Title:
FURANEOL GLYCOSIDE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/121362
Kind Code:
A1
Abstract:
Disclosed are a furaneol glycoside compound, a pharmaceutical composition thereof, a preparation method therefor, and an application thereof. Specifically disclosed are a compound as represented by formula A-1, a pharmaceutically acceptable salt thereof or a crystal form thereof. Also disclosed is a pharmaceutical composition, which comprises the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof or the crystal form thereof, and a pharmaceutical adjuvant. Also disclosed is an application of the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, the crystal form thereof, or the pharmaceutical composition in the preparation of drugs. The drugs are drugs for treating inflammatory bowel diseases. The furaneol glycoside compound has a good effect of treating inflammatory bowel diseases, particularly ulcerative colitis.
Inventors:
CHANG JUN (CN)
JIN LIN (CN)
ZHANG HEYANHAO (CN)
NIU TONG (CN)
JIN LIN (CN)
ZHANG HEYANHAO (CN)
NIU TONG (CN)
Application Number:
PCT/CN2020/137471
Publication Date:
June 24, 2021
Filing Date:
December 18, 2020
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
C07H17/04; A61K31/7048; A61K31/706; A61P1/00; A61P1/04; A61P29/00
Foreign References:
| CN104151379A | 2014-11-19 |
Other References:
COMTE GILLES, ALLAIS DAOVY P, CHULIA ALBERT J, VERCAUTERENT JOSEPH, DELAGE CHRISTIANE: "Two Furanone Glucoside Derivatives from Junoperus Phctnicea", PHYTOCHEMISTRY, vol. 41, no. 5, 1 March 1996 (1996-03-01), pages 1329 - 1322, XP055822355, ISSN: 0031-9422, DOI: 10.1016/0031-9422(95)00730-X
COMTE, G. ALLAIS, D.P. CHULIA, A.J. VERCAUTEREN, J. BOSSO, C.: "Phoeniceroside, the First Natural Bis-Furanone Propane Derivative from Juniperus Phoenicea L.", TETRAHEDRON LETTERS, vol. 37, no. 17, 22 April 1996 (1996-04-22), pages 2955 - 2958, XP004029690, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)00453-4
MAYERL, F , NAF, R , THOMAS, A.F: "2, 5-Dimethyl-4-Hydroxy-3(2H)-Furanone Glucoside: Isolation from Strawberries and Synthesis", PHYTOCHEMISTRY, vol. 28, no. 2, 1 January 1989 (1989-01-01), pages 631 - 633, XP026647599, ISSN: 0031-9422, DOI: 10.1016/0031-9422(89)80068-8
NAHRSTEDT A, ROCKENBACH JURGEN, WRAY VICTOR: "Phenylpropanoid Glycosides, A Furanone Glucoside and Geniposidic Acid from Members of the Rubiaceae", PHYTOCHEMISTRY, vol. 39, no. 2, 1 May 1995 (1995-05-01), pages 375 - 378, XP055822361, ISSN: 0031-9422, DOI: 10.1016/0031-9422(94)00906-A
STADLER NICOLE CHRISTINA, SOMOZA VERONIKA, SCHWAB WILFRIED: "Absorption of 3(2H)-Furanones by Human Intestinal Epithelial Caco-2 Cells", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 57, no. 9, 1 April 2009 (2009-04-01), pages 3949 - 3954, XP055822363, ISSN: 0021-8561, DOI: 10.1021/jf9001704
COMTE, G. ALLAIS, D.P. CHULIA, A.J. VERCAUTEREN, J. BOSSO, C.: "Phoeniceroside, the First Natural Bis-Furanone Propane Derivative from Juniperus Phoenicea L.", TETRAHEDRON LETTERS, vol. 37, no. 17, 22 April 1996 (1996-04-22), pages 2955 - 2958, XP004029690, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)00453-4
MAYERL, F , NAF, R , THOMAS, A.F: "2, 5-Dimethyl-4-Hydroxy-3(2H)-Furanone Glucoside: Isolation from Strawberries and Synthesis", PHYTOCHEMISTRY, vol. 28, no. 2, 1 January 1989 (1989-01-01), pages 631 - 633, XP026647599, ISSN: 0031-9422, DOI: 10.1016/0031-9422(89)80068-8
NAHRSTEDT A, ROCKENBACH JURGEN, WRAY VICTOR: "Phenylpropanoid Glycosides, A Furanone Glucoside and Geniposidic Acid from Members of the Rubiaceae", PHYTOCHEMISTRY, vol. 39, no. 2, 1 May 1995 (1995-05-01), pages 375 - 378, XP055822361, ISSN: 0031-9422, DOI: 10.1016/0031-9422(94)00906-A
STADLER NICOLE CHRISTINA, SOMOZA VERONIKA, SCHWAB WILFRIED: "Absorption of 3(2H)-Furanones by Human Intestinal Epithelial Caco-2 Cells", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 57, no. 9, 1 April 2009 (2009-04-01), pages 3949 - 3954, XP055822363, ISSN: 0021-8561, DOI: 10.1021/jf9001704
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF: