Title:
G PROTEIN-COUPLED RECEPTORS FROM HUMAN CLONE "26908" AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2001090150
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated 26908 nucleic acid molecules, which encode novel G-protein coupled receptor family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26908 gene has been introduced or disrupted. The invention still further provides isolated 26908 proteins, fusion proteins, antigenic peptides and anti-26908 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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Inventors:
GLUCKSMANN MARIA ALEXANDRA (US)
Application Number:
PCT/US2001/016657
Publication Date:
October 03, 2002
Filing Date:
May 22, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
GLUCKSMANN MARIA ALEXANDRA (US)
GLUCKSMANN MARIA ALEXANDRA (US)
International Classes:
C07K14/705; A61K38/00; (IPC1-7): C07K14/705; C07K14/72; A61K38/16; G01N33/68; C07K16/28; C12N15/10
Domestic Patent References:
| WO1999063087A1 | 1999-12-09 | |||
| WO2001036471A2 | 2001-05-25 | |||
| WO2001090189A2 | 2001-11-29 |
Foreign References:
| US5891720A | 1999-04-06 |
Other References:
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147
MARCHESE ET AL: "Discovery of three novel orphan G-protein-coupled receptors", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 56, no. 1, 15 February 1999 (1999-02-15), pages 12 - 21, XP002108432, ISSN: 0888-7543
DATABASE EMBL DATABASE [online] 8 February 2000 (2000-02-08), BIRREN B ET AL.: "Mus musculus chromosome X clone RP23-157B8", XP002197027, Database accession no. AC022773
DATABASE EMBL [online] 15 February 2001 (2001-02-15), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTD-2042J7", XP002197028, Database accession no. AC090068
WILSON S ET AL: "ORPHAN G-PROTEIN-COUPLED RECEPTORS: THE NEXT GENERATION OF DRUG TARGETS?", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 125, no. 7, December 1998 (1998-12-01), pages 1387 - 1392, XP001010584, ISSN: 0007-1188
PELLICCIARI R ET AL: "METABOTROPIC G-PROTEIN-COUPLED GLUTAMATE RECEPTORS AS THERAPEUTIC TARGETS", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 3, no. 4, 1999, pages 433 - 440, XP000886873, ISSN: 1367-5931
SONNHAMMER E L L ET AL: "PFAM: A COMPREHENSIVE DATABASE OF PROTEIN DOMAIN FAMILIES BASED ON SEED ALIGNMENTS", PROTEINS, ALAN R. LISS, US, vol. 28, 1997, pages 405 - 420, XP002929239, ISSN: 0887-3585
MARCHESE ET AL: "Discovery of three novel orphan G-protein-coupled receptors", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 56, no. 1, 15 February 1999 (1999-02-15), pages 12 - 21, XP002108432, ISSN: 0888-7543
DATABASE EMBL DATABASE [online] 8 February 2000 (2000-02-08), BIRREN B ET AL.: "Mus musculus chromosome X clone RP23-157B8", XP002197027, Database accession no. AC022773
DATABASE EMBL [online] 15 February 2001 (2001-02-15), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 5 clone CTD-2042J7", XP002197028, Database accession no. AC090068
WILSON S ET AL: "ORPHAN G-PROTEIN-COUPLED RECEPTORS: THE NEXT GENERATION OF DRUG TARGETS?", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 125, no. 7, December 1998 (1998-12-01), pages 1387 - 1392, XP001010584, ISSN: 0007-1188
PELLICCIARI R ET AL: "METABOTROPIC G-PROTEIN-COUPLED GLUTAMATE RECEPTORS AS THERAPEUTIC TARGETS", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 3, no. 4, 1999, pages 433 - 440, XP000886873, ISSN: 1367-5931
SONNHAMMER E L L ET AL: "PFAM: A COMPREHENSIVE DATABASE OF PROTEIN DOMAIN FAMILIES BASED ON SEED ALIGNMENTS", PROTEINS, ALAN R. LISS, US, vol. 28, 1997, pages 405 - 420, XP002929239, ISSN: 0887-3585
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