Title:
FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1998/037070
Kind Code:
A1
Abstract:
Novel compounds which are compounds represented by general formula (I) or salts thereof having a steroid C�17-20? lyase inhibitory activity and being useful as preventives or remedies for tumors such as prostatism and mammary cancer. In said formula, A�1? represents a five- or six-membered ring optionally having substituent(s) excluding cyclic ones; A�2? represents an optionally substituted aromatic ring; X represents a divalent group; Y represents nitrogen or methine; Z represents optionally substituted ethenylene or ethynylene; and R represents an optionally substituted heterocyclic group, provided that 3,4-dihydro-6-[3-(1H-imidazol-1-yl)-1-propenyl]-2(1H)-quinolone and 2-[3-[5-ethyl-6-methyl-2-(benzyloxy)-3-pyridyl]-1-propenyl-benzoxazole] are excluded therefrom.
More Like This:
Inventors:
AONO TETSUYA (JP)
ITOH FUMIO (JP)
KAKU TOMOHIRO (JP)
YAMAOKA MASUO (JP)
ITOH FUMIO (JP)
KAKU TOMOHIRO (JP)
YAMAOKA MASUO (JP)
Application Number:
PCT/JP1998/000688
Publication Date:
August 27, 1998
Filing Date:
February 19, 1998
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
AONO TETSUYA (JP)
ITOH FUMIO (JP)
KAKU TOMOHIRO (JP)
YAMAOKA MASUO (JP)
AONO TETSUYA (JP)
ITOH FUMIO (JP)
KAKU TOMOHIRO (JP)
YAMAOKA MASUO (JP)
International Classes:
C07D213/16; C07D233/54; C07D233/56; C07D233/58; C07D249/08; C07D405/06; C07D409/06; C07D521/00; (IPC1-7): C07D213/06; C07D233/58; C07D233/56; C07D401/06; C07D405/06; C07D409/06; C07D249/08; A61K31/415; A61K31/44
Domestic Patent References:
| WO1995009157A1 | 1995-04-06 | |||
| WO1993010113A1 | 1993-05-27 | |||
| WO1998001443A1 | 1998-01-15 | |||
| WO1997033856A1 | 1997-09-18 | |||
| WO1997020815A1 | 1997-06-12 | |||
| WO1997029079A1 | 1997-08-14 | |||
| WO1997017321A1 | 1997-05-15 | |||
| WO1997036864A1 | 1997-10-09 | |||
| WO1996021644A1 | 1996-07-18 | |||
| WO1996023773A1 | 1996-08-08 |
Foreign References:
| JPS6485975A | 1989-03-30 | |||
| JPH06293640A | 1994-10-21 | |||
| JPH07173120A | 1995-07-11 | |||
| JPH01246272A | 1989-10-02 | |||
| JPH06239856A | 1994-08-30 |
Other References:
CRISTALLI G., CAMAIONI E., VITTORI S., VOLPINI R., "Platelet Aggregation Inhibitory Activity of Selective A2 Adenosine Receptor Agonists", NUCLEOSIDES AND NUCLEATIDES, Vol. 14, No. 3-5, (1995), p. 449-453.
LI R., CHEN X., GONG B., DOMINGUES J.N., DAVIDSON E., KURZBAN G., MILLER R.E., NUZUM E.O., ROSENTHAL P.J. et al., "In Vitro Antimalarial Activity of Chalcones and Their Derivatives", J. MED. CHEM., Vol. 38, No. 26, (1995), p. 5031-5037.
ALAIMO R.J., HATTON C.J., "Anthelmitic 1-Cinnamaido-2,4-Imidazolidinediones", J. MED. CHEM., Vol. 19, No. 20, (1976), p. 349-350.
See also references of EP 0974584A4
LI R., CHEN X., GONG B., DOMINGUES J.N., DAVIDSON E., KURZBAN G., MILLER R.E., NUZUM E.O., ROSENTHAL P.J. et al., "In Vitro Antimalarial Activity of Chalcones and Their Derivatives", J. MED. CHEM., Vol. 38, No. 26, (1995), p. 5031-5037.
ALAIMO R.J., HATTON C.J., "Anthelmitic 1-Cinnamaido-2,4-Imidazolidinediones", J. MED. CHEM., Vol. 19, No. 20, (1976), p. 349-350.
See also references of EP 0974584A4
Attorney, Agent or Firm:
Asahina, Tadao (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka, JP)
Download PDF:
Previous Patent: INDOLE DICARBOXYLIC ACID DERIVATIVES
Next Patent: PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLIDINEDIONE
Next Patent: PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLIDINEDIONE