Title:
FUSION PROTEIN COMPRISING ANGPTL3 MONOCLONAL ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2024/041236
Kind Code:
A1
Abstract:
A fusion protein ANGPTL3 monoclonal antibody-B comprising an ANGPTL3 monoclonal antibody is formed by fusing the ANGPTL3 monoclonal antibody with a sequence B. The fusion protein ANGPTL3 monoclonal antibody-B is used for treating diseases or disorders, such as diabetes and complications thereof, such as diabetic nephropathy, diabetic retinopathy, diabetic foot, diabetic cardiovascular complications, diabetic cerebrovascular diseases (cerebral arteriosclerosis and asymptomatic cerebral apoplexy), diabetic neuropathy, kidney-related diseases such as membranous nephropathy, IgA nephropathy, Henoch-Schönlein purpura nephritis, and lupus nephritis, and tumor-related diseases such as hepatocellular carcinoma, renal cell carcinoma, ovarian cancer, cervical cancer, oral cancer, and esophageal cancer.
Inventors:
XU HONG (CN)
JU DIANWEN (CN)
SHEN QIAN (CN)
RAO JIA (CN)
ZHAI YIHUI (CN)
SUN LI (CN)
LIU HAIMEI (CN)
LV QIANYING (CN)
HAN XINLI (CN)
MA QIANQIAN (CN)
SHAO LEILIN (CN)
JU DIANWEN (CN)
SHEN QIAN (CN)
RAO JIA (CN)
ZHAI YIHUI (CN)
SUN LI (CN)
LIU HAIMEI (CN)
LV QIANYING (CN)
HAN XINLI (CN)
MA QIANQIAN (CN)
SHAO LEILIN (CN)
Application Number:
PCT/CN2023/106045
Publication Date:
February 29, 2024
Filing Date:
July 06, 2023
Export Citation:
Assignee:
CHILDRENS HOSPITAL FUDAN UNIV (CN)
GUANGDONG HONG KONG MACAO GREATER BAY AREA PRECISION MEDICINE RES INSTITUTE GUANGZHOU (CN)
GUANGDONG HONG KONG MACAO GREATER BAY AREA PRECISION MEDICINE RES INSTITUTE GUANGZHOU (CN)
International Classes:
C07K19/00; A61K38/20; A61K39/395; A61P3/10; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P27/02; A61P29/00; A61P35/00; C12N15/62
Foreign References:
| CN113831413A | 2021-12-24 | |||
| CN103732624A | 2014-04-16 | |||
| CN110938144A | 2020-03-31 | |||
| CN111655717A | 2020-09-11 | |||
| CN113423722A | 2021-09-21 |
Other References:
MA QIANQIAN, HU XIAOZHI, LIU FANGYU, CAO ZHONGLIAN, HAN LEI, ZHOU KAICHENG, BAI YU, ZHANG YUTING, NAN YANYANG, LV QIANYING, RAO JI: "A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 13, 1 December 2022 (2022-12-01), Lausanne, CH , pages 1011442, XP093142352, ISSN: 1664-3224, DOI: 10.3389/fimmu.2022.1011442
Attorney, Agent or Firm:
BEIJING XIANGHE INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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