GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS

Title:

GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS

Document Type and Number:

WIPO Patent Application WO2004064771

Kind Code:

A3

Abstract:

The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R<1> and R<2> are each independently selected from the group consisting of: C1-6alkyl and C3-6cycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of Aß42 and are therefore useful for preventing, delaying or reversing the progression of Alzheimer s Disease.

Inventors:

MUNOZ BENITO (US)
PRASIT PETPIBOON (US)
STOCK NICHOLAS SIMON (US)

Application Number:

PCT/US2004/000424

Publication Date:

December 23, 2004

Filing Date:

January 09, 2004

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MERCK & CO INC (US)
MUNOZ BENITO (US)
PRASIT PETPIBOON (US)
STOCK NICHOLAS SIMON (US)

International Classes:

C07D207/20; C07D209/28; C07D209/46; C07D209/86; C07D257/04; C07D263/57; C07D333/22; C07D333/24; C07D337/14; C07D263/56; A61K; (IPC1-7): C07D257/04

Foreign References:

US6407253B1

2002-06-18

Other References: