Title:
GALACTOPYRANOSYL-CYCLOHEXYL DERIVATIVES AS E-SELECTIN ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2014/070991
Kind Code:
A3
Abstract:
Provided herein are E-selectin antagonist therapeutic agents and improvements thereto and compositions comprising these E-selectin antagonists. Methods are also provided for using these E-selectin antagonist therapeutic agents to treat and/or prevent diseases and disorders treatable by inhibiting binding of an E-selectin to an E-selectin ligand. Also provided herein improvements to E-selectin antagonist giycomimetic compounds that improve the oral bioavailability of the giycomimetic compounds.
Inventors:
MAGNANI JOHN L (US)
SARKAR ARUN K (US)
PETERSON JOHN M (US)
SARKAR ARUN K (US)
PETERSON JOHN M (US)
Application Number:
PCT/US2013/067711
Publication Date:
July 17, 2014
Filing Date:
October 31, 2013
Export Citation:
Assignee:
GLYCOMIMETICS INC (US)
International Classes:
C07H15/207; A61K31/7034; A61P35/00
Domestic Patent References:
| WO2008100453A1 | 2008-08-21 | |||
| WO2010126888A1 | 2010-11-04 | |||
| WO2012037034A1 | 2012-03-22 | |||
| WO2012061662A1 | 2012-05-10 | |||
| WO2007022089A2 | 2007-02-22 | |||
| WO2005058934A2 | 2005-06-30 | |||
| WO2013096926A1 | 2013-06-27 |
Other References:
DANIEL SCHWIZER ET AL: "Pre-organization of the Core Structure of E-Selectin Antagonists", CHEMISTRY - A EUROPEAN JOURNAL, vol. 18, no. 5, 27 January 2012 (2012-01-27), pages 1342 - 1351, XP055100242, ISSN: 0947-6539, DOI: 10.1002/chem.201102884
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WANG, YI ET AL: "Effect of ginsenoside rg1 and rh1 on the expression of hla-dr, cd25, cd44, cd11c and e - selectin on dendritic cell", XP002719716, retrieved from STN Database accession no. 2007:1235597
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NARITA, TATSUHIKO ET AL: "Corticosteroids and medroxyprogesterone acetate inhibit the induction of breast cancer cells", XP002719813, retrieved from STN Database accession no. 1996:239124
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZHOU, GANG ET AL: "Effect of ET-RA on expression of selectin on the surface of endothelial cell in mice with severe acute pancreatitis", XP002724623, retrieved from STN Database accession no. 2006:584643
JONAS EGGER ET AL: "Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 26, 3 July 2013 (2013-07-03), pages 9820 - 9828, XP055100226, ISSN: 0002-7863, DOI: 10.1021/ja4029582
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WANG, YI ET AL: "Effect of ginsenoside rg1 and rh1 on the expression of hla-dr, cd25, cd44, cd11c and e - selectin on dendritic cell", XP002719716, retrieved from STN Database accession no. 2007:1235597
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NARITA, TATSUHIKO ET AL: "Corticosteroids and medroxyprogesterone acetate inhibit the induction of breast cancer cells", XP002719813, retrieved from STN Database accession no. 1996:239124
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZHOU, GANG ET AL: "Effect of ET-RA on expression of selectin on the surface of endothelial cell in mice with severe acute pancreatitis", XP002724623, retrieved from STN Database accession no. 2006:584643
JONAS EGGER ET AL: "Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 26, 3 July 2013 (2013-07-03), pages 9820 - 9828, XP055100226, ISSN: 0002-7863, DOI: 10.1021/ja4029582
Attorney, Agent or Firm:
GARRETT, Arthur, S. et al. (Henderson Farabow, Garrett & Dunner, LLP,901 New York Avenue, N, Washington DC, US)
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