Title:
GEL MATERIAL FOR OPHTHALMIC TREATMENT USE
Document Type and Number:
WIPO Patent Application WO/2017/119296
Kind Code:
A1
Abstract:
[Problem] To provide a gel material for ophthalmic treatment use which is useful as an artificial vitreous body, wherein the gel material is a novel intraocular tamponade material which has a low swelling pressure and an adequate elastic force, is harmless to an ophthalmic tissue, particularly retina, and can keep the tamponade effect thereof steadily for a long period.
[Solution] A gel material for ophthalmic treatment use, comprising a hydrogel in which gel precursor clusters are crosslinked to each other to form a three-dimensional network structure, said gel material being characterized in that each of the gel precursor clusters has a structure such that monomer units or polymer units at a concentration of lower than the critical gelation concentration of the monomer units or the polymer units are crosslinked to each other, and also has a relationship represented by the formula: G' < G" wherein G' represents a storage elastic modulus and G" represents a loss elastic modulus, and the hydrogel has a polymer content of 50 g/L or less and also has a storage elastic modulus G' of 1 to 10000 Pa and a fractal dimension of 1.5 to 2.5 at a frequency of 1 Hz.
Inventors:
SAKAI TAKAMASA (JP)
TEI YUICHI (JP)
OKAMOTO FUMIKI (JP)
HOSHI SUJIN (JP)
TEI YUICHI (JP)
OKAMOTO FUMIKI (JP)
HOSHI SUJIN (JP)
Application Number:
PCT/JP2016/088111
Publication Date:
July 13, 2017
Filing Date:
December 21, 2016
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV TSUKUBA (JP)
UNIV TSUKUBA (JP)
International Classes:
A61L27/14; A61K9/06; A61K47/34; C08G65/329
Domestic Patent References:
| WO2007083522A1 | 2007-07-26 | |||
| WO2015075024A1 | 2015-05-28 | |||
| WO2016143647A1 | 2016-09-15 | |||
| WO2007083522A1 | 2007-07-26 |
Foreign References:
| JP2011246712A | 2011-12-08 | |||
| JP2014167179A | 2014-09-11 | |||
| JPH05184663A | 1993-07-27 | |||
| JP2010104632A | 2010-05-13 |
Other References:
YU JING ET AL.: "In situ covalently cross-linked PEG hydrogel for ocular drug delivery applications", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 470, 2014, pages 151 - 157, XP028849341, DOI: doi:10.1016/j.ijpharm.2014.04.053
W. HESS; T. A VILGIS; H. H WINTER, MACROMOLECULES, vol. 21, 1988, pages 2536
MATSUNAGA ET AL., MACROMOLECULES, vol. 42, no. 4, 2009, pages 1344 - 1351
See also references of EP 3400972A4
W. HESS; T. A VILGIS; H. H WINTER, MACROMOLECULES, vol. 21, 1988, pages 2536
MATSUNAGA ET AL., MACROMOLECULES, vol. 42, no. 4, 2009, pages 1344 - 1351
See also references of EP 3400972A4
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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