Title:
FUSION PROTEIN COMPRISING THYROTROPIN RECEPTOR VARIANTS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/022776
Kind Code:
A1
Abstract:
Disclosed are a fusion protein comprising a thyrotropin receptor (TSHR) fragment and the use thereof. More specifically, disclosed are a fusion protein comprising a TSHR fragment comprising an extracellular domain of a wild-type TSHR and having a substitution of an amino acid at specific position and an immunoglobulin Fc region or a carboxy-terminal cap (C-CAP), and the use thereof. The fusion protein has improved pharmaceutical efficacy, in-vivo persistence and protein stability and a pharmaceutical composition containing the fusion protein as an active ingredient is useful as a therapeutic agent or diagnostic reagent for the alleviation of Graves' disease and Graves' ophthalmopathy.
Inventors:
SONG MOO YOUNG (KR)
YOON TAEJIN (KR)
LEE JUNG-SUN (KR)
CHOI BYUNG HYUN (KR)
LIM IN HWAN (KR)
PARK MAN SIL (KR)
LEE JIN-HYOUNG (KR)
SEO HYOUNG SIG (KR)
KANG HYEON WOO (KR)
KIM SUNG HO (KR)
LEE EUN JIG (KR)
YOON JIN SOOK (KR)
KU CHEOL RYONG (KR)
YOON TAEJIN (KR)
LEE JUNG-SUN (KR)
CHOI BYUNG HYUN (KR)
LIM IN HWAN (KR)
PARK MAN SIL (KR)
LEE JIN-HYOUNG (KR)
SEO HYOUNG SIG (KR)
KANG HYEON WOO (KR)
KIM SUNG HO (KR)
LEE EUN JIG (KR)
YOON JIN SOOK (KR)
KU CHEOL RYONG (KR)
Application Number:
PCT/KR2019/009177
Publication Date:
January 30, 2020
Filing Date:
July 24, 2019
Export Citation:
Assignee:
YUHAN CORP (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
C07K14/72; A61K38/17; A61K47/64; A61K47/68; A61P5/14
Domestic Patent References:
| WO2000005345A1 | 2000-02-03 | |||
| WO2006016121A1 | 2006-02-16 | |||
| WO2015189543A2 | 2015-12-17 |
Other References:
CHAZENBALK, G. D. ET AL.: "Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in graves' patients' sera", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 30, 25 July 1997 (1997-07-25), pages 18959 - 18965, XP002296096, DOI: 10.1074/jbc.272.30.18959
CUNDIFF, J. G. ET AL.: "Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 86, no. 9, 2001, pages 4254 - 4260, XP002294126, DOI: 10.1210/jc.86.9.4254
DATABASE PROTEIN 14 January 1995 (1995-01-14), ANONYMOUS: "Thyroid stimulatory hormone receptor [Homo sapiens]", XP055681645, retrieved from NCBI Database accession no. AAA61236
CUNDIFF, J. G. ET AL.: "Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 86, no. 9, 2001, pages 4254 - 4260, XP002294126, DOI: 10.1210/jc.86.9.4254
DATABASE PROTEIN 14 January 1995 (1995-01-14), ANONYMOUS: "Thyroid stimulatory hormone receptor [Homo sapiens]", XP055681645, retrieved from NCBI Database accession no. AAA61236
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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