Title:
GELATIN SPONGE CONTAINING PHOSPHATE BUFFER SOLUTION (PBS) OR PHOSPHATE BUFFER AND APPLIED TO TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2016/093412
Kind Code:
A1
Abstract:
The present invention relates to a gelatin sponge containing a phosphate buffer solution (PBS) or phosphate buffer and applied to transcatheter arterial chemoembolization, and a method for preparing the same and, more specifically, to a gelatin sponge containing a phosphate buffer solution (PBS) or phosphate buffer and applied to transcatheter arterial chemoembolization, and a method for preparing the same, wherein the method comprising: a step of immersing a gelatin sponge in a phosphate buffer solution (PBS) or phosphate buffer at 4-37°C for 3-12 hours; a step of freeze-drying the gelatin sponge, which is impregnated with the phosphate buffer solution (PBS) or phosphate buffer, at a temperature condition of -10°C to -35°C for 30 minutes to 16 hours; a step of pulverizing the freeze-dried gelatin sponge; a step of separating the pulverized gelatin sponge into sizes of 10-100 μm, 100-300 μm, 300-500 μm, and 500-700 μm, respectively, wherein, after the pulverized gelatin sponge is transferred to a hospital while being kept in disinfected vials, or in package containers in which the pulverized gelatin sponge is stored in any one of a phosphate buffer solution and a phosphate buffer, the pulverized gelatin sponge is bound to physiological saline, distilled water, and an anticancer agent, which are introduced thereto, to be used as a therapeutic agent for liver cancer.
Inventors:
SON JIU (KR)
Application Number:
PCT/KR2014/012414
Publication Date:
June 16, 2016
Filing Date:
December 16, 2014
Export Citation:
Assignee:
HJMEDICAL CO LTD (KR)
NTH MEDICAL CO LTD (KR)
NTH MEDICAL CO LTD (KR)
International Classes:
A61K47/36; A61F13/36; A61K9/16; A61M35/00; A61M37/00; A61P35/00
Foreign References:
| KR20030097620A | 2003-12-31 |
Other References:
SUN, WEI ET AL.: "Hemostatic Absorbable Gelatin Sponge Loaded with 5-fluorouracil for Treatment of Tumors", INT. J NANOMEDICINE, vol. 8, 2013, pages 1499 - 1506
BAKER, STEVEN GERALD: "In Vitro Elution of Analgesic Medications from an Absorbable Gelatin Sponge", MICHIGAN STATE UNIVERSITY, MASTER'S THESIS, 2011
BANICH, JC ET AL.: "Chemoattraction of CD 34+ Progenitor Cells and Dendritic Cells to the Site of Tumor Excision as the First Step of an Immunotherapeutic Approach to Target Residual Tumor Cells", J. IMMUNOTHER., vol. 26, no. 1, January 2003 (2003-01-01), pages 31 - 40
BAKER, STEVEN GERALD: "In Vitro Elution of Analgesic Medications from an Absorbable Gelatin Sponge", MICHIGAN STATE UNIVERSITY, MASTER'S THESIS, 2011
BANICH, JC ET AL.: "Chemoattraction of CD 34+ Progenitor Cells and Dendritic Cells to the Site of Tumor Excision as the First Step of an Immunotherapeutic Approach to Target Residual Tumor Cells", J. IMMUNOTHER., vol. 26, no. 1, January 2003 (2003-01-01), pages 31 - 40
Attorney, Agent or Firm:
CHOI, JONGHYUK (KR)
최종혁 (KR)
최종혁 (KR)
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