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Patent Searching and Data


Title:
GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS
Document Type and Number:
WIPO Patent Application WO2004064771
Kind Code:
A3
Abstract:
The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -CO2H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R<1> and R<2> are each independently selected from the group consisting of: C1-6alkyl and C3-6cycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of Aß42 and are therefore useful for preventing, delaying or reversing the progression of Alzheimer s Disease.

Inventors:
MUNOZ BENITO (US)
PRASIT PETPIBOON (US)
STOCK NICHOLAS SIMON (US)
Application Number:
US2004000424W
Publication Date:
December 23, 2004
Filing Date:
January 09, 2004
Export Citation:
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Assignee:
MERCK & CO., INC.
MUNOZ, BENITO
PRASIT, PETPIBOON
STOCK, NICHOLAS SIMON
International Classes:
C07D207/20; C07D209/28; C07D209/46; C07D209/86; C07D257/04; C07D263/57; C07D333/22; C07D333/24; C07D337/14; C07D263/56; A61K; (IPC1-7): C07D257/04
Foreign References:
US6407253B12002-06-18
Other References:
See also references of EP 1587798A2
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