Title:
ANGPTL3/8 FUSION POLYPEPTIDES AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2020/131606
Kind Code:
A9
Abstract:
Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodes bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
Inventors:
QIAN YUEWEI (US)
SCHROEDER OLIVER (US)
SIEGEL ROBERT WILLIAM (US)
CHAI QING (US)
DAY JONATHAN WESLEY (US)
KONRAD ROBERT JOHN (US)
SCHROEDER OLIVER (US)
SIEGEL ROBERT WILLIAM (US)
CHAI QING (US)
DAY JONATHAN WESLEY (US)
KONRAD ROBERT JOHN (US)
Application Number:
PCT/US2019/066151
Publication Date:
November 12, 2020
Filing Date:
December 13, 2019
Export Citation:
Assignee:
LILLY CO ELI (US)
International Classes:
C07K16/22
Attorney, Agent or Firm:
CHOLEWA, Brian C. et al. (US)
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