Title:
FUSED HETEROCYCLIC RING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/095663
Kind Code:
A1
Abstract:
Disclosed is a compound represented by formula (I) or a salt thereof, which has GPR 119 agonist action and excellent medicinal effects useful for prevention/treatment of diabetes, adiposis and the like. In the formula, P represents a substituted 6-membered aromatic ring; Q represents a (substituted) 6-membered aromatic ring; A1 represents CR4aR4b, NR4c, O, S, SO, SO2 (wherein R4a-R4c each represents H or the like); L1 represents a (substituted) C1-5 alkylene; L2 represents a bond, a (substituted) C1-3 alkylene; L3 and L4 each represents a (substituted) C1-3 alkylene; R1 represents H, X, CN, a (substituted) hydrocarbon, a (substituted) heterocyclic ring or a (substituted) OH, or alternatively combines with A1 to form a (substituted) 4- to 8-membered (heterocyclic) ring; R2 represents H, CN or a (substituted) hydrocarbon; and R3a represents -COSRA1 or a (substituted) 5- or 6-membered aromatic ring (wherein RA1 represents a (substituted) hydrocarbon or a (substituted) heterocyclic ring).)
Inventors:
RIKIMARU KENTARO (JP)
IMOTO HIROSHI (US)
KAMAURA MASAHIRO (JP)
IMOTO HIROSHI (US)
KAMAURA MASAHIRO (JP)
Application Number:
PCT/JP2010/052374
Publication Date:
August 26, 2010
Filing Date:
February 17, 2010
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
RIKIMARU KENTARO (JP)
IMOTO HIROSHI (US)
KAMAURA MASAHIRO (JP)
RIKIMARU KENTARO (JP)
IMOTO HIROSHI (US)
KAMAURA MASAHIRO (JP)
International Classes:
C07D401/14; A61K31/454; A61K31/506; A61K31/519; A61K31/5377; A61K31/55; A61P1/00; A61P1/02; A61P1/04; A61P1/08; A61P1/12; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/10; A61P13/12; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P21/04; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P27/12; A61P27/16; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P43/00; C07D405/14; C07D413/14; C07D487/04
Domestic Patent References:
| WO2008137436A1 | 2008-11-13 | |||
| WO2006083491A2 | 2006-08-10 | |||
| WO2005121121A2 | 2005-12-22 | |||
| WO2005007647A1 | 2005-01-27 | |||
| WO2009141238A1 | 2009-11-26 | |||
| WO2009051119A1 | 2009-04-23 |
Other References:
See also references of EP 2399914A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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