Title:
GALACTOSE DERIVATIVE, DRUG CARRIER AND MEDICINAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2006/022325
Kind Code:
A1
Abstract:
It is intended to provide a novel and useful galactose derivative constituting a drug carrier by which a drug can be efficiently transported into the liver, a drug carrier containing this derivative and a medicinal composition containing this carrier together with a drug. Namely, a galactose derivative comprising galactose, an appropriate spacer and a definite lipid; a drug carrier containing this derivative and a cationic lipid; and a medicinal composition containing this carrier together with a drug (preferably a double-stranded RNA, a double-stranded DNA or an oligonucleic acid).
Inventors:
OHGI TADAAKI (JP)
UEDA TOSHIHIRO (JP)
UEDA TOSHIHIRO (JP)
Application Number:
PCT/JP2005/015424
Publication Date:
March 02, 2006
Filing Date:
August 25, 2005
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
OHGI TADAAKI (JP)
UEDA TOSHIHIRO (JP)
OHGI TADAAKI (JP)
UEDA TOSHIHIRO (JP)
International Classes:
C07H15/04; A61K47/24; A61K47/26; C07H3/04; C07H15/08
Domestic Patent References:
| WO1994018987A1 | 1994-09-01 | |||
| WO1994019314A1 | 1994-09-01 |
Foreign References:
| JPH09235292A | 1997-09-09 | |||
| JPH07188274A | 1995-07-25 | |||
| JPH06271597A | 1994-09-27 |
Other References:
POHLENTZ G ET AL: "1-Deoxy-1-phosphatidylethanolamino-lactitol-type neoglycolipids serve as acceptors for sialyltransferases from rat liver Golgi vesicles.", EUROPEAN JOURNAL OF BIOCHEMISTRY., vol. 203, no. 3, 1992, pages 387 - 389, XP002987503
POHLENTZ G ET AL: "Neoglycolipids Derived from Phosphatidylethanolamine Serve as Probes in Cell Culture Studies on Glycolipid Metabolism.", BIOLOGICAL CHEMISTRY., vol. 381, no. 1, 2000, pages 29 - 34, XP002987714
POHLENTZ G ET AL: "Neoglycolipids of 1-deoxy-1-phosphatidylethanolaminolactitol type: synthesis, structure analysis, and use as probes for characterization of glycosyltransferases.", METHODS IN ENZYMOLOGY., vol. 242, 1994, pages 127 - 145, XP002987710
XU Z ET AL: "Synthesis and Characterization of Oligomaltose-Grafted Lipids with Application to Liposomes.", JOURNAL OF COLLOID AND INTERFACE SCIENCE., vol. 252, no. 1, 2002, pages 57 - 65, XP002987711
See also references of EP 1783137A4
POHLENTZ G ET AL: "Neoglycolipids Derived from Phosphatidylethanolamine Serve as Probes in Cell Culture Studies on Glycolipid Metabolism.", BIOLOGICAL CHEMISTRY., vol. 381, no. 1, 2000, pages 29 - 34, XP002987714
POHLENTZ G ET AL: "Neoglycolipids of 1-deoxy-1-phosphatidylethanolaminolactitol type: synthesis, structure analysis, and use as probes for characterization of glycosyltransferases.", METHODS IN ENZYMOLOGY., vol. 242, 1994, pages 127 - 145, XP002987710
XU Z ET AL: "Synthesis and Characterization of Oligomaltose-Grafted Lipids with Application to Liposomes.", JOURNAL OF COLLOID AND INTERFACE SCIENCE., vol. 252, no. 1, 2002, pages 57 - 65, XP002987711
See also references of EP 1783137A4
Attorney, Agent or Firm:
Shimizu, Naoto (Intellectual Property Dept., 14, Kisshoin
Nishinosho Monguchicho,, Minami-ku, Kyoto-sh, Kyoto, JP)
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