Title:
G PROTEIN-COUPLED RECEPTOR ASSAY
Document Type and Number:
WIPO Patent Application WO/2003/013551
Kind Code:
A1
Abstract:
The present invention relates to novel methods and compositions for the diagnosis, treatment and prognosis of G-protein coupled receptor (GPCR)-related disorders through inhibition of regulators of G-protein signaling (RGS) proteins. The present invention relates to methods of screening and assessing test compounds useful in the intervention and prevention of GPCR-related disorders including neuropsychiatric and cardiopulmonary disorders. The invention further relates to methods to identify inhibitors for RGS expression or activity which are useful in the modulation of GPCR signaling pathways.
Inventors:
HO GUYU
YOUNG KATHLEEN HART
YOUNG KATHLEEN HART
Application Number:
PCT/US2002/025213
Publication Date:
February 20, 2003
Filing Date:
August 08, 2002
Export Citation:
Assignee:
WYETH CORP (US)
International Classes:
A61K31/00; A61K31/70; C12Q1/68; G01N33/566; G01N33/567; G01N33/74; (IPC1-7): A61K31/7105; G01N33/53
Other References:
HUANG ET AL.: "Attenuation of Gi- and Cq-mediated signaling by expression of RGS4 or GAIP in mammalian cells", PROC. NATL. ACAD. SCI. USA, vol. 94, June 1997 (1997-06-01), pages 6159 - 6163, XP002058414
BERMAN ET AL.: "Mammalian RGS proteins: barbarians at the gates", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 3, 16 January 1998 (1998-01-16), pages 1269 - 1272, XP002956840
TU ET AL.: "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits", SCIENCE, vol. 278, 7 November 1997 (1997-11-07), pages 1132 - 1135, XP002956841
WELSBY ET AL.: "Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists", MOLECULAR PHARMACOLOGY, vol. 61, no. 5, May 2002 (2002-05-01), pages 1211 - 1221, XP002956842
BERMAN ET AL.: "Mammalian RGS proteins: barbarians at the gates", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 3, 16 January 1998 (1998-01-16), pages 1269 - 1272, XP002956840
TU ET AL.: "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits", SCIENCE, vol. 278, 7 November 1997 (1997-11-07), pages 1132 - 1135, XP002956841
WELSBY ET AL.: "Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists", MOLECULAR PHARMACOLOGY, vol. 61, no. 5, May 2002 (2002-05-01), pages 1211 - 1221, XP002956842
Attorney, Agent or Firm:
Brazil, Bill T. (Patent Law Department Five Giralda Farm, Madison NJ, US)
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