Title:
FUSION PROTEINS COMPRISING MGF AND IL-3
Document Type and Number:
WIPO Patent Application WO/1993/010229
Kind Code:
A1
Abstract:
A fusion protein which comprises MGF and IL-3. Such fusion proteins have enhanced biological activity.
More Like This:
Inventors:
WILLIAMS DOUGLAS E (US)
Application Number:
PCT/US1992/009848
Publication Date:
May 27, 1993
Filing Date:
November 19, 1992
Export Citation:
Assignee:
IMMUNEX CORP (US)
International Classes:
A61P29/00; A61P37/00; C07K14/475; A61K38/00; C07K14/52; C07K14/54; C07K19/00; C12N15/00; C12N15/09; C12P21/02; C12R1/865; C12R1/91; (IPC1-7): C07K13/00; C12N15/00; C12P21/06
Foreign References:
| EP0275598A1 | 1988-07-27 |
Other References:
PNAS, Vol. 88, issued July 1991, CURTIS et al., "Enhanced Hematopoietic Activity of a Human Granulocyte/ Macrophage Colony-Stimulating Factor-Interleukin 3 Fusion Protein", pp. 5809-5813, see entire document.
Cell, Vol. 63, issued 05 October 1990, ANDERSON et al., "Molecular Cloning of Mast Cell Growth Factor, a Hematopoietin that is Active in Both Membrane Bound and Soluble Forms", pages 235-243, see entire document.
Cell, Vol. 63, issued 05 October 1990, ZSEBO et al., "Identification, Purification, and Biological Characterization of Hematopoietic Stem Cell Factor from Buffalo Rat Liver-Conditioned Medium", pages 195-201, see entire document.
Cell, Vol. 63, issued 05 October 1990, MARTIN et al., "Primary Structure and Functional Expression of Rat and Human Stem Cell Factor DNAs", pp. 203-211, see entire document.
Journal of Cell Physiology, Vol. 148, No. 3, issued September 1991, TSUJI et al., "Murine Mast Cell Colony Formation Supported by IL-3, IL-4, and Recombinant Rat Stem Cell Factor, Ligand for c-kit", pages 362-369, Abstract only.
Journal of Experimental Medicine, Vol. 174, No. 2, issued 01 August 1991, BROXMEYER et al., "CD45 Cell Surface Antigens are Linked to Stimulation of Early Human Myeloid Progenitor Cells by Interleukin 3 (IL-3), Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF), a GM-CSF/IL-3 Fusion Protein, and Mast Cell Growth Factor (a
See also references of EP 0672152A4
Cell, Vol. 63, issued 05 October 1990, ANDERSON et al., "Molecular Cloning of Mast Cell Growth Factor, a Hematopoietin that is Active in Both Membrane Bound and Soluble Forms", pages 235-243, see entire document.
Cell, Vol. 63, issued 05 October 1990, ZSEBO et al., "Identification, Purification, and Biological Characterization of Hematopoietic Stem Cell Factor from Buffalo Rat Liver-Conditioned Medium", pages 195-201, see entire document.
Cell, Vol. 63, issued 05 October 1990, MARTIN et al., "Primary Structure and Functional Expression of Rat and Human Stem Cell Factor DNAs", pp. 203-211, see entire document.
Journal of Cell Physiology, Vol. 148, No. 3, issued September 1991, TSUJI et al., "Murine Mast Cell Colony Formation Supported by IL-3, IL-4, and Recombinant Rat Stem Cell Factor, Ligand for c-kit", pages 362-369, Abstract only.
Journal of Experimental Medicine, Vol. 174, No. 2, issued 01 August 1991, BROXMEYER et al., "CD45 Cell Surface Antigens are Linked to Stimulation of Early Human Myeloid Progenitor Cells by Interleukin 3 (IL-3), Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF), a GM-CSF/IL-3 Fusion Protein, and Mast Cell Growth Factor (a
See also references of EP 0672152A4
Download PDF:
Previous Patent: DNA ENCODING A GLYCINE TRANSPORTER AND USES THEREOF
Next Patent: LIGAND-STIMULATED GENE EXPRESSION
Next Patent: LIGAND-STIMULATED GENE EXPRESSION