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Patent Searching and Data


Title:
GASTRODIN PRODUCTION PROCESS
Document Type and Number:
WIPO Patent Application WO/2016/004704
Kind Code:
A1
Abstract:
Disclosed is a gastrodin production process comprising the preparation of acetoxymethyl phenol, the preparation of pentacetyl gastrodin, and the preparation and refining of gastrodin, including: stirring hydroxybenzyl alcohol, glacial acetic acid and ethyl acetate to react to obtain a wet acetyloxymethylphenol product; stirring pentacetyl glucose, acetoxymethyl phenol and acetonitrile to react, and then stabilizing for layering; drying an organic phase via anhydrous sodium sulfate to obtain the pentacetyl gastrodin; and finally stirring the pentacetyl gastrodin and methyl alcohol to react, decolorizing, cooling for crystallizing, spin-drying and vacuum drying to obtain gastrodin. The present invention provides a stable process, and enables preparation of a gastrodin pharmaceutical agent satisfying the requirements of each index of the Chinese Pharmacopoeia.

Inventors:
WANG, Duoping (Yao Town, Zhi Tang TownChangshu, Jiangsu 0, 215500, CN)
Application Number:
CN2014/089422
Publication Date:
January 14, 2016
Filing Date:
October 24, 2014
Export Citation:
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Assignee:
JIANGSU HI-STONE PHARMACEUTICAL CO., LTD. (Yao Town, Zhi Tang TownChangshu, Jiangsu 0, 215500, CN)
International Classes:
C07H15/203; C07H1/00
Foreign References:
CN102977161A2013-03-20
CN104072549A2014-10-01
Attorney, Agent or Firm:
NANJING ZHONGSHAN INTELLESTUAL PROPERTY SERVICE CO., LTD (Xuan Wu Da Dao 699-1, Nanjing, Jiangsu 2, 210042, CN)
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