Title:
FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2012/016073
Kind Code:
A3
Abstract:
The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for Fc Rs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.
Inventors:
BLOCK DAVID S (US)
OLSEN HENRIK (US)
OLSEN HENRIK (US)
Application Number:
PCT/US2011/045768
Publication Date:
August 09, 2012
Filing Date:
July 28, 2011
Export Citation:
Assignee:
GLIKNIK INC (US)
BLOCK DAVID S (US)
OLSEN HENRIK (US)
BLOCK DAVID S (US)
OLSEN HENRIK (US)
International Classes:
A61K39/395; C07K16/28
Domestic Patent References:
| WO2008151088A2 | 2008-12-11 |
Foreign References:
| US20090136485A1 | 2009-05-28 | |||
| US20090117133A1 | 2009-05-07 | |||
| US20100239633A1 | 2010-09-23 |
Other References:
See also references of EP 2598533A4
Attorney, Agent or Firm:
TUSCAN, Michael S. et al. (777 6th Street N.W.,Suite 110, Washington District of Columbia, US)
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