Title:
FUSION PROTEIN COMPRISING GLUTATHIONE-S-TRANSFERASE AND PROTEIN HAVING BINDING AFFINITY TARGET CELL OR TARGET PROTEIN, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/107896
Kind Code:
A1
Abstract:
The present invention relates to a fusion protein comprising glutathione-S-transferase and a protein having binding affinity for a target cell or a target protein, and a use thereof as a drug delivery carrier and a pharmaceutical composition. A fusion protein and a drug delivery carrier comprising the same according to an aspect can prolong the retention time in vivo and have enhanced targeting ability toward target cells. Hence, the protein can be effectively delivered to the target cells and has the effect of being useful as an agent for targeted therapy.
Inventors:
RYU JA HYOUNG (KR)
OH JOON YONG (KR)
KIM HAN SOL (KR)
KIM CHAE KYU (KR)
KANG SE BYUNG (KR)
OH JOON YONG (KR)
KIM HAN SOL (KR)
KIM CHAE KYU (KR)
KANG SE BYUNG (KR)
Application Number:
PCT/KR2018/014782
Publication Date:
June 06, 2019
Filing Date:
November 28, 2018
Export Citation:
Assignee:
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
International Classes:
A61K9/51; A61K9/50; A61K47/64; A61K47/69
Domestic Patent References:
| WO1993019091A1 | 1993-09-30 |
Foreign References:
| KR20170028637A | 2017-03-14 |
Other References:
MA, W.: "Protein Conjugation to Nanoparticles by Designer Affinity Tags", MATERIALS TODAY: PROCEEDINGS, vol. 4, no. 7, 1 September 2017 (2017-09-01), pages 6923 - 6929, XP055618923
HA, T. H.: "Oriented Immobilization of Antibodies with GST-Fused Multiple Fc-Specific B-Domains on a Gold Surface", ANAL. CHEM., vol. 79, no. 2, 15 January 2007 (2007-01-15), pages 546 - 556, XP055618926
MAHMOUDI, M.: "Emerging understanding of the protein corona at the nano-bio interfaces", NANO TODAY, vol. 11, no. 6, December 2016 (2016-12-01), pages 817 - 832, XP029840844
VINLUAN, III, R. D .: "Glutathione-coated luminescent gold nanoparticles: a surface ligand for minimizing serum protein adsorption", ACS APPLIED MATERIALS & INTERFACES, vol. 6, no. 15, 18 July 2014 (2014-07-18), pages 11829 - 11833, XP055618931
STEFAN STAHL ET AL., AFFIBODY MOLECULES IN BIOTECHNOLOGICAL AND MEDICAL APPLICATIONS, TRENDS IN BIOTECHNOLOGY, vol. 35, no. 8, August 2017 (2017-08-01)
MUELLER, L. N.BRUSNIAK, M.-Y.MANI, D.AEBERSOLD, R., JOURNAL OF PROTEOME RESEARCH, vol. 7, 2008, pages 51 - 61
See also references of EP 3718540A4
HA, T. H.: "Oriented Immobilization of Antibodies with GST-Fused Multiple Fc-Specific B-Domains on a Gold Surface", ANAL. CHEM., vol. 79, no. 2, 15 January 2007 (2007-01-15), pages 546 - 556, XP055618926
MAHMOUDI, M.: "Emerging understanding of the protein corona at the nano-bio interfaces", NANO TODAY, vol. 11, no. 6, December 2016 (2016-12-01), pages 817 - 832, XP029840844
VINLUAN, III, R. D .: "Glutathione-coated luminescent gold nanoparticles: a surface ligand for minimizing serum protein adsorption", ACS APPLIED MATERIALS & INTERFACES, vol. 6, no. 15, 18 July 2014 (2014-07-18), pages 11829 - 11833, XP055618931
STEFAN STAHL ET AL., AFFIBODY MOLECULES IN BIOTECHNOLOGICAL AND MEDICAL APPLICATIONS, TRENDS IN BIOTECHNOLOGY, vol. 35, no. 8, August 2017 (2017-08-01)
MUELLER, L. N.BRUSNIAK, M.-Y.MANI, D.AEBERSOLD, R., JOURNAL OF PROTEOME RESEARCH, vol. 7, 2008, pages 51 - 61
See also references of EP 3718540A4
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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