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Title:
FUSION PROTEIN
Document Type and Number:
WIPO Patent Application WO/2019/163871
Kind Code:
A1
Abstract:
The present invention provides a prospective means for use in a novel drug delivery system (DDS), an electronic device production, etc. More particularly, the present invention provides: a fusion protein containing (a) a ferritin monomer, and (b) a functional peptide inserted in a flexible linker region between α-helices of B- and C-regions in the ferritin monomer; and a polymer which has a lumen and is composed of a fusion protein containing (a) a ferritin monomer, and (b) a functional peptide inserted in a flexible linker region between α-helices of B- and C-regions in the ferritin monomer.

Inventors:
INOUE, Ippei (Inc. 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-sh, Kanagawa 81, 〒2108681, JP)
Application Number:
JP2019/006473
Publication Date:
August 29, 2019
Filing Date:
February 21, 2019
Export Citation:
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Assignee:
AJINOMOTO CO., INC. (15-1, Kyobashi 1-chome Chuo-k, Tokyo 15, 〒1048315, JP)
International Classes:
C12N15/62; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63
Domestic Patent References:
WO2012086647A12012-06-28
Foreign References:
US20160060307A12016-03-03
Other References:
ZHANG, YU ET AL.: "Self-Assembly in the Ferritin Nano-Cage Protein Superfamily", INT. J. MOL. SCI., vol. 12, no. 12, 22 August 2011 (2011-08-22), pages 5406 - 5421, XP055427570, DOI: 10.3390/ijms12085406
KIM, SOO-JI ET AL.: "Designing Peptide Bunches on Nanocage for Bispecific or Superaffinity Targeting", BIOMACROMOLECULES, vol. 17, no. 3, 22 February 2016 (2016-02-22), pages 1150 - 1159, XP055633374
JI, TIANJIAO ET AL.: "Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging", SMALL, vol. 9, no. 14, 22 July 2013 (2013-07-22), pages 2427 - 2431, XP055633376
CARMONA, FERNANDO ET AL.: "Study of ferritin self- assembly and heteropolymer formation by the use of Fluorescence Resonance Energy Transfer (FRET) technology", BBA, vol. 1861, 18 December 2016 (2016-12-18), pages 522 - 532, XP029897101, DOI: 10.1016/j.bbagen.2016.12.011
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (Toranomon Mitsui Building, 8-1 Kasumigaseki 3-chome, Chiyoda-k, Tokyo 13, 〒1000013, JP)
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