Title:
FUSED BICYCLIC SGC STIMULATORS
Document Type and Number:
WIPO Patent Application WO/2018/045276
Kind Code:
A8
Abstract:
The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula (I).
Inventors:
RENNIE GLEN ROBERT (US)
IYENGAR RAJESH R (US)
LEE THOMAS WAI-HO (US)
NAKAI TAKASHI (US)
MERMERIAN ARA (US)
JIA LEI (US)
IM G-YOON JAMIE (US)
RENHOWE PAUL ALLAN (US)
JUNG JOON (US)
GERMANO PETER (US)
IYER KARTHIK (US)
BARDEN TIMOTHY CLAUDE (US)
TANG KIM (US)
IYENGAR RAJESH R (US)
LEE THOMAS WAI-HO (US)
NAKAI TAKASHI (US)
MERMERIAN ARA (US)
JIA LEI (US)
IM G-YOON JAMIE (US)
RENHOWE PAUL ALLAN (US)
JUNG JOON (US)
GERMANO PETER (US)
IYER KARTHIK (US)
BARDEN TIMOTHY CLAUDE (US)
TANG KIM (US)
Application Number:
PCT/US2017/049834
Publication Date:
April 26, 2018
Filing Date:
September 01, 2017
Export Citation:
Assignee:
IRONWOOD PHARMACEUTICALS INC (US)
International Classes:
C07D487/04; A61K31/4985; A61P25/28; C07D471/04
Attorney, Agent or Firm:
DAVIS, Steven G. et al. (US)
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