Title:
FUSED MULTI-HETEROCYCLIC COMPOUNDS AS KRAS G12D MODULATORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041573
Kind Code:
A1
Abstract:
This application discloses compounds of formula (I), which can be inhibitors of KRAS G12D or other KRAS mutants, and their uses.
Inventors:
HE YONG (CN)
JIA LANQI (CN)
WU WENTING (CN)
LI SHANGFENG (CN)
LU JUN (CN)
GU YUGUI (CN)
LU XIAOJIE (CN)
JIA LANQI (CN)
WU WENTING (CN)
LI SHANGFENG (CN)
LU JUN (CN)
GU YUGUI (CN)
LU XIAOJIE (CN)
Application Number:
PCT/CN2023/114491
Publication Date:
February 29, 2024
Filing Date:
August 23, 2023
Export Citation:
Assignee:
ZAI LAB SHANGHAI CO LTD (CN)
International Classes:
C07D498/06; A61K31/519; A61K31/55; A61P35/00; C07D498/14; C07D498/16; C07D498/22; C07D519/00
Domestic Patent References:
| WO2023172737A1 | 2023-09-14 | |||
| WO2023046135A1 | 2023-03-30 | |||
| WO2022216762A1 | 2022-10-13 | |||
| WO2023103906A1 | 2023-06-15 | |||
| WO2023030385A1 | 2023-03-09 | |||
| WO2023001141A1 | 2023-01-26 | |||
| WO2023001123A1 | 2023-01-26 | |||
| WO2022268051A1 | 2022-12-29 | |||
| WO2022206723A1 | 2022-10-06 | |||
| WO2022199587A1 | 2022-09-29 | |||
| WO2022194245A1 | 2022-09-22 | |||
| WO2022188729A1 | 2022-09-15 | |||
| WO2022173678A1 | 2022-08-18 |
Foreign References:
| CN116514846A | 2023-08-01 | |||
| CN116199703A | 2023-06-02 | |||
| CN115557974A | 2023-01-03 |
Other References:
KARGBO, ROBERT B.: "Targeting KRASG12D Mutations: Discovery of Small Molecule Inhibitors for the Potential Treatment of Intractable Cancers", ACS MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 8, 11 July 2023 (2023-07-11), pages 1041 - 1042, XP093133604, DOI: 10.1021/acsmedchemlett.3c00277
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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