotopes of lower abundance (e.g., 37 Cl, 81 Br) is not reported. The reported MS peaks were observed by mass spectrometry using electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI).

INDEX TABLE A

Cmpd. No. R 13 L A NMR MS

1 (Ex. 1) EtOC(=0) CH 2 OCH 2 *

5 EtOC(=0) CH 2 OCH(Me) *

35 EtOC(=0) CH(Me) OCH 2 *

36 c-PrCH 2 NHC(=0) CH 2 OCH 2 * 400 (M+l)

37 MeOC(=0) CH 2 OCH 2 * 361 (M+l)

38 CH 2 =CHCF 2 0C(=0) CH 2 OCH 2 423 (M+l)

39 7-Pr0C(=0) CH 2 OCH 2 * 389 (M+l)

40 CH 2 =C(Me)CH 2 0C(=0) CH 2 OCH 2 * 401 (M+l)

42 «-PrOC(=0) CH 2 OCH 2 * 389 (M+l)

43 CH 2 =CHCH 2 0C(=0) CH 2 OCH 2 * 387 (M+l)

44 HCºCCH 2 0C(=0) CH 2 OCH 2 * 385 (M+l)

45 CF 3 CH 2 0C(=0) CH 2 OCH 2 * 429 (M+l)

46 CF 3 CF 2 CH 2 0C(=0) CH 2 OCH 2 * 479 (M+l)

47 PhCH 2 0C(=0) CH 2 OCH 2 * 437 (M+l)

48 CH 3 (CH 2 ) 5 0C(=0) CH 2 OCH 2 * 431 (M+l)

49 3 ,4 -di-Cl-PhCH 2 OC(=0) CH 2 OCH 2 * 505 (M+l)

50 3 ,4 -di-F -PhCH 2 0C(=0) CH 2 OCH 2 * 473 (M+l)

51 Et0C(=0) CH 2 CH(OH)CH 2 *

66 Et0C(=0) CH 2 CH 2 CH 2 * 355 (M+l) 131 Et0C(=0) CH 2 CH 2 OCH 2 *

206 NºC CH 2 OCH 2 *

227 Et0C(=0) CH 2 OCF 2 *

286 Et0C(=0) (CH 2 ) 3 OCH 2 * 403 (M+l)

322 Br CH 2 OCH 2 * 383 (M+l) Cmpd. No. R 13 L A NMR MS

329 H0C(=0) CH 2 OCH 2 * 327 (M-1)

*See Index Table data.

INDEX TABLE Al

Cmpd. No. MS m.p. (°C) 68 CF 3 CH 2 NHC(=0) CH 2 OCH 2 445 (M+l) 116-120

69 c-PrCH 2 NHC(=0) CH 2 OCH 2 417 (M+l)

135 CH 2 OCH 2 453 (M+l)

136 EtOC(=0) CH 2 OCH 2 392 (M+l)

215 OCH 2 403 (M+l) 140-144

2

223 Me0CH 2 CH 2 NHC(=0) CH 2 OCH 2 421 (M+l)

INDEX TABLE B

A dash in the L column means that L is a direct bond.

m.p.

Cmpd. No. E L A NMR MS (°C) 105-109

29 CH 3 CH 2 S(=0) 2 CH 2 OCH 2

30 1-indolyl CH 2 CH 2 CH 2 332 (M+l) m.p.

Cmpd. No. (°C) 31 102-106

33 MeOC(=0)NHN=CH OCH 2 140-145

34 Me 2 NS(=0) 2 OCH 2 142-146 41 3-(Me 2 NC(=0))-4,5-dihydro-5-isoxazolyl OCH 2

80 CH 3 C(=0) OCH 2

97 EtOC(=0)CH=CHCH 2 0 OCH 2

142 NºC OCH 2

177 HC(=0) OCH 2

229 MeOC(=0) OCH 2 279 (M-l)

233 3 -(EtOC(=0))- l //-pyrazol- 1 -y 1 CH 2 OCH 2

234 5 -(EtOC(=0))- 1 //-pyrazol- 1 -y 1 CH 2 OCH 2

247 5-(c-PrCH 2 NHC(=0))-2-oxazolyl CH 2 OCH 2 401 (M+l)

256 5-(c-PrCH 2 NHC(=0))-2-thiazolyl CH 2 OCH 2 417 (M+l) 126-130 274 5 -(CF 3 CH 2 NHC(=0))-2-oxazolyl CH 2 OCH 2 429 (M+l) 75-79 277 5 -(CF 3 CH 2 NHC(=0))-2 -thiazoly 1 CH 2 OCH 2 445 (M+l) 110-114 280 NO 2 OCH 2

295 5-(F 2 CHCH 2 NHC(=0))-2-thiazolyl CH 2 OCH 2 427 (M+l)

366 (Ex. 8) 4-(EtOC(=0))- 1/7-pyrazol- 1 -y 1-CH 2 0 OCH 2

*See Index Table data.

**See Index Table N for Iff NMR data.

INDEX TABLE C

Cmpd. No. R13 M NMR MS

3 n-PrOC(=0) CH OCHi CH 415 (M+l) Cmpd. No. R 13 L A M NMR MS 4 EtOC(=0) CH 2 OCH 2 C(=0) * 415 (M+l) 6 EtOC(=0) CH 2 OCH(Me) CH 2 *

7 [Note 1] EtOC(=0) CH 2 OCH 2 CH(Me) *

8 [Note 2] EtOC(=0) CH 2 OCH 2 CH(Me) *

12 (Ex. 3) EtOC(=0) CH 2 OCH 2 C(Me) 2 *

13 MeOC(=0) CH 2 OCH 2 CH 2 * 387 (M+l)

14 7-Pr0C(=0) CH 2 OCH 2 CH 2 * 415 (M+l)

15 HCºCCH 2 0C(=0) CH 2 OCH 2 CH 2 * 411 (M+l)

16 CH 3 (CH 2 ) 5 0C(=0) CH 2 OCH 2 CH 2 * 457 (M+l)

17 3 ,4 -di-Cl-PhCH 2 OC(=0) CH 2 OCH 2 CH 2 * 531 (M+l)

18 3 ,4 -di-F -PhCH 2 0C(=0) CH 2 OCH 2 CH 2 * 499 (M+l) 26 EtOC(=0) CH(CH 3 ) OCH 2 CH 2 * 413 (M-l)

32 (Ex. 2)

EtOC(=0) CH 2 OCH 2 CH 2 *

and (Ex. 4)

67 EtOC(=0) CH 2 CH 2 CH 2 CH 2 * 397 (M-l)

93 H0C(=0) CH 2 OCH 2 CH 2 *

115 EtOC(=0) CH 2 SCH 2 CH 2 417 (M+l)

125 T?-BUOC(=0) CH 2 OCH 2 CH 2 429 (M+l)

126 7-BU0C(=0) CH 2 OCH 2 CH 2 * 429 (M+l) 127 c-PrCH 2 0C(=0) CH 2 OCH 2 CH 2 * 427 (M+l)

133 EtOC(=0) CH 2 CH 2 OCH 2 CH 2 *

134 CF 3 CH 2 0C(=0) CH 2 OCH 2 CH 2 * 453 (M-l) 141 EtOC(=0) CH 2 CH 2 OCH 2 CH 2 *

161 C1(CH 2 ) 3 0C(=0) CH 2 OCH 2 CH 2 * 449 (M+l) 162 Me0CH 2 CH 2 0C(=0) CH 2 OCH 2 CH 2 * 431 (M+l)

163 CH 3 CºCCH 2 0C(=0) CH 2 OCH 2 CH 2 * 425 (M+l)

164 NºCCH 2 NHC(=0) CH 2 OCH 2 CH 2 * 411 (M+l) Cmpd. No. R 1 L A M NMR MS

169 CH 3 C(=0)CH 2 0C(=0) CH 2 OCH 2 c¾ 429 (M+l)

P0 PhC(=0)CH 2 0C(=0) CH 2 OCH 2 CH 2 * 491 (M+l)

171 NºC(CH 2 ) 3 0C(=0) CH 2 OCH 2 CH 2 * 440 (M+l)

172 NºCCH 2 0C(=0) CH 2 OCH 2 CH 2 *

188 CH 2 =CHCH 2 0C(=0) CH 2 OCH 2 CH 2 413 (M+l)

197 CF 3 CH 2 NHC(=0) CH 2 OCH 2 CH 2 * 454 (M+l)

198 Me 2 NC(=0) CH 2 OCH 2 CH 2 * 400 (M+l)

199 2-pyridyl-CH 2 0C(=0) CH 2 OCH 2 CH 2 * 464 (M+l)

200 3 -pyridyl-CH 2 0C(=0) CH 2 OCH 2 CH 2 * 464 (M+l)

201 4-pyridyl-CH 2 0C(=0) CH 2 OCH 2 CH 2 * 464 (M+l)

202 c-hexyl-C(=0)CH 2 0C(=0) CH 2 OCH 2 CH 2 * 497 (M+l)

203 Me0C(=0)CH 2 0C(=0) CH 2 OCH 2 CH 2 * 445 (M+l)

204 l,3-dioxolan-2-yl-CH 2 OC(=0) C¾ OCH 2 CH 2 * 459 (M+l)

209 NºC CH 2 OCH 2 CH 2 *

228 CH 2 =C(CH 3 )CH 2 0C(=0) C¾ OCH 2 CH 2 * 427 (M+l)

240 EtOCH 2 CH 2 OCH 2 CH 2 * 387 (M+l)

249 C-BUCH 2 0C(=0) CH 2 OCH 2 CH 2 * 441 (M+l)

272 c-hexyl-CH 2 0C(=0) CH 2 OCH 2 CH 2 * 469 (M+l)

284 c-pentyl-CH 2 0C(=0) CH 2 OCH 2 CH 2 * 455 (M+l)85 [Note 4] CH 3 CH=CHCH 2 0C(=0) C¾ OCH 2 CH 2 * 427 (M+l)

296 Et0C(=0) (CH 2 ) 3 OCH 2 CH 2 * 429 (M+l)

318 c-Bu0C(=0) CH 2 OCH 2 CH 2 * 427 (M+l)

319 Et0C(=0) CH 2 OCF 2 CH 2 * 437 (M+l)

*See Index Table data.

Note 1 : 87:13 mixture of diastereomers.

Note 2: 33 :67 mixture of diastereomers.

Note 4: 60:40 mixture of cis-trans isomers.

Cmpd. No

*See Index Table data.

A dash ” in the L column means that L is a direct bond.

Cmpd. No. E L A NMR MS 22 3-(Me2NC(=0))-4,5-dihydro-5-isoxazolyl OCH 2

23 CH 3 CH 2 S(=0) 2 CH 2 OCH 2

24 CH 3 S(=0) 2 OCH 2

25 (Me) 2 NS(=0) 2 OCH 2

27 MeOC(=0)NHN=CH OCH 2

76 /-BUS(=0) 2 NH CH 2 OCH 2 396 (M-l)

77 c-hexyl-NHC(=S)NH CH 2 OCH 2 419 (M+l)

78 EtOC(=0)NH CH 2 OCH 2 350 (M+l) 98 NºC OCH 2 274 (M+l) 112 7-BU0C(=0)NH CH 2 OCH 2

160 5-(EtOC(=0)-l-indazolyl CH 2 OCH 2

166 NO 2 OCH 2

173 5-(CF 3 )- 1 ,2,4-oxadiazol-3 -y 1 OCH 2 385 (M+l)

174 NH 2 CH 2 OCH 2

175 7-PrC(=0)NH CH 2 OCH 2 348 (M+l)

176 c-PrC(=0)NH CH 2 OCH 2

178 OH CH 2 OCH 2 301 (M+23)

179 3 -CF 3 -PhC(=0)NH CH 2 OCH 2

189 MeOC(=0) OCH 2 307 (M+l) Cmpd. No. E L A NMR MS

190 Ph OC¾

191 PhO OCH 2

192 Ph CH 2 OCH 2

207 CF 3 S(=0) 2 NH CH 2 OCH 2 408 (M-l) 212 CF 3 CH 2 C(=0)NH CH 2 OCH 2 388 (M+l) 214 MeOCH(CH 3 )C(=0)NH CH 2 OCH 2

232 3-(Et0C(=0))- l //-pyrazol- l -yl CH 2 OCH 2

235 /-PrC(=0)N(0Me) CH 2 OCH 2

236 c-PrC(=0)N(0Me) CH 2 OCH 2

237 n -PrC(=0)N (OMe) CH 2 OCH 2

238 f-BuOC(=0)N(OMe) CH 2 OCH 2 430 (M+23)

239 NºC CH 2 OCH 2

281 2-(MeS)-4-pyrimidinyl CH 2 OCH 2 387 (M+l) 282 2-(MeS(=0) 2 )-4-pyrimidinyl CH 2 OCH 2 419 (M+l) 283 2-(F 2 CHCH 2 0)-4-pyrimidinyl CH 2 OCH 2 421 (M+l)

289 CH 2 OCH 2 *

290 CH 2 OCH 2

314 CH 2 OCH 2 457 (M+l)

*See Index Table data.

INDEX TABLE El

Cmpd. No. A MS m.p. (°C)

70 4-(CF 3 CH 2 NHC(=0)) S CH 2 OCH 2 471 (M+l)

71 4-(c-PrCH 2 NHC(=0)) S CH 2 OCH 2 443 (M+l) 88-92 137 4-(Et0C(=0)) S C¾ OCH 2 418 (M+l) 74-78 248 5-(c-PrCH 2 NHC(=0)) O CH 2 OCH 2 427 (M+l)

257 5-(CF 3 CH 2 NHC(=0)) O CH 2 OCH 2 455 (M+l) 99-103 259 5-(c-PrCH 2 NHC(=0)) S CH 2 OCH 2 443 (M+l) 117-121 275 5-(CF 3 CH 2 NHC(=0)) S CH 2 OCH 2 471(M+1)

*See Index Table M for ^F NMR data.

INDEX TABLE F

A dash in the colunui means no substituent is present and the remaining carbon valence is occupied by a hydrogen atom. A dash in the L column means that L is a direct bond. Unless otherwise indicated, the configuration of substituents about that double bond in the above structure are as shown.

Cmpd. No.

53

54 Et0C(=0) CH 2 O CH 2 CH 2 OMe *

55 Et0C(=0) CH 2 O CH 2 CH=CH 2 *

56 Et0C(=0) CH 2 O CH 2 CºCH *

57 Et0C(=0) CH 2 O CH(CH 3 ) 2 * MS m.p.

Cmpd. No. Rl3 L A R 2C NMR (M+l) (°C)

64 (Ex. 5) EtOC(=0) ~ CH 2 O ~ CH 2 CH 3 58-59 65 EtOC(=0) CH 2 O CH 2 CH 2 CH 3

89 i-BuOC(=0) CH 2 O CH 2 CH 3

106 CF 3 CH 2 NHC(=0) CH 2 O CH 2 CH 3 109-113 107 NºCCH 2 NHC(=0) CH 2 O CH 2 CH 3 114-118 116 H0C(=0) CH 2 O CH 2 CH 3 127-131

117 c-PrCH 2 NHC(=0) CH 2 O CH 2 CH 3 106-110

118 /-PrNHC(=0) CH 2 O CH 2 CH 3 114-118 132 EtOC(=0) (CH 2 ) 2 O CH 2 CH 3

138 MeOC(=0) CH 2 O CH 2 CH 3 105-109

139 7-Pr0C(=0) CH 2 O CH 2 CH 3 399

140 EtOC(=0) CH 2 CH 2 CH 2 CH 3

145 EtOC(=0) CH 2 O CH 2 CH 2 OH

151 CH 2 O CH 2 CH 3

167 EtOC(=0) CH 2 CH 2 O CH 2 CH 3

180 Cl CH 2 O CH 2 CH 3

182 CF 3 CH 2 O CH 2 CH 3

183 Br CH 2 O CH 2 CH 3

185 CHºCCH 2 0C(=0) CH 2 O CH 2 CH 3 69-73

186 PhCH 2 0C(=0) CH 2 O CH 2 CH 3 63-67 205 NºC CH 2 O CH 2 CH 3

216 MeC(=0)CH 2 0C(=0) CH 2 O CH 2 CH 3 64-68

217 «-Pr0C(=0) CH 2 O CH 2 CH 3 399

218 T?-BU0C(=0) CH 2 O CH 2 CH 3 413

219 7-BU0C(=0) CH 2 O CH 2 CH 3 413

220 c-PrCH 2 0C(=0) CH 2 O CH 2 CH 3 411 MS rn.p.

Cmpd. No. R 1 L A R2C NMR (M+l) (°C)

221 C1(CH 2 ) 3 0C(=0) CH 2 O CH 2 CH 3 433

222 Me0CH 2 CH 2 0C(=0) CH 2 O CH 2 CH 3 79-83

242 CH 2 =C(Me)CH 2 0C(=0) CH 2 O CH 2 CH 3 411

243 CH 3 CºCCH 2 0C(=0) CH 2 o CH 2 CH 3 105-109

244 PhC(=0)CH 2 0C(=0) CH 2 o CH 2 CH 3 114-118

245 NºCCH 2 CH 2 0C(=0) CH 2 o CH 2 CH 3 81-85

246 CH 2 =CHCH 2 0C(=0) CH 2 o CH 2 CH 3 397

267 EtOC(=0) CH(Me) o CH 2 CH 3

294 4-(Et0C(=0)) (CH 2 ) 3 o CH 2 CH 3 413

298 EtOC(=0) CH 2 o CH 2 CF 3

316 EtOC(=0) o CH 2 CH 3 371

328 H0C(=0) (CH 2 ) 2 o CH 2 CH 3

354 MeOC(=0) (CH 2 ) 2 o CH 2 CH 3 385

*See Index Table data.

INDEX TABLE G

A dash in the L colunui means that L is a direct bond. Unless otherwise indicated, the configuration of substituents about that double bond in the above structure are as shown.

Cmpd. No. E L A R 2d R 2C NMR MS

60 CH 3 S(=0) 2 o H CH 2 CH 3

62 CH 3 CH 2 S(=0) 2 CH 2 O H CH 2 CH 3 *

72 H0C(=0) - O H CH 2 CH 3 * 275 (M-l)

73 7-PrOC(=0) - O H CH 2 CH 3 * 318 (M+l)

74 CH 2 =CHCH 2 0C(=0) - o H CH 2 CH 3 * 317 (M+l)

75 CHºCCH 2 OC(=0) - o H CH 2 CH 3 * 313 (M-l) 79 CH 3 C(=0) - o H CH 2 CH 3 *

83 CH 2 O H CH 2 CH 3 * 401 (M+l)

84 CH 2 O H CH 2 CH 3 * 401 (M+l)

85 5-(CH 3 0C(=0))- I //-imidazol- 1 -yl CH 2 O H CH 2 CH 3 * 371 (M+l)

86 4-(CH 3 OC(=0))-l/7-imidazol- 1 -yl CH 2 O H CH 2 CH 3 * 371 (M+l)

87 CH 2 O H CH 2 CH 3 * 364 (M+l)

88 CH 2 O H CH 2 CH 3 * 364 (M+l)

90 3-(EtOC(=0)-5-(MeO))-l/7-pyrazol-l-yl CH 2 O H CH 2 CH 3 * 415 (M+l)

94 «-PrOC(=0) - O H CH 2 CH 3 *

95 EtOC(=0) - O H CH 2 CH 3 * 305 (M+l)

96 Et0C(=0)CH=CHCH 2 0 - O H CH 2 CH 3 *

99 NH 2 C(=0) - O H CH 2 CH 3 * 274 (M+l)

100 c-PrNHC(=0) - O H CH 2 CH 3 * 316 (M+l) 101 /-PrNHC(=0) - O H CH 2 CH 3 * 318 (M+l) 102 CHºCCH 2 NHC(=0) - O H CH 2 CH 3 * 314 (M+l)

103 CH 2 =CHCH 2 NHC(=0) - O H CH 2 CH 3 * 316 (M+l)

104 «-PrNHC(=0) - O H CH 2 CH 3 * 318 (M+l)

105 MeNHC(=0) - O H CH 2 CH 3 * 290 (M+l)

109 i-BuOC(=0)NH CH 2 O H CH 2 CH 3 261 (M+l)

110 NH 2 CH 2 O H CH 2 CH 3 262 (M+l) 111 EtOC(=0)NH CH 2 O H CH 2 CH 3 *

113 CF 3 CH 2 C(=0)NH CH 2 O H CH 2 CH 3 *

114 MeOCH(CH 3 )C(=0)NH CH 2 O H CH 2 CH 3 *

119 CH 2 O H CH 2 CH 3 * 386 (M+l) Cm

121 CH 2 o H CH 2 CH 3 * 386 (M+l)

143 o H CH 2 CH 3 *

144 o H CH 2 CH 3 *

148 HC(=0) o H CH 2 CH 3

149 EtS(=0) 2 NH CH 2 o H CH 2 CH 3 *

150 EtC(=0)NH CH 2 o H CH 2 CH 3 *

152 3 , 5 -di-Me - 1 H- py razo 1- 1 -y 1 CH 2 o H CH 2 CH 3 * 341 (M+l)

153 4-(Et0C(=0))- 1/7-imidazol- 1 -yl CH 2 o H CH 2 CH 3 * 385 (M+l)

154 NºC CH 2 o H CH 2 CH 3 *

155 NºCS CH 2 o H CH 2 CH 3 *

156 1/7-imidazol- 1 -y 1 CH 2 o H CH 2 CH 3 * 313 (M+l)

184 CH 2 o H CH 2 CH 3 *

193 CH 2 o H CH 2 CH 3 *

195 OH CH 2 o H CH 2 CH 3 *

196 EtNHC(=0)0 CH 2 o H CH 2 CH 3 *

210 /-PrC(=0)NH CH 2 o H CH 2 CH 3 * 332 (M+l) Cmpd. No. MS 211 331 (M+l)

224 CH 2 o H CH 2 CH 3 * 330 (M+l)

225 CH 2 o H CH 2 CH 3 * 358 (M+l)

226 CH 2 o H CH 2 CH 3 * 380 (M+l)

230 MeOC(=0) o H CH 2 CH 3 * 291 (M+l)

268 4 -(EtOC(=0))- 1 -piperidiny 1 CH 2 o H CH 2 CH 3 * 402 (M+l)

269 3 -(EtOC(=0))- 1 -piperidinyl CH 2 o H CH 2 CH 3 * 402 (M+l)70 [Note 7] 4-(Et0C(=0))-pyiidin-l-yl CH 2 o H CH 2 CH 3 *

71 [Note 7] 3 -(EtOC(=0))-py ridin- 1 -y 1 CH 2 o H CH 2 CH 3 *

278 o H CH 2 CH 3 *

279 N0 2 o H CH 2 CH 3 *

287 CH 2 o H CH 2 CH 3 * Cm

297 4-(EtOC(=0))-l/7-pyrazol-l-yl-CH 2 0 CH 2 o H CH 2 CH 3 412 (M-l)

306 CH 2 O H CH 2 CH 3 405 (M+l)

307 CH 2 O H CH 2 CH 3 403 (M+l)

308 CH 2 O H CH 2 CH 3 371 (M+l)

309 4-(Me0C(=0))- 1 -piperidiny 1 CH 2 O H CH 2 CH 3 388 (M+l)

310 3 -(Me0C(=0))- 1 -pyrrolidinyl CH 2 O H CH 2 CH 3 374 (M+l)

311 4-(NºC)-l -piperidinyl CH 2 O H CH 2 CH 3 355 (M+l)

312 4-(MeO)- 1 -piperidinyl CH 2 O H CH 2 CH 3 360 (M+l)

313 CH 2 O H CH 2 CH 3 441 (M+l)

364 (Ex. 9) 4-(EtOC(=0))-l/7-pyrazol-l-yl-CH 2 0 o H CH 2 CH 3 401 (M+l)

*See Index Table data.

Note 7: HBr salt.

INDEX TABLE H

Unless otherwise indicated, the configuration of substituents about that double bond in the above structure are as shown.

Cmpd. No. Rl3 A R 2d R2C NMR MS

158 3-CH 3 CH 2 o H CH 2 CH 3 371 (M+l) 181 3-CF3 CH 2 O H CH 2 CH 3 379 (M-l) 231 3-(Et0C(=0)) CH 2 O H CH 2 CH 3

241 5-(Et0C(=0)) CH 2 o H CH 2 CH 3

250 5-(Me0C(=0)) CH 2 o H CH 2 CH 3 371 (M+l)

251 3-(Me0C(=0)) CH 2 o H CH 2 CH 3 371 (M+l)

252 5-(i-Bu0C(=0)) CH 2 o H CH 2 CH 3 411 (M-l)

253 3-(i-Bu0C(=0)) CH 2 o H CH 2 CH 3 411 (M-l)

291 3 -(CH 2 =CHCH 2 0C(=0)) CH 2 o H CH 2 CH 3 397 (M+l)

292 3-(«-Pr0C(=0)) CH 2 o H CH 2 CH 3 399 (M+l)

293 3-(CH 3 CºCCH 2 0C(=0)) CH 2 o H CH 2 CH 3 409 (M+l) 299 3-(H0C(=0)) CH 2 o H CH 2 CH 3

325 3-(HCºCCH 2 0C(=0)) CH 2 o H CH 2 CH 3 395 (M+l)

326 3-(CH 3 CH 2 CºCCH 2 0C(=0)) CH 2 o H CH 2 CH 3 423 (M+l)

327 3-(/-Pr0C(=0)) CH 2 o H CH 2 CH 3 399 (M+l)

356 3-(«-Bu0C(=0)) CH 2 o H CH 2 CH 3 413 (M+l)

357 3-(/-Bu0C(=0)) CH 2 o H CH 2 CH 3 413 (M+l)

358 3 -(CH 2 =C(Me)CH 2 0C(=0)) CH 2 o H CH 2 CH 3 411 (M+l)

359 3 -(CH 3 C(=0)CH 2 0C(=0)) CH 2 o H CH 2 CH 3 413 (M+l)

360 3-(Me0CH 2 CH 2 0C(=0)) CH 2 o H CH 2 CH 3 415 (M+l)

361 3-(C-BUCH 2 0C(=0)) CH 2 o H CH 2 CH 3 425 (M+l) Cmpd. No. R 13 L A R 2d R 2c NMR MS

362 3-(ClCH 2 CH 2 CH 2 0C(=0)) CH 2 O H CH 2 CH 3 * 433 (M+l)

*See Index Table data.

A dash in the R 33 column means no R 33 substituent is present and the remaining carbon valences are occupied by hydrogen atoms. Unless otherwise indicated, the configuration of substituents about that double bond in the above structure are as shown.

Cmpd. No. Rl3 R 2d R 2C NMR MS

81 5-CN CH 2 o H CH 2 CH 3 337 (M-l) 82 3-CN CH 2 o H CH 2 CH 3 337 (M-l) 122 5-(Me0C(=0)) CH 2 o H CH 2 CH 3 370 (M-l) 123 3-(Me0C(=0)) CH 2 o H CH 2 CH 3 370 (M-l) 157 CH 2 o H CH 2 CH 3 312 (M-l) 260 5-MeS CH 2 o H CH 2 CH 3 358 (M-l) 261 3-MeS CH 2 o H CH 2 CH 3 360 (M+l)

*Scc Index Table data.

INDEX TABLE J

Unless otherwise indicated, the configuration of substituents about that double bond in the above structure are as shown. Cmpd. No.

129

130 4-(c-PrCH 2 NHC(=0)) s CH 2 O H CH 2 CH 3

254 5-(c-PrCH 2 NHC(=0)) s CH 2 o H CH 2 CH 3 427 (M+l)

255 5-(CHF 2 CH 2 NHC(=0)) o CH 2 o H CH 2 CH 3 421 (M+l) 258 5-(c-PrCH 2 NHC(=0)) o CH 2 o H CH 2 CH 3 411 (M+l)

276 5-(CHF 2 CH 2 NHC(=0)) s CH 2 o H CH 2 CH 3 437 (M+l)

*See Index Table M for ^F NMR data.

INDEX TABLE K

A dash in the L column means that L is a direct bond. Unless otherwise indicated, the configuration of substituents about that double bond in the above structure are as shown.

Cmpd. No. MS

265 (Ex. 7) 385 (M+l) 300 CH 3 CºCCH 2 0C(=0) CH 2 H CH 2 CH 3 409 (M+l) 304 EtOC(=0) CH(Me) CH 2 CH 3 399 (M+l) 317 EtOC(=0) CH 2 CH 3 371 (M+l)

323 HOC(=0) CH 2 CH 2 CH 3 357 (M+l)

324 EtOC(=0) CH 2 n-Pr 399 (M+l)

330 MeOC(=0) CH 2 CH 2 CH 3 371 (M+l)

331 n-PrOC(=0) CH 2 CH 2 CH 3 399 (M+l)

332 7-PrOC(=0) CH 2 CH 2 CH 3 399 (M+l)

333 CH 2 =CHCH 2 0C(=0) CH 2 CH 2 CH 3 397 (M+l)

334 7-BUOC(=0) CH 2 H CH 2 CH 3 413 (M+l)

335 CH 2 =C(Me)CH 2 0C(=0) CH 2 H CH 2 CH 3 411 (M+l) Cmpd. No. R 13 L R 2d R 2C NMR MS

336 CHºCCH 2 OC(=0) CH 2 H CH 2 CH 3 * 395 (M+l)

337 CH 3 C(=0)CH 2 0C(=0) CH 2 H CH 2 CH 3 * 413 (M+l)

338 C1(CH 2 ) 3 0C(=0) CH 2 H CH 2 CH 3 * 433 (M+l)

339 n-BuOC(=0) CH 2 H CH 2 CH 3 * 413 (M+l)

340 CH 3 0(CH 2 ) 2 0C(=0) CH 2 H CH 2 CH 3 * 415 (M+l)

341 c-PrCH 2 OC(=0) CH 2 H CH 2 CH 3 * 411 (M+l)

342 C-BUCH 2 OC(=0) CH 2 H CH 2 CH 3 * 425 (M+l)

343 EtNHC(=0) CH 2 H CH 2 CH 3 * 382 (M+l) 345 EtOC(=0) CH 2 CH 2 H CH 2 CH 3 * 399 (M+l)

347 CHF 2 CH 2 0C(=0) CH 2 H CH 2 CH 3 * 421 (M+l)

348 CF 3 CH 2 CH 2 0C(=0) CH 2 H CH 2 CH 3 * 453 (M+l)

349 CF 2 =CFCH 2 CH 2 0C(=0) CH 2 H CH 2 CH 3 * 465 (M+l)

350 (Me) 2 CH(CH 2 ) 2 0C(=0) CH 2 H CH 2 CH 3 *

351 CH 3 0(CH 2 ) 3 0C(=0) CH 2 H CH 2 CH 3 * 429 (M+l)

352 CF 3 0(CH 2 ) 2 0C(=0) CH 2 H CH 2 CH 3 * 469 (M+l) 355 CF 3 (CH 2 ) 3 0C(=0) CH 2 H CH 2 CH 3 * 467 (M+l) 365 EtOC(=0) CH 2 H CH 3 *

*See Index Table M for 3 ^F NMR data.

INDEX TABLE L

MS

Cmpd. No. Structure NMR (M+l) m.p. (°C)

Note 6: 3 :2 mixture of geometric isomers. *See Index Table data. **See Index Table N for ' H NMR data.

INDEX TABLE M

Cmpd. Cmpd.

No . 19 F NMR Data a No. 19 F NMR Data a

1 d -84.92 (s). 169 d -81.38 (s).

2 5 (DMSO-<¾) -81.80 (s). 170 d -81.38 (s).

3 d -81.39 (s). 171 d -81.37 (s).

4 d (DMSO-<%) -81.50 (s). 172 d -81.37 (s).

5 d -82.61 (s), -75.48 (s). 174 d -80.00 (s).

6 d -79.03 (s). 176 d -81.40 (s).

7 d -81.50 (s), -81.71 (s). 177 d -84.85 (s).

8 d -81.50 (s), -81.71 (s). 179 d -62.79 (s), -81.40 (s).

9 d -81.27 (s). 180 d -70.10 (s).

10 d -79.64 (s). 181 d -61.85 (s).

12 d -81.01 (s). 182 d -56.40 (s).

13 d -81.38 (s). 183 d -70.09 (s).

14 d -81.39 (s). 184 d -70.11 (s).

15 d -81.38 (s). 189 d -81.42 (s).

16 d -81.39 (s). 190 d -81.38 (s).

17 d -81.38 (s). 191 d -81.42 (s).

18 d -81.38 (s). 192 d -81.39 (s).

20 d -78.49 (s). 193 d -70.01 (s).

21 d -80.99 (s). 195 d -70.04 (s).

22 d -81.39 (s). 196 d -70.08 (s)..

23 d -81.37 (s). 197 d -72.38 (s), 81.38 (s).

24 d -81.37 (s). 198 d -81.38 (s).

25 d -81.37 (s). 199 d -81.38 (s).

26 d -81.39 (s). 200 d -81.38 (s).

27 d -81.41 (s). 201 d -81.38 (s).

28 d -81.38 (s). 202 d -81.39 (s).

29 d -84.92 (s). 203 d -81.39 (s).

31 d (DMSO-i¾) -81.91 (s). 204 d -81.38 (s).

32 d -81.39 (s). 205 d -70.14 (s).

Cmpd. Cmpd.

No. 19 F NMR Data a No. 19 F NMR Data a

33 d (DMSO-i/ 6 ) -81.83 (s). 206 d -84.95 (s).

34 d (DMSO-<¾) -81.89 (s). 209 d -81.36 (s).

35 d -84.94 (s). 210 d -70.08 (s).

36 d (DMSO -d 6 ) -81.37 (s). 214 d -81.43 (s).

37 d (DMSO-<¾) -81.82 (s). 224 d -70.09 (s).

39 d -84.93 (s). 225 d -70.08 (s).

40 d (acetone-i/g) -83.12 (s). 226 d -70.10 (s).

41 d -84.81 (s). 227 d -81.57 (s), -84.95 (s).

42 d (DMSO-i/ 6 ) -81.82 (s). 228 d -81.39 (s).

43 d (DMSO-<¾) -81.82 (s). 230 d -70.21 (s).

44 d -84.21 (s). 231 d -70.12 (s).

45 d (DMSO-i/ 6 ) -81.82 (s), -72.3 232 d -81.39 (s).

d (DMSO-i/ 6 ) -81.83 (s), -82.9

46 233 d -84.87 (s).

-122.29 (t).

47 d (DMSO-i/ 6 ) -81.82 (s). 234 d -84.95 (s).

48 d (DMSO-i/ 6 ) -81.82 (s). 235 d -81.45 (s).

49 d (DMSO-<¾) -81.82 (s). 236 d -81.46 (s).

d (DMSO-i/ 6 ) -81.82 (s), -138.

50 237 d -81.44 (s).

-139.66 (m).

51 d -87.93 (s). 239 d -81.42 (s).

52 d -76.89 (s). 240 d -81.39 (s)

53 d -70.09 (s). 241 d -70.11 (s).

54 d -69.99 (s). 245 d -68.61 (s).

55 d -69.95 (s). 249 d -81.39 (s).

56 d -69.73 (s). 250 d -70.11 (s).

57 d -69.75 (s). 251 d -70.13 (s).

58 d -70.10 (s). 252 d -70.09 (s).

60 d -70.30 (s). 253 d -70.11 (s).

61 d -70.26 (s). 260 d -70.12 (s).

62 d -70.15 (s). 261 d -70.12 (s).

Cmpd. Cmpd.

No . 19 F NMR Data a No . 19 F NMR Data a

63 d -63.30 (s), -63.67 (s). 262 d -70.33 (s).

64 d -70.13 (s). 263 d -81.60 (s), -132.13 (s).

65 d -70.03 (s). 264 d -84.92 (s).

66 d -85.74 (s). 265 d -70.09 (s).

67 d -82.36 (s). 266 d -84.88 (s).

72 d -70.24 (s). 267 d -70.13 (s).

73 d -70.20 (s). 268 d -70.03 (s).

74 d -70.22 (s). 269 d -70.03 (s).

75 d -70.22 (s). 270 d -70.12 (s).

79 d -70.22 (s). 271 d -70.12 (s).

80 d -84.87 (s). 272 d -69.99 (s).

81 d -70.17 (s). 278 d -70.11 (s).

82 d -70.14 (s). 279 d -70.31 (s).

83 d -70.17 (s). 280 d -84.80 (s).

84 d -70.16 (s). 284 d -81.38 (s).

85 d -70.14 (s). 285 d -81.39 (s).

86 d -70.12 (s). 286 d -84.94 (s).

87 d -70.11 (s). 287 d -70.05 (s).

88 d -70.19 (s). 288 d -70.04 (s).

89 d -70.13 (s). 289 d -81.39 (s).

90 d -70.16 (s). 290 d -81.37 (s).

91 d -70.12 (s). 291 d -70.12 (s).

92 d -70.13 (s). 292 d -70.13 (s).

93 d -81.42 (s). 293 d -70.13 (s).

94 d -70.21 (s). 294 d -70.01 (s).

95 d -70.21 (s). 296 d -81.38 (s).

96 d -69.98 (s). 297 d -70.01 (s).

97 d -84.95 (s). 298 d -70.05 (s), -74.96 (s).

98 d -81.40 (s). 299 d -70.12 (s).

99 d -70.19 (s). 300 d -70.10 (s).

100 d -70.16 (s). 305 d -84.85 (s).

101 d -70.15 (s). 309 d -70.02 (s).

Cmpd. Cmpd.

No. 19 F NMR Data a No. 19 F NMR Data a

102 d -70.18 (s). 310 d -70.04 (s).

103 d -70.16 (s). 311 d -70.01 (s).

104 d -70.16 (s). 312 d -70.03 (s).

105 d -70.16 (s). 318 d -81.38 (s).

111 d -70.08 (s). 319 d -79.29 (s), 82.67 (s).

112 d -81.43 (s). 321 d -68.60 (s).

113 d -63.01 (s), -70.10 (s). 322 d -81.70 (s).

114 d -70.09 (s). 323 d -70.10 (s).

116 d -70.14 (s). 325 d -70.11 (s).

119 d -70.16 (s). 326 d -70.13 (s).

120 d -70.15 (s). 327 d -70.13 (s).

121 d -70.16 (s). 328 d -68.54 (s).

122 d -70.14 (s). 329 d -77.08 (s).

123 d -70.15 (s). 330 d -70.09 (s).

126 d -81.38 (s). 331 d -70.10 (s).

127 d -81.38 (s). 332 d -70.08 (s).

129 d -70.06 (s), -72.25 (s). 333 d -70.09 (s).

130 d 70.06 (s). 334 d -70.09 (s).

131 d -84.93 (s). 335 d -70.09 (s).

132 d -70.05 (s). 336 d -70.08 (s).

133 d -81.40 (s). 337 d -70.08 (s).

134 d -81.40 (s), -73.70 (s). 338 d -70.06 (s).

140 d -69.16 (s). 339 d -70.10 (s).

164 d -81.33 (s). 340 d -70.09 (s).

165 d -81.34 (s). 341 d -70.09 (s).

166 d -81.38 (s). 342 d -70.11 (s).

167 d -69.60 (s). 343 d -70.11 (s).

141 d -81.28 (s). 344 d -70.50 (s).

142 d -84.83 (s). 345 d -68.59 (s).

143 d - 60.46(s), -70.25 (s). 346 d -81.82 (s).

144 d -70.30 (s). 347 d -70.09 (s), -125.54 (s).

145 d -69.79 (s). 348 d -64.93 (s), -70.09 (s).

Cmpd. Cmpd.

No. 19 F NMR Data a No. 19 F NMR Data a

d -70.13 (s), -103.21 (s),

146 d -81.37 (s). 349

-123.98 (s), -175.15 (s).

147 d -81.36 (s). 350 d -70.09 (s).

149 d -70.07 (s). 351 d -70.09 (s).

150 d -70.07 (s). 352 d -60.95 (s), -70.12 (s).

151 d -70.09 (s). 353 d -81.41 (s).

152 d -70.09 (s). 354 d -70.03 (s).

153 d -70.12 (s). 355 d -66.44 (s), -70.09 (s).

154 d -70.10 (s). 356 d -70.14 (s).

155 d -70.05 (s). 357 d -70.13 (s).

156 d -70.05 (s). 358 d -70.12 (s).

157 d -70.19 (s). 359 d -70.11 (s).

158 d -70.10 (s). 360 d -70.12 (s).

160 d -81.44 (s). 361 d -70.13 (s).

161 d -81.38 (s). 362 d -70.11 (s).

162 d (DMSO-<¾) -80.02 (s). 365 d -70.05 (s).

163 d -81.38 (s).

a l 9 F NMR spectra are reported in ppm relative to CF3CCI3, in CDCI3 solution unless indicated otherwise.

Couplings are designated by (s)-singlet, (t)-triplet and (m)-multiplet.

INDEX TABLE N

Compound

¾ NMR Data a

No.

(CDC1 3 ): d 1.36-1.32 (t, 3H), 4.21 (s, 6H), 4.32-4.25 (q, 2H), 5.32 (s, 2H), 6.20 (s, 1H),

273

6.70 (s, 1H), 7.89 (s, 1H), 7.95 (s, 1H).

(DMSO-i¾): d 1.26 (t, 3H), 3.98 (s, 2H), 4.21 (q, 2H), 6.03 (s, 2H), 6.86-6.94 (m, 2H),

366

6.95-7.06 (m, 2H), 7.27 (s, 2H), 7.94 (s, 1H), 8.53 (s, 1H).

a ' H NMR data are reported in ppm downfield from tetramethylsilane. Couplings are designated by (s)-singlet, (t) -triplet, (q) -quartet.

BIOLOGICAL EXAMPLES OP THE INVENTION General protocol for preparing test suspensions for Tests A-C: the test compounds were first dissolved in acetone in an amount equal to 3% of the final volume and then suspended at the desired concentration (in ppm) in acetone and purified water (50/50 mix by volume) containing 250 ppm of the surfactant PEG400 (polyhydric alcohol esters). The resulting test suspensions were then used in Tests A-C.

TEST A

The test solution was sprayed to the point of run-off on soybean seedlings. The following day the seedlings were inoculated with a spore suspension of Phakopsora pachyrhizi (the causal agent of Asian soybean rust) and incubated in a saturated atmosphere at 22 °C for 24 h, and then moved to a growth chamber at 22 °C for 8 days, after which time visual disease ratings were made.

TEST B

The test solution was sprayed to the point of run-off on wheat seedlings. The following day the seedlings were inoculated with a spore suspension of Puccinia recondita f. sp. tritici (the causal agent of wheat leaf rust) and incubated in a saturated atmosphere at 20 °C for 24 h, and then moved to a growth chamber at 20 °C for 6 days, after which time disease ratings were made.

TEST C

The test solution was sprayed to the point of run-off on grape seedlings. The following day the seedlings were inoculated with a spore suspension of Uncinula necator (the causal agent of grape powdery mildew) and incubated in a growth chamber at 20 °C for 12 days, after which time disease ratings were made.

Results for Tests A-C are given in Table A. In the Table, a rating of 100 indicates 100% disease control and a rating of 0 indicates no disease control (relative to the controls). An asterisk “*” or a double asterisk next to the rating value indicates a 50 ppm or 10 ppm test suspension was used, respectively. A dash (-) indicates the compound was not tested.

TABLE A

Cmpd. No. Rate in ppm Test A Test B Test C

1 250 100 91

2 10 77 32

3 10 100 0

4 10 100 89 100 Cmpd. No. Rate in ppm Test A Test B Test C

5 10 0 0

6 10 0 0

7 10 94 0

8 10 96 9

9 10 98 86

10 10 100 86

12 10 13 0

13 10 99 0

14 10 100 0

15 10 100 0

16 10 99 0

17 10 100 0

18 10 100 0

20 10 98 86

21 10 84 23

22 10 38 0

23 10 0 19

24 10 81 91

25 10 0 0

26 10 99 0

27 10 0 0

28 10 0 0

29 10 84 28

30 10 0 0

31 10 44 93

32 50 100 68 100

33 10 96 86

34 10 0 80

35 10 99 32

36 10 70 0

37 10 99 86

38 10 97 89 Cmpd. No. Rate in ppm Test A Test B Test C

39 10 91 79

40 10 91 68

41 10 92 23

42 10 99 85

43 10 96 60

44 10 97 85

45 10 87 85

46 10 64 85

47 50 100 95

48 50 100 91

49 10 0 86

50 10 54 91

51 10 0 0

52 10 99 0

53 50 100 67

54 10 0 0

55 10 0 0

56 10 38 0

57 250 100 0 100

58 10 0 0

60 10 0 0

61 10 0 0

62 10 0 0

63 10 0 0

64 250 100 99 100

65 10 100 0

66 50 92 89

67 50 65 0

68 10 100 95

69 10 98 96

70 250 100 100

71 10 100 96 Cmpd. No. Rate in ppm Test A Test B Test C

72 50 13 0

73 10 0 0

74 10 0 0

75 10 0 0

76 10 0 0

77 10 0 0

78 10 94 0

79 50 0 0

80 50 99 100

81 10 0 0

82 10 97 0

83 10 82 0

84 10 0 0

85 10 89 0

86 10 99 0

87 10 0 0

88 10 65 0

89 10 0 0

90 10 100 0

91 10 0 0

92 10 0 0

93 10 96 0

94 10 0 0

95 10 0 0

96 10 13 0

97 50 94 0

98 250 100 100

99 10 0 80

100 10 0 0

101 10 0 0

102 10 0 0

103 10 0 0 Cmpd. No. Rate in ppm Test A Test B Test C

104 10 0 80

105 10 68

106 10 0

107 10 0

109 10 0

110 50 0

111 10 0

112 10 0

113 10 0

114 50 0

115 250 0

116 10 0

117 10 0

118 10 0

119 10 0

120 10 0

121 10 0

122 10 0

123 10 0

124 50 0 100

125 10 0

126 10 0 100 127 10 0 100

129 10 0

130 10 0

131 50 86

132 10 0 98

133 10 0

134 10 32

135 10 61

136 10 98 83

137 10 79 0 Cmpd. No. Rate in ppm Test A Test B Test C

138 10 100 0 100

139 10 0

140 10 23

141 10 0

142 10 100

143 10 0

144 10 0

145 10 0

146 50 0

147 50 0

148 10 0

149 10 0

150 10 0

151 10 0

152 10 0

153 10 0

154 10 0

155 10 0

156 10 0

157 10 9

158 10 0

160 10 0

161 10 0

162 10 0 100

163 10 0 100

164 10 0

165 10 0

166 10 95

167 10 0

168 10 0

169 10 100 0

170 10 100 0 100 Cmpd. No. Rate in ppm Test A Test B Test C

171 10 100 0 99

172 10 0

173 10 0

174 10 0

175 10 0

176 10 0

177 50 89

178 10 0

179 10 0

180 10 0

181 10 0

182 10 0

183 10 0

184 10 0

185 10 0 100

186 10 0 100

187 10 74

188 10 0

189 10 0

190 10 0

191 10 0

192 10 0

193 10 86

195 10 0

196 10 74

197 10 0

198 10 0

199 10 0

200 10 0

201 10 0

202 10 100 0

203 10 50 0 Cmpd. No. Rate in ppm Test A Test B Test C

204 10 100 0

205 10 0

206 50 98

207 10 0

209 10 0

210 10 0

211 10 0

212 10 0

214 10 0

215 10 55

216 10 0 100

217 10 0 100

218 10 0 100

219 10 0 100

220 10 0 100 221 10 0 100 222 10 0

223 10 0

224 10 0

225 10 0

226 10 0

227 10 55

228 10 0

229 50 100

230 10 0

231 10 0

232 10 0

233 50 96

234 50 92

235 10 0

236 10 75 0

237 10 97 0 Cmpd. No. Rate in ppm Test A Test B Test C

238 10 73 0

239 10 0

240 10 0

241 10 0

242 10 0

243 10 0

244 10 0

245 10 0 98

246 10 0

247 10 0

248 10 0

249 10 0

250 10 0

251 10 9

252 10 0

253 10 0

254 10 0

255 10 0

256 10 0

257 10 0

258 10 0

259 10 0

260 10 0

261 10 0

262 10 0 99

263 10 0

264 10 80

265 50 0 100

266 50 74

267 10 0

268 10 99 0

269 10 100 0 Cmpd. No. Rate in ppm Test A Test B Test C

270 10 25 0

271 10 0 0

272 10 100 0

273 50 100 0

274 10 48 0

275 10 0 0

276 10 13 0 100

277 10 50 45

278 50 94 0

279 50 0 0

280 50 100 100

281 50 95 98

282 50 0 0

283 50 100 99

284 10 100 0

285 10 100 0

286 10 87 55

287 50 77 0

288 50 96 0

289 10 0 0

290

291 10 100 0

292 10 100 0

293 10 100 0

294 10 100 0

295 50 99 80

296 10 0 0

297 10 100 0

298 10 0 0

299 10 100 0

300 10 100 0

301 50 100 0 Cmpd. No. Rate in ppm Test A Test B Test C

302 50 99 0

303 50

304 50

305 10 70 0

306

307 50

308 50

309 10

310 10

311 10

312 10

313 50

314 50

316 50

317

318 10 100 0

319 50 100 41

320

321

322

323 50 100 0

324 10 0 0

325 10 100 0

326 10 100 0

327 10 100 0

328

329 50 100 41

330 10 100 0

331 10 100 0

332 10 100 0

333 10 100 0

334 10 100 0 Cmpd. No. Rate in ppm Test A Test B Test C

335 10 100 0

336 10

337 10

338 10

339 10

340 10

341 10

342 10 100 0

343 10 0 0

344

345

346

347

348

349

350

351

352

353

354

355

356 10 100 0

357 10 100 9

358 10 100 0

359 10 100 0

360 10 100 0

361 10 100 0

362 10 100 0

364 50 100 0

365 10 100 0

366