Title:
FUROXAN-BASED COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/140194
Kind Code:
A1
Abstract:
Described herein are compounds of the formula (I), as well as pharmaceutical compositions comprising such compounds, and methods for using such compounds/pharmaceutical compositions for treating neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis (MS).
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Inventors:
HARDY JEANNE A (US)
MEKA PENCHALA NARASIMHARA (US)
MEKA PENCHALA NARASIMHARA (US)
Application Number:
PCT/US2019/013201
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
Assignee:
UNIV MASSACHUSETTS (US)
International Classes:
C07D413/10; C07D413/14; C07D493/04
Other References:
SAMSONOV ET AL.: "INTERACTION OF 4-AMINOBENZOFURAZAN WITH ARYLDIAZONIUM SALTS", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 30, no. 10, 1994, pages 1243 - 1249, XP055624554
SCHIEFER ET AL.: "Furoxans (1, 2, 5 Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents", J MED CHEM., vol. 55, no. 7, 2012, pages 3076 - 3087, XP055486003, DOI: 10.1021/jm201504s
ASCENZI ET AL.: "Inactivation of parasite cysteine proteinases by the NO -donor 4- (phenylsulfonyl)-3-((2-(dimethylamino)ethyl)thio)-furoxan oxalate", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1703, 2004, pages 69 - 77, XP004657471, DOI: 10.1016/j.bbapap.2004.09.027
WANG ET AL.: "A Small-molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis", MOL CANCER THER., vol. 10, no. 1, 2011, pages 69 - 79, XP055624556
SCHIEFER ET AL.: "Furoxans (1, 2, 5 Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents", J MED CHEM., vol. 55, no. 7, 2012, pages 3076 - 3087, XP055486003, DOI: 10.1021/jm201504s
ASCENZI ET AL.: "Inactivation of parasite cysteine proteinases by the NO -donor 4- (phenylsulfonyl)-3-((2-(dimethylamino)ethyl)thio)-furoxan oxalate", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1703, 2004, pages 69 - 77, XP004657471, DOI: 10.1016/j.bbapap.2004.09.027
WANG ET AL.: "A Small-molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis", MOL CANCER THER., vol. 10, no. 1, 2011, pages 69 - 79, XP055624556
Attorney, Agent or Firm:
SCHEER, Bradley W. et al. (US)
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