Title:
FUSION POLYPEPTIDE OF GLP-1 ANALOG
Document Type and Number:
WIPO Patent Application WO/2023/051462
Kind Code:
A1
Abstract:
The present invention relates to a fusion polypeptide of GLP-1 analog. Specifically, the present invention relates to a fusion polypeptide of GLP-1 analog or a pharmaceutically acceptable salt thereof, wherein the fusion polypeptide of GLP-1 analog comprise a GLP-l(7-37) analog, a C-terminal extension of the GLP-1(7- 37) analog, and a fusion protein fragment. Further, the present invention relates to a composition comprising the fusion polypeptide of GLP-1 analog or the pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
Inventors:
SUN LEI (CN)
LV HUI (CN)
ZHANG LEI (CN)
LV HUI (CN)
ZHANG LEI (CN)
Application Number:
PCT/CN2022/121356
Publication Date:
April 06, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
HEFEI TIANHUI BIOTECH CO LTD (CN)
International Classes:
C07K19/00; A61K38/26; A61P5/48; C12N15/11
Domestic Patent References:
| WO2003103572A2 | 2003-12-18 |
Foreign References:
| CN111607004A | 2020-09-01 | |||
| CN110128552A | 2019-08-16 | |||
| CN108191981A | 2018-06-22 | |||
| CN113105536A | 2021-07-13 |
Other References:
LI, Y. ET AL.: "Disulfide bond prolongs the half-life of therapeutic peptide-GLP-1", PEPTIDES, vol. 32, 11 May 2011 (2011-05-11), pages 1400 - 1407, XP028236671, DOI: 10.1016/j.peptides.2011.05.003
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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