Title:
FXA INHIBITORS WITH CYCLIC AMIDOXIME OR CYCLIC AMIDRAZONE AS P4 SUBUNIT, PROCESSES FOR THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS AND DERIVATIVES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/002115
Kind Code:
A3
Abstract:
The present invention relates to novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.
Inventors:
SONG HO YOUNG (KR)
CHO YOUNG LAG (KR)
LEE DAE YON (KR)
PARK HEE SOCK (KR)
BAEK SUNG YOON (KR)
CHAE SANG EUN (KR)
JO SANG HUI (KR)
KIM YEON OK (KR)
LEE HYANG SOOK (KR)
PARK JU HYUN (KR)
PARK TAE KYO (KR)
WOO SUNG HO (KR)
KIM YONG ZU (KR)
CHO YOUNG LAG (KR)
LEE DAE YON (KR)
PARK HEE SOCK (KR)
BAEK SUNG YOON (KR)
CHAE SANG EUN (KR)
JO SANG HUI (KR)
KIM YEON OK (KR)
LEE HYANG SOOK (KR)
PARK JU HYUN (KR)
PARK TAE KYO (KR)
WOO SUNG HO (KR)
KIM YONG ZU (KR)
Application Number:
PCT/KR2009/003008
Publication Date:
March 11, 2010
Filing Date:
June 05, 2009
Export Citation:
Assignee:
LEGOCHEM BIOSCIENCE LTD (KR)
SONG HO YOUNG (KR)
CHO YOUNG LAG (KR)
LEE DAE YON (KR)
PARK HEE SOCK (KR)
BAEK SUNG YOON (KR)
CHAE SANG EUN (KR)
JO SANG HUI (KR)
KIM YEON OK (KR)
LEE HYANG SOOK (KR)
PARK JU HYUN (KR)
PARK TAE KYO (KR)
WOO SUNG HO (KR)
KIM YONG ZU (KR)
SONG HO YOUNG (KR)
CHO YOUNG LAG (KR)
LEE DAE YON (KR)
PARK HEE SOCK (KR)
BAEK SUNG YOON (KR)
CHAE SANG EUN (KR)
JO SANG HUI (KR)
KIM YEON OK (KR)
LEE HYANG SOOK (KR)
PARK JU HYUN (KR)
PARK TAE KYO (KR)
WOO SUNG HO (KR)
KIM YONG ZU (KR)
International Classes:
C07D413/12
Domestic Patent References:
| WO2001047919A1 | 2001-07-05 | |||
| WO2008140220A1 | 2008-11-20 |
Foreign References:
| US20040242660A1 | 2004-12-02 |
Other References:
ROEHRIG, S. ET AL.: "Discovery of the Novel Antithrombotic Agent 5-Chloro-N ({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophenene-2-carboxamide(BAYv59-7939): An Oral, Direct Factor Xa Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5900 - 5908, XP002418821
Attorney, Agent or Firm:
KWON, Oh-Sig et al. (921Dunsan-dong, Seo-gu, Daejeon 302-120, KR)
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