Title:
GANGLIOSIDE HAVING FLUORESCENCE-LABELLED CERAMIDE PORTION AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/1995/032211
Kind Code:
A1
Abstract:
A ganglioside having a fluorescence-labelled ceramide portion and represented by general formula (I), wherein -O-R-O- represents a sugar chain constituting a ganglioside; R' represents an ether, sulfide, amide, urethane, thiourea or amino group having a fluorescent dye; one of R5 and R6 represents a single bond and the other represents hydrogen; 1 represents an integer of 1 to 8; m represents an integer of 2 or above; and n represents an integer of 0 to 12. This derivative, having the recognition characteristics of the sugar chain portion thereof and the labelling function of the fluorescent dye introduced into the ceramide portion, is utilizable as a reagent which can trace dynamic behaviors of glycolipid receptors, a reagent for laboratory diagnosis of bacteria and viruses, and so forth.
Inventors:
IIDA TAKAO (JP)
OHIRA YUTAKA (JP)
OHIRA YUTAKA (JP)
Application Number:
PCT/JP1995/000951
Publication Date:
November 30, 1995
Filing Date:
May 18, 1995
Export Citation:
Assignee:
DAIKIN IND LTD (JP)
IIDA TAKAO (JP)
OHIRA YUTAKA (JP)
IIDA TAKAO (JP)
OHIRA YUTAKA (JP)
International Classes:
C07H15/10; C07H15/24; C08B37/00; C09K11/06; C07H15/26; (IPC1-7): C07H15/04; C07H15/18; C07H15/26
Other References:
BIOCHEMISTRY, (1992), Vol. 31, No. 6, BREWER G.J., "Congregation of Gangliosides at the Junction Between Two Model Membranes", pages 1816-1820.
BIOCHEMISTRY, (1989), Vol. 28, No. 10, SONG W., "Synthesis and Characterization of N-Parinaroyl Gangliosides GM1: Effect of Choleragen Binding on Fluorescence Anisotropy in Model Membranes", pages 4194-4200.
BIOLOGICHESKIE MEMBRANY, (1989), Vol. 6, No. 1, KOZTEB L.S., "Primenenie Fluorespentno Mechennykh Lililnykh Zonlov Dlya Analiza Svyazyvaniya Veshestva R I EGO Proizvolnykh S Repeltorami Takhikininov V Mozge Krysy", pages 34-41.
See also references of EP 0765883A4
BIOCHEMISTRY, (1989), Vol. 28, No. 10, SONG W., "Synthesis and Characterization of N-Parinaroyl Gangliosides GM1: Effect of Choleragen Binding on Fluorescence Anisotropy in Model Membranes", pages 4194-4200.
BIOLOGICHESKIE MEMBRANY, (1989), Vol. 6, No. 1, KOZTEB L.S., "Primenenie Fluorespentno Mechennykh Lililnykh Zonlov Dlya Analiza Svyazyvaniya Veshestva R I EGO Proizvolnykh S Repeltorami Takhikininov V Mozge Krysy", pages 34-41.
See also references of EP 0765883A4
Download PDF:
Previous Patent: CEPHALOSPORIN COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF
Next Patent: PROCESS FOR PRODUCING ARABINO-NUCLEOSIDES
Next Patent: PROCESS FOR PRODUCING ARABINO-NUCLEOSIDES