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Title:
FUSED BICYCLIC COMPOUND AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2018/233553
Kind Code:
A1
Abstract:
Disclosed are a fused bicyclic compound and the use thereof in a medicine, particularly a novel fused bicyclic compound used as an ASK1 activity regulator and a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the use of the compound in the preparation of a medicine for treating a disease and/or condition regulated by ASK1. Also disclosed are a pharmaceutical composition comprising the compound and a method for treating a disease and/or condition regulated by ASK1 by using the compound or the pharmaceutical composition thereof.

Inventors:
PAN SHENGQIANG (CN)
MA FACHENG (CN)
ZHANG YINGXUN (CN)
XIONG SHAOHUI (CN)
YANG XINYE (CN)
WANG XIAOJUN (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2018/091392
Publication Date:
December 27, 2018
Filing Date:
June 15, 2018
Export Citation:
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Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61P9/00; A61P25/28; A61P29/00; A61P37/00
Domestic Patent References:
WO2008016131A12008-02-07
WO2016025474A12016-02-18
Foreign References:
CN101878212A2010-11-03
CN102482257A2012-05-30
CN102834393A2012-12-19
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