Title:
GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS
Document Type and Number:
WIPO Patent Application WO2000044216
Kind Code:
A8
Abstract:
The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by general Formulae (I-III) wherein R1-R5 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I-III) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled cell growth and spread of abnormal cells occurs.
Inventors:
CAI SUI XIONG
ZHANG HAN-ZHONG
WANG YAN
TSENG BEN
KASIBHATLA SHAILAJA
DREWE JOHN A
ZHANG HAN-ZHONG
WANG YAN
TSENG BEN
KASIBHATLA SHAILAJA
DREWE JOHN A
Application Number:
PCT/US2000/002332
Publication Date:
November 15, 2001
Filing Date:
February 01, 2000
Export Citation:
Assignee:
CYTOVIA INC (US)
International Classes:
A61K31/352; A61K31/4025; A61K31/4178; A61K31/4188; A61K31/4433; A61K31/453; A61K31/496; A61K31/497; A61K31/5377; A61K31/5513; C07D493/20; C07D493/22; C07D519/00; (IPC1-7): A61K31/4025; A61K31/4155; A61K31/4178; A61K31/4453; A61K31/496; A61K31/5377; A61K31/55; A61P1/00; A61P17/00; A61P17/06; A61P19/02; A61P35/00; A61P37/02; C07D493/18
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