Title:
FUSED QUINONE OXIME IMIDAZOLE, ONIUM DERIVATIVE THEREOF, PREPARATION THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/168908
Kind Code:
A1
Abstract:
Disclosed are fused quinone oxime imidazole, an onium derivative thereof, a preparation therefor and a use thereof. The structure of the fused quinone oxime imidazole is represented by the following general formulas (I), (II), (III) and (IV). The disclosure has a novel structure wherein a substituted quinone imidazole and the onium derivative thereof are fused with an aromatic carbon ring or a heterocyclic ring, and is characterized by oximation substitution. Test results both in vitro and in vivo of the derivative shows good inhibition activity against tumor cell growth, exhibits excellent selectivity, and has a good anti-tumor application prospect. Moreover, the anti-virus and antibacterial effects are good.
Inventors:
ZHANG WANBIN (CN)
YAN DEYUE (CN)
YUAN JING (CN)
ZHANG ZHENFENG (CN)
YAN DEYUE (CN)
YUAN JING (CN)
ZHANG ZHENFENG (CN)
Application Number:
PCT/CN2022/112932
Publication Date:
September 14, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
UNIV SHANGHAI JIAOTONG (CN)
International Classes:
C07D235/02; A61K31/4184; A61K31/497; A61P31/04; A61P31/12; A61P35/00; C07D403/06; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D409/06
Foreign References:
| CN108530365A | 2018-09-14 | |||
| CN108794403A | 2018-11-13 | |||
| CN1400969A | 2003-03-05 | |||
| RU2545091C1 | 2015-03-27 |
Other References:
SHANAB, K. ET AL.: "Synthesis and Biological Evaluation of Novel Cytotoxic Azanaphthoquinone Annelated Pyrrolo Oximes", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 22, 18 September 2007 (2007-09-18), XP022297103, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.09.054
PUNKVANG, A. ET AL.: "Molecular Dynamics Simulations of Azanaphthoquinone Annelated Pyrrole Derivatives as Anticancer Agent in DNA Duplex", INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, vol. 113, no. 4, 7 April 2012 (2012-04-07), XP071308132, ISSN: 0020-7608, DOI: 10.1002/qua.24120
KAMSRI PHARIT, PUNKVANG AURADEE, PONGPROM NIPAWAN, SRISUPAN APINYA, SAPARPAKORN PATCHREENART, HANNONGBUA SUPA, WOLSCHANN PETER, PU: "Key Structural Features of Azanaphthoquinone Annelated Pyrrole Derivative as Anticancer Agents Based on the Rational Drug Design Approaches", MOLECULAR INFORMATICS, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 32, no. 5-6, 1 June 2013 (2013-06-01), Hoboken, USA, pages 541 - 554, XP093090523, ISSN: 1868-1743, DOI: 10.1002/minf.201200132
PUNKVANG, A. ET AL.: "Molecular Dynamics Simulations of Azanaphthoquinone Annelated Pyrrole Derivatives as Anticancer Agent in DNA Duplex", INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, vol. 113, no. 4, 7 April 2012 (2012-04-07), XP071308132, ISSN: 0020-7608, DOI: 10.1002/qua.24120
KAMSRI PHARIT, PUNKVANG AURADEE, PONGPROM NIPAWAN, SRISUPAN APINYA, SAPARPAKORN PATCHREENART, HANNONGBUA SUPA, WOLSCHANN PETER, PU: "Key Structural Features of Azanaphthoquinone Annelated Pyrrole Derivative as Anticancer Agents Based on the Rational Drug Design Approaches", MOLECULAR INFORMATICS, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 32, no. 5-6, 1 June 2013 (2013-06-01), Hoboken, USA, pages 541 - 554, XP093090523, ISSN: 1868-1743, DOI: 10.1002/minf.201200132
Attorney, Agent or Firm:
DUAN&DUAN LAW FIRM (CN)
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