Title:
FUSION POLYPEPTIDE FOR INHIBITING COMPLEMENT ACTIVATION PATHWAY
Document Type and Number:
WIPO Patent Application WO/2018/070521
Kind Code:
A1
Abstract:
In one embodiment, the present invention addresses the problem of: providing an agent for inhibiting a lectin pathway and an alternative pathway; and others. In one embodiment, the present invention relates to: a fusion polypeptide containing a first region on the N-terminal side and a second region on the C-terminal side, wherein the first region contains a CUB1 domain and an EGF domain of MASP-2 protein or sMAP protein and the second region contains an SCR domain of factor H protein; a polynucleotide encoding the fusion polypeptide; a vector carrying the polynucleotide; and others.
Inventors:
SEKINE HIDEHARU (JP)
TAKASUMI MIKA (JP)
TAKASUMI MIKA (JP)
Application Number:
PCT/JP2017/037188
Publication Date:
April 19, 2018
Filing Date:
October 13, 2017
Export Citation:
Assignee:
UNIV FUKUSHIMA MEDICAL (JP)
International Classes:
C12N15/09; A61K35/76; A61K38/54; A61K48/00; A61P1/04; A61P9/10; A61P13/02; A61P13/12; A61P19/02; A61P27/02; A61P29/00; A61P31/04; A61P37/02; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; A61P43/00; C12N9/50
Domestic Patent References:
| WO2005123776A1 | 2005-12-29 |
Foreign References:
| JP2013520979A | 2013-06-10 |
Other References:
SEKINE, EIJI ET AL., DISEASE THAT SHOW ABNORMAL SERUM COMPLEMENT LEVELS : MECHANISM OF ALTERATION IN SERUM COMPLEMENT LEVELS, COMPLEMENT, vol. 52, no. 2, 2015, pages 14 - 26, ISSN: 1288-8205
DATABASE GenBank PROTEIN; 15 February 2015 (2015-02-15), XP055500451, Database accession no. NP_034018
IWAKI, D. ET AL.: "Small Mannose-Binding Lectin-Associated Protein Plays a Regulatory Role in the Lectin Complement Pathway", THE JOURNAL OF IMMUNOLOGY, vol. 177, 2006, pages 8626 - 8632, XP055500458
TAKASUMI, MIKA ET AL., DEVELOPMENT OF SMAP-FH, WHICH IS NOVEL ANTI-COMPLEMENTARY DRUG, HAVING, AS TARGET, COMPLEMENTARY LECTIN PATHWAY AND SECOND PATH, vol. 54, no. 1, September 2017 (2017-09-01), pages 49 - 50, ISSN: 1288-8205
SEKINE, EIJI: "Complement in the pathogenesis of rheumatic disease and possible complement-targeted", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 257, no. 8, May 2016 (2016-05-01), pages 854 - 860, ISSN: 0039-2359
DATABASE GenBank PROTEIN; 15 February 2015 (2015-02-15), XP055500451, Database accession no. NP_034018
IWAKI, D. ET AL.: "Small Mannose-Binding Lectin-Associated Protein Plays a Regulatory Role in the Lectin Complement Pathway", THE JOURNAL OF IMMUNOLOGY, vol. 177, 2006, pages 8626 - 8632, XP055500458
TAKASUMI, MIKA ET AL., DEVELOPMENT OF SMAP-FH, WHICH IS NOVEL ANTI-COMPLEMENTARY DRUG, HAVING, AS TARGET, COMPLEMENTARY LECTIN PATHWAY AND SECOND PATH, vol. 54, no. 1, September 2017 (2017-09-01), pages 49 - 50, ISSN: 1288-8205
SEKINE, EIJI: "Complement in the pathogenesis of rheumatic disease and possible complement-targeted", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 257, no. 8, May 2016 (2016-05-01), pages 854 - 860, ISSN: 0039-2359
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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