Title:
FURANOSE DERIVATIVES AND THEIR APPLICATIONS IN SYNTHESIS OF STATINS
Document Type and Number:
WIPO Patent Application WO/2012/032534
Kind Code:
A3
Abstract:
The present invention relates to compounds of formula XXII and their synthesis from furanose derivatives as shown hereunder. Compounds of formula XXII are of use in the synthesis of statins.
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Inventors:
PRADHAN BRAJA SUNDER (IN)
GHOSH PRASANTA K (IN)
RANGARAO CH (IN)
VEMPALA NARESH (IN)
APPARAO THOOMU (IN)
GHOSH PRASANTA K (IN)
RANGARAO CH (IN)
VEMPALA NARESH (IN)
APPARAO THOOMU (IN)
Application Number:
PCT/IN2011/000523
Publication Date:
August 02, 2012
Filing Date:
August 08, 2011
Export Citation:
Assignee:
HELVETICA IND P LTD (IN)
PRADHAN BRAJA SUNDER (IN)
GHOSH PRASANTA K (IN)
RANGARAO CH (IN)
VEMPALA NARESH (IN)
APPARAO THOOMU (IN)
PRADHAN BRAJA SUNDER (IN)
GHOSH PRASANTA K (IN)
RANGARAO CH (IN)
VEMPALA NARESH (IN)
APPARAO THOOMU (IN)
International Classes:
C07D303/26; C07C255/07; C07C317/04; C07D307/32; C07D307/60; C07D407/12
Other References:
LIPSHUTZ B H ET AL: "More highly mixed, higher order cyanocuprates ''RT(2-thienyl)Cu(CN)Li2''. Efficient reagents which promote selective ligand transfer", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH, vol. 285, no. 1-3, 16 April 1985 (1985-04-16), pages 437 - 447, XP026619807, ISSN: 0022-328X, [retrieved on 19850416], DOI: 10.1016/0022-328X(85)87388-5
BECUCCI T ET AL: "3-deoxy-D-glycero-pentulose: a convenient starting material for the synthesis of 4-hydroxyprolinol", GAZZETTA CHIMICA ITALIANA, SOCIETA CHIMICA, ITALIANA, ROME; IT, vol. 127, no. 2, 1 January 1997 (1997-01-01), pages 73 - 78, XP008145363, ISSN: 0016-5603
J ARIZA: "Stereoselective Synthesis of 4,5-Dihydroxy-D-erythro- and 4,5-Dihydroxy-D-threo-L-norvaline from D-Ribonolactone", TETRAHEDRON, vol. 49, no. 6, 5 February 1993 (1993-02-05), pages 1315 - 1326, XP055012374, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)85821-X
DANIEL SCHLAWE ET AL: "Iron-Containing Nucleoside Analogues with Pronounced Apoptosis-Inducing Activity", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 43, no. 13, 19 March 2004 (2004-03-19), pages 1731 - 1734, XP055012317, ISSN: 1433-7851, DOI: 10.1002/anie.200353132
STEPHEN V ATTWOOD AND ANTHONY G M BARRETT: "A convenient procedure for the deoxygenation and homologation of D-ribose derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1984 (1984-01-01), pages 1315 - 1322, XP008145385, ISSN: 0300-922X, DOI: 10.1039/P19840001315
KAZUTOSHI MIYAZAWA ET AL: "A Convenient Synthesis of (2S,4R)-1-Acetoxy-2,4-O-Isopropylidene-1,2, 5-Pentanetriol by Using Lipase Catalyzed Regio- and Enantioselective Reactions", CHEMISTRY LETTERS, vol. 22, no. 9, 1 January 1993 (1993-01-01), CHEMICAL SOCIETY OF JAPAN, JP, pages 1529 - 1530, XP008145352, ISSN: 0366-7022, DOI: 10.1246/CL.1993.1529
BECUCCI T ET AL: "3-deoxy-D-glycero-pentulose: a convenient starting material for the synthesis of 4-hydroxyprolinol", GAZZETTA CHIMICA ITALIANA, SOCIETA CHIMICA, ITALIANA, ROME; IT, vol. 127, no. 2, 1 January 1997 (1997-01-01), pages 73 - 78, XP008145363, ISSN: 0016-5603
J ARIZA: "Stereoselective Synthesis of 4,5-Dihydroxy-D-erythro- and 4,5-Dihydroxy-D-threo-L-norvaline from D-Ribonolactone", TETRAHEDRON, vol. 49, no. 6, 5 February 1993 (1993-02-05), pages 1315 - 1326, XP055012374, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)85821-X
DANIEL SCHLAWE ET AL: "Iron-Containing Nucleoside Analogues with Pronounced Apoptosis-Inducing Activity", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 43, no. 13, 19 March 2004 (2004-03-19), pages 1731 - 1734, XP055012317, ISSN: 1433-7851, DOI: 10.1002/anie.200353132
STEPHEN V ATTWOOD AND ANTHONY G M BARRETT: "A convenient procedure for the deoxygenation and homologation of D-ribose derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1984 (1984-01-01), pages 1315 - 1322, XP008145385, ISSN: 0300-922X, DOI: 10.1039/P19840001315
KAZUTOSHI MIYAZAWA ET AL: "A Convenient Synthesis of (2S,4R)-1-Acetoxy-2,4-O-Isopropylidene-1,2, 5-Pentanetriol by Using Lipase Catalyzed Regio- and Enantioselective Reactions", CHEMISTRY LETTERS, vol. 22, no. 9, 1 January 1993 (1993-01-01), CHEMICAL SOCIETY OF JAPAN, JP, pages 1529 - 1530, XP008145352, ISSN: 0366-7022, DOI: 10.1246/CL.1993.1529
Attorney, Agent or Firm:
TRIPATHI, Vishal (D-22 2nd Floor Panchsheel Enclave, New Delhi 7, IN)
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