Title:
FUSED BENZODIAZEPINONE DERIVATIVES AND MEDICINAL COMPOSITION OF THE SAME
Document Type and Number:
WIPO Patent Application WO/1996/038422
Kind Code:
A1
Abstract:
Fused benzodiazepinone derivatives represented by general formula (I) or salts thereof which have medicinal effects,in particular, preventive or therapeutic effects on heart diseases in which muscarine M2 receptors participate, wherein X represents CH or N; Y represents oxygen, NR4, S(O)n or NR5CO, wherein R4 and R5 are the same of different and each represents hydrogen or lower alkyl; and n is an integer of from 0 to 2; A represents lower alkylene; R1 and R2 are the same or different and each represents hydrogen, lower alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl, or R1 and R2 together with the nitrogen atom to which they are bonded may form a 4- to 9-membered nitrogen-containing saturated heterocycle optionally further containing one of oxygen, sulfur and nitrogen atoms and optionally having substituent(s); and R3 represents hydrogen, optionally substituted lower alkyl, hydroxy, lower alkoxy, nitro, halogeno, lower acyl or optionally substituted amino.
Inventors:
WATANABE TOSHIHIRO (JP)
KAKEFUDA AKIO (JP)
TANAKA AKIHIRO (JP)
KAKEFUDA AKIO (JP)
TANAKA AKIHIRO (JP)
Application Number:
PCT/JP1996/001462
Publication Date:
December 05, 1996
Filing Date:
May 30, 1996
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
WATANABE TOSHIHIRO (JP)
KAKEFUDA AKIO (JP)
TANAKA AKIHIRO (JP)
WATANABE TOSHIHIRO (JP)
KAKEFUDA AKIO (JP)
TANAKA AKIHIRO (JP)
International Classes:
C07D243/38; (IPC1-7): C07D243/38; A61K31/645
Other References:
EUR. J. MED. CHEM., 30(1), (1995), COHEN V.I.; JIN B.; GITLER M.S.; DE LA CRUZ R.A.; BOULAY S.F.; SOOD V.K.; ZEEBERG B.R.; REBA R.C., "Novel Potent and m2-Selective Antimuscarinic Compounds which Penetrate the Blood-Brain Barrier", p. 61-69.
LIFE SCI., Vol. 53, No. 23, (1993), GITLER MIRIAM S.; COHEN VICTOR I.; DE LA CRUZ ROSANNA; BOULAY SHEILA F.; JIN BIYUN; ZEEBERG BARRY R.; REBA RICHARD C., "A Novel Muscarinic Receptor Ligand which Penetrates the Blood Brain Barrier and Displays In Vivo Selectivity for the m2 Subtype", p. 1743-1751.
J. HETEROCYCL. CHEM., Vol. 20, No. 5, (1983), OKLOBDZIJA M.; COMISSO G.; DECORTE E.; KOVAC T.; ANGELI C.; MOIMAS F.; ZANON P.; ZONNO F.; TOSO R.; SUNJIC V., "Attempts at New Synthesis of 5,11-Dehydro-6H-Pyrido(2,3-b)(1,4)Benzodiazepin-6-One", p. 1335-1338.
FARMACO, ED. SCI., Vol. 37, No. 12, (1982), DECORTE E.; GRATTON G.; KOVAC T.; MIHALIC M.; COMISSO G.; ANGELI C.; TOSO R.; SUNJIC V., "Synthesis and Properties of Some New 11-Acyl-5,11-Dihydro-6H-Pyrido(2,3-b)(1,4)Benzodiazepin-6-Ones", p. 787-796.
LIFE SCI., Vol. 53, No. 23, (1993), GITLER MIRIAM S.; COHEN VICTOR I.; DE LA CRUZ ROSANNA; BOULAY SHEILA F.; JIN BIYUN; ZEEBERG BARRY R.; REBA RICHARD C., "A Novel Muscarinic Receptor Ligand which Penetrates the Blood Brain Barrier and Displays In Vivo Selectivity for the m2 Subtype", p. 1743-1751.
J. HETEROCYCL. CHEM., Vol. 20, No. 5, (1983), OKLOBDZIJA M.; COMISSO G.; DECORTE E.; KOVAC T.; ANGELI C.; MOIMAS F.; ZANON P.; ZONNO F.; TOSO R.; SUNJIC V., "Attempts at New Synthesis of 5,11-Dehydro-6H-Pyrido(2,3-b)(1,4)Benzodiazepin-6-One", p. 1335-1338.
FARMACO, ED. SCI., Vol. 37, No. 12, (1982), DECORTE E.; GRATTON G.; KOVAC T.; MIHALIC M.; COMISSO G.; ANGELI C.; TOSO R.; SUNJIC V., "Synthesis and Properties of Some New 11-Acyl-5,11-Dihydro-6H-Pyrido(2,3-b)(1,4)Benzodiazepin-6-Ones", p. 787-796.
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