FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF

WIPO Patent Application WO/2004/087727

A1

A fused heterocyclic derivative represented by the general formula (I) (wherein R¹ is hydrogen, OH, etc.; R² is hydrogen, halogeno, or alkyl; R³ and R⁴ each is hydrogen, OH, halogeno, etc.; Q is alkylene, etc.; ring A is aryl or heteroaryl; and G is the group represented by the formula (G1) or (G2)), (G1) (G2) a pharmacologically acceptable salt of the derivative, or a prodrug of either. They have excellent inhibitory activity against human SGLT and are useful as preventive or therapeutic agents for diseases attributable to hyperglycemia, such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, complications of diabetes, and obesity.

FUSHIMI NOBUHIKO (JP)
YONEKUBO SHIGERU (JP)
MURANAKA HIDEYUKI (JP)
SHIOHARA HIROAKI (JP)
TERANISHI HIROTAKA (JP)
SHIMIZU KAZUO (JP)
ITO FUMIAKI (JP)
ISAJI MASAYUKI (JP)

PCT/JP2004/004009

October 14, 2004

March 24, 2004

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KISSEI PHARMACEUTICAL (JP)
FUSHIMI NOBUHIKO (JP)
YONEKUBO SHIGERU (JP)
MURANAKA HIDEYUKI (JP)
SHIOHARA HIROAKI (JP)
TERANISHI HIROTAKA (JP)
SHIMIZU KAZUO (JP)
ITO FUMIAKI (JP)
ISAJI MASAYUKI (JP)

A61K31/7036; A61K31/7042; A61K31/7048; A61K31/7056; A61K31/706; A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00; C07H15/203; C07H17/00; C07H17/02; C07H17/04; (IPC1-7): C07H15/203; A61K31/7036; A61K31/7042; A61K31/7048; A61K31/7056; A61P3/04; A61P3/06; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00; C07H17/00; C07H17/02; C07H17/04

WO2002064606A1	2002-08-22
WO2001074834A1	2001-10-11

JP2003511458A

2003-03-25

See also references of EP 1609798A4
None

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