Title:
FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
Document Type and Number:
WIPO Patent Application WO2005025293
Kind Code:
A3
Abstract:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions. .
Inventors:
MCNAUGHTON-SMITH GRANT ANDREW (US)
AMATO GEORGE SALVATORE (US)
THOMAS JAMES BARNWELL JR (US)
AMATO GEORGE SALVATORE (US)
THOMAS JAMES BARNWELL JR (US)
Application Number:
PCT/US2004/029868
Publication Date:
June 16, 2005
Filing Date:
September 10, 2004
Export Citation:
Assignee:
ICAGEN INC (US)
MCNAUGHTON-SMITH GRANT ANDREW (US)
AMATO GEORGE SALVATORE (US)
THOMAS JAMES BARNWELL JR (US)
MCNAUGHTON-SMITH GRANT ANDREW (US)
AMATO GEORGE SALVATORE (US)
THOMAS JAMES BARNWELL JR (US)
International Classes:
C07D239/92; C07D285/24; C07D401/12; C07D409/12; C07D413/12; C07D471/04; C07D487/04; C07D498/04; C07D513/04; (IPC1-7): A61K31/497; A01N43/54; A61K31/517; C07D401/00; C07D403/00; C07D413/00; C07D417/00; C07D419/00
Domestic Patent References:
| WO2001092283A2 | 2001-12-06 |
Other References:
DATABASE CAPLUS [online] MOHAMED M.M: "Reaction of 3-amino-2-propyl-4(3H)-quinazolinone with aromatic aldehydes, nitrogen nucleophiles, and esters", XP002986013, Database accession no. (1983:438433)
DATABASE CAPLUS [online] VARNAVAS A. ET AL: "Quinazolinone derivatives : synthesis and binding evaluation oncholecystokinin receptors", XP002986014, Database accession no. (1983:377707)
DATABASE CAPLUS [online] DESAI N.C. ET AL: "Synthesis of substituted quinazolone derivatives as potential anti-HIV agents(Part III)", XP002986015, Database accession no. (1996:377710)
DATABASE CAPLUS [online] KLOSA J. ET AL: "Synthesis of amides in the quinazolone series", XP002986016, Database accession no. (1966:412304)
DATABASE CAPLUS [online] BUU-HOI N.P. ET AL: "Synthesis of pharmacological properties of urethan and urea derivatives of heterocayclis amines", XP002986017, Database accession no. (1966:412305)
SMITH K. ET AL: "Lithiation of 3-(Acylamino)-2-unsubstituted-, 3-(Acylamino)-2-ethyl-, and 3-(Acylamino)-2-propyl-4(3H)-quinazolinones: Convenient Syntheses of More Complex Quinazolinones(1).", J ORG CHEM, vol. 61, no. 2, 1996, pages 647 - 655, XP002986018
See also references of EP 1663237A4
DATABASE CAPLUS [online] VARNAVAS A. ET AL: "Quinazolinone derivatives : synthesis and binding evaluation oncholecystokinin receptors", XP002986014, Database accession no. (1983:377707)
DATABASE CAPLUS [online] DESAI N.C. ET AL: "Synthesis of substituted quinazolone derivatives as potential anti-HIV agents(Part III)", XP002986015, Database accession no. (1996:377710)
DATABASE CAPLUS [online] KLOSA J. ET AL: "Synthesis of amides in the quinazolone series", XP002986016, Database accession no. (1966:412304)
DATABASE CAPLUS [online] BUU-HOI N.P. ET AL: "Synthesis of pharmacological properties of urethan and urea derivatives of heterocayclis amines", XP002986017, Database accession no. (1966:412305)
SMITH K. ET AL: "Lithiation of 3-(Acylamino)-2-unsubstituted-, 3-(Acylamino)-2-ethyl-, and 3-(Acylamino)-2-propyl-4(3H)-quinazolinones: Convenient Syntheses of More Complex Quinazolinones(1).", J ORG CHEM, vol. 61, no. 2, 1996, pages 647 - 655, XP002986018
See also references of EP 1663237A4
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