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Title:
FUSED PYRIMIDINE COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/043398
Kind Code:
A1
Abstract:
Disclosed are a fused pyrimidine compound, an intermediate, a preparation method therefor, and a composition and an application thereof. The present invention provides a fused pyrimidine compound shown in formula I, pharmaceutically accepted salt, hydrate, solvate, and an optical isomer or prodrug of the compound. The present invention further provides applications of the fused pyrimidine compound shown in formula I, the pharmaceutically accepted salt, the hydrate, solvate, and the optical isomer or the prodrug of the compound in preparing drugs for curing and/or preventing a kinase-related disease. The fused pyrimidine compound I of the present invention is an efficient PI3 kinase depressor, and can be used to prepare drugs for preventing and/or curing cell-proliferative diseases such as cancer, infection, inflammation, and an autoimmune disease.

Inventors:
XU ZUSHENG (CN)
Application Number:
CN2014/086683
Publication Date:
April 02, 2015
Filing Date:
September 17, 2014
Export Citation:
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Assignee:
SHANGHAI YINGLI PHARMACEUTICAL CO LTD (201203, CN)
International Classes:
C07D495/04; A61K31/5377; A61K31/5386; A61P3/00; A61P9/00; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; C07D491/048; C07D519/00
Domestic Patent References:
WO2007132171A12007-11-22
WO2009052145A12009-04-23
WO2013152717A12013-10-17
WO2008064093A22008-05-29
WO2007044729A22007-04-19
WO2008127594A22008-10-23
WO2007127183A12007-11-08
WO2007129161A22007-11-15
WO2007072163A22007-06-28
WO2009147187A12009-12-10
WO2009147190A12009-12-10
WO2010120987A12010-10-21
WO2010120994A22010-10-21
WO2010091808A12010-08-19
WO2011101429A12011-08-25
WO2011041399A22011-04-07
WO2012040634A12012-03-29
WO2012037226A12012-03-22
WO2012032065A12012-03-15
WO2012007493A12012-01-19
WO2012135160A12012-10-04
WO2007023382A22007-03-01
WO2007023382A22007-03-01
WO2003087088A22003-10-23
WO2012032067A12012-03-15
WO2011079230A22011-06-30
WO2012037108A12012-03-22
WO2010139731A12010-12-09
WO2009147187A12009-12-10
WO2010008847A22010-01-21
Foreign References:
CN102014914A2011-04-13
US20040266780A12004-12-30
CN101675053A2010-03-17
Other References:
See also references of EP 3053926A4
TRENDS, BIOCHEM. SCI., vol. 22, 1997, pages 267 - 272
NAT.REV.CANCER, vol. 2, 2002, pages 489 - 501
ORG. LETT., vol. 8, no. 10, 2006, pages 2031 - 2034
J. ORG. CHERN., vol. 76, 2011, pages 2762 - 2769
TETRAHEDRON, vol. 63, 2007, pages 3623 - 3658
CHERN. REV., vol. 108, 2008, pages 288 - 325
CHEM. REV., vol. 95, 1995, pages 2457 - 2483
TETRAHEDRON, vol. 54, 1998, pages 8275 - 8319
ANGEW. CHEM. INT. ED., vol. 48, 2009, pages 7595 - 7599
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 2920 - 2923
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 2924 - 2929
CHERN. REV., vol. 95, 1995, pages 2457 - 2483
TETRAHEDRON, vol. 68, 2012, pages 329 - 339
TETRAHEDRON, vol. 63, 2007, pages 3608 - 3614
JOURNAL OF MEDICINAL CHEMISTRY, 2011, pages 5887 - 5900
J. ORG. CHEM., vol. 76, 2011, pages 2762 - 2769
CHEMICAL COMMUNICATION, 2008, pages 5824 - 5826
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (21st Floor, SFECO MansionNo. 681 Xiaomuqiao Road, Shanghai 2, 200032, CN)
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