Title:
FUSION PROTEINS WITH IMPROVED PROPERTIES
Document Type and Number:
WIPO Patent Application WO/2018/028371
Kind Code:
A1
Abstract:
It provides novel fusion proteins that are capable of self-crystallization and exhibit improved physical properties such as enhanced tolerance to organic solvents and increased thermostability. Polynucleotides encoding the fusion proteins as well as methods of making and using such fusion proteins are also described.
Inventors:
CHAN MICHAEL (CN)
LEE MARIANNE (CN)
HEATER BRADLEY (CN)
LEE MARIANNE (CN)
HEATER BRADLEY (CN)
Application Number:
PCT/CN2017/092393
Publication Date:
February 15, 2018
Filing Date:
July 10, 2017
Export Citation:
Assignee:
UNIV HONG KONG CHINESE (CN)
International Classes:
C07K14/32; C07K19/00; C12N15/62; C12N15/63
Domestic Patent References:
| WO2012158555A2 | 2012-11-22 |
Foreign References:
| US5306628A | 1994-04-26 | |||
| CN102276728A | 2011-12-14 |
Other References:
NAIR, M.S. ET AL.: "Cry Protein Crystals: A Novel Platform for Protein Delivery", PLOS ONE, vol. 10, no. 6, 1 June 2015 (2015-06-01), XP055463443
FENG, W.W. ET AL.: "Research Progress on Crystallized Proteins and Its Impact Factors", JOURNAL OF ANHUIAGRI.SCI., vol. 38, no. 18, 31 December 2010 (2010-12-31)
GUO, C.H. ET AL.: "Bacillus thuringiensis Cry3Aa fused to a cellulase-binding peptide shows increased toxicity against the longhomed beetle", APPL MICROBIOL BIOTECHNOL, vol. 93, 13 August 2011 (2011-08-13), pages 1249 - 1256, XP035006055
FENG, W.W. ET AL.: "Research Progress on Crystallized Proteins and Its Impact Factors", JOURNAL OF ANHUIAGRI.SCI., vol. 38, no. 18, 31 December 2010 (2010-12-31)
GUO, C.H. ET AL.: "Bacillus thuringiensis Cry3Aa fused to a cellulase-binding peptide shows increased toxicity against the longhomed beetle", APPL MICROBIOL BIOTECHNOL, vol. 93, 13 August 2011 (2011-08-13), pages 1249 - 1256, XP035006055
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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