Title:
FXR ACTIVATION COMPOUND
Document Type and Number:
WIPO Patent Application WO/2005/092328
Kind Code:
A1
Abstract:
A more potent therapeutic agent for hyperlipemia. It contains a compound having FXR activity and represented by the following formula (1) or (2).
Inventors:
KAWANISHI TORU (JP)
SUZUKI TAKUO (JP)
MOGAMI TOMOKO (JP)
INOUE KAZUHIDE (JP)
HAYAKAWA TAKAO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
SUZUKI TAKUO (JP)
MOGAMI TOMOKO (JP)
INOUE KAZUHIDE (JP)
HAYAKAWA TAKAO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
Application Number:
PCT/JP2005/003600
Publication Date:
October 06, 2005
Filing Date:
March 03, 2005
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND (JP)
KAWANISHI TORU (JP)
SUZUKI TAKUO (JP)
MOGAMI TOMOKO (JP)
INOUE KAZUHIDE (JP)
HAYAKAWA TAKAO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
KAWANISHI TORU (JP)
SUZUKI TAKUO (JP)
MOGAMI TOMOKO (JP)
INOUE KAZUHIDE (JP)
HAYAKAWA TAKAO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
International Classes:
A61K31/357; A61P1/16; A61P3/06; A61P43/00; C07D321/00; (IPC1-7): A61K31/357; A61P1/16; A61P3/06; A61P43/00; C07D321/00
Domestic Patent References:
| WO2002072598A1 | 2002-09-19 | |||
| WO2002011708A2 | 2002-02-14 | |||
| WO2003030612A2 | 2003-04-17 |
Foreign References:
| JPS6092284A | 1985-05-23 |
Other References:
SCHWARTNER C. ET AL: "Effect of marchantins and related compounds on 5-lipoxygenase and cyclooxygenase and their antioxidant properties: a structure activity relationship study", PHYTOMEDICINE, vol. 2, no. 2, 1995, pages 113 - 117, XP002989421
SCHWARTNER C. ET AL: "Marchantins and related polyphenols from liverwort: physico-chemical studies of their radical-scavenging properties", FREE RADICAL BIOLOGY & MEDICINE, vol. 20, no. 2, 1996, pages 237 - 244, XP002989422
HSIAO G. ET AL: "Marchantin H as a natural antioxidant and free radical scavenger", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 334, no. 1, 1996, pages 18 - 26, XP002989423
KAMORY E. ET AL: "Isolation and antibacterial activity of marchantin A, a cyclic bis (bibenzyl) constituent of Hungarian Marchantia polymorpha", PLANTA MEDICA, vol. 61, no. 4, 1995, pages 387 - 388, XP001084991
KESERU G.M. ET AL: "Molecular similarity analysis on biologically active macrocyclic bis (biphenyls)", JOURNAL OF MOLECULAR RECOGNITION, vol. 9, no. 2, 1996, pages 133 - 138, XP002989424
SCHWARTNER C. ET AL: "Marchantins and related polyphenols from liverwort: physico-chemical studies of their radical-scavenging properties", FREE RADICAL BIOLOGY & MEDICINE, vol. 20, no. 2, 1996, pages 237 - 244, XP002989422
HSIAO G. ET AL: "Marchantin H as a natural antioxidant and free radical scavenger", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 334, no. 1, 1996, pages 18 - 26, XP002989423
KAMORY E. ET AL: "Isolation and antibacterial activity of marchantin A, a cyclic bis (bibenzyl) constituent of Hungarian Marchantia polymorpha", PLANTA MEDICA, vol. 61, no. 4, 1995, pages 387 - 388, XP001084991
KESERU G.M. ET AL: "Molecular similarity analysis on biologically active macrocyclic bis (biphenyls)", JOURNAL OF MOLECULAR RECOGNITION, vol. 9, no. 2, 1996, pages 133 - 138, XP002989424
Attorney, Agent or Firm:
ISSHIKI & CO. (12-7 Shinbashi 2-chom, Minato-ku Tokyo 4, JP)
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