Title:
GCL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/085367
Kind Code:
A1
Abstract:
Provided is a compound having a GCL inhibitory activity. A compound represented by general formula (I) (all symbols in the formula are as defined in the description) or a salt thereof has GCL inhibitory activity, and therefore is useful for inhibiting progression, inhibiting reoccurrence, and/or treatment of GCL-related diseases such as cancer.
Inventors:
OKADA TAKUYA (JP)
UMEMURA SHUHEI (JP)
INUKAI TAKAYUKI (JP)
KAWAMATA TAKAHIRO (JP)
KASANO MIKI (JP)
UMEMURA SHUHEI (JP)
INUKAI TAKAYUKI (JP)
KAWAMATA TAKAHIRO (JP)
KASANO MIKI (JP)
Application Number:
PCT/JP2022/041944
Publication Date:
May 19, 2023
Filing Date:
November 10, 2022
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07C381/10; A61K31/198; A61P35/00
Foreign References:
| JPH02503570A | 1990-10-25 |
Other References:
CRUZ ADRIANA, MOTA PEDRO, RAMOS CRISTIANO, PIRES RITA F., MENDES CINDY, SILVA JOSÉ P., NUNES SOFIA C., BONIFÁCIO VASCO D. B., SERP: "Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance", ANTIOXIDANTS, vol. 9, no. 2, 3 February 2020 (2020-02-03), pages 133, XP093065390, DOI: 10.3390/antiox9020133
GUIJARRO LUIS G., SANMARTIN-SALINAS PATRICIA, PÉREZ-CUEVAS EVA, TOLEDO-LOBO M. VAL, MONSERRAT JORGE, ZOULLAS SOFIA, SÁEZ MIGUEL A.: "Actinomycin D Arrests Cell Cycle of Hepatocellular Carcinoma Cell Lines and Induces p53-Dependent Cell Death: A Study of the Molecular Mechanism Involved in the Protective Effect of IRS-4", PHARMACEUTICALS, vol. 14, no. 9, 25 August 2021 (2021-08-25), pages 845, XP093065392, DOI: 10.3390/ph14090845
ZHOU WEN-BO; ZHANG XIN-XIN; CAI YUN; SUN WU; LI HAO: "Osthole prevents tamoxifen-induced liver injury in mice", ACTA PHARMACOLOGICA SINICA, NATURE PUBLISHING GROUP, GB, vol. 40, no. 5, 12 October 2018 (2018-10-12), GB , pages 608 - 619, XP036769744, ISSN: 1671-4083, DOI: 10.1038/s41401-018-0171-y
GUIJARRO LUIS G., SANMARTIN-SALINAS PATRICIA, PÉREZ-CUEVAS EVA, TOLEDO-LOBO M. VAL, MONSERRAT JORGE, ZOULLAS SOFIA, SÁEZ MIGUEL A.: "Actinomycin D Arrests Cell Cycle of Hepatocellular Carcinoma Cell Lines and Induces p53-Dependent Cell Death: A Study of the Molecular Mechanism Involved in the Protective Effect of IRS-4", PHARMACEUTICALS, vol. 14, no. 9, 25 August 2021 (2021-08-25), pages 845, XP093065392, DOI: 10.3390/ph14090845
ZHOU WEN-BO; ZHANG XIN-XIN; CAI YUN; SUN WU; LI HAO: "Osthole prevents tamoxifen-induced liver injury in mice", ACTA PHARMACOLOGICA SINICA, NATURE PUBLISHING GROUP, GB, vol. 40, no. 5, 12 October 2018 (2018-10-12), GB , pages 608 - 619, XP036769744, ISSN: 1671-4083, DOI: 10.1038/s41401-018-0171-y
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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