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Title:
GALECTIN 9-BINDING PROTEIN FACTOR
Document Type and Number:
WIPO Patent Application WO/2006/009309
Kind Code:
A1
Abstract:
Galectin 9 shows various functions depending on its localization. On the other hand, it is considered that galectin 9 participates in various biological functions. Thus, it has been required to clarify the detailed biological activities of galectin 9 and develop galectin 9-related techniques including drug development. To clarify these activities, it is required to separate and identify a galectin 9-binding protein. As a candidate for a biological protein capable of binding to human galectin 9, use can be made of a specific protein, i.e., one selected from the group consisting of (1) HSP70, (2) ATP1B3 and (3) HSP90. By analyzing the interaction and/or binding of the candidate protein with galectin 9, it is possible to develop an antitumor agent, an antiallergic agent, an immunosuppressant, a drug for autoimmune diseases, an antiinflammatory agent and an active ingredient agent usable as a substitute for adrenocorticosteroid hormone.

Inventors:
HIRASHIMA MITSUOMI (JP)
NISHI NOZOMU (JP)
YAMAUCHI AKIRA (JP)
KASHIO YUMIKO (JP)
Application Number:
PCT/JP2005/013792
Publication Date:
January 26, 2006
Filing Date:
July 21, 2005
Export Citation:
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Assignee:
GALPHARMA CO LTD (JP)
HIRASHIMA MITSUOMI (JP)
NISHI NOZOMU (JP)
YAMAUCHI AKIRA (JP)
KASHIO YUMIKO (JP)
International Classes:
C07K14/47; A61K38/00; A61K39/395; A61K45/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C12N5/10; G01N33/15; G01N33/50
Domestic Patent References:
WO2002089831A12002-11-14
WO2004064857A12004-08-05
Foreign References:
JP2003189874A2003-07-08
Attorney, Agent or Firm:
Mizuno, Akinobu (303 22-12, Maruyama-ch, Shibuya-ku Tokyo, JP)
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Claims:
CLAIMS
1. A method for reducing electrical alternating fields generated by a video display unit (1) in the surroundings of the unit to a minimum, said video display unit being provided with a voltageconnected part (5) on which undesirable signal variations occur, c h a r a c t e r i z e d by indicating the undesir able voltage variations, generating a signal which is phase inverted in relation to the indicated voltage variations, and feeding the generated phase inverted signal to the voltage connected part (5).
2. A method according to Claim 1, c h a r a c ¬ t e r i z e d by indicating the voltage variations of the voltage connected part within a frequency band having a preselected bottom limit frequency.
3. A method according to Claim l or 2, c h a r ¬ a c t e r i z e d by detecting the signal strength of the indicated signal variation, and servoadjusting the signal strength of the signal supplied to the voltage connected part (5) with the aid of the detect ed signal strength.
4. A method according to Claim 1 or 2, c h a r ¬ a c t e r i z e d in that the signal strength of the indicated signal variation is fixed but can be adjust ed manually in the phase inverting process.
5. An arrangement for reducing electrical alternating fields generated in the surroundings of a visual display unit to a minimum, said unit being provided with a voltage connected part (5) on which undesirable voltage variations occur, c h a r a c t e r i z e d by an indicating unit (20) which indicates variations in the acceleration voltage; a signal generating unit (14; 21, 23; 32) which generates a signal which is phase inverted in relation to the voltage variations detected by the detecting unit; and in that the output signal of the signal generating unit is coupled to the voltage connected part (5) of the video display unit.
6. An arrangement according to Claim 5, c h a r ¬ a c t e r i z e d in that the output signal of the signal generating unit is coupled to the coating via a coupling capacitor (C3).
7. An arrangement according to Claim 5 or 6, c h a r a c t e r i z e d in that the detecting unit (20) includes a sensing means (20) having a pre¬ determined lower limit frequency.
Description:
A Method and an Arrangement Relating to Visual Display Units , for Reducing the Electric Alternating Field in the Unit Surroundings

The present invention relates to an arrangement of the kind defined in the preamble of Claim 1.

TECHNICAL FIELD

The hazards of working in front of video display units have been discussed in the 1980s. As a result of these discussions, it is now a standard requirement that emissions of various kinds, such as magnetic fields, electrical fields, etc., shall be held at the lowest possible level.

The discussions have resulted in methods for volun¬ tarily testing video screens. As from 1987, there has been a strong commercial demand to fulfil certain recommended measurement values in conjunction with the recommended measuring method. In certain instances, it is necessary to fulfil still more stringent, customer- specific requirements. The ability to show compara¬ tively low measurement values in these voluntary tests has given a competitive edge to retailers. The revised methods for voluntarily testing video display units have included testing for electrical alternating fields. These fields are often measured in two fre¬ quency bands, band I (5Hz-2kHz) and band II (2kHz- 400kHz).

BACKGROUND ART

The electrical alternating fields deriving from a video display unit, primarily a CRT-type unit (cathode ray tube-unit) are generated by a number of different electrical components included in the unit. It is a relatively easy matter to screen the electrical alter¬ nating fields in all directions with the exception of

the forward direction immediately in front of the screen, for instance with the aid of screening plates, electrically conductive outer casings or housings, or with the aid of electrically conductive layers or coatings on a plastic outer casing. The electrical alternating field extending forwardly from the screen surface of a CRT-type video display unit is caused by variations in the acceleration voltage applied inward¬ ly of the front glass of the video display unit.

One method of dealing with the effect of, among other things, the electrical alternating fields that are generated in front of a display screen involves the use of a transformer in the high voltage part with low internal impedance, although this solution is expen¬ sive if the result is to be effective. Another method involves coupling an external capacitor across the acceleration voltage. Although this solution will smooth the acceleration voltage, particularly at the low frequencies that fall within band I, it has been found that the solution is not effective enough to provide satisfactory equalization of the more high- frequency voltage variations found within band II.

Other methods involve the provision of an electrically conductive panel or like device in front of the pic¬ ture tube. This solution requires a panel of very high conductivity, in order to be able to reduce the alter¬ nating fields in both band I and band II. Consequent- ly, such panels are expensive and/or result in im¬ paired synergonomical properties. For instance, the picture becomes out of focus, i.e. blurred, and the light yield is inferior than the light yield of a standard screen, i.e. the panel does not have full light transmission.

The object of the present invention is to achieve with a video display unit, and primarily a CRT- ype unit, the smallest possible electrical alternating fields in

the surroundings of the picture tube, and particularly in front of the screen of the unit.

Another object of the invention is to compensate for relatively high-frequency voltage ripple on the ac¬ celeration voltage of a CRT-type visual display unit, particularly within band II.

These objects are achieved in accordance with the invention with an arrangement of the kind set forth in Claim 1. Other characteristic features of the inven¬ tive arrangement and further developments thereof are set forth in the remaining Claims.

Thus, the invention relates to a method of reducing to a minimum the electrical alternating fields generated in the surroundings of a visual display unit, such as a picture tube, in which the display unit is provided with a voltage connected or live part, e.g. an elec- trically conductive coating, on which undesirable signal variations occur. The method comprises the steps of indicating the undesirable voltage varia¬ tions, generating a signal which is phase-reversed in relation to the indicated voltage variations, and delivering the generated phase-reversed signal to the voltage-connected or live part.

The invention will now be described in more detail with reference to the accompanying drawings, in which Figure 1 is a sectional view of a CRT-type picture tube together with a coupling circuit ac¬ cording to one embodiment of the inventive arrangement;

Figure 2 is an equivalent diagram illustrating the electrical supply circuit for the accelera¬ tion voltage in the arrangement;

Figure 3 is a block schematic of a first embodiment of the current generator illustrated in Figures 1 and 2; and

Figure 4 is a circuit diagram of a second embodiment of the current generator illustrated in Figures 1 and 2.

The picture tube illustrated in Figure l comprises a glass outer casing 1. The glass casing has a picture tube face 2 which is generally flat and rectangular in the direction facing forwards towards a viewer. The tube narrows rearwardly and terminates in a tubular part 3, referred to as the tube neck.

The inner surface of the front face 2 of the tube is coated with a layer 4 of fluorescent salts. A thin aluminium layer 5, which is both reflective and elec- trically conductive, is applied to the inner surface of the outer casing 1, inwardly of the fluorescent layer 4 at the front of the tube and directly against the casing surface on the narrowing part of the casing between the tube neck 3 and the tube front 2 and also over a short distance on the inner surface of the tube neck 3, and is connected electrically to the accelera¬ tion electrode 6 of the picture tube. An electrically conductive carbon layer 7 is applied on the outer surface of the outer casing 1, between the tube neck 3 and the tube front 2.

The neck 3 of the picture tube, or cathode-ray tube, contains an electron gun, a heating filament 8, a cathode 9 which is heated by the heating filament, an acceleration electrode 6 and control grids 10, 11, 12. Electrons can be permitted to pass through the grids in the electron gun and are accelerated by the accel¬ eration voltage applied to the acceleration electrode and the layer 5, to impinge on the fluorescent layer 5 on the front 2 of the picture tube 1. As the electrons impinge on the fluorescent salt layer 4, light is emitted from the layer.

A deflecting coil package 13 is mounted around the neck of the tube. This coil pack includes two pairs of windings and a magnetic field which is variable in two mutually opposed perpendicular directions can be generated with the aid of these windings and by con¬ trolling the windings in an appropriate manner. The electrons are deflected as they pass through this magnetic field. The point of impact of the electrons on the front face of the picture tube is controlled with the aid of the deflecting coil pack, and there¬ with also where light is generated on the front of the tube.

When the picture tube is switched-on, an acceleration voltage is applied between the aluminium layer 5 and the cathode 9. The carbon layer 7 is connected to 0V, i.e. ground potential. The acceleration voltage be¬ tween cathode and acceleration electrode is coupled to the acceleration electrode side on one side of the picture tube in a separate contact VG5, which is connected to the aluminium layer 5 and normally reach¬ es to between 12kV and 30kV, depending upon applica¬ tion. The layers 5 and 7 thereby form a capacitance Cl, which is charged to the acceleration voltage and which forms an energy reservoir.

The electrons leaving the electron gun and impinging on the fluorescent layer 7 result in the flow of electric current IB from the aluminium layer 5 to the electron gun cathode 9. This has been indicated as a current generator 14 in Figure 2. A current II is also conducted through the capacitance Cl formed between the layers 5 and 7, meaning that the current IB will take energy from the capacitance Cl and therewith discharge the same.

The technique described above is quite conventional. In normal video screen applications, the acceleration voltage is generated by the secondary winding of a

transformer Tl. This delivers energy to the capaci¬ tance Cl, normally in the form of current pulses IT at acceleration voltage. The capacitance Cl is relatively large, and thereby functions as a smoothing capacitor which holds the acceleration voltage at an approxi¬ mately constant level.

A diode D coupled in series with the transformer Tl ensures that current is able to flow in only one direction. Nevertheless, variations in the accelera¬ tion voltage to the picture tube will still occur, due to internal impedance in the transformer Tl and to load variations caused by variations in the beam current in the picture tube.

This voltage variation contributes to the generation of electrical alternating fields in front of the picture tube, particularly within band I, i.e. within the frequency range of 5Hz-2kHz. Although this can be alleviated partially by using a transformer Tl of relatively low internal impedance, it is usual, how¬ ever, to also connect an external capacitor over the acceleration voltage, i.e. in practice parallel with the capacitance Cl, so as to further smooth the accel- eration voltage.

However, there is another factor which contributes greatly to variations in the acceleration voltage. The deflection coil pack is formed along the picture tube and the coil pair seated nearest the tube obtains a capacitive coupling C2 to the aluminium layer 5 within the tube 1 on the inside of the casing. This coil pair is comprised of the so-called line deflecting coils which are operated at high voltages (a top voltage of lkV is not unusual) and at frequencies of between

15kHz and 100kHz, i.e. within band II. A current 12 will flow from these coils to the aluminium layer 5.

As a result of this contribution, the voltage varia¬ tion on the acceleration voltage becomes so pronounced as to render it impossible in practice to compensate for the variation with the aid of solely one external capacitor.

The disturbance occurring as a result of this varia¬ tion will, in turn, contribute to the electrical alternating fields in front of the picture tube within band II, i.e. within the frequency range of 2kHz- 400kHz.

In accordance with the present invention, the voltage ripple on the acceleration voltage of the picture tube is compensated for, or balanced out, by supplying a compensating alternating current 13 to the aluminium layer 5 via a coupling capacitor C3, or alternatively directly to the acceleration electrode 6. In this way, a ripple compensation voltage is superimposed on the acceleration voltage. The compensation current 13 is therewith added to the aforesaid current IB flowing between the aluminium layer 5 and the cathode 9 (or the carbon layer 7). This compensation current is adjusted so as to become equal to but phase-reversed in comparison with the disturbance currents within the frequency band II, which cause the voltage variations on the acceleration voltage. This results in a reduc¬ tion in the electrical alternating fields in front of the picture tube screen.

The compensation current 13 is generated by a voltage or current generator 15. This can have many different forms. One embodiment of a current generator is illus¬ trated in Figure 3. The acceleration voltage AV is applied over the input of a sensor unit 20. This unit may be adapted for band II, but may also be broader. The output signal from the sensor unit 20 is fed to the input of a phase inverter arrangement 21 which reverses the phase of the signal from the unit 20. The

phase inverter arrangement 21 may optionally include a plurality of parallel units, each being intended to reverse the phase of a respective frequency part in the incoming signal. The output signal from the sensor unit 20 is also delivered to a rectifier circuit 22. The output of the rectifier circuit 22 has a signal which gives the size of the ripple. The output of the phase inverter arrangement 21 is coupled to the signal input of a controllable amplifier 23 which has the current 13 on its output. The output of the rectifier circuit is coupled to the control input of the ampli¬ fier 23 so as to servo-adjust the amplifier 23 to an appropriate signal strength 13.

Figure 4 illustrates a much simpler kind of compensa¬ tion circuit. The circuit is included as a part of the picture tube control circuits, not shown. The acceler¬ ation voltage is obtained across a secondary winding 30 of a high voltage transformer Tr. The secondary winding 30 is connected between earth and the electri¬ cal contact VG5, through the intermediary of a diode Dl, so that the coating 5 and the acceleration elec¬ trode 6 will only be charged by voltage pulses which exceed the acceleration voltage and avoid discharge through the winding 30. A high-ohmic protective resis¬ tor Rl is coupled between earth and the electrical contact VG5.

Voltage variations on the acceleration voltage are not detected directly, but across a secondary winding 31 which has a much lower voltage and which can be han¬ dled readily. One end of the secondary winding 31 is connected to earth and the other end is connected to earth through a diode D2, a resistor R2, and a large capacitor C4. This coupling is a rectifying stage which generates a drive voltage +V across the capaci¬ tor C4, which functions as a smoothing capacitor. This direct current voltage +V is coupled as a drive volt¬ age source for a phase inverter stage 32.

The coupling point between the secondary winding 31 and the diode D3 is connected to the input of a phase inverter stage 32, via a resistor R3. This produces a first input signal i . The deflection coil pack 13 is also supplied from the high voltage transformer (not shown) . Consequently, a second current i is also fed from the deflection coil pack 13 to the input of the phase inverter stage 32, via a resistor R4, and is added to the current i in an appropriate proportion.

The phase inverter stage 32 includes a first NPN- transistor Tl, which is common-emitter coupled and the emitter of which is connected to earth via a capacitor C5 and a resistor R5 connected in parallel. This parallel coupling functions as a high-pass filter and the transistor Tl functions as a phase inverter. The circuit in Figure 4 does not include means for servo- controlling signal level, and instead the signal level is adjusted with a potentiometer P mounted in the branch between the base of the transistor Tl and earth by the voltage dividing coupling having the resistors R6 and R7, P coupled to the base of the transistor Tl so as to maintain the base at an appropriate working point. In practice, those disturbance voltages to be compensated for have a relatively stable size and a fixed adjustment of this kind can therefore suffice.

The collector of the transistor Tl is coupled to the input of an amplifier and buffer stage which comprises an NPN-transistor T2 and a PNP-transistor T3 with mutually coupled emitters and with their collector/ emitter paths connected in series and coupled between the drive voltage source +V and earth. The collector of the transistor Tl is connected to the base of the transistor T3 and also, via a diode D3, to the base of the transistor T2 and in series with the diode D3 to the drive voltage source +v. The output of the phase inverter stage 32 between the emitters of the transis¬ tors T2 and T3 is coupled to a node n between two

diodes D4 and D5 which are coupled in their inverse direction between earth and the drive voltage +V. The node is coupled to the electrical contact VG5 via the capacitor C3' which corresponds to the capacitor C3 in Figures 1 and 2.

Practical laboratory tests of the invention carried out with the circuit solution illustrated in Figure 4 have shown that the electrical alternating fields for band II (2-400 Khz) can be reduced to about 1/30 of the original value. It was also found that the elec¬ trical alternating fields within band I (5Hz-2kHz) were reduced at the same time, due to the presence of the coupling capacitor C3', which functions purely as a decoupling capacitor in this frequency range. Conse¬ quently, it was not necessary to use an extra decoup¬ ling capacitor.

Comparison tests have been carried out on a 15" mono- chrome monitor and the results obtained are given in the following Table. The subject measured were the high frequency alternating fields within band II immediately in front of the picture screen, at a distance of 30 cm from the screen. The values first presented in the Table are those that were obtained originally, i.e. when no measures at all were taken to reduce the electric alternating fields. The values obtained when using solely one external capacitor having the capacitance 3nF coupled between the alumin- ium layer 5 and the carbon layer 7 are presented next. The third set of values presented are those obtained when mounting a panel in front of the picture screen. In this case, the panel used was of the so-called OCLI-type, i.e. the panel was made of glass and had a conductive layer on one side thereof and had been anti-reflex treated on its other side. The values obtained when compensating in accordance with the invention are presented last.

The recommended limit value is 2.5V/m measured at a distance of 50 cm, and it will be seen from the above Table that a value well below this limit value is obtained when practicing the inventive method.

It will be understood that the invention is not re¬ stricted to this type of video display unit or to the aforedescribed materials in its coatings. The essen¬ tial feature resides in compensating for voltage variations which occur with a video display unit and which give rise to electrical alternating fields in front of said unit by measuring the voltage variation and by generating a phase inverted voltage-variation signal and feeding said signal back in order to com¬ pensate for the voltage variations and therewith reduce the electrical alternating field to a minimum.




 
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