Title:
G PROTEIN-COUPLED RECEPTOR (GPCR) MODULATION BY IMIPRIDONES
Document Type and Number:
WIPO Patent Application WO/2017/132661
Kind Code:
A3
Abstract:
Imipridones has been found to selectively modulate Class A G protein-coupled receptors (GPCRs), such as the D2-like subfamily of dopamine receptors, and to be useful for the treatment of conditions and disorders in need of such modulation, such as cancers, psychiatric disorders, and bacterial infections. In addition, methods of identifying whether a subject having these condition, is likely to be responsive to a treatment regimen, such as administration of an imipridone, are provided. Furthermore, methods of assessing the effectiveness of a treatment regimen, such as administration of an imipridone, monitoring, or providing a prognosis for a subject with these condition are also provided.
Inventors:
ALLEN JOSHUA E (US)
STOGNIEW MARTIN (US)
PRABHU VARUN VIJAY (US)
STOGNIEW MARTIN (US)
PRABHU VARUN VIJAY (US)
Application Number:
PCT/US2017/015608
Publication Date:
August 31, 2017
Filing Date:
January 30, 2017
Export Citation:
Assignee:
ONCOCEUTICS INC (US)
International Classes:
C07K16/28; C07D257/04; C07D401/04; C07K14/705; C07K14/72; G01N33/566
Domestic Patent References:
| WO2004082570A2 | 2004-09-30 | |||
| WO2015153468A1 | 2015-10-08 |
Foreign References:
| US20140335048A1 | 2014-11-13 | |||
| US20090022717A1 | 2009-01-22 | |||
| US4867973A | 1989-09-19 | |||
| US20150202206A1 | 2015-07-23 | |||
| US20130065887A1 | 2013-03-14 | |||
| US20070026402A1 | 2007-02-01 |
Other References:
LUTZ, PE ET AL.: "Opioid Receptors: Distinct Roles in Mood Disorders", TRENDS IN NEUROSCIENCE, vol. 36, no. 3, 6 December 2012 (2012-12-06), pages 1 - 24, XP055409989
YUNG, SC ET AL.: "Host Chemokines Bind to Staphylococcus aureus and Stimulate Protein A Release", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 7, 7 December 2010 (2010-12-07), pages 5069 - 5077, XP055409992
SOARES, AC ET AL.: "Role of the Platelet-Activating Factor (PAF) Receptor during Pulmonary Infection with Gram Negative Bacteria", BRITISH JOURNAL OF PHARMACOLOGY, vol. 137, no. 5, November 2002 (2002-11-01), pages 621 - 628, XP055409993
LI, J ET AL.: "Genome-Wide shRNA Screen Revealed Integrated Mitogenic Signaling Between Dopamine Receptor D2 (DRD2) and Epidermal Growth Factor Receptor (EGFR) in Glioblastoma", ONCOTARGET, vol. 5, no. 4, 28 February 2014 (2014-02-28), pages 882 - 893, XP055409994
POLLARD, TD: "A Guide to Simple and Informative Binding Assays", MOLECULAR BIOLOGY OF THE CELL, vol. 21, no. 23, December 2010 (2010-12-01), pages 4061 - 4067, XP055063698
FOWLER, JC ET AL.: "Receptor Conformations Involved in Dopamine D2L Receptor Functional Selectivity Induced by Selected Transmembrane-5 Serine Mutations", MOLECULAR PHARMACOLOGY, vol. 81, no. 16, 13 March 2012 (2012-03-13), pages 820 - 831, XP055409997
JULLY, B ET AL.: "Potential Molecular Targets for Ewing's Sarcoma Therapy", INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY, vol. 33, no. 4, October 2012 (2012-10-01), pages 1 - 13, XP055410003
ZHAO, Z ET AL.: "p53 Loss Promotes Acute Myeloid Leukemia by Enabling Aberrant Self-Renewal", GENES AND DEVELOPMENT, vol. 24, no. 13, 1 July 2010 (2010-07-01), pages 1389 - 1402, XP055410006
AIHARA, K ET AL.: "H3F3A K27M Mutations in Thalamic Gliomas from Young Adult Patients", NEURO-ONCOLOGY, vol. 16, no. 1, 26 November 2013 (2013-11-26), pages 140 - 146, XP055410007
SOEJIMA, H ET AL.: "Epigenetic Silencing of the MGMT Gene in Cancer", BIOCHEMISTRY AND CELL BIOLOGY, vol. 83, no. 4, August 2005 (2005-08-01), pages 429 - 437, XP009513035, ISSN: 0829-8211, DOI: 10.1139/o05-140
LABURTHE, M ET AL.: "The Orexin Receptor OX1R in Colon Cancer: a Promising Therapeutic Target and a New Paradigm in G Protein-Coupled Receptor Signalling Through ITIMs", BRITISH JOURNAL OF PHARMACOLOGY, vol. 165, no. 6, 1 March 2012 (2012-03-01), pages 1678 - 1687, XP055196628
ALLEN, J ET AL.: "Discovery and Clinical Introduction of First-in-Class Imipridone ONC201", ONCOTARGET ., vol. 7, no. 45, 13 September 2016 (2016-09-13), pages 1 - 14, XP055410010
YUNG, SC ET AL.: "Host Chemokines Bind to Staphylococcus aureus and Stimulate Protein A Release", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 7, 7 December 2010 (2010-12-07), pages 5069 - 5077, XP055409992
SOARES, AC ET AL.: "Role of the Platelet-Activating Factor (PAF) Receptor during Pulmonary Infection with Gram Negative Bacteria", BRITISH JOURNAL OF PHARMACOLOGY, vol. 137, no. 5, November 2002 (2002-11-01), pages 621 - 628, XP055409993
LI, J ET AL.: "Genome-Wide shRNA Screen Revealed Integrated Mitogenic Signaling Between Dopamine Receptor D2 (DRD2) and Epidermal Growth Factor Receptor (EGFR) in Glioblastoma", ONCOTARGET, vol. 5, no. 4, 28 February 2014 (2014-02-28), pages 882 - 893, XP055409994
POLLARD, TD: "A Guide to Simple and Informative Binding Assays", MOLECULAR BIOLOGY OF THE CELL, vol. 21, no. 23, December 2010 (2010-12-01), pages 4061 - 4067, XP055063698
FOWLER, JC ET AL.: "Receptor Conformations Involved in Dopamine D2L Receptor Functional Selectivity Induced by Selected Transmembrane-5 Serine Mutations", MOLECULAR PHARMACOLOGY, vol. 81, no. 16, 13 March 2012 (2012-03-13), pages 820 - 831, XP055409997
JULLY, B ET AL.: "Potential Molecular Targets for Ewing's Sarcoma Therapy", INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY, vol. 33, no. 4, October 2012 (2012-10-01), pages 1 - 13, XP055410003
ZHAO, Z ET AL.: "p53 Loss Promotes Acute Myeloid Leukemia by Enabling Aberrant Self-Renewal", GENES AND DEVELOPMENT, vol. 24, no. 13, 1 July 2010 (2010-07-01), pages 1389 - 1402, XP055410006
AIHARA, K ET AL.: "H3F3A K27M Mutations in Thalamic Gliomas from Young Adult Patients", NEURO-ONCOLOGY, vol. 16, no. 1, 26 November 2013 (2013-11-26), pages 140 - 146, XP055410007
SOEJIMA, H ET AL.: "Epigenetic Silencing of the MGMT Gene in Cancer", BIOCHEMISTRY AND CELL BIOLOGY, vol. 83, no. 4, August 2005 (2005-08-01), pages 429 - 437, XP009513035, ISSN: 0829-8211, DOI: 10.1139/o05-140
LABURTHE, M ET AL.: "The Orexin Receptor OX1R in Colon Cancer: a Promising Therapeutic Target and a New Paradigm in G Protein-Coupled Receptor Signalling Through ITIMs", BRITISH JOURNAL OF PHARMACOLOGY, vol. 165, no. 6, 1 March 2012 (2012-03-01), pages 1678 - 1687, XP055196628
ALLEN, J ET AL.: "Discovery and Clinical Introduction of First-in-Class Imipridone ONC201", ONCOTARGET ., vol. 7, no. 45, 13 September 2016 (2016-09-13), pages 1 - 14, XP055410010
Attorney, Agent or Firm:
PEARL COHEN ZEDEK LATZER BARATZ LLP et al. (US)
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