Title:
FUSED PYRROLOPYRIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/119875
Kind Code:
A1
Abstract:
Disclosed is a fused pyrrolopyridine derivative which is useful as an active ingredient for a pharmaceutical composition, in particular a pharmaceutical composition for prevention or treatment of diseases that are caused by undesirable cytokine signaling or diseases that are caused by abnormal cytokine signaling.
The inventors have intensively studied on compounds having JAK inhibitory activity, and found that the compound of the present invention, namely a fused pyrrolopyridine derivative has excellent JAK inhibitory activity and is thus useful as an agent for prevention or treatment of diseases that are caused by undesirable cytokine signaling or diseases that are caused by abnormal cytokine signaling.
Inventors:
SHIRAKAMI SHOHEI (JP)
NAKAJIMA YUTAKA (JP)
MAEDA JUN (JP)
TOMINAGA HIROAKI (JP)
YAMAGISHI HIROAKI (JP)
HONDO TAKESHI (JP)
INAMI MASAMICHI (JP)
MORIO HIROKI (JP)
INOUE TAKAYUKI (JP)
MIZUTANI TSUYOSHI (JP)
ISHIOKA HIROKI (JP)
NAKAJIMA YUTAKA (JP)
MAEDA JUN (JP)
TOMINAGA HIROAKI (JP)
YAMAGISHI HIROAKI (JP)
HONDO TAKESHI (JP)
INAMI MASAMICHI (JP)
MORIO HIROKI (JP)
INOUE TAKAYUKI (JP)
MIZUTANI TSUYOSHI (JP)
ISHIOKA HIROKI (JP)
Application Number:
PCT/JP2010/056619
Publication Date:
October 21, 2010
Filing Date:
April 13, 2010
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
SHIRAKAMI SHOHEI (JP)
NAKAJIMA YUTAKA (JP)
MAEDA JUN (JP)
TOMINAGA HIROAKI (JP)
YAMAGISHI HIROAKI (JP)
HONDO TAKESHI (JP)
INAMI MASAMICHI (JP)
MORIO HIROKI (JP)
INOUE TAKAYUKI (JP)
MIZUTANI TSUYOSHI (JP)
ISHIOKA HIROKI (JP)
SHIRAKAMI SHOHEI (JP)
NAKAJIMA YUTAKA (JP)
MAEDA JUN (JP)
TOMINAGA HIROAKI (JP)
YAMAGISHI HIROAKI (JP)
HONDO TAKESHI (JP)
INAMI MASAMICHI (JP)
MORIO HIROKI (JP)
INOUE TAKAYUKI (JP)
MIZUTANI TSUYOSHI (JP)
ISHIOKA HIROKI (JP)
International Classes:
C07D471/14; A61K31/437; A61K31/439; A61K31/4545; A61K31/497; A61K31/541; A61K31/55; A61P1/04; A61P1/16; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/08; A61P17/10; A61P17/14; A61P19/02; A61P21/04; A61P25/00; A61P25/06; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P43/00; C07D519/00
Domestic Patent References:
| WO2008084861A1 | 2008-07-17 | |||
| WO2007007919A2 | 2007-01-18 | |||
| WO2006069080A2 | 2006-06-29 | |||
| WO2007022268A2 | 2007-02-22 | |||
| WO2007022268A2 | 2007-02-22 | |||
| WO2009152133A1 | 2009-12-17 | |||
| WO2007007919A2 | 2007-01-18 | |||
| WO2008084861A1 | 2008-07-17 |
Other References:
J. J. O'SHEA ET AL., CELL, vol. 109, 2002, pages 121
K. OZAKI ET AL., SCIENCE, vol. 298, 2002, pages 1630
P. MACCHI ET AL., NATURE, vol. 377, 1995, pages 65
S. M. RUSSELL ET AL., SCIENCE, vol. 270, 1995, pages 797
PETER J. MURRAY, J IMMUNOL., vol. 178, 2007, pages 2623 - 2629
STAERK J ET AL., PATHOL BIOL., vol. 55, 2007, pages 88 - 91
YOO JH ET AL., CANCER GENET CYTOGENET., vol. 189, 2009, pages 43 - 47
VAINCHENKER W ET AL., SEMIN CELL DEV BIOL., vol. 19, 2008, pages 385 - 393
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Pharmaceutical Research and Development, Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, pages: 163 - 189
P. G. M. WUTS, T. W. GREENE: "Greene's Protective Groups in Organic Synthesis(4th Ed.,)", 2006
S. R. SANDLER, W. KARO: "Organic Functional Group Preparations, 2nd Ed.,", vol. 1, 1991, ACADEMIC PRESS INC.
THE CHEMICAL SOCIETY OF JAPAN,: "Courses in Experimental Chemistry(5th edition)", vol. 14, 2005, MARUZEN
SYNTHESIS, vol. 4, 2006, pages 629 - 632
S. R. SANDLER, W. KARO: "Organic Functional Group Preparations, 2" Ed.,", 1991, ACADEMIC PRESS INC.
M. HUDLICKY: "Reductions in Organic Chemistry, 2nd ed.", 1996, ACS
R.C.LAROCK: "Comprehensive Organic Transformations, 2nd ed.", 1999, VCH PUBLISHERS, INC.
T. J. DONOHOE: "Oxidation and Reduction in Organic Synthesis (Oxford Chemistry Primers 6", 2000, SCIENCE PUBLICATIONS
B. M. TROST, COMPREHENSIVE ORGANIC SYNTHESIS, vol. 7, 1991
M. HUDLICKY: "Oxidation in Organic Chemistry", 1990, ACS
THE CHEMICAL SOCIETY OF JAPAN,: "Courses in Experimental Chemistry(5th edition)", vol. 17, 2005, MARUZEN
K. ONE, E. S LINDSEY: "Improved technique of heart transplantation in rats", J. THORAC. CARDIORAS. SURG, vol. 57, 1969, pages 225
MASUMI NOZAWA: "Manual for Organ Transplantation Experiment", 1999, KLUWER ACADEMIC PUBLISHERS
BR. J. PHARMACOL., vol. 139, no. 5, July 2003 (2003-07-01), pages 927 - 34
See also references of EP 2420502A4
K. OZAKI ET AL., SCIENCE, vol. 298, 2002, pages 1630
P. MACCHI ET AL., NATURE, vol. 377, 1995, pages 65
S. M. RUSSELL ET AL., SCIENCE, vol. 270, 1995, pages 797
PETER J. MURRAY, J IMMUNOL., vol. 178, 2007, pages 2623 - 2629
STAERK J ET AL., PATHOL BIOL., vol. 55, 2007, pages 88 - 91
YOO JH ET AL., CANCER GENET CYTOGENET., vol. 189, 2009, pages 43 - 47
VAINCHENKER W ET AL., SEMIN CELL DEV BIOL., vol. 19, 2008, pages 385 - 393
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Pharmaceutical Research and Development, Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, pages: 163 - 189
P. G. M. WUTS, T. W. GREENE: "Greene's Protective Groups in Organic Synthesis(4th Ed.,)", 2006
S. R. SANDLER, W. KARO: "Organic Functional Group Preparations, 2nd Ed.,", vol. 1, 1991, ACADEMIC PRESS INC.
THE CHEMICAL SOCIETY OF JAPAN,: "Courses in Experimental Chemistry(5th edition)", vol. 14, 2005, MARUZEN
SYNTHESIS, vol. 4, 2006, pages 629 - 632
S. R. SANDLER, W. KARO: "Organic Functional Group Preparations, 2" Ed.,", 1991, ACADEMIC PRESS INC.
M. HUDLICKY: "Reductions in Organic Chemistry, 2nd ed.", 1996, ACS
R.C.LAROCK: "Comprehensive Organic Transformations, 2nd ed.", 1999, VCH PUBLISHERS, INC.
T. J. DONOHOE: "Oxidation and Reduction in Organic Synthesis (Oxford Chemistry Primers 6", 2000, SCIENCE PUBLICATIONS
B. M. TROST, COMPREHENSIVE ORGANIC SYNTHESIS, vol. 7, 1991
M. HUDLICKY: "Oxidation in Organic Chemistry", 1990, ACS
THE CHEMICAL SOCIETY OF JAPAN,: "Courses in Experimental Chemistry(5th edition)", vol. 17, 2005, MARUZEN
K. ONE, E. S LINDSEY: "Improved technique of heart transplantation in rats", J. THORAC. CARDIORAS. SURG, vol. 57, 1969, pages 225
MASUMI NOZAWA: "Manual for Organ Transplantation Experiment", 1999, KLUWER ACADEMIC PUBLISHERS
BR. J. PHARMACOL., vol. 139, no. 5, July 2003 (2003-07-01), pages 927 - 34
See also references of EP 2420502A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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