Title:
FUSION PROTEIN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/280133
Kind Code:
A9
Abstract:
A fusion protein and an application thereof, the fusion protein containing a human GLP-1 polypeptide variant and an immunoglobulin Fc region; compared to the amino acid sequence shown in SEQ ID NO: 2, the amino acid sequence of the human GLP-1 polypeptide variant contains at least two amino acid mutations, and the at least two amino acid mutations are located at amino acid positions selected from the group consisting of W31, K26, and Y19. Also provided is an application of the fusion protein in the treatment of diseases or conditions.
Inventors:
XU TING (CN)
JIN YUHAO (CN)
WANG XIAOXIAO (CN)
WANG PILIN (CN)
GUO KANGPING (CN)
JIN YUHAO (CN)
WANG XIAOXIAO (CN)
WANG PILIN (CN)
GUO KANGPING (CN)
Application Number:
PCT/CN2022/103777
Publication Date:
February 02, 2023
Filing Date:
July 05, 2022
Export Citation:
Assignee:
SUZHOU ALPHAMAB CO LTD (CN)
International Classes:
C07K14/605; A61K38/26; A61K47/68; C07K19/00
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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